JPS57149270A - Preparation of 3,4,5,6,7,8-hexahydrocarbostyril-5-one - Google Patents
Preparation of 3,4,5,6,7,8-hexahydrocarbostyril-5-oneInfo
- Publication number
- JPS57149270A JPS57149270A JP56036298A JP3629881A JPS57149270A JP S57149270 A JPS57149270 A JP S57149270A JP 56036298 A JP56036298 A JP 56036298A JP 3629881 A JP3629881 A JP 3629881A JP S57149270 A JPS57149270 A JP S57149270A
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- aminocyclohexenone
- hexahydrocarbostyril
- absence
- acrylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KNRFNTVMEIIKEB-UHFFFAOYSA-N 1,3,4,6,7,8-hexahydroquinoline-2,5-dione Chemical compound N1C(=O)CCC2=C1CCCC2=O KNRFNTVMEIIKEB-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 3
- ZZMRPOAHZITKBV-UHFFFAOYSA-N 3-aminocyclohex-2-en-1-one Chemical compound NC1=CC(=O)CCC1 ZZMRPOAHZITKBV-UHFFFAOYSA-N 0.000 abstract 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000002876 beta blocker Substances 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
Abstract
PURPOSE: To obtain the titled compound useful as a synthetic intermediate for β-blockers, in high yield and purity by easy reaction operations, by using easily available raw materials 3-aminocyclohexenone with acrylic acid under heating.
CONSTITUTION: 3-Aminocyclohexenone of formulaIis reacted with acrylic acid in the absence of a solvent or in a suitable solvent at 100W150°C for 1W6hr under heating to give 3,4,5,6,7,8-hexahydrocarbostyril-5-one of formula II. The reaction is preferably carried out in te absence of the solvent.
EFFECT: No special reaction apparatus is required, and the aimed compound can be easily separated and purified.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56036298A JPS645025B2 (en) | 1981-03-12 | 1981-03-12 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56036298A JPS645025B2 (en) | 1981-03-12 | 1981-03-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57149270A true JPS57149270A (en) | 1982-09-14 |
| JPS645025B2 JPS645025B2 (en) | 1989-01-27 |
Family
ID=12465900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56036298A Expired JPS645025B2 (en) | 1981-03-12 | 1981-03-12 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS645025B2 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS549284A (en) * | 1977-06-22 | 1979-01-24 | Otsuka Pharmaceut Co Ltd | Quinoline derivatives and process for their preparation |
-
1981
- 1981-03-12 JP JP56036298A patent/JPS645025B2/ja not_active Expired
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS549284A (en) * | 1977-06-22 | 1979-01-24 | Otsuka Pharmaceut Co Ltd | Quinoline derivatives and process for their preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS645025B2 (en) | 1989-01-27 |
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