JPS55138393A - Semisynthesis of insulin - Google Patents

Semisynthesis of insulin

Info

Publication number
JPS55138393A
JPS55138393A JP4571079A JP4571079A JPS55138393A JP S55138393 A JPS55138393 A JP S55138393A JP 4571079 A JP4571079 A JP 4571079A JP 4571079 A JP4571079 A JP 4571079A JP S55138393 A JPS55138393 A JP S55138393A
Authority
JP
Japan
Prior art keywords
insulin
enzyme
thr
des
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4571079A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5718799B2 (enExample
Inventor
Kazuyuki Morihara
Tatsu Oka
Hiroshige Tsuzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP4571079A priority Critical patent/JPS55138393A/ja
Priority to US06/138,514 priority patent/US4320196A/en
Priority to EP80101966A priority patent/EP0017938B1/en
Priority to CA000349679A priority patent/CA1145698A/en
Priority to DE8080101966T priority patent/DE3064479D1/de
Priority to DK155680A priority patent/DK146482C/da
Priority to NO801048A priority patent/NO153061C/no
Publication of JPS55138393A publication Critical patent/JPS55138393A/ja
Priority to DK545181A priority patent/DK155887C/da
Priority to US06/336,071 priority patent/US4400465A/en
Publication of JPS5718799B2 publication Critical patent/JPS5718799B2/ja
Priority to US06/500,915 priority patent/US4511505A/en
Priority to NO844636A priority patent/NO163531C/no
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/824—Achromobacter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/896—Streptomyces fradiae

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP4571079A 1979-04-13 1979-04-13 Semisynthesis of insulin Granted JPS55138393A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP4571079A JPS55138393A (en) 1979-04-13 1979-04-13 Semisynthesis of insulin
US06/138,514 US4320196A (en) 1979-04-13 1980-04-09 Semi-synthesis of human insulin
DK155680A DK146482C (da) 1979-04-13 1980-04-11 Fremgangsmaade til fremstilling af et b30-threonin-insulin
CA000349679A CA1145698A (en) 1979-04-13 1980-04-11 Semi-synthesis of insulin
DE8080101966T DE3064479D1 (en) 1979-04-13 1980-04-11 Process for preparing a b30-threonine insulin
EP80101966A EP0017938B1 (en) 1979-04-13 1980-04-11 Process for preparing a b30-threonine insulin
NO801048A NO153061C (no) 1979-04-13 1980-04-11 Fremgangsmaate for fremstilling av et b30-threonininsulin
DK545181A DK155887C (da) 1979-04-13 1981-12-09 Fremgangsmaade til fremstilling af oeb30-thr(r1)(r2)aa - insulin
US06/336,071 US4400465A (en) 1979-04-13 1981-12-31 Semi-synthesis of human insulin
US06/500,915 US4511505A (en) 1979-04-13 1983-06-03 Semi-synthesis of human insulin
NO844636A NO163531C (no) 1979-04-13 1984-11-21 Beskyttet b30-thr(r1)(r2)-insulin egnet for fremstilling av et b30-threonininsulin.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4571079A JPS55138393A (en) 1979-04-13 1979-04-13 Semisynthesis of insulin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP56175030A Division JPS57155997A (en) 1981-10-30 1981-10-30 Insulin derivative

Publications (2)

Publication Number Publication Date
JPS55138393A true JPS55138393A (en) 1980-10-29
JPS5718799B2 JPS5718799B2 (enExample) 1982-04-19

Family

ID=12726899

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4571079A Granted JPS55138393A (en) 1979-04-13 1979-04-13 Semisynthesis of insulin

Country Status (3)

Country Link
US (3) US4320196A (enExample)
JP (1) JPS55138393A (enExample)
CA (1) CA1145698A (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5836399A (ja) * 1981-08-10 1983-03-03 ノボ　ノルディスク　アクティーゼルスカブ ヒトインシユリン誘導体の製造方法
JPS58501455A (ja) * 1981-09-15 1983-09-01 ノルデイスク　インシユリンラボラトリユ−ム 人インシユリンまたはそのｂ−３０エステルの製造法
JPS58189149A (ja) * 1982-04-21 1983-11-04 アクゾ・エヌ・ヴエ− ヒトインシユリンの半合成方法
JPS58190398A (ja) * 1982-03-13 1983-11-07 ヘキスト・アクチエンゲゼルシヤフト インシユリンへのプレプロインシユリン類似体の変換法
JP2009542235A (ja) * 2006-07-11 2009-12-03 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 二塩基性ｂ鎖末端を有するインスリン類似体の生産方法

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
US5332664A (en) * 1981-07-15 1994-07-26 Celltech Limited Human calcitonin precursor polyprotein structural gene
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
US5157021A (en) * 1985-03-15 1992-10-20 Novo Nordisk A/S Insulin derivatives and pharmaceutical preparations containing these derivatives
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
AU641631B2 (en) * 1988-12-23 1993-09-30 Novo Nordisk A/S Human insulin analogues
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
US5366862A (en) * 1990-02-14 1994-11-22 Receptor Laboratories, Inc. Method for generating and screening useful peptides
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
WO1992010284A2 (en) 1990-12-07 1992-06-25 Cnc Development, Inc. Catalytic chemical reactor
JP2001521004A (ja) 1997-10-24 2001-11-06 イーライ・リリー・アンド・カンパニー 脂肪酸−アシル化インスリン類似体
CO4970787A1 (es) * 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
UA46666C2 (en) * 2001-12-29 2006-01-16 Omakooe Ltd Liability Company Method for preparing dosage form of short-term acting insulin
US20080085298A1 (en) * 2004-03-12 2008-04-10 Biodel, Inc. Rapid Mucosal Gel or Film Insulin Compositions
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US20080096800A1 (en) * 2004-03-12 2008-04-24 Biodel, Inc. Rapid mucosal gel or film insulin compositions
PL2319500T3 (pl) * 2004-03-12 2013-05-31 Biodel Inc Szybko działające kompozycje do dostarczania leku
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
US8084420B2 (en) * 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7713929B2 (en) * 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
JP2009533471A (ja) * 2006-04-12 2009-09-17 バイオデル， インコーポレイテッド 即効型および長時間作用型組合せインスリン製剤
US20090175840A1 (en) * 2008-01-04 2009-07-09 Biodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
WO2011064316A2 (en) 2009-11-25 2011-06-03 Paolo Botti Mucosal delivery of peptides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US3950517A (en) * 1970-05-08 1976-04-13 National Research Development Corporation Insulin derivatives
US3903068A (en) * 1972-12-26 1975-09-02 Us Health Education & Welfare Facile synthesis of human insulin by modification of porcine insulin
DE2460753A1 (de) * 1974-12-21 1976-06-24 Hoechst Ag Verfahren zur herstellung von humaninsulin
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5836399A (ja) * 1981-08-10 1983-03-03 ノボ　ノルディスク　アクティーゼルスカブ ヒトインシユリン誘導体の製造方法
JPS58501455A (ja) * 1981-09-15 1983-09-01 ノルデイスク　インシユリンラボラトリユ−ム 人インシユリンまたはそのｂ−３０エステルの製造法
JPS58190398A (ja) * 1982-03-13 1983-11-07 ヘキスト・アクチエンゲゼルシヤフト インシユリンへのプレプロインシユリン類似体の変換法
JPS58189149A (ja) * 1982-04-21 1983-11-04 アクゾ・エヌ・ヴエ− ヒトインシユリンの半合成方法
JPH05339290A (ja) * 1982-04-21 1993-12-21 Akzo Nv 変性ヒトインシュリン
JP2009542235A (ja) * 2006-07-11 2009-12-03 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 二塩基性ｂ鎖末端を有するインスリン類似体の生産方法

Also Published As

Publication number Publication date
US4320196A (en) 1982-03-16
US4400465A (en) 1983-08-23
CA1145698A (en) 1983-05-03
US4511505A (en) 1985-04-16
JPS5718799B2 (enExample) 1982-04-19

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