JPS55108890A - Aklavin derivative and its preparation - Google Patents

Info

Publication number

JPS55108890A

JPS55108890A JP1638179A JP1638179A JPS55108890A JP S55108890 A JPS55108890 A JP S55108890A JP 1638179 A JP1638179 A JP 1638179A JP 1638179 A JP1638179 A JP 1638179A JP S55108890 A JPS55108890 A JP S55108890A

Authority

JP

Japan

Prior art keywords

formula

compound

aklavin

preparation

aclacinomycin

Prior art date

1979-02-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• LJZPVWKMAYDYAS-QKKPTTNWSA-N aclacinomycin T Chemical class O([C@H]1C[C@]([C@@H](C2=CC=3C(=O)C4=CC=CC(O)=C4C(=O)C=3C(O)=C21)C(=O)OC)(O)CC)[C@H]1C[C@H](N(C)C)[C@H](O)[C@H](C)O1 LJZPVWKMAYDYAS-QKKPTTNWSA-N 0.000 title abstract 2
• 238000002360 preparation method Methods 0.000 title abstract 2
• PITHJRRCEANNKJ-UHFFFAOYSA-N Aclacinomycin A Natural products C12=C(O)C=3C(=O)C4=CC=CC=C4C(=O)C=3C=C2C(C(=O)OC)C(CC)(O)CC1OC(OC1C)CC(N(C)C)C1OC(OC1C)CC(O)C1OC1CCC(=O)C(C)O1 PITHJRRCEANNKJ-UHFFFAOYSA-N 0.000 abstract 2
• 239000002253 acid Substances 0.000 abstract 2
• USZYSDMBJDPRIF-SVEJIMAYSA-N aclacinomycin A Chemical compound O([C@H]1[C@@H](O)C[C@@H](O[C@H]1C)O[C@H]1[C@H](C[C@@H](O[C@H]1C)O[C@H]1C[C@]([C@@H](C2=CC=3C(=O)C4=CC=CC(O)=C4C(=O)C=3C(O)=C21)C(=O)OC)(O)CC)N(C)C)[C@H]1CCC(=O)[C@H](C)O1 USZYSDMBJDPRIF-SVEJIMAYSA-N 0.000 abstract 2
• 229960004176 aclarubicin Drugs 0.000 abstract 2
• 150000001875 compounds Chemical class 0.000 abstract 2
• -1 2-tetrahydropyranyl Chemical group 0.000 abstract 1
• BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 abstract 1
• 239000003377 acid catalyst Substances 0.000 abstract 1
• 230000002622 anti-tumorigenesis Effects 0.000 abstract 1
• 230000015572 biosynthetic process Effects 0.000 abstract 1
• 239000003795 chemical substances by application Substances 0.000 abstract 1
• 210000004748 cultured cell Anatomy 0.000 abstract 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
• 208000032839 leukemia Diseases 0.000 abstract 1
• 239000000463 material Substances 0.000 abstract 1
• 150000007523 nucleic acids Chemical class 0.000 abstract 1
• 102000039446 nucleic acids Human genes 0.000 abstract 1
• 108020004707 nucleic acids Proteins 0.000 abstract 1
• 230000035755 proliferation Effects 0.000 abstract 1
• 238000003786 synthesis reaction Methods 0.000 abstract 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1