BE1002248A5 - NOVEL CEPHALOSPORINS WITH ANTIBIOTIC ACTIVITY. - Google Patents

NOVEL CEPHALOSPORINS WITH ANTIBIOTIC ACTIVITY. Download PDF

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Publication number
BE1002248A5
BE1002248A5 BE8701088A BE8701088A BE1002248A5 BE 1002248 A5 BE1002248 A5 BE 1002248A5 BE 8701088 A BE8701088 A BE 8701088A BE 8701088 A BE8701088 A BE 8701088A BE 1002248 A5 BE1002248 A5 BE 1002248A5
Authority
BE
Belgium
Prior art keywords
represent
antibiotic activity
ceph
compounds
formula
Prior art date
Application number
BE8701088A
Other languages
French (fr)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868623212A external-priority patent/GB8623212D0/en
Priority claimed from GB878705986A external-priority patent/GB8705986D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of BE1002248A5 publication Critical patent/BE1002248A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/60—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 3 and 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

L'invention concerne des composés de la formule (I). Dans cette formule, R1 et R2, identiques ou différents, représentent H ou un groupe bloquant la fonction carboxyle; R3 représente H ou un groupe protégeant la fonction amino; R4 et R5 représentent chacun un radical hydroxyle substitué ou non, ou bien R4 et R5 représentent ensemble un radical diol cyclique protégé, Z représente -S- ou -SO- (alpha- ou beta-) et la ligne en traits interrompus indique que le composé est un céph-2-ème ou un céph-3-éme. Ces composés sont des antibiotiques.The invention relates to compounds of formula (I). In this formula, R1 and R2, identical or different, represent H or a group blocking the carboxyl function; R3 represents H or a group protecting the amino function; R4 and R5 each represent a substituted or unsubstituted hydroxyl radical, or else R4 and R5 together represent a protected cyclic diol radical, Z represents -S- or -SO- (alpha- or beta-) and the dashed line indicates that the compound is a ceph-2-th or a ceph-3-th. These compounds are antibiotics.

BE8701088A 1986-09-26 1987-09-25 NOVEL CEPHALOSPORINS WITH ANTIBIOTIC ACTIVITY. BE1002248A5 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868623212A GB8623212D0 (en) 1986-09-26 1986-09-26 Chemical compounds
GB878705986A GB8705986D0 (en) 1987-03-13 1987-03-13 Chemical compounds

Publications (1)

Publication Number Publication Date
BE1002248A5 true BE1002248A5 (en) 1990-11-06

Family

ID=26291340

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8701088A BE1002248A5 (en) 1986-09-26 1987-09-25 NOVEL CEPHALOSPORINS WITH ANTIBIOTIC ACTIVITY.

Country Status (21)

Country Link
KR (1) KR880003956A (en)
AT (1) ATA244087A (en)
AU (1) AU607937B2 (en)
BE (1) BE1002248A5 (en)
CH (1) CH676850A5 (en)
DE (1) DE3732457A1 (en)
DK (1) DK503787A (en)
ES (1) ES2008739A6 (en)
FI (1) FI874211A (en)
FR (1) FR2604437A1 (en)
GB (1) GB2197649B (en)
GR (1) GR871487B (en)
HU (1) HU201946B (en)
IL (1) IL83993A0 (en)
IT (1) IT1221510B (en)
LU (1) LU87002A1 (en)
NL (1) NL8702295A (en)
NO (1) NO874044L (en)
PH (1) PH25299A (en)
PT (1) PT85792B (en)
SE (1) SE8703701L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0400805A1 (en) * 1989-04-25 1990-12-05 Toshiyasu Ishimaru Cephalosporin compounds and their use
KR970005896B1 (en) * 1993-07-23 1997-04-21 주식회사 엘지화학 Cephalsoporins derivatives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2017702A (en) * 1978-03-31 1979-10-10 Roussel Uclaf O-substituted oxime derivatives of 7-[[2-(2-amino-thiazol-4-yl)-2- hydroxyimino-acetyl]-amino]-ceph- 3-em-4-carboxylic acid
FR2503712A1 (en) * 1981-04-09 1982-10-15 Yamanouchi Pharma Co Ltd CEPHALOSPORINE COMPOUNDS AND PROCESS FOR THEIR PREPARATION
EP0197409A1 (en) * 1985-04-01 1986-10-15 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS62167784A (en) * 1985-07-27 1987-07-24 Mochida Pharmaceut Co Ltd Novel cephalosporin derivative, production thereof and antimicrobial agent containing said derivative as active ingredient

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2017702A (en) * 1978-03-31 1979-10-10 Roussel Uclaf O-substituted oxime derivatives of 7-[[2-(2-amino-thiazol-4-yl)-2- hydroxyimino-acetyl]-amino]-ceph- 3-em-4-carboxylic acid
FR2503712A1 (en) * 1981-04-09 1982-10-15 Yamanouchi Pharma Co Ltd CEPHALOSPORINE COMPOUNDS AND PROCESS FOR THEIR PREPARATION
EP0197409A1 (en) * 1985-04-01 1986-10-15 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS62167784A (en) * 1985-07-27 1987-07-24 Mochida Pharmaceut Co Ltd Novel cephalosporin derivative, production thereof and antimicrobial agent containing said derivative as active ingredient

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN, vol. 12, no. 11 (C-468)[2858], 13 janvier 1988; & JP-A-62 167 784 (MOCHIDA) 24-07-1987 *

Also Published As

Publication number Publication date
PH25299A (en) 1991-04-30
SE8703701L (en) 1988-03-27
HU201946B (en) 1991-01-28
GB2197649A (en) 1988-05-25
LU87002A1 (en) 1988-03-02
GR871487B (en) 1988-02-04
PT85792B (en) 1990-08-31
AU607937B2 (en) 1991-03-21
PT85792A (en) 1987-10-01
IT1221510B (en) 1990-07-06
CH676850A5 (en) 1991-03-15
GB8722574D0 (en) 1987-11-04
NO874044L (en) 1988-03-28
HUT45539A (en) 1988-07-28
NO874044D0 (en) 1987-09-25
DK503787D0 (en) 1987-09-25
DE3732457A1 (en) 1988-03-31
FI874211A (en) 1988-03-27
SE8703701D0 (en) 1987-09-25
DK503787A (en) 1988-03-27
IT8748421A0 (en) 1987-09-25
FR2604437A1 (en) 1988-04-01
FI874211A0 (en) 1987-09-25
AU7896087A (en) 1988-03-31
IL83993A0 (en) 1988-02-29
KR880003956A (en) 1988-05-31
GB2197649B (en) 1990-03-28
ATA244087A (en) 1991-02-15
ES2008739A6 (en) 1989-08-01
NL8702295A (en) 1988-04-18

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GLAXO GROUP LTD

Effective date: 19910930