JPS5495581A - Novel 2,3-dioxopiperazine derivative and its acid adduct and their preparation - Google Patents
Novel 2,3-dioxopiperazine derivative and its acid adduct and their preparationInfo
- Publication number
- JPS5495581A JPS5495581A JP16031877A JP16031877A JPS5495581A JP S5495581 A JPS5495581 A JP S5495581A JP 16031877 A JP16031877 A JP 16031877A JP 16031877 A JP16031877 A JP 16031877A JP S5495581 A JPS5495581 A JP S5495581A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- derivative
- compound
- dioxopiperazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
Abstract
NEW MATERIAL:2,3-Dioxopiperazine derivatives of formula I (R1 is H, alkyl, cycloalkyl; R2, R3 is H, alkyl, acyl or incorporate to form heterocyclic ring along with adjacent N) and their acid adducts.
EXAMPLE: 1,4-Bis(1-piperidinylmethyl)-2,3-dioxopiperazine.
USE: Carcinostatic agent with good antitumoregenic action and high toxic selectivity.
PREPARATION: The reaction of a compound of formula II or its derivative with a compound of formula III or its derivative is conducted in an inert solvent as water or THF at -20 W 100°C for 5 min - 12 hr to yield a compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16031877A JPS5495581A (en) | 1977-12-30 | 1977-12-30 | Novel 2,3-dioxopiperazine derivative and its acid adduct and their preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16031877A JPS5495581A (en) | 1977-12-30 | 1977-12-30 | Novel 2,3-dioxopiperazine derivative and its acid adduct and their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5495581A true JPS5495581A (en) | 1979-07-28 |
Family
ID=15712351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16031877A Pending JPS5495581A (en) | 1977-12-30 | 1977-12-30 | Novel 2,3-dioxopiperazine derivative and its acid adduct and their preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5495581A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6441172B1 (en) * | 1996-11-07 | 2002-08-27 | Torrey Pines Institute For Molecular Studies | Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof |
-
1977
- 1977-12-30 JP JP16031877A patent/JPS5495581A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6441172B1 (en) * | 1996-11-07 | 2002-08-27 | Torrey Pines Institute For Molecular Studies | Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof |
US6809202B2 (en) | 1996-11-07 | 2004-10-26 | Torrey Pines Institute For Molecular Studies | Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof |
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