JPS5732299A - 5-and/or 6"-deoxy derivative of 3'-deoxyamikacin and their preparation - Google Patents
5-and/or 6"-deoxy derivative of 3'-deoxyamikacin and their preparationInfo
- Publication number
- JPS5732299A JPS5732299A JP10720280A JP10720280A JPS5732299A JP S5732299 A JPS5732299 A JP S5732299A JP 10720280 A JP10720280 A JP 10720280A JP 10720280 A JP10720280 A JP 10720280A JP S5732299 A JPS5732299 A JP S5732299A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- groups
- protecting group
- amino
- protecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The compound of formula I (R1 and R2 are H or OH; provided that R1 and R2 are not OH at the same time) and its acid addition salt.
EXAMPLE: 3',6"-Dideoxyamikacin.
USE: Semi-synthesized aminoglycoside antibiotic substance.
PROCESS: The four amino groups of 3'-deoxyamikacin are protected with amino- protecting groups, the two OH groups at the 4"- and 6"-positions are together protected with one OH-protecting group, and the four OH groups at the 2', 4'-, 2"-, and 2'''- positions are protected with univalent OH-protecting groups, to obtain the compound of formula II [A is H; B is univalent amino-protecting group, etc.; the group of formula III (X and Y are H, alkyl, etc.) is bivalent OH-protecting groups, etc.; D is OH-protecting group of the form of acyl group]. The 4"- and 6"-OH- protecting group is eliminated from the compond of formula II to obtain the compound of formula IV, which is selectively converted to sulfonic acid ester at the 6"- OH, iodized, catalytically reduced to remove the halogen atom, and subjected to the elimination of the remaining OH-protecting group and the amino-protecting group to obtain one of the compounds of formula I wherein R1 is OH and R2 is H.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10720280A JPS5732299A (en) | 1980-08-06 | 1980-08-06 | 5-and/or 6"-deoxy derivative of 3'-deoxyamikacin and their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10720280A JPS5732299A (en) | 1980-08-06 | 1980-08-06 | 5-and/or 6"-deoxy derivative of 3'-deoxyamikacin and their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5732299A true JPS5732299A (en) | 1982-02-20 |
| JPS632273B2 JPS632273B2 (en) | 1988-01-18 |
Family
ID=14453062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10720280A Granted JPS5732299A (en) | 1980-08-06 | 1980-08-06 | 5-and/or 6"-deoxy derivative of 3'-deoxyamikacin and their preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5732299A (en) |
-
1980
- 1980-08-06 JP JP10720280A patent/JPS5732299A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS632273B2 (en) | 1988-01-18 |
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