JPS5481292A - Preparation of cephalosporin compound - Google Patents
Preparation of cephalosporin compoundInfo
- Publication number
- JPS5481292A JPS5481292A JP14971977A JP14971977A JPS5481292A JP S5481292 A JPS5481292 A JP S5481292A JP 14971977 A JP14971977 A JP 14971977A JP 14971977 A JP14971977 A JP 14971977A JP S5481292 A JPS5481292 A JP S5481292A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- formula
- reacted
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
PURPOSE: To obtain the title compound useful as an intermediate for synthesis of antibacterials in a high yield, by protecting the COOH group at the 4-position with an easily removable phosphorous compound in cleaving the acylamido group at the 7-position of a cephalosporin.
CONSTITUTION: One mole of a compound of formula I: (R1 is amino group which may be protected) or its salt is reacted with 2W10 moles of a compound of formula II or III: (R8 is lower alkyl or aryl group; R9 is lower alkylene group) in an inert solvent, preferably in the presence of a tertiary amine to protect the COOH group. The protected compound is then reacted with an iminohalogenating agent and a lower alkanol to form an imino ether derivative, which is hydrolyzed to afford the compound of formula IV of its salt.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14971977A JPS5481292A (en) | 1977-12-12 | 1977-12-12 | Preparation of cephalosporin compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14971977A JPS5481292A (en) | 1977-12-12 | 1977-12-12 | Preparation of cephalosporin compound |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5481292A true JPS5481292A (en) | 1979-06-28 |
Family
ID=15481316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14971977A Pending JPS5481292A (en) | 1977-12-12 | 1977-12-12 | Preparation of cephalosporin compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5481292A (en) |
-
1977
- 1977-12-12 JP JP14971977A patent/JPS5481292A/en active Pending
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