GB2017702A - O-substituted oxime derivatives of 7-[[2-(2-amino-thiazol-4-yl)-2- hydroxyimino-acetyl]-amino]-ceph- 3-em-4-carboxylic acid - Google Patents
O-substituted oxime derivatives of 7-[[2-(2-amino-thiazol-4-yl)-2- hydroxyimino-acetyl]-amino]-ceph- 3-em-4-carboxylic acidInfo
- Publication number
- GB2017702A GB2017702A GB7911275A GB7911275A GB2017702A GB 2017702 A GB2017702 A GB 2017702A GB 7911275 A GB7911275 A GB 7911275A GB 7911275 A GB7911275 A GB 7911275A GB 2017702 A GB2017702 A GB 2017702A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- alkyl
- amino
- hydrogen atom
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
New cephalosporin derivatives which are useful as antibiotics and as disinfectants are derivatives of the general formula: <IMAGE> (wherein: B represents a radical <IMAGE> in which X represents a sulphur or oxygen atom and R' represents an alkyl, alkoxy, or phenyl radical or a radical -(CH2)n-NR2R3 in which n represents 0 or an integer from 1 to 4 and R2 and R3 each represent a hydrogen atom or an alkyl radical or together with the adjacent N atom form a piperidino, morpholino or phthalimido group; or B represents a radical -CHR4CO2A', in which A' represents a hydrogen atom, a salt- forming group or an ester-forming group and R4 represents a phenyl, hydroxyethyl or nitrile radical; or B represents a gamma -lactone radical; or B represents a radical -(CH2)n'-R5c in which n' represents an integer of from 1 to 4 and R5c represents an alkoxy radical, an alkylthio radical, an alkylsulphinyl radical, an alkylsulphonyl radical, a radical NR6R7 [in which R6 and R7 each represent a hydrogen atom or an alkyl radical or together with the adjacent N atom form a phthalimido or 1-pyridinio group], a cyano radical, a carbamoyl or thiocarbamoyl radical, a 4-methyl- or 4-amino-1,3-thiazol-2-yl radical, a 1,2,3,4-tetrazol-5-yl radical, an azido radical, an acyl radical having from 2 to 4 carbon atoms, a halogen atom, a phenylthio radical, an optionally- substituted heterocyclylthio radical, or an imidazolyl, morpholinyl or N-alkyl- piperazinyl radical; R1 represents a chloro or methoxy radical, an alkyl, cycloalkyl or alkylthio radical, a radical -CH2-S-R12 [in which R12 represents an optionally-substituted heterocyclic radical containing nitrogen, an acyl radical, the 2-oxo- [3H]-thiazolin-4-yl-carbonyl radical or the 3-methyl-1,2-oxazol-5-yl-carbonyl radical], an acetoxymethyl or carbamoyloxymethyl radical or an alkylcarbonylamino radical; and A represents a hydrogen atom, a salt- forming group or an easily-cleavable ester-forming group) and their acid addition salts.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IE85279A IE49867B1 (en) | 1978-03-31 | 1979-08-08 | O-substituted oxime derivatives of 7-((2-(2-aminothiazol-4-yl)-2-hydroxyimino-acetyl)-amino)-ceph-3-em-4-carboxylic acid |
IE24385A IE49868B1 (en) | 1978-03-31 | 1979-08-08 | New o-substituted oxime derivatives of 2-amino-thiazol-4-yl-2-hydroxyimino acetic acid |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7809617A FR2432521A1 (en) | 1978-03-31 | 1978-03-31 | NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS |
FR7824563A FR2438050A2 (en) | 1978-03-31 | 1978-08-24 | NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS |
FR7901611A FR2447380A2 (en) | 1978-03-31 | 1979-01-23 | NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS |
FR8001300A FR2474034A2 (en) | 1978-03-31 | 1980-01-22 | NOVEL 0-SUBSTITUTED OXIMES DERIVED FROM 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2017702A true GB2017702A (en) | 1979-10-10 |
GB2017702B GB2017702B (en) | 1983-02-02 |
Family
ID=27446376
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7911275A Expired GB2017702B (en) | 1978-03-31 | 1979-03-30 | O-substituted oxime derivatives of 7-((2-(2-aminothiazol 4-yl)-2-hydroxyiminoacetyl)-amino)-ceph-3-em-4-carboxylic acid |
GB08134540A Expired GB2101117B (en) | 1978-03-31 | 1979-03-30 | New o-substituted oxime derivatives of 2-amino-thiazol-4-yl-2-hydroxyimino acetic acid |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB08134540A Expired GB2101117B (en) | 1978-03-31 | 1979-03-30 | New o-substituted oxime derivatives of 2-amino-thiazol-4-yl-2-hydroxyimino acetic acid |
Country Status (9)
Country | Link |
---|---|
JP (1) | JPS54132593A (en) |
AT (1) | AT367423B (en) |
AU (1) | AU526990B2 (en) |
BE (1) | BE875217A (en) |
DE (1) | DE2912829A1 (en) |
FR (4) | FR2432521A1 (en) |
GB (2) | GB2017702B (en) |
LU (1) | LU81104A1 (en) |
NL (1) | NL7902555A (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0007633A2 (en) * | 1978-07-31 | 1980-02-06 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds, processes for their preparation and pharmaceutical compositions containing them |
EP0009548A2 (en) * | 1978-07-17 | 1980-04-16 | Fujisawa Pharmaceutical Co., Ltd. | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them |
EP0075805A1 (en) * | 1981-09-18 | 1983-04-06 | Kyowa Hakko Kogyo Co., Ltd | Beta-lactam compound and a pharmaceutical composition containing the same |
EP0127992A2 (en) | 1983-06-03 | 1984-12-12 | Ici Pharma | Cephalosporin derivatives |
EP0142274A2 (en) * | 1983-10-11 | 1985-05-22 | Yamanouchi Pharmaceutical Co. Ltd. | Cephalosporin compounds and salts thereof, their production, and medicaments containing them |
EP0148007A2 (en) * | 1983-12-26 | 1985-07-10 | Yamanouchi Pharmaceutical Co. Ltd. | Cephalosporin compounds and medicaments and their production |
FR2604437A1 (en) * | 1986-09-26 | 1988-04-01 | Glaxo Group Ltd | NOVEL COMPOUNDS OF THE TYPE OF CEPHALOSPORINS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. |
EP0266060A2 (en) * | 1986-09-26 | 1988-05-04 | Glaxo Group Limited | Cephalosporins, process for their preparation and pharmaceutical compositions containing them |
WO1989004313A1 (en) * | 1987-11-10 | 1989-05-18 | The Upjohn Company | Cephalosporin antibiotics |
US4840945A (en) * | 1985-04-01 | 1989-06-20 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
US4866055A (en) * | 1986-11-25 | 1989-09-12 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives and their crystalline derivatives |
US4868173A (en) * | 1984-11-20 | 1989-09-19 | Ici Pharma | Cephalosporin derivatives |
US4880798A (en) * | 1986-11-25 | 1989-11-14 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
US4888332A (en) * | 1983-12-29 | 1989-12-19 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
US5064953A (en) * | 1983-12-29 | 1991-11-12 | Mochida Pharmaceutical Co., Ltd. | Intermediates cephalosporin derivatives |
US5223496A (en) * | 1987-11-10 | 1993-06-29 | The Upjohn Company | Cephalosporin antibiotics |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE878514A (en) * | 1978-09-04 | 1980-02-29 | Fujisawa Pharmaceutical Co | PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY |
US4409217A (en) | 1977-03-14 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
BE878637A (en) * | 1978-09-11 | 1980-03-06 | Fujisawa Pharmaceutical Co | PROCESS FOR THE PREPARATION OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIMICROBIAL ACTIVITIES |
JPS5585594A (en) * | 1978-11-13 | 1980-06-27 | Fujisawa Pharmaceut Co Ltd | Cephem compound and their preparation |
DE2945248A1 (en) * | 1978-11-13 | 1980-05-22 | Fujisawa Pharmaceutical Co | CEPHEM COMPOUNDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL PHARMACEUTICAL AGENTS CONTAINING THE SAME |
ZA806977B (en) * | 1979-11-19 | 1981-10-28 | Fujisawa Pharmaceutical Co | 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
IL61458A0 (en) * | 1979-12-07 | 1980-12-31 | Erba Farmitalia | N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them |
US4252802A (en) * | 1980-03-13 | 1981-02-24 | E. R. Squibb & Sons, Inc. | Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins |
PH19163A (en) * | 1982-04-06 | 1986-01-16 | Daiichi Seiyaku Co | Cephalosporin derivatives |
JPS59184186A (en) * | 1983-04-01 | 1984-10-19 | Meiji Seika Kaisha Ltd | Novel cephem compound |
GB8519606D0 (en) * | 1985-08-05 | 1985-09-11 | Fujisawa Pharmaceutical Co | 3 7-d substituted-3-cephem compounds |
DE3911322A1 (en) * | 1989-04-07 | 1990-10-11 | Hoechst Ag | METHOD FOR PRODUCING CEFODIZIM DINATRIUM |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1536281A (en) * | 1975-06-09 | 1978-12-20 | Takeda Chemical Industries Ltd | Cephem compounds |
SE440655B (en) * | 1976-01-23 | 1985-08-12 | Roussel Uclaf | SET TO MAKE NEW OXIME DERIVATIVES OF 7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID |
GB1576625A (en) * | 1976-04-12 | 1980-10-08 | Fujisawa Pharmaceutical Co | Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof |
DK162391C (en) * | 1976-04-12 | 1992-03-09 | Fujisawa Pharmaceutical Co | ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS |
GB1592149A (en) * | 1976-10-08 | 1981-07-01 | Fujisawa Pharmaceutical Co | 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof |
NL7713136A (en) * | 1976-11-30 | 1978-06-01 | Glaxo Lab Ltd | PROCESS FOR PREPARING CEPHALOSPORIN COMPOUNDS. |
JPS53101393A (en) * | 1977-02-17 | 1978-09-04 | Takeda Chem Ind Ltd | Cephalosporin derivatives and process for their preparation |
PH17188A (en) * | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
FR2384779A1 (en) * | 1977-03-25 | 1978-10-20 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-CHLORO OR 3-METHOXY 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
SE439312B (en) * | 1977-03-25 | 1985-06-10 | Roussel Uclaf | SET TO MAKE NEW OXIME DERIVATIVES OF 3-ACETOXIMETHYL-7-AMINOTIAZOLYLACETAMIDO CEPHALOSPORANIC ACID |
DE2714880A1 (en) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
DE2716677C2 (en) * | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephem derivatives and processes for their preparation |
GB1599232A (en) * | 1977-06-03 | 1981-09-30 | Hoffmann La Roche | 7-(2-oximinoacetamido)-cephalosporin derivatives |
JPS609719B2 (en) * | 1977-08-06 | 1985-03-12 | 武田薬品工業株式会社 | Cephalosporin derivatives and their production method |
US4284631A (en) * | 1978-07-31 | 1981-08-18 | Fujisawa Pharmaceutical Co., Ltd. | 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them |
US4313945A (en) * | 1978-11-23 | 1982-02-02 | Ciba-Geigy Corporation | 7-Thiazolyl-acetamido-cephem derivatives with terminal aminocarboxylic acid grouping |
-
1978
- 1978-03-31 FR FR7809617A patent/FR2432521A1/en active Granted
- 1978-08-24 FR FR7824563A patent/FR2438050A2/en active Granted
-
1979
- 1979-01-23 FR FR7901611A patent/FR2447380A2/en active Granted
- 1979-03-30 JP JP3717479A patent/JPS54132593A/en active Granted
- 1979-03-30 AT AT0240379A patent/AT367423B/en not_active IP Right Cessation
- 1979-03-30 GB GB7911275A patent/GB2017702B/en not_active Expired
- 1979-03-30 AU AU45666/79A patent/AU526990B2/en not_active Ceased
- 1979-03-30 BE BE0/194319A patent/BE875217A/en not_active IP Right Cessation
- 1979-03-30 LU LU81104A patent/LU81104A1/en unknown
- 1979-03-30 GB GB08134540A patent/GB2101117B/en not_active Expired
- 1979-03-30 DE DE19792912829 patent/DE2912829A1/en not_active Withdrawn
- 1979-04-02 NL NL7902555A patent/NL7902555A/en not_active Application Discontinuation
-
1980
- 1980-01-22 FR FR8001300A patent/FR2474034A2/en active Granted
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0009548A3 (en) * | 1978-07-17 | 1980-06-25 | Fujisawa Pharmaceutical Co. Ltd. | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them, and their starting derivatives and their preparation |
EP0009548A2 (en) * | 1978-07-17 | 1980-04-16 | Fujisawa Pharmaceutical Co., Ltd. | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them |
EP0059486A1 (en) * | 1978-07-17 | 1982-09-08 | Fujisawa Pharmaceutical Co., Ltd. | New starting compounds for preparing cephem compounds and processes for their preparation |
EP0007633A2 (en) * | 1978-07-31 | 1980-02-06 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds, processes for their preparation and pharmaceutical compositions containing them |
EP0049539A1 (en) * | 1978-07-31 | 1982-04-14 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives for preparing cephem compounds and processes for their preparation |
EP0007633A3 (en) * | 1978-07-31 | 1980-06-25 | Fujisawa Pharmaceutical Co. Ltd. | Cephem compounds, processes for their preparation, pharmaceutical compositions containing them, their starting derivatives and their preparation |
EP0075805A1 (en) * | 1981-09-18 | 1983-04-06 | Kyowa Hakko Kogyo Co., Ltd | Beta-lactam compound and a pharmaceutical composition containing the same |
EP0127992A2 (en) | 1983-06-03 | 1984-12-12 | Ici Pharma | Cephalosporin derivatives |
EP0142274A2 (en) * | 1983-10-11 | 1985-05-22 | Yamanouchi Pharmaceutical Co. Ltd. | Cephalosporin compounds and salts thereof, their production, and medicaments containing them |
EP0142274A3 (en) * | 1983-10-11 | 1986-08-27 | Yamanouchi Pharmaceutical Co. Ltd. | Cephalosporin compounds and salts thereof, their production, and medicaments containing them |
EP0148007A3 (en) * | 1983-12-26 | 1986-04-02 | Yamanouchi Pharmaceutical Co. Ltd. | Cephalosporin compounds and medicaments and their production |
EP0148007A2 (en) * | 1983-12-26 | 1985-07-10 | Yamanouchi Pharmaceutical Co. Ltd. | Cephalosporin compounds and medicaments and their production |
US4888332A (en) * | 1983-12-29 | 1989-12-19 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
US5064953A (en) * | 1983-12-29 | 1991-11-12 | Mochida Pharmaceutical Co., Ltd. | Intermediates cephalosporin derivatives |
US4868173A (en) * | 1984-11-20 | 1989-09-19 | Ici Pharma | Cephalosporin derivatives |
US4956474A (en) * | 1985-04-01 | 1990-09-11 | Mochida Pharmaceutical Co., Ltd. | Intermediates of cephalosporin compounds |
US4840945A (en) * | 1985-04-01 | 1989-06-20 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
US4904791A (en) * | 1985-04-01 | 1990-02-27 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
FR2604437A1 (en) * | 1986-09-26 | 1988-04-01 | Glaxo Group Ltd | NOVEL COMPOUNDS OF THE TYPE OF CEPHALOSPORINS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. |
EP0266060A3 (en) * | 1986-09-26 | 1989-11-08 | Glaxo Group Limited | Cephalosporins, process for their preparation and pharmaceutical compositions containing them |
BE1002248A5 (en) * | 1986-09-26 | 1990-11-06 | Glaxo Group Ltd | NOVEL CEPHALOSPORINS WITH ANTIBIOTIC ACTIVITY. |
EP0266060A2 (en) * | 1986-09-26 | 1988-05-04 | Glaxo Group Limited | Cephalosporins, process for their preparation and pharmaceutical compositions containing them |
US4880798A (en) * | 1986-11-25 | 1989-11-14 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
US4866055A (en) * | 1986-11-25 | 1989-09-12 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives and their crystalline derivatives |
WO1989004313A1 (en) * | 1987-11-10 | 1989-05-18 | The Upjohn Company | Cephalosporin antibiotics |
US5223496A (en) * | 1987-11-10 | 1993-06-29 | The Upjohn Company | Cephalosporin antibiotics |
Also Published As
Publication number | Publication date |
---|---|
FR2432521B1 (en) | 1981-12-04 |
GB2101117A (en) | 1983-01-12 |
AU4566679A (en) | 1979-10-18 |
JPS54132593A (en) | 1979-10-15 |
AT367423B (en) | 1982-07-12 |
AU526990B2 (en) | 1983-02-10 |
FR2474034B2 (en) | 1982-01-29 |
JPH0314039B2 (en) | 1991-02-25 |
ATA240379A (en) | 1981-11-15 |
NL7902555A (en) | 1979-10-02 |
FR2438050B2 (en) | 1983-04-15 |
FR2432521A1 (en) | 1980-02-29 |
FR2438050A2 (en) | 1980-04-30 |
FR2447380B2 (en) | 1981-10-09 |
FR2447380A2 (en) | 1980-08-22 |
DE2912829A1 (en) | 1979-10-04 |
GB2101117B (en) | 1983-06-02 |
FR2474034A2 (en) | 1981-07-24 |
BE875217A (en) | 1979-10-01 |
LU81104A1 (en) | 1979-10-30 |
GB2017702B (en) | 1983-02-02 |
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