JPS57212142A - Purification of dihydrovitamin k derivative - Google Patents

Purification of dihydrovitamin k derivative

Info

Publication number
JPS57212142A
JPS57212142A JP56097431A JP9743181A JPS57212142A JP S57212142 A JPS57212142 A JP S57212142A JP 56097431 A JP56097431 A JP 56097431A JP 9743181 A JP9743181 A JP 9743181A JP S57212142 A JPS57212142 A JP S57212142A
Authority
JP
Japan
Prior art keywords
alcohol solution
dihydrovitamin
vitamin
acetate
synthetic resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56097431A
Other languages
Japanese (ja)
Other versions
JPH0148253B2 (en
Inventor
Hitoshi Toyoda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Nisshin Chemical Co Ltd
Original Assignee
Nisshin Seifun Group Inc
Nisshin Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc, Nisshin Chemical Co Ltd filed Critical Nisshin Seifun Group Inc
Priority to JP56097431A priority Critical patent/JPS57212142A/en
Publication of JPS57212142A publication Critical patent/JPS57212142A/en
Publication of JPH0148253B2 publication Critical patent/JPH0148253B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as an intermediate for vitamin K in high purity in high yield without causing side reactions, by treating an alcohol solution or water-containing alcohol solution of dihydovitamin K acetate with a nonpolar porous synthetic resin column.
CONSTITUTION: An alcohol solution or water-containing alcohol solution of dihydrovitamin K acetate obtained from isoprenyl alcohol and menadiol acylated compound is passed through a nonpolar porous synthetic resin (e.g., styrene- divinylbenzene copolymer, etc.) column, to give dihydrovitamin K acetate having enough purity to prepare vitamin K. If necessary, it is further purified, saponified with an alcoholic caustic alkali, and oxidized so that it is converted into vitamin K.
COPYRIGHT: (C)1982,JPO&Japio
JP56097431A 1981-06-25 1981-06-25 Purification of dihydrovitamin k derivative Granted JPS57212142A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56097431A JPS57212142A (en) 1981-06-25 1981-06-25 Purification of dihydrovitamin k derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56097431A JPS57212142A (en) 1981-06-25 1981-06-25 Purification of dihydrovitamin k derivative

Publications (2)

Publication Number Publication Date
JPS57212142A true JPS57212142A (en) 1982-12-27
JPH0148253B2 JPH0148253B2 (en) 1989-10-18

Family

ID=14192199

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56097431A Granted JPS57212142A (en) 1981-06-25 1981-06-25 Purification of dihydrovitamin k derivative

Country Status (1)

Country Link
JP (1) JPS57212142A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744624A (en) * 1995-12-20 1998-04-28 Roche Vitamins Inc. Method of making vitamin K1

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5315305A (en) * 1976-04-30 1978-02-13 Hoffmann La Roche Transsphytol * its derivatives and vitamin k

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5315305A (en) * 1976-04-30 1978-02-13 Hoffmann La Roche Transsphytol * its derivatives and vitamin k

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744624A (en) * 1995-12-20 1998-04-28 Roche Vitamins Inc. Method of making vitamin K1

Also Published As

Publication number Publication date
JPH0148253B2 (en) 1989-10-18

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