JPS5481292A - Preparation of cephalosporin compound - Google Patents

Preparation of cephalosporin compound

Info

Publication number
JPS5481292A
JPS5481292A JP14971977A JP14971977A JPS5481292A JP S5481292 A JPS5481292 A JP S5481292A JP 14971977 A JP14971977 A JP 14971977A JP 14971977 A JP14971977 A JP 14971977A JP S5481292 A JPS5481292 A JP S5481292A
Authority
JP
Japan
Prior art keywords
compound
group
formula
reacted
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14971977A
Other languages
Japanese (ja)
Inventor
Susumu Tsushima
Norichika Matsumoto
Masayasu Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP14971977A priority Critical patent/JPS5481292A/en
Publication of JPS5481292A publication Critical patent/JPS5481292A/en
Pending legal-status Critical Current

Links

Landscapes

  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To obtain the title compound useful as an intermediate for synthesis of antibacterials in a high yield, by protecting the COOH group at the 4-position with an easily removable phosphorous compound in cleaving the acylamido group at the 7-position of a cephalosporin.
CONSTITUTION: One mole of a compound of formula I: (R1 is amino group which may be protected) or its salt is reacted with 2W10 moles of a compound of formula II or III: (R8 is lower alkyl or aryl group; R9 is lower alkylene group) in an inert solvent, preferably in the presence of a tertiary amine to protect the COOH group. The protected compound is then reacted with an iminohalogenating agent and a lower alkanol to form an imino ether derivative, which is hydrolyzed to afford the compound of formula IV of its salt.
COPYRIGHT: (C)1979,JPO&Japio
JP14971977A 1977-12-12 1977-12-12 Preparation of cephalosporin compound Pending JPS5481292A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14971977A JPS5481292A (en) 1977-12-12 1977-12-12 Preparation of cephalosporin compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14971977A JPS5481292A (en) 1977-12-12 1977-12-12 Preparation of cephalosporin compound

Publications (1)

Publication Number Publication Date
JPS5481292A true JPS5481292A (en) 1979-06-28

Family

ID=15481316

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14971977A Pending JPS5481292A (en) 1977-12-12 1977-12-12 Preparation of cephalosporin compound

Country Status (1)

Country Link
JP (1) JPS5481292A (en)

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