JPS5290616A - Stable antibiotic composition - Google Patents

Stable antibiotic composition

Info

Publication number
JPS5290616A
JPS5290616A JP15613476A JP15613476A JPS5290616A JP S5290616 A JPS5290616 A JP S5290616A JP 15613476 A JP15613476 A JP 15613476A JP 15613476 A JP15613476 A JP 15613476A JP S5290616 A JPS5290616 A JP S5290616A
Authority
JP
Japan
Prior art keywords
antibiotic composition
stable antibiotic
stable
composition
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15613476A
Other languages
English (en)
Japanese (ja)
Other versions
JPS565368B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
William Wellesley Armstrong
Saurabhkumar Jayavantrai Desai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Original Assignee
Pfizer Corp Belgium
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium filed Critical Pfizer Corp Belgium
Publication of JPS5290616A publication Critical patent/JPS5290616A/ja
Publication of JPS565368B2 publication Critical patent/JPS565368B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyrrole Compounds (AREA)
JP15613476A 1976-01-02 1976-12-24 Stable antibiotic composition Granted JPS5290616A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/646,295 US4018889A (en) 1976-01-02 1976-01-02 Oxytetracycline compositions
CA268,177A CA1075603A (en) 1976-01-02 1976-12-17 Stable solutions of doxycycline in aqueous 2-pyrrolidone
KR7700012A KR810000900B1 (ko) 1976-01-02 1977-01-06 항생물질 조성제의 안정화 방법

Publications (2)

Publication Number Publication Date
JPS5290616A true JPS5290616A (en) 1977-07-30
JPS565368B2 JPS565368B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-02-04

Family

ID=27164830

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15613476A Granted JPS5290616A (en) 1976-01-02 1976-12-24 Stable antibiotic composition

Country Status (29)

Country Link
US (3) US4018889A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5290616A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR810000900B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR209242A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT345977B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE849885A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BG (1) BG36493A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (2) CA1075603A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH616080A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (1) CS205030B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD129997A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2659152C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK145753C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EG (1) EG12291A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI56116C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2336937A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1520197A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR65305B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK30181A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE44767B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN145845B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KE (1) KE3166A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU76493A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL166620C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
OA (1) OA05524A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT66017B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE435997B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU1309901A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA767689B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11426351B2 (en) 2019-12-26 2022-08-30 Sunstar Inc. Process for producing a pharmaceutical composition containing micro particles

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4126680A (en) * 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
EP0009559B1 (de) * 1978-08-01 1982-08-25 Ciba-Geigy Ag Stabile flüssige Arzneimittelformulierung, ihre Herstellung und Verwendung
DE2965917D1 (en) * 1978-12-08 1983-08-25 Beecham Group Plc A process for the preparation of a solid sodium amoxycillin and aqueous solutions thereof
US4259331A (en) * 1979-04-16 1981-03-31 Pfizer Inc. Oxytetracycline compositions
EP0021847B1 (en) * 1979-07-02 1983-07-20 Pfizer Inc. Long acting sulfonamide injectable compositions
EP0022342B1 (en) * 1979-07-05 1983-06-15 Pfizer Inc. Sulfonamide solutions
US4303643A (en) * 1979-07-05 1981-12-01 Pfizer Inc. Sulfonamide compositions
CA1163197A (en) * 1980-04-10 1984-03-06 Herman Horn Injectable oxytetracycline compositions
US4399127A (en) * 1980-04-10 1983-08-16 Diamond Shamrock Corporation Injectable oxytetracycline compositions
US4386083A (en) * 1980-04-10 1983-05-31 Walter Hacke Injectable oxytetracycline compositions
US4374826A (en) * 1980-07-21 1983-02-22 Pfizer Inc. Sulfonamide compositions
NL178941C (nl) * 1982-06-15 1986-06-16 Aesculaap Bv Werkwijze voor de bereiding van een waterig oxytetracyclinepreparaat.
US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
IE74244B1 (en) * 1985-10-01 1997-07-16 Bimeda Res Dev Ltd A process for preparing an antibiotic composition
HU194493B (en) * 1985-11-27 1988-02-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing primycin-containing colloidal basic gel and compositions comprising the same
FR2608044B1 (fr) * 1986-12-10 1992-09-11 Sogeval Composition antibiotique aqueuse a usage veterinaire
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0626171A1 (de) * 1993-05-26 1994-11-30 Winfried Dörnhöfer Injektionslösung für die intravenöse oder intramuskuläre Verabreichung an Tiere
ES2130069B1 (es) * 1997-04-10 2000-03-01 Basf Labiana S A Preparacion farmaceutica con liberacion retardada del producto activo.
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
CN1399627A (zh) * 1999-09-14 2003-02-26 塔夫茨大学信托人 用基于过渡金属的化学制备取代四环素的方法
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
EP1255565A1 (de) * 2000-01-13 2002-11-13 MERCK PATENT GmbH Pharmazeutische zubereitungen enthaltend 2-pyrrolidon als lösungsvermittler
EP1263442A1 (en) 2000-01-24 2002-12-11 Trustees Of Tufts College TETRACYCLINE COMPOUNDS FOR TREATMENT OF i CRYPTOSPORIDIUM PARVUM /i RELATED DISORDERS
IL151971A0 (en) 2000-03-31 2003-04-10 Tufts College 7-and 9-carbamate, urea, thiourea, thiocarbabamate, and heteroaryl-amino substituted tetracycline compounds
WO2001087824A2 (en) * 2000-05-15 2001-11-22 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020128238A1 (en) * 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
CZ2003343A3 (cs) * 2000-07-07 2003-05-14 Trustees Of Tufts College 7-Substituované tetracyklinové sloučeniny
US6846939B2 (en) 2000-07-07 2005-01-25 Paratek Pharmaceuticals, Inc. 9-substituted minocycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
JP2004502751A (ja) 2000-07-07 2004-01-29 トラスティーズ・オブ・タフツ・カレッジ １３−置換されたメタサイクリン化合物
AU2001271556A1 (en) 2000-07-07 2002-01-21 Trustees Of Tufts College 7,8 and 9-substituted tetracycline compounds
RU2178698C1 (ru) * 2000-11-28 2002-01-27 Закрытое Акционерное Общество "Нита-Фарм" Способ получения композиции магниевого комплекса окситетрациклина пролонгированного действия
MXPA03008165A (es) 2001-03-13 2003-12-12 Paratek Pharm Innc Compuestos tetraciclina sustituidos en la posicion 7,9.
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1379255A2 (en) 2001-03-14 2004-01-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
CA2440757A1 (en) 2001-03-14 2002-09-19 Michael Draper Substituted tetracycline compounds as synergistic antifungal agents
US20040092490A1 (en) 2001-04-24 2004-05-13 Michael Draper Substituted tetracycline compounds for the treatment of malaria
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
EP2995610A1 (en) * 2002-01-08 2016-03-16 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EP1482926A4 (en) 2002-03-08 2006-04-12 Paratek Pharm Innc AMINO METHYL SUBSTITUTED TETRACYCLINE COMPOUNDS
WO2003079984A2 (en) 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US6958161B2 (en) 2002-04-12 2005-10-25 F H Faulding & Co Limited Modified release coated drug preparation
CN1700922A (zh) 2002-07-12 2005-11-23 帕拉特克药品公司 3、10或12a位取代的四环素化合物
CA2502464A1 (en) 2002-10-24 2004-05-06 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
JP2006516252A (ja) * 2002-12-27 2006-06-29 アンジオテック インターナショナル アクツィエン ゲゼルシャフト コラーゲンおよびｍｍｐｉを用いる組成物および方法
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2319828A3 (en) 2003-07-09 2011-07-06 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20050137174A1 (en) 2003-07-09 2005-06-23 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CN103040773A (zh) * 2003-07-25 2013-04-17 沃纳奇尔科特有限责任公司 多西环素金属络合物固体剂型
JP5010284B2 (ja) * 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族ａ環誘導体
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
US7858601B2 (en) * 2004-10-25 2010-12-28 Paratek Pharmaceuticals, Inc. 4-substituted tetracyclines and methods of use thereof
EP2284164A3 (en) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2006206359B2 (en) * 2005-01-21 2011-03-31 Allergan Pharmaceuticals International Limited A tetracycline metal complex in a solid dosage form
US8088755B2 (en) * 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080242642A1 (en) 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US9192615B2 (en) 2008-08-06 2015-11-24 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US8252776B2 (en) 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
US7919483B2 (en) * 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
US7544373B2 (en) * 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
EP1910273A2 (en) * 2005-07-21 2008-04-16 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
EP2298324A1 (en) 2006-01-24 2011-03-23 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
WO2007120913A2 (en) * 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
SI2016045T1 (sl) * 2006-04-24 2015-03-31 Teva Pharmaceutical Industries, Ltd. 5 Basel Street Kristalinična oblika tigeciklina in postopek za njegovo pripravo
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
EP2537934A3 (en) * 2006-05-15 2013-04-10 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
WO2008045507A2 (en) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of bacillus anthracis infections
US8318706B2 (en) 2006-12-21 2012-11-27 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2120963B1 (en) 2006-12-21 2018-09-12 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
WO2008127722A1 (en) * 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
AU2008246119A1 (en) 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
WO2009009042A1 (en) 2007-07-06 2009-01-15 Paratek Pharmaceuticals, Inc. Methods for synthesizing substituted tetracycline compounds
RU2010140682A (ru) 2008-03-05 2012-04-10 Пэрэтек Фамэсьютикэлс, Инк. (US) Способ лечения пациента от инфекции, фармацевтическая композиция (варианты) и лекарственное средство
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
EP2276342A4 (en) * 2008-04-14 2012-02-22 Paratek Pharm Innc SUBSTITUTED TETRACYCLIN COMPOUNDS
TW202436282A (zh) 2008-05-19 2024-09-16 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
WO2010033939A1 (en) * 2008-09-19 2010-03-25 Paratek Pharmaceuticals, Inc. Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment
CA2758322C (en) 2009-04-10 2019-04-02 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
PL2568987T3 (pl) 2010-05-12 2017-06-30 Rempex Pharmaceuticals, Inc. Kompozycje tetracyklinowe
EP2707003B1 (en) 2011-05-12 2019-05-01 Paratek Pharmaceuticals, Inc. Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
WO2015021387A2 (en) * 2013-08-09 2015-02-12 Britt George N Formulations for control and prevention of periodontal and perimplant diseases and other diseases and conditions of the mouth, and supra and sub-gingival delivery methods and systems for such formulations
CN103536530A (zh) * 2013-10-30 2014-01-29 王玉万 盐酸多西环素长效注射剂及制备方法
SG11201707784XA (en) 2015-03-23 2017-10-30 Biopharmx Inc Pharmaceutical tetracycline composition for dermatological use
CN104721133B (zh) * 2015-04-14 2018-05-18 四川美嘉龙生物科技有限公司 一种土霉素制剂及制备方法
EP3534908B1 (en) 2016-11-01 2025-07-09 Paratek Pharmaceuticals, Inc. 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
EP3654988B1 (en) 2017-07-21 2023-09-06 Almirall, LLC Sarecycline for the treatment of non-inflammatory acne lesions
US11421207B2 (en) 2017-11-28 2022-08-23 C-Lecta Gmbh Method for producing trehalose employing a trehalose phosphorylase variant

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB805026A (en) * 1956-03-02 1958-11-26 Konink Nl Gisten Spiritusfabri Process for enhancing the solubility of medicines in water
GB802111A (en) * 1956-09-25 1958-10-01 Irwin Irville Lubowe Improved non-toxic pesticidal compositions
US2990331A (en) * 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
DE1091287B (de) * 1957-04-09 1960-10-20 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung stabiler, waessriger Loesungen von Tyrothricin und Subtilin
US2980584A (en) * 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US2987437A (en) * 1958-03-06 1961-06-06 Gen Aniline & Film Corp Nematocidal composition
US3062717A (en) * 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
NL6607516A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1966-05-31 1967-12-01
US3957972A (en) * 1966-05-31 1976-05-18 Koninklijke Nederlandsche Gist-En Spiritusfabriek N.V. Stable solutions of oxytetracycline suitable for parenteral and peroral administration and process of preparation
DE1767891C3 (de) * 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) * 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
GB1508601A (en) * 1974-01-19 1978-04-26 Norbrook Labor Ltd Oxytetracycline solution
DK138974B (da) * 1974-02-19 1978-11-27 Ciba Geigy Ag Fremgangsmåde til fremstilling af vandige oxytetracyclinopløsninger til parenteral, peroral og lokal anvendelse.
US3969516A (en) * 1974-12-19 1976-07-13 Nelson Research & Development Company Composition and method for treatment of acne
US3932653A (en) * 1974-12-19 1976-01-13 Nelson Research & Development Co. Composition and method for topical administration of griseofulvin
US3957994A (en) * 1974-12-19 1976-05-18 Nelson Research & Development Company Topical anti-inflammatory composition and method of use
GB1538903A (en) 1975-04-11 1979-01-24 Nelson Res & Dev Carrier for a topically applied physiologically active agent or cosmetic agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11426351B2 (en) 2019-12-26 2022-08-30 Sunstar Inc. Process for producing a pharmaceutical composition containing micro particles

Also Published As

Publication number Publication date
IN145845B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1979-01-06
PT66017A (en) 1977-01-01
EG12291A (en) 1978-09-30
ATA971776A (de) 1978-02-15
KE3166A (en) 1981-11-06
SU1309901A3 (ru) 1987-05-07
FR2336937A1 (fr) 1977-07-29
FI763716A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1977-07-03
FR2336937B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-06-27
CS205030B2 (en) 1981-04-30
DK145753C (da) 1983-08-08
DK584676A (da) 1977-07-03
IE44767L (en) 1977-07-02
HK30181A (en) 1981-07-10
AT345977B (de) 1978-10-10
AR209242A1 (es) 1977-03-31
FI56116B (fi) 1979-08-31
US4086332A (en) 1978-04-25
CH616080A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-03-14
KR810000900B1 (ko) 1981-08-19
PT66017B (en) 1978-06-19
JPS565368B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-02-04
BE849885A (fr) 1977-06-28
CA1072012A (en) 1980-02-19
OA05524A (fr) 1981-04-30
DE2659152A1 (de) 1977-07-14
NL166620C (nl) 1981-09-15
US4081528A (en) 1978-03-28
NL7614470A (nl) 1977-07-05
SE435997B (sv) 1984-11-05
FI56116C (fi) 1979-12-10
US4018889A (en) 1977-04-19
GR65305B (en) 1980-08-01
IE44767B1 (en) 1982-03-24
AU2057176A (en) 1978-09-28
LU76493A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1977-07-05
ZA767689B (en) 1977-12-28
NL166620B (nl) 1981-04-15
CA1075603A (en) 1980-04-15
DE2659152C2 (de) 1984-04-05
GB1520197A (en) 1978-08-02
SE7613959L (sv) 1977-07-03
DK145753B (da) 1983-02-21
DD129997A5 (de) 1978-03-01
BG36493A3 (en) 1984-11-15

Similar Documents

Publication Publication Date Title
JPS5290616A (en) Stable antibiotic composition
JPS53136514A (en) Stable antibiotics composition
JPS5316787A (en) Specificcreactive composition
AU2732277A (en) Soil-hardening composition
JPS5355360A (en) Heattactivating composition
JPS52117437A (en) Antiicoccidium composition
ZA773288B (en) Antibiotic bl580delta
JPS5341436A (en) Antiiparasite composition
IL51365A0 (en) Coccidiocidal composition
JPS52142752A (en) Moistureeresistant composition
AU3168077A (en) Antibiotic formulations
IE44735L (en) Fibrinogenase composition
JPS52105293A (en) Antibiotic composition
ZA771089B (en) Antibiotic
JPS533533A (en) Antibiotic composition
ZA774715B (en) Novel antibiotic
JPS5344615A (en) Silverrcontaining antibiotic
JPS533532A (en) Antibiotic composition
JPS5326395A (en) Novel antibiotic
JPS5283992A (en) Novel antibiotic
JPS52103201A (en) Photoosensitive composition
JPS52134025A (en) Antibiotic composition
GB1533677A (en) Antibiotic
IL52205A0 (en) Antibiotic bl580delta
JPS52142292A (en) Conductiveeresin composition