JPH10316543A - Composition for head - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a composition for a head having excellent activities for preventing depilation, etc., and promoting hair growth, and utilized in drug, unregulated drug and cosmetic fields by formulating a specific plant extract. SOLUTION: This composition for a head is obtained by formulating at least one kind of an extract of a plant belonging to the genus Tabebuia of Bignoniaceae. A preferable plant belonging to the genus Tabebuia of Bignoniaceae is exemplified by Tabebuia heptaphylla, Tabebuia caraiba, Tabebuia cassinoides and Tabebuia chrysotricha. The formulating amount of the extract is 0.005-20.0 wt.%.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a composition for a head having an excellent effect of preventing hair loss and promoting hair growth by blending a specific plant extract. The head composition of the present invention is specifically used in the fields of pharmaceuticals, quasi-drugs, and cosmetics.

[0002]

2. Description of the Related Art Conventionally, causes of baldness and hair loss include the activation of male hormones in organs such as hair roots and sebaceous glands, decreased blood flow to hair follicles, and excessive secretion of sebum. It is considered that abnormalities of the scalp due to the generation of peroxides and the like are caused. For this reason, a compound having an action of removing or reducing the above-mentioned causes is generally added to conventional hair restorers. Examples of such compounds include vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as assembly extract and acetylcholine derivatives, anti-inflammatory agents such as purple root extract and hinokitiol, estradiol and the like. And a skin function-enhancing agent such as cepharanthin, etc., are used for the prevention and treatment of alopecia.

[0003] However, conventional hair nourishes are said to be effective in preventing and improving dandruff, itchiness, hair loss and the like and to promote hair growth and hair growth, but none of them have yet exhibited satisfactory effects. This is probably due to a variety of causes of hair loss and the very complex mechanism of hair growth. In view of the variety of causes of such hair loss, it is desired to provide a further new hair restoration.

[0004]

As a solution to these problems, the present inventors have investigated the effectiveness of a variety of substances in preventing hair loss and hair growth and the like. As a result, the present inventors have found that the species Bignoniaceae Tabebuia ( Tabebuia) An extract of a plant belonging to the genus Tabebuia has been found to exhibit an effect of preventing hair loss and promoting hair growth and is excellent in safety, and has completed the present invention.

That is, the present invention relates to
gnoniaceae) It is a composition for a head characterized by comprising an extract of a plant of the genus Tabebuia. The head composition of the present invention is preferably a hair nourishing agent. Here, the term "hair nourishing agent" is used in a concept having at least one of the effects of preventing hair loss, promoting hair growth, and preventing dandruff, especially when administered to the human scalp.

Hereinafter, the configuration of the present invention will be described in detail. Among the plants of the genus Tabigna (Bignoniaceae) of the genus Tabebuia used in the present invention, preferred are Ipe Rosso (scientific name: Tabebuia heptaphyll)
a), Carobela (scientific name: Tabebuia caraiba), Caixetta (scientific name: Tabebuia cassinoides), Ipe Amarero (scientific name: Tabebuia chrysotricha), Ipe Rosa (scientific name: Tabebuia impetiginosa), Pau d'Arco amarero (scientific name: ifabuia) And Ipe Komung (scientific name: Tabebuia vellozoi Toledo).

[0007] The swelling family (Bi) used in the present invention
The extract of the genus gnoniaceae Tabebuia plant comprises components that are extracted from plant constituent parts of one or a plurality thereof. The plant constituent part used for the extraction is not particularly limited, and the leaves, stems, flowers, bark, seeds, materials, branches or fruits of the plant, or the whole plant or the like are immersed or heated under reflux with the extraction solvent. Thereafter, it is obtained by filtration and concentration. Extraction from these plant constituents is carried out, if necessary, after drying and pulverizing these constituents, methanol, ethanol, isopropanol, lower alcohols such as n-butanol, acetone, ketones such as methyl ethyl ketone, ethyl acetate,
Esters such as butyl acetate, glycols such as ethylene glycol, propylene glycol and 1,3-butylene glycol, hydrocarbons such as n-hexane, n-heptane, n-pentane and cyclohexane, dioxane, tetrahydrofuran, diethyl ether , Di-isopropyl ether, etc., petroleum ether, benzene, chloroform, dichloromethane, acetonitrile alone or a mixture thereof, or, if necessary, by immersion or reflux extraction. be able to.

The extract used in the present invention may be used as it is, as a concentrated concentrate, or concentrated to dryness and pulverized, depending on the dosage form of the head composition containing the extract. It can be used as a converted powder.

[0009] In the present invention, the swelling family (Bignon
iaceae) The content of an extract of a plant of the genus Tabebuia is not limited because the optimal amount varies depending on the dosage form, but generally the content of the extract is 0.0%.
05 to 20.0% by weight, preferably 0.01 to 10.0
It is adjusted to be% by weight. If the amount is less than 0.005% by weight, the effect of the present invention cannot be sufficiently exhibited.
If it exceeds 0.0% by weight, it is disadvantageous in formulation and is not preferred.

The head composition of the present invention may be in the form of a liquid, an emulsion, an ointment, or the like. In addition to the above-mentioned essential components, depending on the purpose of use, within the range not impairing the effects of the present invention, Various components commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., for example, oils such as polyoxyethylene oleyl alcohol ether, glyceryl monooleate, nicotinamide, benzyl nicotinate, vitamin E acetate, assembly extract, chloride Vasodilators such as carpronium, assembly extract, and acetylcholine derivatives; amino acids such as serine and methionine; vitamin B6, vitamin E and derivatives thereof; testosterone 5α reductase inhibitors such as glycyrrhetinic acid and hinokitiol; hormones such as ethinyl estradiol. Preparation, vitamin H, pantothenyl ethyl ether Hair root activating agent such as ether, salicylic acid,
Menthol, sorbitan monolaurate, sorbitan monopalmitate, sorbitan sesquioleate, sorbitan trioleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyethylene glycol monooleate, polyoxyethylene alkyl ether, polyglycol Diesters, nonionic surfactants such as laurylethanolamide, fatty acid isopropanolamide, cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride, sodium palmitate, sodium laurate, sodium lauryl sulfate, potassium lauryl sulfate, Triethanolamine alkyl sulfate, funnel oil, linear dodecylbenzene sulfate, polyoxyethylene hard Castor oil, anionic surfactants such as polyoxyethylene hydrogenated castor oil maleate, lauryl dimethyl amine oxide semipolar surfactants such as oleic dimethyl amine oxide, amphoteric surfactants,
Organic acids such as citric acid, amino acids such as arginine, olive oil, squalane, liquid paraffin, isopropyl myristate, cetylpyridinium chloride, undecylenic acid, antibacterial agents such as trichlorocarbanilide and bithionol, zinc and its derivatives, lactic acid and its Alkyl esters, glycerin, polyhydric alcohols such as propylene glycol, fragrances, antioxidants, ultraviolet absorbers, dyes, ethanol, water, humectants, thickeners, etc. are appropriately compounded within a range not to impair the effects of the present invention. Can be.

[0011]

Next, the present invention will be described in further detail with reference to examples. Note that the present invention is not limited by this. The compounding amount is% by weight. Prior to the examples, test methods for hair growth promotion, hair loss inhibitory effects, and the like and the results thereof will be described.

Hair growth promotion and hair loss prevention effects Preparation of Sample (1) Preparation Example 1 500 g of a whole dried product of Ipea Rosso (scientific name: Tabebuia heptaphylla) was added to 5 liters of methanol at room temperature.
Dipped for days. The solvent was distilled off from the extract, and then dried under reduced pressure.
g was obtained. This extract was dissolved in 75% ethanol.
A 0% by weight solution was prepared.

(2) Preparation Example 2 Total dried product of Carobela (scientific name: Tabebuia caraiba) 50
0 g was immersed in 5 liters of 70% ethanol at room temperature for 7 days. The solvent was distilled off from the extract, followed by drying under reduced pressure to obtain 25 g of a dried 70% ethanol extract of Calovaira. This extract was dissolved in 75% ethanol to prepare a 1.0% by weight solution.

(3) Preparation Example 3 A total of 500 g of dried Caishetta (scientific name: Tabebuia cassinoides) was immersed in 5 liters of ethanol at room temperature for 7 days. The solvent was distilled off from the extract, and then dried under reduced pressure to obtain 19 g of a dried product of Caishetta ethanol extract. This extract was dissolved in 75% ethanol to prepare a 1.0% by weight solution.

(4) Preparation Example 4 Ipe Amarello (scientific name: Tabebuia chrysotricha)
Was immersed in 5 liters of n-hexane at room temperature for 7 days. The solvent was distilled off from the extract, and then dried under reduced pressure to obtain 18 g of a dry n-hexane extract of Ipe amarero. This extract was dissolved in 75% ethanol to prepare a 1.0% by weight solution.

(5) Preparation Example 5 A total of 500 g of IPE Rosa (scientific name: Tabebuia impetiginosa) was immersed in 5 liters of 50% ethanol at room temperature for 7 days. The solvent was distilled off from the extract and dried under reduced pressure to obtain 23 g of a dry 50% ethanol extract of IPE ROSA. This extract was dissolved in 75% ethanol to prepare a 1.0% by weight solution.

(6) Preparation Example 6 Pau d'Arco amarero (scientific name: Tabebuia serratifo)
lia) 500 g of the total dry matter in 5 liters of 50% 1,
It was immersed in 3-butylene glycol at room temperature for 7 days. The solvent was distilled off from the extract, followed by drying under reduced pressure to obtain 26 g of a dry product of Pau d'Arco amarero, 50% 1,3-butylene glycol extract. This extract was dissolved in 75% ethanol to prepare a 1.0% by weight solution.

(7) Preparation Example 7 A total of 500 g of a dried product of Ipe Komung (scientific name: Tabebuia vellozoi Toledo) was immersed in 5 liters of 50% ethanol at room temperature for 7 days. The solvent was distilled off from the extract, followed by drying under reduced pressure to obtain 27 g of a dry 50% ethanol extract of IPE-COMUN. This extract was dissolved in 75% ethanol to prepare a 1.0% by weight solution.

2. Test method and results (1) Hair growth test C3H / HeNC in rest period of hair cycle as experimental animal
Using rj mice, the method of Ogawa et al. [Normal and Abnormal Epidermal Differentiation
), Edited by M. Seiji and IABernstein, 159-
170 pages, 1982, The University of Tokyo Press].

The back hair of the mouse was shaved to a size of about 2 × 4 cm, and from the next day, the sample of the preparation example shown in Table 1 was applied once a day, 0.1 ml each day, every day, and the portion where hair regeneration started The change in area was determined and hair regeneration was examined. Each sample consisted of 10 mice, and the average value of the hair regeneration area was determined. The results of the hair regeneration area after 25 days were summarized in percentage. In addition, as a comparative control, the same operation was performed for a drug-free product (Control Example 1). Table 1 also shows the results.

[0021]

[Table 1] 面積 Hair regeneration area ─────── ───────────────────────────── Ipe / Roscio extract (Preparation example 1) 74 Calovaira extract (Preparation example 2) 69 Caishetta Extract (Preparation Example 3) 72 Ipea Amarero Extract (Preparation Example 4) 67 Ipe Rosa Extract (Preparation Example 5) 73 Pau Dalco Amarello Extract (Preparation Example 6) 70 Ipe Comun Extract (Preparation Example 6) Example 7) 70 75% ethanol 5────────────────────────────────────

As is clear from the results in Table 1, a significant effect on hair regeneration was recognized.

(2) Actual use test Sample 8 of the present invention Hair tonic (1) Extract (dried product) obtained in Preparation Example 1.0 (2) Propylene glycol 5.0 (3) Sodium hyaluronate 0 .01 (4) 75% ethanol residue

The effects of the hair tonics prepared according to the above formulation on symptoms such as dandruff, hair growth and hair loss were examined by actual use. Symptoms such as dandruff, hair growth inhibition, and hair loss 15
1 to 2 times a day for 1 to 3 males (aged 25 to 55)
The solution was administered for 4 months by ml, and the dandruff-preventing effect, the hair growth-promoting effect and the hair loss-preventing effect were tested according to the evaluation criteria described below. Table 2 shows the results.

Evaluation Criteria (1) Dandruff Prevention Effect Test Ineffective: No improvement was observed despite treatment. Effective: Those with reduced occurrence of dandruff. Significant effect: The occurrence of dandruff has stopped.

(2) Hair growth effect test Ineffective: Despite the treatment, no improvement is observed. Effective: Hair growth is observed in 2/3 or more of the hair loss part. Significant effect: Hair that has grown on the epilation area

(3) Hair loss effect test Ineffective: No improvement observed despite treatment. Effective: those with reduced progression of hair loss. Significant effect: Hair loss has stopped.

[0028]

[Table 2] 被 験 者 Subject Age Dandruff Hair loss and hair loss ────── ──────────────────────────── 1 31 Effective Effective Effective 2 44 Effective Effective Effective 3 46 Effective Effective Effective 4 37 Effective Effective Invalid 5 32 Effective Disabled Significant 6 27 Effective Significant Significant 7 38 Disabled Effective Disabled 8 54 Effective Disabled Disabled 9 33 Significant Effective Valid 10 27 Significant Effective Significant 11 52 Effective Disabled Effective 12 41 Significant Effective Significant 13 53 Valid Invalid Valid 14 48 Valid Valid Valid 15 30 Valid Valid Valid ──────────────────────────────────

As is clear from the results in Table 2, this hair tonic has excellent effects on promoting hair growth, preventing dandruff and preventing hair loss.

Preparation Example 9 of the Present Invention Hair Tonic (1) Extract (dry product) obtained in Preparation Example 1.0 (2) Polyoxypropylene butyl ether 15.0 (3) Sodium hyaluronate 0.01 (4) ) 75% ethanol residue

The formulation of Preparation Example 9 of the present invention was also shown to be effective in promoting hair growth and preventing dandruff and hair loss.

Preparation Example 10 of the Present Invention Hair Tonic (1) Extract (dry product) obtained in Preparation Example 1.0 (2) Propylene glycol 5.0 (3) Sodium hyaluronate 0.01 (4) 75 % Ethanol residue

The formulation of Preparation Example 10 of the present invention was also shown to be effective for promoting hair growth and preventing dandruff and hair loss.

Preparation Example 11 of the Present Invention Hair Tonic (1) Extract (Dried Product) Obtained in Preparation Example 1.0 (2) Propylene Glycol 5.0 (3) Sodium Hyaluronate 0.01 (4) 75 % Ethanol residue

The formulation of Preparation Example 11 of the present invention was also shown to be effective for promoting hair growth and preventing dandruff and hair loss.

Preparation Example 12 of the Present Invention Hair Tonic (1) Extract (dried product) obtained in Preparation Example 1.0 (2) Propylene glycol 5.0 (3) Sodium hyaluronate 0.01 (4) 75 % Ethanol residue

The formulation of Preparation Example 12 of the present invention was also shown to be effective for promoting hair growth and preventing dandruff and hair loss.

Preparation Example 13 of the Present Invention Hair Tonic (1) Extract (Dried Product) Obtained in Preparation Example 1.0 (2) Propylene Glycol 5.0 (3) Sodium Hyaluronate 0.01 (4) 75 % Ethanol residue

The formulation of Preparation Example 13 of the present invention was also shown to be effective for promoting hair growth and preventing dandruff and hair loss.

Preparation Example 14 of the Present Invention Hair Tonic (1) Extract (dried product) obtained in Preparation Example 1.0 (2) Propylene glycol 5.0 (3) Polyoxyethylene hydrogenated castor oil 1.0 ( 4) 75% ethanol residue

The formulation of Preparation Example 14 of the present invention was also shown to be effective for promoting hair growth and preventing dandruff and hair loss.

Hereinafter, examples of formulations of head compositions of the present invention in various dosage forms will be described as examples.

Example 1 Hair Tonic (1) Hinokitiol 0.1 (2) Assembly Extract 1.0 (3) Vitamin B6 0.2 (4) Vitamin E 0.01 (5) Menthol 0.2 (6) Salicylic Acid 0.1 (7) Extract (dry product) obtained in Preparation Example 1 1.0 (8) Surfactant 0.1 (9) Propylene glycol 2.0 (10) 70% ethanol Residue

Example 2 Hair Tonic (1) Hinokitiol 0.1 (2) Assembly Extract 1.0 (3) Vitamin B6 0.2 (4) Vitamin E 0.01 (5) Menthol 0.2 (6) Salicylic Acid 0.1 (7) Extract (dry product) obtained in Preparation Example 2 1.0 (8) Extract (dry product) obtained in Preparation Example 3 1.0 (9) Surfactant 0.1 (10) Propylene glycol 2.0 (11) 75% ethanol residue

Example 3 Hair Tonic (1) Hinokitiol 0.1 (2) Assembly Extract 1.0 (3) Vitamin B6 0.2 (4) Vitamin E 0.01 (5) Menthol 0.2 (6) Salicylic Acid 0.1 (7) Extract (dry product) obtained in Preparation Example 3 1.0 (8) Extract (dry product) obtained in Preparation Example 1.0 (9) Surfactant 0.1 (10) Propylene glycol 2.0 (11) 75% ethanol residue

Example 4 Hair Tonic (1) Hinokitiol 0.1 (2) Assembly Extract 1.0 (3) Vitamin B6 0.2 (4) Vitamin E 0.01 (5) Menthol 0.2 (6) Salicylic Acid 0.1 (7) Extract (dried product) obtained in Preparation Example 5 1.0 (8) Extract (dried product) obtained in Preparation Example 1.0 (9) Surfactant 0.1 (10) Propylene glycol 2.0 (11) 75% ethanol residue

Example 5 Hair Tonic (1) Hinokitiol 0.1 (2) Assembly Extract 1.0 (3) Vitamin 0.2 (4) Vitamin 0.01 (5) Menthol 0.2 (6) Salicylic Acid 1 (7) Extract (dry product) obtained in Preparation Example 6 1.0 (8) Extract (dry product) obtained in Preparation Example 1.0 (9) Surfactant 0.1 (10 ) Propylene glycol 2.0 (11) 75% ethanol residue

Example 6 Shampoo (1) Sodium Cocoyl Methyl Taurine 2.0 (2) Polyoxyethylene (8 mol) Oleyl Alcohol 2.0 (3) Lauric Acid Diethanolamide 4.0 (4) Ethylene Glycol Fatty Ester 1 0.0 (5) Glycerin 0.2 (6) Menthol 0.1 (7) Extract (dried product) obtained in Preparation Example 1.0 (8) Proper amount of perfume (9) Propylene glycol 2.0 (10 ) Remaining purified water

Example 7 Shampoo (1) Sodium Cocoylmethyltaurine 2.0 (2) Polyoxyethylene (8 mol) oleyl alcohol 2.0 (3) Lauric acid diethanolamide 4.0 (4) Ethylene glycol fatty acid ester 1 0.0 (5) Glycerin 0.2 (6) Menthol 0.1 (7) Extract (dried product) obtained in Preparation Example 0.5 (8) Extract (Dried product) obtained in Preparation Example 3 0.5) (9) Proper amount of perfume (10) Propylene glycol 2.0 (11) Remaining purified water

Example 8 Shampoo (1) Sodium Cocoyl Methyl Taurine 2.0 (2) Polyoxyethylene (8 mol) Oleyl Alcohol 2.0 (3) Lauric Acid Diethanolamide 4.0 (4) Ethylene Glycol Fatty Ester 1 0.0 (5) Glycerin 0.2 (6) Menthol 0.1 (7) Extract obtained in Preparation Example 4 (dried product) 1.0 (8) Extract obtained in Preparation Example 5 (dried product) 1.0) (9) Proper amount of perfume (10) Propylene glycol 2.0 (11) Remaining purified water

Example 9 Shampoo (1) Sodium Cocoylmethyltaurine 2.0 (2) Polyoxyethylene (8 mol) oleyl alcohol 2.0 (3) Lauric acid diethanolamide 4.0 (4) Ethylene glycol fatty acid ester 1 0.0 (5) Glycerin 0.2 (6) Menthol 0.1 (7) Extract (dried product) obtained in Preparation Example 1.0 1.0 (8) Extract obtained in Preparation Example 6 (Dried product) 1.0) (9) Suitable amount of fragrance (10) Propylene glycol 2.0 (11) Remaining purified water

Example 10 Shampoo (1) Sodium Cocoyl Methyl Taurine 2.0 (2) Polyoxyethylene (8 mol) Oleyl Alcohol 2.0 (3) Lauric Acid Diethanolamide 4.0 (4) Ethylene Glycol Fatty Ester 1 0.0 (5) Glycerin 0.2 (6) Menthol 0.1 (7) Extract (dried product) obtained in Preparation Example 1.0 (8) Extract (Dried product) obtained in Preparation Example 7 1.0) (9) Proper amount of perfume (10) Propylene glycol 2.0 (11) Remaining purified water

[0053]

As described above, the head composition of the present invention is effective in preventing and improving dandruff and hair loss and promoting hair growth.

Continued on the front page (72) Inventor Hirohiko Sakamoto 1050 Nippa-cho, Kohoku-ku, Yokohama-shi, Kanagawa Inside Shiseido Daiichi Research Center Co., Ltd.

Claims (10)

[Claims] 1. A composition for a head comprising at least one extract of a plant belonging to the genus Tabigna (Bignoniaceae) of the genus Tabebuia. 2. A plant belonging to the genus Tabigna (Bignoniaceae) Tabebuia (scientific name: Ipe Rosso)
The head composition according to claim 1, which is Tabebuia heptaphylla). 3. A plant belonging to the genus Tabigna (Bignoniaceae) Tabebuia (scientific name: Tabebu)
ia caraiba). 4. A plant belonging to the genus Tabignia (Bignoniaceae) Tabebuia (scientific name: Tabeia).
The head composition according to claim 1, which is buia cassinoides). 5. The head composition according to claim 1, wherein the plant belonging to the genus Tabigniaceae (Bignoniaceae) Tabebuia is Ipe amarero (scientific name: Tabebuia chrysotricha). 6. The plant belonging to the genus Tabigna (Bignoniaceae) Tabebuia is scientifically described as Ipe Rosa (scientific name: Ta).
2. The head composition according to claim 1, which is bebuia impetiginosa). 7. The head composition according to claim 1, wherein the plant belonging to the genus Tabigna (Bignoniaceae) Tabebuia is Pau darco amarero (scientific name: Tabebuia serratifolia). 8. The plant belonging to the genus Tabigna (Bignoniaceae) belonging to the genus Tabebuia (scientific name: Taipebum)
2. The head composition according to claim 1, which is bebuia vellozoi Toledo). 9. The amount of an extract of a plant belonging to the genus Tabigna (Bignoniaceae) of the genus Tabebuia is 0.005 to 20.0% by weight in terms of dry matter.
The composition for a head according to any one of the above. 10. The composition for a head according to claim 1, which is a hair tonic.