JPS54144389A - Purification of 7-aminocephem compound - Google Patents

Purification of 7-aminocephem compound

Info

Publication number
JPS54144389A
JPS54144389A JP5074878A JP5074878A JPS54144389A JP S54144389 A JPS54144389 A JP S54144389A JP 5074878 A JP5074878 A JP 5074878A JP 5074878 A JP5074878 A JP 5074878A JP S54144389 A JPS54144389 A JP S54144389A
Authority
JP
Japan
Prior art keywords
aca
eluted
amino
methyl
high purity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5074878A
Other languages
Japanese (ja)
Other versions
JPS6052753B2 (en
Inventor
Kazuyuki Shibuya
Hiroshi Hayashi
Hirataka Ito
Kunihiko Ishii
Tsutomu Sano
Mitsuaki Akamine
Keiichi Kadoi
Takumi Sano
Nobuhiro Tamura
Torao Ishii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP5074878A priority Critical patent/JPS6052753B2/en
Publication of JPS54144389A publication Critical patent/JPS54144389A/en
Publication of JPS6052753B2 publication Critical patent/JPS6052753B2/en
Expired legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To prepare the title compound useful as an intermediate for the synthesis of antibiotics, in high purity, by adsorbing a crude 7-aminocephem compound containing 7-amino-cephalosporanic acid (7-ACA) with specific resin, and eluting only the impurity with aqueous solution of NaCl.
CONSTITUTION: 7-Amino-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (7-ACA-TE) is prepared by reacting 7-ACA with 1-methyl-5- mercapto-1H-tetrazole. The 7-ACA-TE thus obtained is adsorbed from an aqueous solution of pH6.5W8.5 with a nonionic resin comprising a cross-linked copolymer of styrene-divinyl benzene, an eluted with 0.2W3.0 M NaCl solution. The impurities such as 7-ACA, etc., are selectively eluted. The remaining 7-ACA-TE is eluted with a solvent such as methanol, etc. and crystallized, etc., to obtain the high purity 7-ACA-TE.
COPYRIGHT: (C)1979,JPO&Japio
JP5074878A 1978-05-01 1978-05-01 Purification method of 7-aminocephem compound Expired JPS6052753B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5074878A JPS6052753B2 (en) 1978-05-01 1978-05-01 Purification method of 7-aminocephem compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5074878A JPS6052753B2 (en) 1978-05-01 1978-05-01 Purification method of 7-aminocephem compound

Publications (2)

Publication Number Publication Date
JPS54144389A true JPS54144389A (en) 1979-11-10
JPS6052753B2 JPS6052753B2 (en) 1985-11-21

Family

ID=12867447

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5074878A Expired JPS6052753B2 (en) 1978-05-01 1978-05-01 Purification method of 7-aminocephem compound

Country Status (1)

Country Link
JP (1) JPS6052753B2 (en)

Also Published As

Publication number Publication date
JPS6052753B2 (en) 1985-11-21

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