JPS55151561A - Isonicotinic acid hydrazide derivatives and their preparation - Google Patents
Isonicotinic acid hydrazide derivatives and their preparationInfo
- Publication number
- JPS55151561A JPS55151561A JP6088579A JP6088579A JPS55151561A JP S55151561 A JPS55151561 A JP S55151561A JP 6088579 A JP6088579 A JP 6088579A JP 6088579 A JP6088579 A JP 6088579A JP S55151561 A JPS55151561 A JP S55151561A
- Authority
- JP
- Japan
- Prior art keywords
- acid hydrazide
- isonicotinic acid
- substituted
- preparation
- hydrazide derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Isonicotinic acid hydrazide derivatives of the formula (R is lower dialkylamino, cyclic amino which may be substituted with hydroxyl or piperazino which may be substituted with lower alkyl).
EXAMPLE: 2-(4-Methyl-1-piperazinylsulfonyl)benzalisonicotinylhydrazone.
USE: They show high antibacterial activity against pathogenic bacteria, especially TB, thus being used as remedy for tuberculosis with low toxicity.
PREPARATION: o-Formylbenzenesulfonyl halide is made to react with a secondary amine selected from hydroxyl-substituted or unsubstituted lower dialkylamines or cyclic amines in a solvent such as chloroform at 10W30°C. Then, the product is made to react with isonicotinic acid hydrazide to give the compound of the formula.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6088579A JPS6058911B2 (en) | 1979-05-16 | 1979-05-16 | Isonicotinic acid hydrazide derivative and method for producing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6088579A JPS6058911B2 (en) | 1979-05-16 | 1979-05-16 | Isonicotinic acid hydrazide derivative and method for producing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55151561A true JPS55151561A (en) | 1980-11-26 |
JPS6058911B2 JPS6058911B2 (en) | 1985-12-23 |
Family
ID=13155264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6088579A Expired JPS6058911B2 (en) | 1979-05-16 | 1979-05-16 | Isonicotinic acid hydrazide derivative and method for producing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6058911B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2764290A1 (en) * | 1997-06-04 | 1998-12-11 | Nihon Bayer Agrochem Kk | HYDRAZIDE DERIVATIVES OF ISONICOTINIC ACID |
-
1979
- 1979-05-16 JP JP6088579A patent/JPS6058911B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2764290A1 (en) * | 1997-06-04 | 1998-12-11 | Nihon Bayer Agrochem Kk | HYDRAZIDE DERIVATIVES OF ISONICOTINIC ACID |
Also Published As
Publication number | Publication date |
---|---|
JPS6058911B2 (en) | 1985-12-23 |
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