JPS50105623A - - Google Patents
Info
- Publication number
- JPS50105623A JPS50105623A JP49124717A JP12471774A JPS50105623A JP S50105623 A JPS50105623 A JP S50105623A JP 49124717 A JP49124717 A JP 49124717A JP 12471774 A JP12471774 A JP 12471774A JP S50105623 A JPS50105623 A JP S50105623A
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/29—Polyamino acid or polypeptide with an uninterrupted series of peptide repeating units
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US412419A US3891696A (en) | 1973-11-02 | 1973-11-02 | Novel, transient pro-drug forms of l-dopa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS50105623A true JPS50105623A (https=) | 1975-08-20 |
| JPS5756907B2 JPS5756907B2 (https=) | 1982-12-02 |
Family
ID=23632886
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP49124718A Pending JPS50105624A (https=) | 1973-11-02 | 1974-10-29 | |
| JP49124717A Expired JPS5756907B2 (https=) | 1973-11-02 | 1974-10-29 | |
| JP49126692A Pending JPS5088043A (https=) | 1973-11-02 | 1974-11-02 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP49124718A Pending JPS50105624A (https=) | 1973-11-02 | 1974-10-29 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP49126692A Pending JPS5088043A (https=) | 1973-11-02 | 1974-11-02 |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US3891696A (https=) |
| JP (3) | JPS50105624A (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0249757A (ja) * | 1988-08-12 | 1990-02-20 | Nippon Kayaku Co Ltd | （−）−Ｎ−（１−アルコキシカルボニルプロペン−２−イル）−ａ−アミノ−ａ−（ｐ−ヒドロキシフエニル）酢酸アルカリ金属塩の製造法 |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998799A (en) * | 1973-11-02 | 1976-12-21 | Interx Research Corporation | Novel, transient pro-drug forms of l-dopa |
| JPS5157813A (en) * | 1974-11-14 | 1976-05-20 | Sankyo Co | Ll dooba mataha sonojudotaiseizaino seiho |
| DE2510634A1 (de) * | 1975-03-12 | 1976-09-23 | Boehringer Mannheim Gmbh | L-3-(3,4-dihydroxy-phenyl)-2- methyl-alanin-peptide und verfahren zu deren herstellung |
| US4254273A (en) * | 1975-06-11 | 1981-03-03 | Merck & Co., Inc. | Process for preparing esters of α-methyl-3,4-dihydroxyphenylalanine |
| US4031242A (en) * | 1975-09-11 | 1977-06-21 | Abbott Laboratories | Diacylated derivatives of γ-glutamyl dopamine |
| PH14064A (en) * | 1977-05-06 | 1981-01-26 | Pfizer | Phenylgycine derivatives,pharmaceutical compositions and method of use |
| US4271187A (en) * | 1978-06-05 | 1981-06-02 | Merck & Co., Inc. | Substituted phenyl alanine antihypertensive agents |
| ZA794723B (en) * | 1978-09-11 | 1980-08-27 | Univ Miami | Anti-hypertensive agents |
| US4311706A (en) * | 1980-01-22 | 1982-01-19 | Interx Research Corporation | Novel dopa/dopamine prodrugs |
| JPS59112949A (ja) * | 1982-12-20 | 1984-06-29 | Microbial Chem Res Found | 新規なｌ−スレオ−アドレナリン酸 |
| JPH02138A (ja) * | 1987-09-18 | 1990-01-05 | Banyu Pharmaceut Co Ltd | Ｌ‐ドーパ誘導体 |
| IT1226727B (it) * | 1988-07-29 | 1991-02-05 | Simes | Farmaci precursori della dopamina. |
| ES2070994T3 (es) * | 1989-04-20 | 1995-06-16 | Zambon Spa | Profarmaco de dopamina. |
| US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
| US20070225379A1 (en) * | 2001-08-03 | 2007-09-27 | Carrara Dario Norberto R | Transdermal delivery of systemically active central nervous system drugs |
| US20040198706A1 (en) * | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| US7094427B2 (en) * | 2002-05-29 | 2006-08-22 | Impax Laboratories, Inc. | Combination immediate release controlled release levodopa/carbidopa dosage forms |
| ATE534373T1 (de) | 2003-10-10 | 2011-12-15 | Antares Pharma Ipl Ag | Transdermale pharmazeutische formulierung zur minimierung von rückständen auf der haut |
| US20050220865A1 (en) * | 2004-04-02 | 2005-10-06 | Koleng John J | Compressed composition comprising magnesium salt |
| DE102005022276A1 (de) * | 2005-05-13 | 2006-11-16 | Ellneuroxx Ltd. | Derivate von Dihydroxyphenylalanin |
| US8067399B2 (en) | 2005-05-27 | 2011-11-29 | Antares Pharma Ipl Ag | Method and apparatus for transdermal or transmucosal application of testosterone |
| CN101426475A (zh) | 2006-04-21 | 2009-05-06 | 安塔雷斯制药Ipl股份公司 | 使用用于经皮或经粘膜应用的制剂治疗热潮红的方法 |
| CN101910113A (zh) | 2007-12-28 | 2010-12-08 | 怡百克制药公司 | 左旋多巴控释制剂及其用途 |
| EP2273988B1 (en) | 2008-04-18 | 2015-09-09 | Arizona Board Of Regents, A Body Corp. Of The State Of Arizona, Acting For And On Behalf Of The University Of Arizona | L-dopa for treating age-related macular degeneration |
| US10987313B2 (en) | 2013-10-07 | 2021-04-27 | Impax Laboratories, Llc | Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof |
| CN105658211A (zh) | 2013-10-07 | 2016-06-08 | 怡百克制药公司 | 左旋多巴和/或左旋多巴的酯的粘膜粘附性、控制释放调配物和其用途 |
| CN103694127B (zh) * | 2013-12-30 | 2015-04-01 | 上海交通大学 | 链霉菌属菌种所产的化合物及该化合物的制备方法和应用 |
| EP3075723B1 (en) | 2015-03-30 | 2017-05-24 | Berlirem GmbH | Highly soluble l-dopa glycerol esters |
| CN107848954A (zh) | 2015-03-30 | 2018-03-27 | 伯里兰有限责任公司 | 水溶性l‑dopa酯 |
| US20190224153A1 (en) | 2016-09-29 | 2019-07-25 | Berlirem Gmbh | L-dopa derivatives for the treatment of neurological diseases |
| BR112021009353A2 (pt) | 2018-11-15 | 2021-11-23 | Abbvie Inc | Formulações farmacêuticas para administração subcutânea |
| US11969401B2 (en) | 2019-01-31 | 2024-04-30 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for treating or limiting development of age-related macular degeneration |
| KR20230124622A (ko) | 2020-12-22 | 2023-08-25 | 암닐 파마슈티컬스 엘엘씨 | 레보도파 투여 요법 |
| US11986449B2 (en) | 2020-12-22 | 2024-05-21 | Amneal Pharmaceuticals Llc | Levodopa dosing regimen |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH475193A (de) * | 1966-06-07 | 1969-07-15 | Hoffmann La Roche | Verfahren zur Herstellung von Phenylalaninderivaten |
| CH483397A (de) * | 1966-12-01 | 1969-12-31 | Hoffmann La Roche | Verfahren zur Herstellung von Phenylalaninderivaten |
| US3734952A (en) * | 1968-12-27 | 1973-05-22 | Hoffmann La Roche | Preparation of l-dopa |
| US3676482A (en) * | 1969-03-14 | 1972-07-11 | Merck & Co Inc | Racemization of an alpha-methyl dopa derivative |
| US3714241A (en) * | 1969-10-29 | 1973-01-30 | Merck & Co Inc | PREPARATION OF alpha -METHYL-3,4-DISUBSTITUTED PHENYLALANINES |
| DE1963991C3 (de) * | 1969-12-20 | 1975-05-15 | Dynamit Nobel Ag, 5210 Troisdorf | Verfahren zur Gewinnung eines Derivates von L-3,4-dihydroxyphenylalanin |
| US3715382A (en) * | 1970-02-05 | 1973-02-06 | Merck & Co Inc | N-ACYL- alpha -HYDRAZINO- beta -(PHENYL) PROPIONITRILES |
| US3717673A (en) * | 1970-04-04 | 1973-02-20 | L Bernardi | Process for the preparation of l-dopa |
| JPS528820B1 (https=) * | 1970-05-04 | 1977-03-11 | ||
| US3714242A (en) * | 1970-07-06 | 1973-01-30 | Hoffmann La Roche | Process for the preparation of l-dopa |
| DE2039253A1 (de) * | 1970-08-07 | 1972-02-10 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von L-DOPA |
| JPS5025465B1 (https=) * | 1970-12-29 | 1975-08-23 | ||
| US3803120A (en) * | 1971-09-28 | 1974-04-09 | Hoffmann La Roche | Di-and tripeptides of 3-(3,4-dihydroxyphenyl)-alanine |
-
1973
- 1973-11-02 US US412419A patent/US3891696A/en not_active Expired - Lifetime
-
1974
- 1974-10-29 JP JP49124718A patent/JPS50105624A/ja active Pending
- 1974-10-29 JP JP49124717A patent/JPS5756907B2/ja not_active Expired
- 1974-11-02 JP JP49126692A patent/JPS5088043A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0249757A (ja) * | 1988-08-12 | 1990-02-20 | Nippon Kayaku Co Ltd | （−）−Ｎ−（１−アルコキシカルボニルプロペン−２−イル）−ａ−アミノ−ａ−（ｐ−ヒドロキシフエニル）酢酸アルカリ金属塩の製造法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5756907B2 (https=) | 1982-12-02 |
| US3891696A (en) | 1975-06-24 |
| JPS5088043A (https=) | 1975-07-15 |
| JPS50105624A (https=) | 1975-08-20 |