JPH1077292A5 - - Google Patents
Info
- Publication number
- JPH1077292A5 JPH1077292A5 JP1997222854A JP22285497A JPH1077292A5 JP H1077292 A5 JPH1077292 A5 JP H1077292A5 JP 1997222854 A JP1997222854 A JP 1997222854A JP 22285497 A JP22285497 A JP 22285497A JP H1077292 A5 JPH1077292 A5 JP H1077292A5
- Authority
- JP
- Japan
- Prior art keywords
- androstane
- diol
- dione
- dimethylaminoethoxyimino
- dimethylaminopropoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19633349A DE19633349A1 (de) | 1996-08-19 | 1996-08-19 | Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten |
| DE19633349.0 | 1996-08-19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH1077292A JPH1077292A (ja) | 1998-03-24 |
| JPH1077292A5 true JPH1077292A5 (cg-RX-API-DMAC7.html) | 2005-05-19 |
| JP4297994B2 JP4297994B2 (ja) | 2009-07-15 |
Family
ID=7802998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP22285497A Expired - Lifetime JP4297994B2 (ja) | 1996-08-19 | 1997-08-19 | 心臓血管系に活性のある新規の６−ヒドロキシおよび６−オキソ−アンドロスタン誘導体およびそれらを含有する製薬用組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5914324A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0825197B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4297994B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE196768T1 (cg-RX-API-DMAC7.html) |
| DE (2) | DE19633349A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0825197T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2151698T3 (cg-RX-API-DMAC7.html) |
| GR (1) | GR3034821T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT825197E (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1317031B1 (it) * | 2000-05-17 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi. |
| US20080119447A1 (en) * | 2005-09-30 | 2008-05-22 | James Yarger | 6-alkoxyalkyl estradiol derivatives and methods of use |
| US10174070B2 (en) * | 2005-09-30 | 2019-01-08 | Endece Llc | 6-substituted estradiol derivatives and methods of use |
| US8168621B2 (en) | 2005-09-30 | 2012-05-01 | Endece, Llc | 6-substituted estradiol derivatives and methods of use |
| TWI389917B (zh) | 2006-04-13 | 2013-03-21 | Sigma Tau Ind Farmaceuti | 作為心血管疾病治療藥物的雄甾烷與雄甾烯之氮雜環烷基衍生物 |
| TWI392682B (zh) * | 2006-04-13 | 2013-04-11 | Sigma Tau Ind Farmaceuti | 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物 |
| TWI372762B (en) * | 2006-06-23 | 2012-09-21 | Sigma Tau Ind Farmaceuti | Amino derivatives of b-homoandrostanes and b-heteroandrostanes |
| BRPI0721050A2 (pt) | 2006-11-29 | 2014-07-29 | Endece Llc | Derivados de 6-alquoxialquil estradiol e métodos de uso |
| JP5436432B2 (ja) * | 2007-10-12 | 2014-03-05 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | 心臓血管疾患のための医薬としての、２−および／または４−置換のアンドロスタンおよびアンドロステンのアミノオキシム誘導体 |
| WO2010149666A1 (en) | 2009-06-22 | 2010-12-29 | Medexis S.A. | Methods for treating neoplasia |
| US20130303500A1 (en) * | 2010-07-30 | 2013-11-14 | Medexis S.A. | Compounds and methods for treating neoplasia |
| BR112013005843A2 (pt) | 2010-09-14 | 2019-12-10 | Endece Llc | derivativos de er-beta 6-substituído por desmetil-estradiol |
| CN103315968B (zh) * | 2013-06-26 | 2015-04-01 | 中国生命药物治疗有限公司 | 一种注射用粉针剂及其制备方法 |
| CN103360457B (zh) * | 2013-07-31 | 2015-10-07 | 中国生命药物治疗有限公司 | 一种雄甾烷二酮衍生物晶型及其制备方法 |
| EP3599243B1 (en) | 2018-07-26 | 2023-04-12 | CVIE Therapeutics Limited | 17beta-heterocyclyl-digitalis like compounds for the treatment of heart failure |
| KR20210136048A (ko) | 2019-03-05 | 2021-11-16 | 윈드트리 세라퓨틱스, 인크. | 급성 심부전 (ahf)의 치료를 위한 이스타록심-함유 정맥내 제형 |
| EP3805243B1 (en) | 2019-10-09 | 2023-11-15 | Windtree Therapeutics, Inc. | Androstane derivatives with activity as pure or predominantly pure stimulators of serca2a for the treatment of heart failure |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2863885A (en) * | 1958-02-10 | 1958-12-09 | Upjohn Co | 17-isonitrosoandrostanes |
| FR7725M (cg-RX-API-DMAC7.html) * | 1967-06-22 | 1970-03-02 | ||
| CH504427A (de) * | 1967-12-06 | 1971-03-15 | Ciba Geigy Ag | Verfahren zur Herstellung neuer 4-Imino-19-nor-A-homosteroid-triene |
| US5144017A (en) * | 1988-07-13 | 1992-09-01 | University Of Manitoba | Compounds that bind to digitalis receptor |
| GB9201224D0 (en) * | 1992-01-21 | 1992-03-11 | Erba Carlo Spa | Difluoromethylenandrostenone derivatives and process for their preparation |
| DE4227605C2 (de) * | 1992-08-20 | 1995-02-16 | Sigma Tau Ind Farmaceuti | 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten |
| DE4232656C2 (de) * | 1992-09-29 | 1995-01-12 | Sigma Tau Ind Farmaceuti | Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen |
| DE4344236A1 (de) * | 1993-12-23 | 1995-06-29 | Sigma Tau Ind Farmaceuti | Neue 17-Iminomethylalkenyl-5beta,14beta-androstan- und 17-Iminoalkyl-5beta,14beta-androstan-Derivate , die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten |
-
1996
- 1996-08-19 DE DE19633349A patent/DE19633349A1/de not_active Withdrawn
-
1997
- 1997-07-09 DE DE69703228T patent/DE69703228T2/de not_active Expired - Lifetime
- 1997-07-09 AT AT97111651T patent/ATE196768T1/de active
- 1997-07-09 ES ES97111651T patent/ES2151698T3/es not_active Expired - Lifetime
- 1997-07-09 PT PT97111651T patent/PT825197E/pt unknown
- 1997-07-09 EP EP97111651A patent/EP0825197B1/en not_active Expired - Lifetime
- 1997-07-09 DK DK97111651T patent/DK0825197T3/da active
- 1997-07-10 US US08/891,030 patent/US5914324A/en not_active Expired - Lifetime
- 1997-08-19 JP JP22285497A patent/JP4297994B2/ja not_active Expired - Lifetime
-
2000
- 2000-11-10 GR GR20000402508T patent/GR3034821T3/el unknown