JPH1192353A - Skin preparation for external use for inhibiting sebum synthesis - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare the subject preparation for external use, capable of continuously inhibiting the secretion of sebum on skin or scalp, hardly causing side effects and high in safety by formulating an extract of Echinacea angustifolia and E.purpurea, and/or Tropaeolum majus as an active ingredient. SOLUTION: The objective preparation for external use is obtained by formulating 0.01-10 wt.%, preferably 0.5-5 wt.% extract obtained by carrying out an extraction treatment of pulverized material of root or whole plant of Echinacea angustifolia and E.purpurea, and/or leaf of Tropaeolum majus with one or mixture of two or more kinds of ethanol, propylene glycol, 1,3-butylene glycol and water at 3-70 deg.C, in terms of the dried weight based on the amount of the preparation for the external use as an active ingredient.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a skin external preparation for suppressing sebum synthesis, comprising an extract of a crude drug such as echinacea as an active ingredient.

[0002]

2. Description of the Related Art Sebum secreted from the sebaceous glands of the skin and scalp keeps the skin soft and smooth, and keeps the hair supple and beautiful by being supplied to the hair as a necessary and appropriate oil component. It is an active ingredient above and is required for skin and hair. Sebum also plays an important role in preventing various irritants from the outside from invading the skin or the scalp surface, while preventing water loss from the skin or the stratum corneum.

However, if the activity of sebaceous glands is excessively increased and secretion of sebum becomes excessive, dermatitis such as acne and seborrheic dermatosis and various skin troubles are caused, and dandruff is caused on the scalp. Causes increase in hair loss and hair loss. In addition, excessive sebum promotes the growth of microorganisms and pathogenic bacteria, which are undesirable in a cosmetically unsatisfactory state (skin and hair stickiness) on the skin and scalp, and causes various skin abnormalities.

[0004] For the purpose of solving or preventing dermatitis, skin trouble, beauty and cosmetic problems caused by such excessive secretion of sebum, it has conventionally been practiced to remove sebum by washing with soap or the like. Have been done.

[0005]

However, the effect of removing excess sebum using soap or the like is temporary, and it suppresses excessive secretion of sebum, and dermatitis caused by excessive secretion of sebum fundamentally. There is a problem that skin troubles cannot be improved.

Accordingly, an object of the present invention is to provide a skin external preparation for suppressing sebum synthesis, which suppresses sebum secretion in the skin and scalp continuously, has no side effects and is highly safe.

[0007]

Means for Solving the Problems The present inventors have conducted intensive studies to achieve the above object, and as a result, Echinacea, which is conventionally used as a remedy for ulcers and trauma infections and is known as a crude drug without side effects, has been developed. The present inventors have found that an extract of nasturtium has high safety and can continuously suppress sebum secretion in skin and scalp, and completed the present invention.

That is, the present invention provides a skin external preparation for suppressing sebum synthesis, comprising an extract of Echinacea and / or Nasturtium as an active ingredient.

[0009]

DETAILED DESCRIPTION OF THE INVENTION In the present invention, echinacea is
Echinacea angustifolia or E. coli. It is the root or whole plant of purpurea. The main component is echinacoside (Echinac
osid), which is a glycoside having a weak antibiotic action and contains essential oils, inulin, betaine, resins and the like. Echinacea is used as a typical botanical drug aimed at increasing systemic specific resistance to various symptoms, and has no side effects at ordinary doses. In addition, oral administration, intravenous injection, intramuscular injection, and external use are all possible.

Nasturtium is Tropaeolum.
ajus leaves. Nasturtium contains a substance that has a weak but harmless antibiotic action and does not cause resistance or allergy. It has been used as a therapeutic agent for wound infections.

The extracts of Echinacea and Nasturtium used in the present invention can be obtained, for example, by the following method. That is, the pulverized product of the above plant is usually subjected to water and / or petroleum ether, n-hexane, cyclohexane, carbon tetrachloride, toluene, benzene, dichloromethane, chloroform, ether, ethyl acetate, butanol, acetone, propanol, ethanol at 3 to 100 ° C. , Methanol, propylene glycol, a mixture of one or more of 1,3-butylene glycol and the like, preferably, a mixture of one or more of ethanol, propylene glycol, 1,3-butylene glycol, and water. , Usually at 3 to 70 ° C. Such an extract can be further fractionated and used for a more active fraction by a suitable separation means, for example, gel filtration, silica gel column chromatography, high performance liquid chromatography, or the like.

The echinacea and nasturtium extract are as follows:
From the viewpoints of feel and effect at the time of use, it is preferable to mix 0.01 to 10% by weight, particularly preferably 0.5 to 5% by weight, in a dry weight of the skin external preparation for suppressing sebum synthesis.

In the present invention, a surfactant, an oil, a humectant, an astringent, a cooling agent, an antioxidant, an alcohol, a chelate, a pH adjuster, a preservative, and the like, as long as the effects of the present invention are not impaired. Thickeners, pigments, fragrances, anti-inflammatory agents, deflocculants,
Known components generally used in pharmaceuticals, cosmetics, quasi-drugs, and the like, as well as medicinal components such as antibacterial agents and bactericides, can be appropriately compounded.

The dosage form of the skin external preparation for inhibiting sebum synthesis according to the present invention is not particularly limited. For example, it can be in any form such as liquid, ointment, gel, aerosol and the like.
Emulsified skin external preparations, O / W emulsified skin external preparations, creams, cosmetic emulsions, lotions, oily lotions, packs, foundations and the like can be mentioned.

The skin external preparation for inhibiting sebum synthesis according to the present invention comprises the above essential components and optional components as necessary, according to a conventional method.
It can be obtained by mixing and stirring.

[0016]

EXAMPLES Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the following examples.

Example 1 Preparation of a skin external preparation for suppressing sebum synthesis containing an echinacea extract as an active ingredient:
100 g of echinacea extract having an extract solids concentration of 1.1% (v / w)
Was partially diluted with 70% ethanol to a concentration of 5% to prepare 50 g of a skin external preparation for suppressing sebum synthesis.

Example 2 Preparation of a skin external preparation for inhibiting sebum synthesis using a nasturtium extract as an active ingredient:
% Propylene glycol aqueous solution, extract solid concentration is 1.3% (v / w), 130 g of nasturtium extract
Was partially diluted with 70% ethanol to a concentration of 5% to prepare 50 g of a skin external preparation for suppressing sebum synthesis.

Test Example 1 Test for Sebum Synthesis Inhibition: The skin external preparation for sebum synthesis suppression obtained in Examples 1 and 2 was applied to the right auricle of a 10-week-old male hamster once a day. 20 μl was applied continuously for 2 weeks. As a control, 70% ethanol (control product) was applied to the left pinna in the same manner as in the right pinna. After completion of the application (two weeks after the start of application), the skin tissue pieces (diameter 4 mm) of the left and right auricles were organ-cultured, and the sebum synthesizing ability (sebum synthesizing ability of the right auricle x 100 / left ear) using 14C-acetic acid as a tracer The sebum synthesizing ability (%) of the middle part was determined.

As a result, when the skin external preparation for suppressing sebum synthesis (containing echinacea extract) of Example 1 was used, the amount was 68.
5%, and 76.3% when the skin external preparation for sebum synthesis suppression (containing nasturtium extract) of Example 2 was used, and a remarkable sebum synthesis suppression effect was recognized. In particular, when the skin external preparation for suppressing sebum synthesis of Example 1 was used, there was a significant difference by a t-test at a risk factor of 5%, and a more remarkable effect was recognized.

[0021]

The skin external preparation for inhibiting sebum synthesis according to the present invention comprises:
It is highly safe as it suppresses sebum secretion in the skin and scalp continuously and has no side effects.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Yoshinori Nishizawa 2606 Kabane-cho, Akaga-cho, Haga-gun, Tochigi Pref. Within the Kao Co., Ltd. (72) Inventor Kimihiko Hori 2606, Akabane-Akabane, Kaiga-cho, Haga-gun, Tochigi pref.

Claims (1)

[Claims] Claims 1. An echinacea (Echinacea angustifolia and E. purpurea) and / or nasturtium (Tropaeolum m)
A skin external preparation for inhibiting sebum synthesis, comprising an extract of ajus) as an active ingredient.