JPS54132593A - Novel oosubstituted oxime derivatives of 77aminothiazolylacetoamidecephalosporanic acid*their manufacture*their use as drug and composition containing them - Google Patents

Novel oosubstituted oxime derivatives of 77aminothiazolylacetoamidecephalosporanic acid*their manufacture*their use as drug and composition containing them

Info

Publication number
JPS54132593A
JPS54132593A JP3717479A JP3717479A JPS54132593A JP S54132593 A JPS54132593 A JP S54132593A JP 3717479 A JP3717479 A JP 3717479A JP 3717479 A JP3717479 A JP 3717479A JP S54132593 A JPS54132593 A JP S54132593A
Authority
JP
Japan
Prior art keywords
oosubstituted
drug
novel
manufacture
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3717479A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0314039B2 (it
Inventor
Eemu Rune
Biniyo Mishieru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of JPS54132593A publication Critical patent/JPS54132593A/ja
Publication of JPH0314039B2 publication Critical patent/JPH0314039B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP3717479A 1978-03-31 1979-03-30 Novel oosubstituted oxime derivatives of 77aminothiazolylacetoamidecephalosporanic acid*their manufacture*their use as drug and composition containing them Granted JPS54132593A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR7809617A FR2432521A1 (fr) 1978-03-31 1978-03-31 Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR7824563A FR2438050A2 (fr) 1978-03-31 1978-08-24 Nouvelles oximes o-substituees derivees de l'acide 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR7901611A FR2447380A2 (fr) 1978-03-31 1979-01-23 Nouvelles oximes o-substituees derivees de l'acide 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR8001300A FR2474034A2 (fr) 1978-03-31 1980-01-22 Nouvelles oximes 0-substituees derivees de l'acide 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP1250789A Division JPH02138283A (ja) 1978-03-31 1989-09-28 ７‐アミノチアゾリルアセトアミドセファロスポラン酸の新規な０‐置換オキシム誘導体

Publications (2)

Publication Number Publication Date
JPS54132593A true JPS54132593A (en) 1979-10-15
JPH0314039B2 JPH0314039B2 (it) 1991-02-25

Family

ID=27446376

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3717479A Granted JPS54132593A (en) 1978-03-31 1979-03-30 Novel oosubstituted oxime derivatives of 77aminothiazolylacetoamidecephalosporanic acid*their manufacture*their use as drug and composition containing them

Country Status (9)

Country Link
JP (1) JPS54132593A (it)
AT (1) AT367423B (it)
AU (1) AU526990B2 (it)
BE (1) BE875217A (it)
DE (1) DE2912829A1 (it)
FR (4) FR2432521A1 (it)
GB (2) GB2101117B (it)
LU (1) LU81104A1 (it)
NL (1) NL7902555A (it)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5535096A (en) * 1978-09-04 1980-03-11 Fujisawa Pharmaceut Co Ltd 3-cephem compound, its salt, their preparation, and preventive and remedy for microbism comprising thema active constituent
JPS5547690A (en) * 1978-09-11 1980-04-04 Fujisawa Pharmaceut Co Ltd Cephem compound, its salt, their preparation, and preventives and remedies for microbism comprising them as active constituents
JPS5585594A (en) * 1978-11-13 1980-06-27 Fujisawa Pharmaceut Co Ltd Cephem compound and their preparation
JPS56142287A (en) * 1980-03-13 1981-11-06 Squibb & Sons Inc Hydroxamic acid derivatives of aminothiazolyl-oxyiminoacetylaminocephalosporins
JPS59184186A (ja) * 1983-04-01 1984-10-19 Meiji Seika Kaisha Ltd 新規セフエム化合物
US4603198A (en) * 1982-04-06 1986-07-29 Daiichi Seiyaku Co., Ltd. Cephalosporin derivatives
JPS6236385A (ja) * 1985-08-05 1987-02-17 Fujisawa Pharmaceut Co Ltd ３，７−ジ置換−３−セフエム化合物およびその製造法
JPS6263578A (ja) * 1978-07-31 1987-03-20 Fujisawa Pharmaceut Co Ltd アミノチアゾリル酢酸誘導体
JPS63152371A (ja) * 1979-11-19 1988-06-24 Fujisawa Pharmaceut Co Ltd アミノチアゾール誘導体

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409217A (en) 1977-03-14 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
EP0059486B1 (en) * 1978-07-17 1985-10-02 Fujisawa Pharmaceutical Co., Ltd. New starting compounds for preparing cephem compounds and processes for their preparation
DE2945248A1 (de) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co Cephem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende antibakterielle pharmazeutische mittel
IL61458A0 (en) * 1979-12-07 1980-12-31 Erba Farmitalia N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them
JPS5849382A (ja) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
GB8413152D0 (en) 1983-06-03 1984-06-27 Ici Pharma Cephalosporin derivatives
US4690921A (en) * 1983-10-11 1987-09-01 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin compounds and salts thereof
EP0148007A3 (en) * 1983-12-26 1986-04-02 Yamanouchi Pharmaceutical Co. Ltd. Cephalosporin compounds and medicaments and their production
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo, Jp Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
EP0182633A3 (en) * 1984-11-20 1987-09-02 Ici Pharma Cephalosporin derivatives
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
GB8623211D0 (en) * 1986-09-26 1986-10-29 Glaxo Group Ltd Chemical compounds
IL83993A0 (en) * 1986-09-26 1988-02-29 Glaxo Group Ltd Cephalosporins,their preparation and pharmaceutical compositions containing them
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
AU617377B2 (en) * 1987-11-10 1991-11-28 Pharmacia & Upjohn Company Cephalosporin antibiotics
US5223496A (en) * 1987-11-10 1993-06-29 The Upjohn Company Cephalosporin antibiotics
DE3911322A1 (de) * 1989-04-07 1990-10-11 Hoechst Ag Verfahren zur herstellung von cefodizim-dinatrium

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51149296A (en) * 1975-06-09 1976-12-22 Takeda Chem Ind Ltd Cephems or penams and their preparation
JPS52125190A (en) * 1976-04-12 1977-10-20 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acids, their salts and their preparation
JPS53130691A (en) * 1977-04-15 1978-11-14 Hoechst Ag Cephem derivative and process for preparing same
JPS53137988A (en) * 1977-03-14 1978-12-01 Fujisawa Pharmaceut Co Ltd Cephem and cepham compounds and process for their preparation
JPS549296A (en) * 1977-04-02 1979-01-24 Hoechst Ag Cephem derivative and its preparation
JPS5430194A (en) * 1977-08-06 1979-03-06 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE440655B (sv) * 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra
DK162391C (da) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
GB1592149A (en) * 1976-10-08 1981-07-01 Fujisawa Pharmaceutical Co 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof
DE2753220A1 (de) * 1976-11-30 1978-06-01 Glaxo Lab Ltd Neue cephalosporinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
JPS53101393A (en) * 1977-02-17 1978-09-04 Takeda Chem Ind Ltd Cephalosporin derivatives and process for their preparation
FR2384779A1 (fr) * 1977-03-25 1978-10-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-chloro ou 3-methoxy 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
NL7805715A (nl) * 1977-06-03 1978-12-05 Hoffmann La Roche Werkwijze voor het bereiden van acylderivaten.
US4284631A (en) * 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
US4313945A (en) * 1978-11-23 1982-02-02 Ciba-Geigy Corporation 7-Thiazolyl-acetamido-cephem derivatives with terminal aminocarboxylic acid grouping

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51149296A (en) * 1975-06-09 1976-12-22 Takeda Chem Ind Ltd Cephems or penams and their preparation
JPS52125190A (en) * 1976-04-12 1977-10-20 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acids, their salts and their preparation
JPS53137988A (en) * 1977-03-14 1978-12-01 Fujisawa Pharmaceut Co Ltd Cephem and cepham compounds and process for their preparation
JPS549296A (en) * 1977-04-02 1979-01-24 Hoechst Ag Cephem derivative and its preparation
JPS53130691A (en) * 1977-04-15 1978-11-14 Hoechst Ag Cephem derivative and process for preparing same
JPS5430194A (en) * 1977-08-06 1979-03-06 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0333154B2 (it) * 1978-07-31 1991-05-16 Fujisawa Pharmaceutical Co
JPS6263578A (ja) * 1978-07-31 1987-03-20 Fujisawa Pharmaceut Co Ltd アミノチアゾリル酢酸誘導体
JPS5535096A (en) * 1978-09-04 1980-03-11 Fujisawa Pharmaceut Co Ltd 3-cephem compound, its salt, their preparation, and preventive and remedy for microbism comprising thema active constituent
JPH0240678B2 (it) * 1978-09-04 1990-09-12 Fujisawa Pharmaceutical Co
JPS5547690A (en) * 1978-09-11 1980-04-04 Fujisawa Pharmaceut Co Ltd Cephem compound, its salt, their preparation, and preventives and remedies for microbism comprising them as active constituents
JPS62289584A (ja) * 1978-09-11 1987-12-16 Fujisawa Pharmaceut Co Ltd セフエム化合物およびその塩類
JPH0144716B2 (it) * 1978-09-11 1989-09-29 Fujisawa Pharmaceutical Co
JPH0144713B2 (it) * 1978-11-13 1989-09-29 Fujisawa Pharmaceutical Co
JPS5585594A (en) * 1978-11-13 1980-06-27 Fujisawa Pharmaceut Co Ltd Cephem compound and their preparation
JPH0219828B2 (it) * 1979-11-19 1990-05-07 Fujisawa Pharmaceutical Co
JPS63152371A (ja) * 1979-11-19 1988-06-24 Fujisawa Pharmaceut Co Ltd アミノチアゾール誘導体
JPS56142287A (en) * 1980-03-13 1981-11-06 Squibb & Sons Inc Hydroxamic acid derivatives of aminothiazolyl-oxyiminoacetylaminocephalosporins
US4603198A (en) * 1982-04-06 1986-07-29 Daiichi Seiyaku Co., Ltd. Cephalosporin derivatives
JPS59184186A (ja) * 1983-04-01 1984-10-19 Meiji Seika Kaisha Ltd 新規セフエム化合物
JPS6236385A (ja) * 1985-08-05 1987-02-17 Fujisawa Pharmaceut Co Ltd ３，７−ジ置換−３−セフエム化合物およびその製造法

Also Published As

Publication number Publication date
FR2474034B2 (it) 1982-01-29
JPH0314039B2 (it) 1991-02-25
FR2438050A2 (fr) 1980-04-30
DE2912829A1 (de) 1979-10-04
ATA240379A (de) 1981-11-15
GB2101117A (en) 1983-01-12
FR2447380B2 (it) 1981-10-09
LU81104A1 (fr) 1979-10-30
FR2438050B2 (it) 1983-04-15
FR2432521B1 (it) 1981-12-04
BE875217A (fr) 1979-10-01
FR2447380A2 (fr) 1980-08-22
FR2432521A1 (fr) 1980-02-29
GB2017702B (en) 1983-02-02
AU4566679A (en) 1979-10-18
AT367423B (de) 1982-07-12
GB2017702A (en) 1979-10-10
FR2474034A2 (fr) 1981-07-24
AU526990B2 (en) 1983-02-10
NL7902555A (nl) 1979-10-02
GB2101117B (en) 1983-06-02

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