JPH10501527A - 多重薬剤耐性細胞を抗腫瘍剤に対して感受性にするためのインドロカルバゾール誘導体 - Google Patents

多重薬剤耐性細胞を抗腫瘍剤に対して感受性にするためのインドロカルバゾール誘導体

Info

Publication number
JPH10501527A
JPH10501527A JP8500245A JP50024596A JPH10501527A JP H10501527 A JPH10501527 A JP H10501527A JP 8500245 A JP8500245 A JP 8500245A JP 50024596 A JP50024596 A JP 50024596A JP H10501527 A JPH10501527 A JP H10501527A
Authority
JP
Japan
Prior art keywords
formula
group
compound
staurosporine
benzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8500245A
Other languages
English (en)
Japanese (ja)
Inventor
レゲナス，ウルス
カラバッティ，ジョルジオ
フレデンハーゲン，アンドレアス
バッカル，オスカル
Original Assignee
チバ−ガイギー アクチェンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by チバ−ガイギー アクチェンゲゼルシャフト filed Critical チバ−ガイギー アクチェンゲゼルシャフト
Publication of JPH10501527A publication Critical patent/JPH10501527A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP8500245A 1994-06-01 1995-05-19 多重薬剤耐性細胞を抗腫瘍剤に対して感受性にするためのインドロカルバゾール誘導体 Pending JPH10501527A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH171494 1994-06-01
CH1714/94-2 1994-06-01
PCT/EP1995/001910 WO1995032975A1 (fr) 1994-06-01 1995-05-19 Derives d'indolocarbazole destines a sensibiliser a des agents antitumoraux des cellules a resistance multiple aux antitumoraux

Publications (1)

Publication Number Publication Date
JPH10501527A true JPH10501527A (ja) 1998-02-10

Family

ID=4216887

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8500245A Pending JPH10501527A (ja) 1994-06-01 1995-05-19 多重薬剤耐性細胞を抗腫瘍剤に対して感受性にするためのインドロカルバゾール誘導体

Country Status (4)

Country Link
EP (1) EP0763041A1 (fr)
JP (1) JPH10501527A (fr)
AU (1) AU2565895A (fr)
WO (1) WO1995032975A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009504608A (ja) * 2005-08-09 2009-02-05 ヨハネス・グーテンベルク−ウニヴェルジテート・マインツ 薬剤耐性肺癌のタンパク質キナーゼ阻害剤への感作
JP2015063569A (ja) * 2004-11-05 2015-04-09 ノバルティス アーゲー 有機化合物

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232299B1 (en) * 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
CA2245029A1 (fr) 1998-03-13 1999-09-13 University Of British Columbia Composes granulatimide en tant qu'inhibiteurs de controle g2
EP1070068B2 (fr) * 1998-03-13 2007-01-17 The University Of British Columbia Derives de granulatimide utilises dans le traitement du cancer
US6127401A (en) * 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
GB9903547D0 (en) 1999-02-16 1999-04-07 Novartis Ag Organic compounds
CA2379035A1 (fr) 1999-07-13 2001-01-18 Shiro Akinaga Derives de staurosporine
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
EP2949330B1 (fr) * 2014-05-30 2016-11-23 EntreChem, S.L. Activité antitumorale d'inhibiteurs de kinases multiples dans un cancer du sein triple négatif
CN108299467B (zh) * 2018-02-27 2020-04-28 中国海洋大学 具有细胞毒活性的吲哚咔唑类生物碱及制备方法、用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989007105A1 (fr) * 1988-02-04 1989-08-10 Kyowa Hakko Kogyo Co., Ltd. Derives de staurosporine
JPH03220194A (ja) * 1989-11-30 1991-09-27 Asahi Chem Ind Co Ltd スタウロスポリンカルボン酸誘導体
JPH04145085A (ja) * 1990-09-25 1992-05-19 Asahi Chem Ind Co Ltd スタウロスポリンのγ―ラクタム環誘導体とそのアンモニウム塩
EP0630898B1 (fr) * 1992-09-21 2001-11-28 Kyowa Hakko Kogyo Co., Ltd. Remede contre la thrombopenie
WO1994020106A1 (fr) * 1993-03-03 1994-09-15 Kyowa Hakko Kogyo Co., Ltd. Renforceur de sensibilite pour agent antineoplasique
AU7000094A (en) * 1993-06-17 1995-01-17 Ciba-Geigy Ag Indolocarbazole compound useful as proteinkinase c inhibitor

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015063569A (ja) * 2004-11-05 2015-04-09 ノバルティス アーゲー 有機化合物
JP2009504608A (ja) * 2005-08-09 2009-02-05 ヨハネス・グーテンベルク−ウニヴェルジテート・マインツ 薬剤耐性肺癌のタンパク質キナーゼ阻害剤への感作

Also Published As

Publication number Publication date
WO1995032975A1 (fr) 1995-12-07
EP0763041A1 (fr) 1997-03-19
AU2565895A (en) 1995-12-21

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