JPS54144389A - Purification of 7-aminocephem compound - Google Patents
Purification of 7-aminocephem compoundInfo
- Publication number
- JPS54144389A JPS54144389A JP5074878A JP5074878A JPS54144389A JP S54144389 A JPS54144389 A JP S54144389A JP 5074878 A JP5074878 A JP 5074878A JP 5074878 A JP5074878 A JP 5074878A JP S54144389 A JPS54144389 A JP S54144389A
- Authority
- JP
- Japan
- Prior art keywords
- aca
- eluted
- amino
- methyl
- high purity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
PURPOSE: To prepare the title compound useful as an intermediate for the synthesis of antibiotics, in high purity, by adsorbing a crude 7-aminocephem compound containing 7-amino-cephalosporanic acid (7-ACA) with specific resin, and eluting only the impurity with aqueous solution of NaCl.
CONSTITUTION: 7-Amino-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (7-ACA-TE) is prepared by reacting 7-ACA with 1-methyl-5- mercapto-1H-tetrazole. The 7-ACA-TE thus obtained is adsorbed from an aqueous solution of pH6.5W8.5 with a nonionic resin comprising a cross-linked copolymer of styrene-divinyl benzene, an eluted with 0.2W3.0 M NaCl solution. The impurities such as 7-ACA, etc., are selectively eluted. The remaining 7-ACA-TE is eluted with a solvent such as methanol, etc. and crystallized, etc., to obtain the high purity 7-ACA-TE.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5074878A JPS6052753B2 (en) | 1978-05-01 | 1978-05-01 | Purification method of 7-aminocephem compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5074878A JPS6052753B2 (en) | 1978-05-01 | 1978-05-01 | Purification method of 7-aminocephem compound |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54144389A true JPS54144389A (en) | 1979-11-10 |
JPS6052753B2 JPS6052753B2 (en) | 1985-11-21 |
Family
ID=12867447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5074878A Expired JPS6052753B2 (en) | 1978-05-01 | 1978-05-01 | Purification method of 7-aminocephem compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6052753B2 (en) |
-
1978
- 1978-05-01 JP JP5074878A patent/JPS6052753B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS6052753B2 (en) | 1985-11-21 |
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