|
US5843937A
(en)
*
|
1996-05-23 |
1998-12-01 |
Panorama Research, Inc. |
DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
|
|
US6130237A
(en)
*
|
1996-09-12 |
2000-10-10 |
Cancer Research Campaign Technology Limited |
Condensed N-aclyindoles as antitumor agents
|
|
CA2265874C
(en)
*
|
1996-09-12 |
2007-08-28 |
Cancer Research Campaign Technology Limited |
Condensed n-acylindoles as antitumor agents
|
|
EP1408960B1
(en)
|
2001-02-22 |
2006-05-31 |
School Of Pharmacy, University Of London |
Benz-indole and benzo-quinoline derivatives as prodrugs for tumour treatment
|
|
DE10121215A1
(de)
*
|
2001-04-30 |
2002-10-31 |
Merck Patent Gmbh |
Dihydro-imidazo[4,5-e]indol- und 7H-Pyrrolo[3,2-f]chinoxalin Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
|
|
DE10121217A1
(de)
*
|
2001-04-30 |
2002-10-31 |
Merck Patent Gmbh |
6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
|
|
DK1392359T4
(da)
|
2001-05-11 |
2013-06-10 |
Ludwig Inst For Cancer Res Ltd |
Specifikke bindingsproteiner og deres anvendelser.
|
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
CA2448319C
(en)
*
|
2001-05-31 |
2010-07-27 |
Medarex, Inc. |
Cytotoxins, prodrugs, linkers and stabilizers useful therefor
|
|
AU2002323475B2
(en)
*
|
2001-09-13 |
2006-09-28 |
Synta Pharmaceuticals Corp |
2-aroylimidazole compounds for treating cancer
|
|
US6756397B2
(en)
*
|
2002-04-05 |
2004-06-29 |
Immunogen, Inc. |
Prodrugs of CC-1065 analogs
|
|
RU2402548C2
(ru)
*
|
2004-05-19 |
2010-10-27 |
Медарекс, Инк. |
Химические линкеры и их конъюгаты
|
|
AU2005244980B2
(en)
|
2004-05-19 |
2011-09-15 |
E. R. Squibb & Sons, L.L.C. |
Chemical linkers and conjugates thereof
|
|
US7393665B2
(en)
*
|
2005-02-10 |
2008-07-01 |
Population Genetics Technologies Ltd |
Methods and compositions for tagging and identifying polynucleotides
|
|
PL1851250T3
(pl)
*
|
2005-02-18 |
2012-10-31 |
Squibb & Sons Llc |
Ludzkie przeciwciało monoklonalne przeciwko antygenowi błony komórkowej komórek prostaty (PSMA)
|
|
US7714016B2
(en)
*
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
EP1934261B1
(en)
|
2005-09-26 |
2014-10-29 |
Medarex, L.L.C. |
Human monoclonal antibodies to cd70
|
|
ES2416136T3
(es)
*
|
2005-09-26 |
2013-07-30 |
Medarex, Inc. |
Conjugados de anticuerpo-fármaco y su uso
|
|
AU2006305842B2
(en)
*
|
2005-10-26 |
2011-11-03 |
E. R. Squibb & Sons, L.L.C. |
Methods and compounds for preparing CC-1065 analogs
|
|
WO2007059404A2
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
SG177194A1
(en)
|
2005-12-08 |
2012-01-30 |
Medarex Inc |
Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and methods for using anti-ptk7 antibodies
|
|
PL1960434T3
(pl)
|
2005-12-08 |
2012-12-31 |
Squibb & Sons Llc |
Ludzkie przeciwciała monoklonalne przeciw fozylowi-gm1 i sposoby zastosowania antyfukozylu-gm1
|
|
US20090175886A1
(en)
|
2006-01-17 |
2009-07-09 |
Medarex, Inc. |
Monoclonal antibodies against cd30 lacking in fucosyl and xylosyl residues
|
|
JP2010502220A
(ja)
|
2006-09-05 |
2010-01-28 |
メダレックス インコーポレーティッド |
骨形態形成タンパク質およびその受容体に対する抗体ならびにその使用方法
|
|
CA2671457C
(en)
|
2006-12-01 |
2017-09-26 |
Medarex, Inc. |
Human antibodies that bind cd22 and uses thereof
|
|
CL2007003622A1
(es)
|
2006-12-13 |
2009-08-07 |
Medarex Inc |
Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
|
|
IN2009KN02404A
(enExample)
|
2006-12-14 |
2015-08-07 |
Medarex Inc |
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
Medarex Llc |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
MX2009007987A
(es)
|
2007-01-25 |
2010-03-01 |
Dana Farber Cancer Inst Inc |
Uso de anticuerpos anti-egfr en el tratamiento de enfermedad mediada por egfr mutante.
|
|
KR20090122439A
(ko)
|
2007-02-21 |
2009-11-30 |
메다렉스, 인코포레이티드 |
단일 아미노산을 갖는 화학적 링커 및 이의 접합체
|
|
WO2008115404A1
(en)
*
|
2007-03-15 |
2008-09-25 |
Ludwing Institute For Cancer Research |
Treatment method using egfr antibodies and src inhibitors and related formulations
|
|
US9901567B2
(en)
|
2007-08-01 |
2018-02-27 |
Syntarga B.V. |
Substituted CC-1065 analogs and their conjugates
|
|
ES2609915T3
(es)
|
2007-08-14 |
2017-04-25 |
Ludwig Institute For Cancer Research Ltd. |
Anticuerpo monoclonal 175 direccionado al receptor de EGF y derivados y usos del mismo
|
|
EP2227087B1
(en)
*
|
2007-11-13 |
2013-10-09 |
The Scripps Research Institute |
Cbi derivatives subject to reductive activation
|
|
RU2628069C2
(ru)
|
2008-11-03 |
2017-08-14 |
Синтарга Б.В. |
Новые аналоги сс-1065 и их конъюгаты
|
|
US8420084B2
(en)
|
2009-03-05 |
2013-04-16 |
Medarex, Inc. |
Fully human antibodies specific to CADM1
|
|
ES2574236T3
(es)
|
2009-04-20 |
2016-06-16 |
Oxford Biotherapeutics Ltd |
Anticuerpos específicos para cadherina-17
|
|
US20110076232A1
(en)
*
|
2009-09-29 |
2011-03-31 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
|
WO2011047083A1
(en)
|
2009-10-13 |
2011-04-21 |
Oxford Biotherapeutics Ltd. |
Antibodies against epha10
|
|
DE102009051438A1
(de)
|
2009-10-30 |
2011-05-05 |
Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts |
Fluoreszenzfarbstoffe
|
|
LT3108886T
(lt)
|
2010-04-21 |
2020-08-25 |
Syntarga B.V. |
Cc-1065 analogų ir bifunkcinių jungtukų konjugatai
|
|
EP3228325A1
(en)
|
2011-06-10 |
2017-10-11 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
ES2640960T3
(es)
|
2011-06-28 |
2017-11-07 |
Oxford Biotherapeutics Ltd. |
Anticuerpos para ADP-ribosil ciclasa 2
|
|
CA2891280C
(en)
|
2012-11-24 |
2018-03-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
|
|
JP6334553B2
(ja)
|
2012-12-10 |
2018-05-30 |
メルサナ セラピューティクス,インコーポレイティド |
タンパク質−高分子−薬剤コンジュゲート
|
|
WO2014093640A1
(en)
|
2012-12-12 |
2014-06-19 |
Mersana Therapeutics,Inc. |
Hydroxy-polmer-drug-protein conjugates
|
|
AU2013364065B2
(en)
|
2012-12-21 |
2018-10-04 |
Altrubio Inc. |
Hydrophilic self-immolative linkers and conjugates thereof
|
|
ES2719796T3
(es)
*
|
2013-03-28 |
2019-07-16 |
Scripps Research Inst |
Derivado de N-acilo O-aminofenol CBI cíclico
|
|
WO2015050959A1
(en)
|
2013-10-01 |
2015-04-09 |
Yale University |
Anti-kit antibodies and methods of use thereof
|
|
PL3054992T3
(pl)
|
2013-10-11 |
2020-01-31 |
Asana Biosciences, Llc |
Koniugaty białko-polimer-lek
|
|
ES2726850T3
(es)
|
2013-10-11 |
2019-10-09 |
Mersana Therapeutics Inc |
Conjugados de proteína-polímero-fármaco
|
|
TR201810856T4
(tr)
|
2014-01-10 |
2018-08-27 |
Synthon Biopharmaceuticals Bv |
CYS'le bağlı antikor-ilaç konjugatlarını saflaştırmak için usul.
|
|
WO2015127685A1
(en)
|
2014-02-28 |
2015-09-03 |
Hangzhou Dac Biotech Co., Ltd |
Charged linkers and their uses for conjugation
|
|
EA201691589A1
(ru)
|
2014-03-20 |
2017-02-28 |
Бристол-Маерс Сквибб Компани |
Стабилизированные основанные на фибронектине каркасные молекулы
|
|
RU2017101662A
(ru)
|
2014-06-20 |
2018-07-23 |
Биоэллаенс К.В. |
Конъюгаты антитела против фолатного рецептора альфа (fra) c лекарственным средством и способы их применения
|
|
EP3725808B1
(en)
|
2014-11-21 |
2024-07-17 |
Bristol-Myers Squibb Company |
Antibodies against cd73 and uses thereof
|
|
ES2826566T3
(es)
|
2014-11-21 |
2021-05-18 |
Bristol Myers Squibb Co |
Anticuerpos que comprenden regiones constantes pesadas modificadas
|
|
EP3702367B1
(en)
|
2014-11-25 |
2024-05-15 |
Bristol-Myers Squibb Company |
Novel pd-l1 binding polypeptides for imaging
|
|
JP2018510864A
(ja)
|
2015-03-10 |
2018-04-19 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
トランスグルタミナーゼによって結合可能な抗体およびそれによって製造される結合体
|
|
WO2016196228A1
(en)
|
2015-05-29 |
2016-12-08 |
Bristol-Myers Squibb Company |
Antibodies against ox40 and uses thereof
|
|
EP3319936B1
(en)
|
2015-07-12 |
2025-12-17 |
Hangzhou Dac Biotech Co., Ltd. |
Bridge linkers for conjugation of cell-binding molecules
|
|
US9839687B2
(en)
|
2015-07-15 |
2017-12-12 |
Suzhou M-Conj Biotech Co., Ltd. |
Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
|
|
CN104961645A
(zh)
*
|
2015-07-22 |
2015-10-07 |
中国药科大学 |
苯氧乙酸类衍生物、其制备方法及其作为药物的用途
|
|
CA3008678A1
(en)
|
2015-12-21 |
2017-06-29 |
Bristol-Myers Squibb Company |
Variant antibodies for site-specific conjugation
|
|
RU2766000C2
(ru)
|
2016-01-08 |
2022-02-07 |
АльтруБио Инк. |
Четырехвалентные антитела к psgl-1 и их применения
|
|
SG11201806861SA
(en)
|
2016-03-04 |
2018-09-27 |
Bristol Myers Squibb Co |
Combination therapy with anti-cd73 antibodies
|
|
WO2018004338A1
(en)
|
2016-06-27 |
2018-01-04 |
Tagworks Pharmaceuticals B.V. |
Cleavable tetrazine used in bio-orthogonal drug activation
|
|
US10287291B2
(en)
|
2016-08-19 |
2019-05-14 |
Bristol-Myers Squibb Company |
Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use
|
|
WO2018048975A1
(en)
|
2016-09-09 |
2018-03-15 |
Bristol-Myers Squibb Company |
Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment
|
|
JP7138350B2
(ja)
|
2016-11-14 |
2022-09-16 |
ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ. |
共役連結体、該連結体を含有する細胞結合分子-薬物共役体、並びに該共役体及び連結体の使用及び製造方法
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
BR112019024419A2
(pt)
|
2017-05-25 |
2020-07-14 |
Bristol-Myers Squibb Company |
anticorpos compreendendo regiões constantes pesadas modificadas
|
|
CN111315414A
(zh)
|
2017-06-22 |
2020-06-19 |
梅尔莎纳医疗公司 |
产生载药聚合物支架和蛋白-聚合物-药物缀合物的方法
|
|
DK3788032T3
(da)
|
2018-05-04 |
2024-04-15 |
Tagworks Pharmaceuticals B V |
Forbindelser omfattende en linker til øgning af transcyklooctenstabilitet
|
|
CA3099419A1
(en)
|
2018-05-04 |
2019-11-07 |
Tagworks Pharmaceuticals B.V. |
Tetrazines for high click conjugation yield in vivo and high click release yield
|
|
KR20210084546A
(ko)
|
2018-10-29 |
2021-07-07 |
메르사나 테라퓨틱스, 인코포레이티드 |
펩티드 함유 링커를 갖는 시스테인 조작된 항체-약물 접합체
|
|
IL289094A
(en)
|
2019-06-17 |
2022-02-01 |
Tagworks Pharmaceuticals B V |
Tetrazines for increasing the speed and yield of the "click release" reaction
|
|
AU2020297253B2
(en)
|
2019-06-17 |
2024-05-23 |
Tagworks Pharmaceuticals B.V. |
Compounds for fast and efficient click release
|
|
KR20240099150A
(ko)
|
2021-09-06 |
2024-06-28 |
베락사 바이오테크 게엠베하 |
진핵생물에서의 유전자 코드 확장을 위한 신규 아미노아실-tRNA 합성효소 변이체
|
|
CN117980327A
(zh)
|
2021-11-03 |
2024-05-03 |
杭州多禧生物科技有限公司 |
抗体的特异性偶联
|
|
DK4186529T3
(da)
|
2021-11-25 |
2025-08-25 |
Veraxa Biotech Gmbh |
Forbedrede antistof-payload-konjugater (apc) fremstillet ved stedspecifik konjugering ved hjælp af genetisk kodeudvidelse
|
|
KR20240105469A
(ko)
|
2021-11-25 |
2024-07-05 |
베락사 바이오테크 게엠베하 |
유전자 코드 확장을 이용하는 부위-특이적 접합에 의해 제조되는 개선된 항체-페이로드 접합체 (apc)
|
|
CA3239713A1
(en)
|
2021-12-08 |
2023-06-15 |
Edward A. LEMKE |
Hydrophilic tetrazine-functionalized payloads for preparation of targeting conjugates
|
|
WO2023158305A1
(en)
|
2022-02-15 |
2023-08-24 |
Tagworks Pharmaceuticals B.V. |
Masked il12 protein
|
|
IL318188A
(en)
|
2022-07-15 |
2025-03-01 |
Pheon Therapeutics Ltd |
Antibody-drug conjugates
|
|
EP4602023A1
(en)
|
2022-10-12 |
2025-08-20 |
Tagworks Pharmaceuticals B.V. |
Strained bicyclononenes
|
|
CN120569216A
(zh)
|
2023-01-20 |
2025-08-29 |
巴斯夫欧洲公司 |
稳定型生物聚合物组合物、其制造和用途
|
|
WO2024191293A1
(en)
|
2023-03-10 |
2024-09-19 |
Tagworks Pharmaceuticals B.V. |
Trans-cyclooctene with improved t-linker
|
|
WO2025021929A1
(en)
|
2023-07-27 |
2025-01-30 |
Veraxa Biotech Gmbh |
Hydrophilic trans-cyclooctene (hytco) compounds, constructs and conjugates containing the same
|
|
WO2025056807A1
(en)
|
2023-09-15 |
2025-03-20 |
Basf Se |
Stabilized biopolymer composition, their manufacture and use
|
|
WO2025149667A1
(en)
|
2024-01-12 |
2025-07-17 |
Pheon Therapeutics Ltd |
Antibody drug conjugates and uses thereof
|
|
WO2025174248A1
(en)
|
2024-02-16 |
2025-08-21 |
Tagworks Pharmaceuticals B.V. |
Trans-cyclooctenes with "or gate" release
|