JPS55105656A - Preparation of n,n-disubstituted-o-(2,6-dichloroanilino) phenylacetamide - Google Patents
Preparation of n,n-disubstituted-o-(2,6-dichloroanilino) phenylacetamideInfo
- Publication number
- JPS55105656A JPS55105656A JP1404079A JP1404079A JPS55105656A JP S55105656 A JPS55105656 A JP S55105656A JP 1404079 A JP1404079 A JP 1404079A JP 1404079 A JP1404079 A JP 1404079A JP S55105656 A JPS55105656 A JP S55105656A
- Authority
- JP
- Japan
- Prior art keywords
- disubstituted
- title compound
- bromophenylacetamide
- dichloroaniline
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound useful as a raw material through an easy preparation of Diclofenac, a nonsteroid analgic antiphlogistica, by reacting N,N- disubstituted-O-bromophenylacetamide derivative with 2,6-dichloroaniline in the presence of a cupric catalyst.
CONSTITUTION: An N,N-disubstituted-O-bromophenylacetamide derivative shown by the formula I (R1 and R2 are lower alkyl; R1 and R2 link together with N and/or O to form a heterocyclic ring) is reacted with 2,6-dichloroaniline in the presence of a cupric catalyst, e.g., CuBr2 [and, if necessary, an deoxidizer (e.g., an alkali metal carbonate, etc.] and a cocatalyst of NaI in a solvent, e.g., chlorobenzene at a temperature not lower than 80°C to give the title compound shown by the formula II.
EFFECT: The title compound is obtained from low-priced raw materials in extremely few steps in high yields in all processes and the procedures are simple. The compound is very safe and has a good crystallizability.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1404079A JPS55105656A (en) | 1979-02-09 | 1979-02-09 | Preparation of n,n-disubstituted-o-(2,6-dichloroanilino) phenylacetamide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1404079A JPS55105656A (en) | 1979-02-09 | 1979-02-09 | Preparation of n,n-disubstituted-o-(2,6-dichloroanilino) phenylacetamide |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55105656A true JPS55105656A (en) | 1980-08-13 |
Family
ID=11849995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1404079A Pending JPS55105656A (en) | 1979-02-09 | 1979-02-09 | Preparation of n,n-disubstituted-o-(2,6-dichloroanilino) phenylacetamide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55105656A (en) |
-
1979
- 1979-02-09 JP JP1404079A patent/JPS55105656A/en active Pending
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