JPH10501521A - レチナールを含有する組成物 - Google Patents
レチナールを含有する組成物Info
- Publication number
- JPH10501521A JPH10501521A JP7524441A JP52444195A JPH10501521A JP H10501521 A JPH10501521 A JP H10501521A JP 7524441 A JP7524441 A JP 7524441A JP 52444195 A JP52444195 A JP 52444195A JP H10501521 A JPH10501521 A JP H10501521A
- Authority
- JP
- Japan
- Prior art keywords
- retinal
- weight
- composition according
- composition
- fat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 13−シスまたは13−トランス型、またはこれらの異性体の他の総て の混合物の形態の、レチナールを含有する皮膚化粧用組成物であって、本質的に 1種類以上の脂溶性酸化防止剤によって安定化された水中油エマルジョンからな ることを特徴とする、組成物。 2. 脂溶性酸化防止剤が、ブチル化ヒドロキシトルエン(BHT)、ブチル 化ヒドロキシアニソール(BHA)、パルミチン酸アスコルビル、α−トコフェ ロールおよびそのエステル、クエン酸、没食子酸プロピルおよび/またはそれら の混合物を含む群から選択される、請求の範囲第1項に記載の皮膚化粧用組成物 。 3. レチナールが油相に存在している、請求の範囲第1項または第2項に記 載の組成物。 4. 油相中の脂溶性酸化防止剤の濃度が0.005重量%〜0.5重量%で ある、請求の範囲第1〜3項のいずれか1項に記載の組成物。 5. 組成物のレチナール濃度が0.01重量%〜1重量%である、請求の範 囲第1〜4項のいずれか1項に記載の組成物。 6. 脂溶性酸化防止剤/レチナールの濃度比が0.1〜0.6である、請求 の範囲第1〜5項のいずれか1項に記載の組成物。 7. 脂溶性酸化防止剤/レチナールの濃度比が約0.4である、請求の範囲 第6項に記載の組成物。 8. レチナールを0.04重量%〜0.06重量%、好ましくは約0.05 重量%の濃度で、およびBHTを0.01重量%〜0.03重量%、好ましくは 約0.02重量%の濃度で含む、請求の範囲第1〜7項のいずれか1項に記載の 組成物。 9. レチナールを0.04重量%〜0.06重量%、好ましくは約0.05 重量%の濃度で、および没食子酸プロピルを0.01重量%〜0.03重量%、 好ましくは約0.02重量%の濃度で含む、請求の範囲第1〜7項のいずれか1 項に記載の組成物。 10. 組成物のpHが6〜7.5である、請求の範囲第1〜9項のいずれか 1項に記載の組成物。 11. 下記の工程を含むことを特徴とする、請求の範囲第1〜10項のいず れか1項に記載の組成物の製造法。 a) レチナールを1種類以上の有機および/またはミネラル油、ワックス、エス テル、およびシリコーンに溶解させ、 b) 1種類以上の脂溶性酸化防止剤をこの溶液に加え、 c) 得られる溶液を水溶液および/または水−アルコール溶液中で乳化して、水 中油エマルジョンを得る。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9403339A FR2717686B1 (fr) | 1994-03-22 | 1994-03-22 | Composition dermo-cosmétologique et procédé de préparation. |
FR94/03339 | 1994-03-22 | ||
PCT/FR1995/000350 WO1995025507A1 (fr) | 1994-03-22 | 1995-03-22 | Composition contenant du retinal |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10501521A true JPH10501521A (ja) | 1998-02-10 |
JP3768234B2 JP3768234B2 (ja) | 2006-04-19 |
Family
ID=9461298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52444195A Expired - Lifetime JP3768234B2 (ja) | 1994-03-22 | 1995-03-22 | レチナールを含有する組成物 |
Country Status (11)
Country | Link |
---|---|
US (1) | US5776986A (ja) |
EP (1) | EP0751764B1 (ja) |
JP (1) | JP3768234B2 (ja) |
AT (1) | ATE210435T1 (ja) |
AU (1) | AU701657B2 (ja) |
DE (1) | DE69524581T2 (ja) |
DK (1) | DK0751764T3 (ja) |
ES (1) | ES2169126T3 (ja) |
FR (1) | FR2717686B1 (ja) |
PT (1) | PT751764E (ja) |
WO (1) | WO1995025507A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002524405A (ja) * | 1998-09-08 | 2002-08-06 | インダストリア エ コメルシオ デ コスメティコス ナチュラ リミタダ | 個体の細胞活性に対するビタミンaの作用を増強するための方法及び組成物、並びにビタミンcの使用 |
JPWO2003082224A1 (ja) * | 2002-03-29 | 2005-07-28 | 株式会社コーセー | 化粧料 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6080393A (en) * | 1994-07-09 | 2000-06-27 | Johnson & Johnson Consumer Products, Inc. | Skin care composition comprising a retinoid |
US6461622B2 (en) * | 1994-09-07 | 2002-10-08 | Johnson & Johnson Consumer Companies, Inc. | Topical compositions |
US5976555A (en) * | 1994-09-07 | 1999-11-02 | Johnson & Johnson Consumer Products, Inc. | Topical oil-in-water emulsions containing retinoids |
FR2744368B1 (fr) * | 1996-02-02 | 1998-04-24 | Fabre Pierre Dermo Cosmetique | Composition dermocosmetique contenant du retinal |
AR006049A1 (es) | 1996-03-01 | 1999-07-21 | Johnson & Johnson Consumer | Una emulsion de aceite en agua |
US8541469B2 (en) * | 1997-08-23 | 2013-09-24 | Glaxo Group Limited | Treatment of cell-mediated immune diseases |
EP0908179A1 (en) * | 1997-08-23 | 1999-04-14 | Werner Bollag | Treatment of cell-mediated immune diseases |
DE10212865B4 (de) * | 2002-03-22 | 2005-05-04 | Beiersdorf Ag | Verwendung von 9-Retinal-alkanolamin Schiffsche Base in kosmetischen der dermatologischen Formulierungen |
JP2004020220A (ja) * | 2002-06-12 | 2004-01-22 | Pioneer Electronic Corp | 通信システム及び方法、通信端末装置、通信センタ装置、並びにコンピュータプログラム |
CN112263549A (zh) * | 2013-03-15 | 2021-01-26 | 实验室护肤股份有限公司 | 细干颗粒类视黄醇活性剂组合物和包括其的局部制剂 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3906108A (en) * | 1973-10-12 | 1975-09-16 | Johnson & Johnson | Stabilized tretinoin cream emulsion |
DE3372843D1 (en) * | 1982-05-15 | 1987-09-10 | Beecham Group Plc | Skin treatment compositions |
ES2059721T3 (es) * | 1988-02-25 | 1994-11-16 | Beecham Group Plc | Composicion para el tratamiento de la piel. |
US5093360A (en) * | 1989-04-07 | 1992-03-03 | Yu Ruey J | Retinal, derivatives and their therapeutic use |
FI903483A0 (fi) * | 1989-07-13 | 1990-07-10 | Bristol Myers Squibb Co | Tretinoin innehaollande stabila emulsionskraemformulationer. |
JP3435510B2 (ja) * | 1991-06-27 | 2003-08-11 | ジヨンソン・アンド・ジヨンソン・コンシユーマー・プロダクツ・インコーポレーテツド | スキンケア組成物 |
-
1994
- 1994-03-22 FR FR9403339A patent/FR2717686B1/fr not_active Expired - Fee Related
-
1995
- 1995-03-22 PT PT95914397T patent/PT751764E/pt unknown
- 1995-03-22 US US08/716,221 patent/US5776986A/en not_active Expired - Lifetime
- 1995-03-22 WO PCT/FR1995/000350 patent/WO1995025507A1/fr active Search and Examination
- 1995-03-22 DK DK95914397T patent/DK0751764T3/da active
- 1995-03-22 JP JP52444195A patent/JP3768234B2/ja not_active Expired - Lifetime
- 1995-03-22 ES ES95914397T patent/ES2169126T3/es not_active Expired - Lifetime
- 1995-03-22 AT AT95914397T patent/ATE210435T1/de active
- 1995-03-22 DE DE69524581T patent/DE69524581T2/de not_active Expired - Lifetime
- 1995-03-22 EP EP95914397A patent/EP0751764B1/fr not_active Expired - Lifetime
- 1995-03-22 AU AU21408/95A patent/AU701657B2/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002524405A (ja) * | 1998-09-08 | 2002-08-06 | インダストリア エ コメルシオ デ コスメティコス ナチュラ リミタダ | 個体の細胞活性に対するビタミンaの作用を増強するための方法及び組成物、並びにビタミンcの使用 |
JPWO2003082224A1 (ja) * | 2002-03-29 | 2005-07-28 | 株式会社コーセー | 化粧料 |
Also Published As
Publication number | Publication date |
---|---|
DE69524581T2 (de) | 2002-07-25 |
FR2717686B1 (fr) | 1996-06-28 |
ES2169126T3 (es) | 2002-07-01 |
AU701657B2 (en) | 1999-02-04 |
AU2140895A (en) | 1995-10-09 |
WO1995025507A1 (fr) | 1995-09-28 |
EP0751764B1 (fr) | 2001-12-12 |
US5776986A (en) | 1998-07-07 |
PT751764E (pt) | 2002-06-28 |
FR2717686A1 (fr) | 1995-09-29 |
JP3768234B2 (ja) | 2006-04-19 |
ATE210435T1 (de) | 2001-12-15 |
DE69524581D1 (de) | 2002-01-24 |
EP0751764A1 (fr) | 1997-01-08 |
DK0751764T3 (da) | 2002-06-17 |
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