JPH10265454A5 - - Google Patents
Info
- Publication number
- JPH10265454A5 JPH10265454A5 JP1998016362A JP1636298A JPH10265454A5 JP H10265454 A5 JPH10265454 A5 JP H10265454A5 JP 1998016362 A JP1998016362 A JP 1998016362A JP 1636298 A JP1636298 A JP 1636298A JP H10265454 A5 JPH10265454 A5 JP H10265454A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydroxy
- oxo
- enoic acid
- group
- dithiaprost
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10016362A JPH10265454A (ja) | 1997-01-27 | 1998-01-12 | ３，７−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9-27198 | 1997-01-27 | ||
| JP2719897 | 1997-01-27 | ||
| JP10016362A JPH10265454A (ja) | 1997-01-27 | 1998-01-12 | ３，７−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH10265454A JPH10265454A (ja) | 1998-10-06 |
| JPH10265454A5 true JPH10265454A5 (cg-RX-API-DMAC10.html) | 2005-07-28 |
Family
ID=12214403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10016362A Withdrawn JPH10265454A (ja) | 1997-01-27 | 1998-01-12 | ３，７−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5892099A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0855389B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPH10265454A (cg-RX-API-DMAC10.html) |
| AT (1) | ATE218543T1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE69805665T2 (cg-RX-API-DMAC10.html) |
| DK (1) | DK0855389T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2182220T3 (cg-RX-API-DMAC10.html) |
| PT (1) | PT855389E (cg-RX-API-DMAC10.html) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6043275A (en) * | 1998-04-16 | 2000-03-28 | Ono Pharmaceutical Co., Ltd. | 3,7-dithiaprostanoic acid derivative |
| US6437146B1 (en) | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
| AU6427599A (en) * | 1998-10-15 | 2000-05-01 | Merck & Co., Inc. | Methods for stimulating bone formation |
| US6414006B1 (en) | 1998-10-15 | 2002-07-02 | Merck Frosst Canada & Co. | Methods for inhibiting bone resorption |
| CA2364948C (en) | 1999-03-05 | 2011-04-26 | Duke University | C16 unsaturated fp-selective prostaglandins analogs |
| CN1304319A (zh) * | 1999-03-16 | 2001-07-18 | 东丽株式会社 | 子宫颈管成熟剂及子宫颈管成熟方法 |
| US6894175B1 (en) * | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| TWI247606B (en) * | 1999-11-24 | 2006-01-21 | Ono Pharmaceutical Co | Treating agent for osteopenic diseases |
| JP4618548B2 (ja) * | 1999-11-24 | 2011-01-26 | 小野薬品工業株式会社 | 骨量低下疾患治療剤 |
| BR0015781A (pt) * | 1999-11-24 | 2002-12-31 | Ono Pharmaceutical Co | Composição farmacêutica para tratamento de doenças associadas à diminuição de massa óssea |
| ATE327751T1 (de) | 2000-01-31 | 2006-06-15 | Pfizer Prod Inc | Verwendung von aktivatoren des prostaglandinrezeptores 4 zur behandlung von akuter oder chronischer niereninsuffizienz |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US20020172693A1 (en) * | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US20020037914A1 (en) * | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US20020146439A1 (en) * | 2000-03-31 | 2002-10-10 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins |
| AU2001290250A1 (en) * | 2000-09-21 | 2002-04-02 | Ono Pharmaceutical Co. Ltd. | Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient |
| GB0103269D0 (en) * | 2001-02-09 | 2001-03-28 | Glaxo Group Ltd | Napthalene derivatives |
| US6410591B1 (en) | 2001-05-08 | 2002-06-25 | Allergan Sales, Inc. | 3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
| US20050222094A1 (en) * | 2001-06-14 | 2005-10-06 | Burk Robert M | Treatment of inflammatory bowel disease |
| US20030027853A1 (en) | 2001-06-14 | 2003-02-06 | Allergan Sales, Inc. | 3, 7or3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
| US7872045B2 (en) | 2001-06-14 | 2011-01-18 | Allergan, Inc. | Combination therapy for glaucoma treatment |
| EP1490055A1 (en) * | 2002-03-18 | 2004-12-29 | Pfizer Products Inc. | Use of selective ep4 receptor agonists for the treatment of liver failure, loss of patency of the ductus arteriosus, glaucoma or ocular hypertension |
| AU2003224244A1 (en) * | 2002-03-27 | 2003-10-13 | Rosanto Pharmaceuticals Ltd | Improvements in pharmaceutical compositions |
| EP1513589B1 (en) | 2002-06-06 | 2010-11-10 | Merck Frosst Canada Ltd. | 1,5-disubstituted pyrrolid-2-one derivatives for use as ep4 receptor agonists in the treatment of eye diseases such as glaucoma |
| US7053085B2 (en) | 2003-03-26 | 2006-05-30 | Merck & Co. Inc. | EP4 receptor agonist, compositions and methods thereof |
| WO2004073589A2 (en) * | 2003-02-24 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep4 (prostaglandin e2 ep4) |
| CA2565628A1 (en) * | 2004-05-03 | 2005-11-10 | Astellas Pharma Inc. | The combination of prostaglandin e2 receptor antagonist and renin-angiotensin system inhibitor for treating renal diseases |
| EP1782829A1 (en) * | 2004-08-10 | 2007-05-09 | Ono Pharmaceutical Co., Ltd. | Preventive and/or remedy for hyperkalemia containing ep4 agonist |
| WO2006047466A2 (en) | 2004-10-21 | 2006-05-04 | Duke University | Ophthamological drugs |
| UY30121A1 (es) | 2006-02-03 | 2007-08-31 | Glaxo Group Ltd | Nuevos compuestos |
| EP2094839B1 (en) | 2006-12-08 | 2020-02-05 | University of Rochester | Expansion of hematopoietic stem cells |
| JP5069752B2 (ja) | 2006-12-15 | 2012-11-07 | グラクソ グループ リミテッド | Ｅｐ４受容体アゴニストとしてのベンズアミド誘導体 |
| GB0721611D0 (en) | 2007-11-02 | 2007-12-12 | Glaxo Group Ltd | Novel compounds |
| US8623918B2 (en) * | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| CA2738045C (en) | 2010-05-28 | 2019-02-19 | Simon Fraser University | Conjugate compounds, methods of making same, and uses thereof |
| US9650414B1 (en) | 2014-05-30 | 2017-05-16 | Simon Fraser University | Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof |
| CN107849072B (zh) | 2015-06-12 | 2020-12-15 | 西蒙弗雷泽大学 | 酰胺连接的ep4激动剂-二膦酸盐化合物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3168199D1 (en) * | 1980-10-31 | 1985-02-21 | Teijin Ltd | Novel thiaprostaglandin e1 derivatives, process for production thereof, and pharmaceuticals containing these compounds |
| JPS57108065A (en) * | 1980-12-26 | 1982-07-05 | Teijin Ltd | 7-thiaprostaglandin e1 derivative, its preparation, and blood platelet coagulation inhibiting agent containing said derivative as active component |
| JPS58110562A (ja) * | 1981-12-25 | 1983-07-01 | Teijin Ltd | 新規な７−チアプロスタグランジンｅ↓１誘導体類、それらの製造方法及びそれらを活性成分とする薬剤 |
| JPS58148857A (ja) * | 1982-02-26 | 1983-09-05 | Teijin Ltd | 新規な１３，１４−ジヒドロ−７−チアプロスタグランジンｅ↓１類およびその製造方法 |
-
1998
- 1998-01-12 JP JP10016362A patent/JPH10265454A/ja not_active Withdrawn
- 1998-01-26 DE DE69805665T patent/DE69805665T2/de not_active Expired - Fee Related
- 1998-01-26 PT PT98300513T patent/PT855389E/pt unknown
- 1998-01-26 EP EP98300513A patent/EP0855389B1/en not_active Expired - Lifetime
- 1998-01-26 AT AT98300513T patent/ATE218543T1/de not_active IP Right Cessation
- 1998-01-26 ES ES98300513T patent/ES2182220T3/es not_active Expired - Lifetime
- 1998-01-26 DK DK98300513T patent/DK0855389T3/da active
- 1998-01-27 US US09/013,885 patent/US5892099A/en not_active Expired - Fee Related
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