ES2008739A6 - 7-( alpha -(2-amino-4-thiazolyl)- alpha -oximino-acclamido)-cephem antibiotics - Google Patents

7-( alpha -(2-amino-4-thiazolyl)- alpha -oximino-acclamido)-cephem antibiotics

Info

Publication number
ES2008739A6
ES2008739A6 ES8702747A ES8702747A ES2008739A6 ES 2008739 A6 ES2008739 A6 ES 2008739A6 ES 8702747 A ES8702747 A ES 8702747A ES 8702747 A ES8702747 A ES 8702747A ES 2008739 A6 ES2008739 A6 ES 2008739A6
Authority
ES
Spain
Prior art keywords
alpha
amino
acclamido
oximino
thiazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8702747A
Other languages
Spanish (es)
Inventor
Newall Christopher Earle
Looker Brian Edgard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868623212A external-priority patent/GB8623212D0/en
Priority claimed from GB878705986A external-priority patent/GB8705986D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES2008739A6 publication Critical patent/ES2008739A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/60—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 3 and 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Compounds of formula (I> < IMAGE > wherein R<1> and R<2>, which may be the same or different, each represents a hydrogen atom or a carboxyl blocking group R<3> represents a hydrogen atom or an amino protecting group R<4> and R<5> each represents a hydroxy or substrtuted hydroxy group or R<4> and R<5> together represent a cyclic protected diol group Z is -S- or -SO- ( alpha - or beta -) and the dotted line bridging the 2-, 3-, and 4-positions indicates that the compound is a ceph- 2-em or ceph-3-em compound and salts and solvates thereof.
ES8702747A 1986-09-26 1987-09-25 7-( alpha -(2-amino-4-thiazolyl)- alpha -oximino-acclamido)-cephem antibiotics Expired ES2008739A6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868623212A GB8623212D0 (en) 1986-09-26 1986-09-26 Chemical compounds
GB878705986A GB8705986D0 (en) 1987-03-13 1987-03-13 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2008739A6 true ES2008739A6 (en) 1989-08-01

Family

ID=26291340

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8702747A Expired ES2008739A6 (en) 1986-09-26 1987-09-25 7-( alpha -(2-amino-4-thiazolyl)- alpha -oximino-acclamido)-cephem antibiotics

Country Status (21)

Country Link
KR (1) KR880003956A (en)
AT (1) ATA244087A (en)
AU (1) AU607937B2 (en)
BE (1) BE1002248A5 (en)
CH (1) CH676850A5 (en)
DE (1) DE3732457A1 (en)
DK (1) DK503787A (en)
ES (1) ES2008739A6 (en)
FI (1) FI874211A (en)
FR (1) FR2604437A1 (en)
GB (1) GB2197649B (en)
GR (1) GR871487B (en)
HU (1) HU201946B (en)
IL (1) IL83993A0 (en)
IT (1) IT1221510B (en)
LU (1) LU87002A1 (en)
NL (1) NL8702295A (en)
NO (1) NO874044L (en)
PH (1) PH25299A (en)
PT (1) PT85792B (en)
SE (1) SE8703701L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0400805A1 (en) * 1989-04-25 1990-12-05 Toshiyasu Ishimaru Cephalosporin compounds and their use
KR970005896B1 (en) * 1993-07-23 1997-04-21 주식회사 엘지화학 Cephalsoporins derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2432521A1 (en) * 1978-03-31 1980-02-29 Roussel Uclaf NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS
JPS6011917B2 (en) * 1981-04-09 1985-03-28 山之内製薬株式会社 Novel cephalosporin compounds
JPS62167784A (en) * 1985-07-27 1987-07-24 Mochida Pharmaceut Co Ltd Novel cephalosporin derivative, production thereof and antimicrobial agent containing said derivative as active ingredient
NZ215527A (en) * 1985-04-01 1989-06-28 Mochida Pharm Co Ltd Cephalosporin derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
PH25299A (en) 1991-04-30
SE8703701L (en) 1988-03-27
HU201946B (en) 1991-01-28
GB2197649A (en) 1988-05-25
LU87002A1 (en) 1988-03-02
GR871487B (en) 1988-02-04
PT85792B (en) 1990-08-31
BE1002248A5 (en) 1990-11-06
AU607937B2 (en) 1991-03-21
PT85792A (en) 1987-10-01
IT1221510B (en) 1990-07-06
CH676850A5 (en) 1991-03-15
GB8722574D0 (en) 1987-11-04
NO874044L (en) 1988-03-28
HUT45539A (en) 1988-07-28
NO874044D0 (en) 1987-09-25
DK503787D0 (en) 1987-09-25
DE3732457A1 (en) 1988-03-31
FI874211A (en) 1988-03-27
SE8703701D0 (en) 1987-09-25
DK503787A (en) 1988-03-27
IT8748421A0 (en) 1987-09-25
FR2604437A1 (en) 1988-04-01
FI874211A0 (en) 1987-09-25
AU7896087A (en) 1988-03-31
IL83993A0 (en) 1988-02-29
KR880003956A (en) 1988-05-31
GB2197649B (en) 1990-03-28
ATA244087A (en) 1991-02-15
NL8702295A (en) 1988-04-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000128