JPS51113838A - Paraaaryl*alkyl or alkenyl*amino benzoic acid derivative*method of depleting serum lipid and therapeutical composition therefor - Google Patents

Paraaaryl*alkyl or alkenyl*amino benzoic acid derivative*method of depleting serum lipid and therapeutical composition therefor

Info

Publication number
JPS51113838A
JPS51113838A JP51026980A JP2698076A JPS51113838A JP S51113838 A JPS51113838 A JP S51113838A JP 51026980 A JP51026980 A JP 51026980A JP 2698076 A JP2698076 A JP 2698076A JP S51113838 A JPS51113838 A JP S51113838A
Authority
JP
Japan
Prior art keywords
paraaaryl
alkenyl
alkyl
benzoic acid
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP51026980A
Other languages
English (en)
Inventor
Donarudo Aruburaito Jiei
Gearii Mainaa Toomasu
Goodon Shiepaado Robaato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of JPS51113838A publication Critical patent/JPS51113838A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP51026980A 1975-03-12 1976-03-12 Paraaaryl*alkyl or alkenyl*amino benzoic acid derivative*method of depleting serum lipid and therapeutical composition therefor Pending JPS51113838A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/557,550 US4185115A (en) 1975-03-12 1975-03-12 Antilipidemic para-[aryl(alkyl or alkenyl)amino]-benzoic acid derivatives

Publications (1)

Publication Number Publication Date
JPS51113838A true JPS51113838A (en) 1976-10-07

Family

ID=24225890

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51026980A Pending JPS51113838A (en) 1975-03-12 1976-03-12 Paraaaryl*alkyl or alkenyl*amino benzoic acid derivative*method of depleting serum lipid and therapeutical composition therefor

Country Status (24)

Country Link
US (1) US4185115A (ja)
JP (1) JPS51113838A (ja)
AR (1) AR215241A1 (ja)
AU (1) AU504690B2 (ja)
BE (1) BE839382A (ja)
CH (1) CH628614A5 (ja)
CS (1) CS212758B2 (ja)
DD (1) DD125926A5 (ja)
DE (1) DE2609962A1 (ja)
ES (1) ES445994A1 (ja)
FR (2) FR2303534A1 (ja)
GB (1) GB1535967A (ja)
HK (1) HK69179A (ja)
HU (1) HU173416B (ja)
IE (1) IE44285B1 (ja)
IL (1) IL49012A (ja)
MX (1) MX3788E (ja)
NL (1) NL7602332A (ja)
PL (1) PL112967B1 (ja)
RO (1) RO71822A (ja)
SE (1) SE7602869L (ja)
SU (1) SU803856A3 (ja)
YU (1) YU47676A (ja)
ZA (1) ZA76902B (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1576841A (en) * 1977-01-22 1980-10-15 Beecham Group Ltd Substituted n-acyl phenylamine compounds having hypolipidaemic activity
US4192884A (en) 1977-04-07 1980-03-11 The Dow Chemical Company Substituted 4-(((thienyl)methyl)-amino)benzoic acids and a method for treating hypolipidemia
CH629796A5 (en) * 1977-04-07 1982-05-14 Dow Chemical Co Therapeutically active compounds of 4-(2-thienylmethylamino)benzoic acid
IL56517A0 (en) * 1978-02-02 1979-03-12 American Cyanamid Co Novel 4-(cycloalkyl or cyclalkenyl substituted) amino, alkylamino or alkenylamino benzoic acids, salts and derivatives
US4230878A (en) 1978-03-08 1980-10-28 American Cyanamid Company Hypolipidemic and antiatherosclerotic 4-[(cyclopropyl alkyl)amino]benzoic acids and derivatives
US4178385A (en) 1978-03-03 1979-12-11 The Dow Chemical Company Method for treating hyperlipidemia in primates using 4-((4-fluorophenylmethyl)amino)benzoic acid
US4181737A (en) 1978-05-18 1980-01-01 The Dow Chemical Company 4-((3-Methoxyphenyl)amino)benzoic acid, a method for treating hyperlipidemia, and compositions thereof
EP0006452B1 (en) * 1978-06-23 1983-02-16 The Dow Chemical Company Hypoglycemic phenylpropynylamino benzoic acids, their salts, pharmaceutical compositions containing said compounds and their application
US4207330A (en) * 1978-07-03 1980-06-10 The Dow Chemical Company Method for treating hyperglycemia in mammals using arylamino benzoic acids
US4143151A (en) * 1978-07-03 1979-03-06 The Dow Chemical Company Method for treating hyperglycemia in mammals using arylamino benzoic acids
US4206223A (en) * 1979-01-05 1980-06-03 The Dow Chemical Company Method for treating hyperglycemia in mammals using 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid or derivatives thereof
US4281019A (en) * 1979-02-01 1981-07-28 American Cyanamid Company 4-[(Unsaturated or cyclopropylated alkyl)amino]phenyl compounds useful as hypolipidemic and antiatherosclerotic agents
US4263320A (en) * 1979-06-04 1981-04-21 The Dow Chemical Company Hypoglycemic phenylpropynylamino benzoic acids
US4375478A (en) * 1982-03-02 1983-03-01 Abbott Laboratories Aminobenzoic acid derivatives
US7214825B2 (en) * 2003-10-17 2007-05-08 Honeywell International Inc. O-(3-chloropropenyl) hydroxylamine free base
WO2008121570A1 (en) * 2007-03-29 2008-10-09 Irm Llc Compounds and methods for modulating g protein-coupled receptors
CN109206333A (zh) * 2018-10-16 2019-01-15 河南师范大学 一种具有抗菌活性的苯佐卡因单取代衍生物的合成方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868416A (en) * 1973-10-01 1975-02-25 American Cyanamid Co Hypolipidemic 4-(monoalkylamino)benzoic acid derivatives
GB1576007A (en) * 1976-02-11 1980-10-01 Beecham Group Ltd Hypolipidaemic compositions

Also Published As

Publication number Publication date
CH628614A5 (de) 1982-03-15
YU47676A (en) 1983-04-30
PL112967B1 (en) 1980-11-29
FR2303534A1 (fr) 1976-10-08
AR215241A1 (es) 1979-09-28
IE44285B1 (en) 1981-10-07
SE7602869L (sv) 1976-12-06
BE839382A (fr) 1976-09-10
FR2436132A1 (fr) 1980-04-11
ES445994A1 (es) 1977-10-01
US4185115A (en) 1980-01-22
HK69179A (en) 1979-10-05
IL49012A0 (en) 1976-04-30
FR2303534B1 (ja) 1981-08-28
AU504690B2 (en) 1979-10-25
DD125926A5 (ja) 1977-06-01
IE44285L (en) 1976-09-12
SU803856A3 (ru) 1981-02-07
ZA76902B (en) 1977-01-26
AU1103676A (en) 1977-08-18
NL7602332A (nl) 1976-09-14
CS212758B2 (en) 1982-03-26
MX3788E (es) 1981-07-20
DE2609962A1 (de) 1976-09-30
IL49012A (en) 1980-12-31
HU173416B (hu) 1979-05-28
RO71822A (ro) 1982-02-01
GB1535967A (en) 1978-12-13

Similar Documents

Publication Publication Date Title
JPS51113838A (en) Paraaaryl*alkyl or alkenyl*amino benzoic acid derivative*method of depleting serum lipid and therapeutical composition therefor
ZA7654B (en) Amino acid formulations for patients with liver disease and method of using same
JPS52116479A (en) Novel derivative of 33quinolinecarboxylic acid and method for its preparation and phamaceutical composition thereof
JPS52102293A (en) Novel oxim derivative of 77 aminothiazolylacetoamide cephalospolanate process for preparing same and pharmaceutical composition
IL61058A0 (en) Derivatives of amino acids and process for their preparation
JPS5294453A (en) Enhancement of food by amino acid and derivative thereof
IT1068320B (it) Composizione fosfatante liquida e metodo di suo impiego
IL52996A0 (en) New derivatives of 2-(3-phenyl-2-aminopropionyloxy) acetic acid their preparation and pharmaceutical compositions containing them
JPS51127083A (en) Preparation method of nicotinic acid amide
GR61276B (en) Preparation process of 4-aroyl substituted phenoxy acetic acids and tetrazoles
IL49264A0 (en) Preparation of 2-arylpropionic acids and certain new compounds
CS191172B2 (en) Method of preparation of non-irritating products enriched by protein
JPS5239680A (en) Preparation method of nicotinic acid amide
ZM4476A1 (en) Method for the preparation of amino acids
JPS5373535A (en) Phthalic acid derivative * method of its preparation and hardening mixture containing said compound
NZ184603A (en) Phosphonic acid derivatives of certain peptides and pharmaceutical compositions
IT1046399B (it) Procedimento per la preparazione di d carbamil amminoacidi e dei corrispondenti d amminoacidi
PH13389A (en) Substituted n-(phenyl)-dithiocarbamic acid ester,pharmaceutical compositions and method of using same
JPS51141837A (en) Prodution of para isobutylphenyl acetic acid derivatives
IL57859A0 (en) Salts of benzene and thiophene-carbothioic acid 2-aminoalkl esters and pharmaceutical compositions containing them
GB1532087A (en) Preparation of phenylacetic acids and intermediates
GR60029B (en) Analogs of prostanic acids and process for their preparation
IL53567A0 (en) Novel derivatives of dithiosalicyclic acid amides their preparation and pharmaceutical compositions containing them
JPS51148012A (en) Nicotinate of ppaminobenzoic acid betaaamino alkyl ester and its preparation and medicine including it
JPS5233619A (en) Method of direct preparation of nnacyl derivatives of alphaaaminoo gammaaketo acid and its new compound