JPH09506251A - Bmpレセプターをコードするdna配列 - Google Patents
Bmpレセプターをコードするdna配列Info
- Publication number
- JPH09506251A JPH09506251A JP7515213A JP51521395A JPH09506251A JP H09506251 A JPH09506251 A JP H09506251A JP 7515213 A JP7515213 A JP 7515213A JP 51521395 A JP51521395 A JP 51521395A JP H09506251 A JPH09506251 A JP H09506251A
- Authority
- JP
- Japan
- Prior art keywords
- bmp
- brk
- cell
- protein
- dna sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 配列番号4のアミノ酸配列またはその可溶性断片を有する単離されたB MPレセプターキナーゼタンパク質。 2. 請求項1のBMPレセプターキナーゼタンパク質をコードする単離され たDNA配列。 3. DNA配列が配列番号3である、請求項2に記載のDNA配列。 4. 配列番号2のアミノ酸配列またはその可溶性断片を有する単離された末 端が切り取られたBMPレセプターキナーゼタンパク質。 5. 請求項4の末端が切り取られたBMPレセプターキナーゼタンパク質を コードする単離されたDNA配列。 6. DNA配列が配列番号1である、請求項5に記載のDNA配列。 7. 可溶性断片が配列番号6のアミノ酸配列を有する、請求項4に記載の可 溶性断片。 8. 請求項7の可溶性断片をコードするDNA配列。 9. DNA配列が配列番号5である、請求項8に記載のDNA配列。 10. 請求項2のDNA配列を含んでなる組換え発現ベクター。 11. 請求項3のDNA配列を含んでなる組換え発現ベクター。 12. ベクターがATCC No.69457の中に含有されるpJT4− J159Fの同定特性のすべてを有するプラスミドである、請求項11の組換え 発現ベクター。 13. 請求項5のDNA配列を含んでなる組換え発現ベクター。 14. 請求項6のDNA配列を含んでなる組換え発現ベクター。 15. ベクターがATCC No.69474の中に含有されるpJT6− J159Tの同定特性のすべてを有するプラスミドである、請求項14の組換え 発現ベクター。 16. 請求項10の組換え発現ベクターを含んでなる宿主細胞。 17. 請求項11の組換え発現ベクターを含んでなる宿主細胞。 18. 請求項12の組換え発現ベクターを含んでなる哺乳動物宿主細胞。 19. 細胞がチャイニーズハムスター卵巣細胞である、請求項18に記載の 哺乳動物宿主細胞。 20. 細胞がCOS細胞である、請求項18に記載の哺乳動物宿主細胞。 21. 請求項13の組換え発現ベクターを含んでなる宿主細胞。 22. 請求項14の組換え発現ベクターを含んでなる宿主細胞。 23. 請求項15の組換え発現ベクターを含んでなる哺乳動物宿主細胞。 24. 細胞がチャイニーズハムスター卵巣細胞である、請求項22に記載の 哺乳動物宿主細胞。 25. 細胞がCOS細胞である、請求項22に記載の哺乳動物宿主細胞。 26. BMPレセプターキナーゼタンパク質を発現させる方法で請求項16 に記載の宿主細胞を培養し、そしてBMPレセプターキナーゼタンパク質を単離 することを含んでなる、BMPレセプターキナーゼタンパク質を生産する方法。 27. 末端が切り取られたBMPレセプターキナーゼタンパク質を発現させ る方法で請求項17に記載の宿主細胞を培養し、そして前記BMPレセプターキ ナーゼタンパク質を単離することを含んでなる、末端が切り取られたBMPレセ プターキナーゼタンパク質を生産する方法。 28. BMPレセプターキナーゼタンパク質に結合できる化合物を含んでな る試料をBMPレセプターキナーゼタンパク質に導入し、そして前記化合物をB MPレセプターキナーゼタンパク質に結合させることを含んでなる、BMPレセ プターキナーゼタンパク質に結合できる化合物を同定する方法であって、BMP レセプターキナーゼタンパク質が配列番号4のアミノ酸配列もしくはその 可溶性断片または配列番号2もしくはその可溶性断片を有する方法。 29. 請求項1のBMPレセプターキナーゼタンパク質に対して向けられた 抗体。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/158,735 | 1993-11-24 | ||
US08/158,735 US6248554B1 (en) | 1993-11-24 | 1993-11-24 | DNA sequence coding for a BMP receptor |
PCT/US1994/013534 WO1995014778A2 (en) | 1993-11-24 | 1994-11-23 | Dna sequence coding for a bmp receptor |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09506251A true JPH09506251A (ja) | 1997-06-24 |
JP3632977B2 JP3632977B2 (ja) | 2005-03-30 |
Family
ID=22569457
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51521395A Expired - Fee Related JP3632977B2 (ja) | 1993-11-24 | 1994-11-23 | Bmpレセプターをコードするdna配列 |
Country Status (15)
Country | Link |
---|---|
US (1) | US6248554B1 (ja) |
EP (1) | EP0730647A1 (ja) |
JP (1) | JP3632977B2 (ja) |
CN (1) | CN1135771A (ja) |
BR (1) | BR9408139A (ja) |
CA (1) | CA2173102C (ja) |
CZ (1) | CZ151696A3 (ja) |
FI (1) | FI962182A0 (ja) |
HU (1) | HUT74838A (ja) |
NO (1) | NO962084L (ja) |
NZ (1) | NZ277389A (ja) |
PL (1) | PL179196B1 (ja) |
SG (1) | SG52721A1 (ja) |
WO (1) | WO1995014778A2 (ja) |
ZA (1) | ZA949326B (ja) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE234920T1 (de) | 1992-11-17 | 2003-04-15 | Ludwig Inst Cancer Res | Aktivin-rezeptor-ähnliche kinasen, proteine mit serin/threonin kinase domänen und deren anwendungen |
US6692925B1 (en) | 1992-11-17 | 2004-02-17 | Ludwig Institute For Cancer Research | Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use |
US5863738A (en) * | 1994-04-29 | 1999-01-26 | Creative Biomolecules, Inc. | Methods of antagonizing OP-1 binding to a cell surface receptor utilizing ALK polypeptides |
JPH07313169A (ja) * | 1994-05-26 | 1995-12-05 | Nippon Ham Kk | 骨形成因子受容体改変体の遺伝子 |
US6306622B1 (en) | 1994-11-04 | 2001-10-23 | The Procter & Gamble Co. | cDNA encoding a BMP type II receptor |
US6210899B1 (en) | 1994-11-04 | 2001-04-03 | The Procter & Gamble Company | Use of a BMP protein receptor complex for screening bone metabolism actives and cells co-transfected with a type II BMP receptor and type I BMP receptor |
EP0955313B1 (en) | 1995-04-19 | 2006-05-03 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Novel protein and process for producing the same |
CA2229557A1 (en) * | 1995-08-14 | 1997-02-27 | Creative Biomolecules, Inc. | Binding of osteogenic protein-i (op-1) and analogs thereof to the cell surface receptor alk-1 and analogs thereof |
EP0981745A1 (en) * | 1997-05-16 | 2000-03-01 | The Procter & Gamble Company | The use of a bone morphogenetic protein (bmp) receptor complex for screening |
AU2001245209A1 (en) * | 2000-11-06 | 2002-05-21 | Thrasos, Inc. | Screening methods for bone morphogenetic mimetics |
WO2003072014A2 (en) | 2002-02-25 | 2003-09-04 | Mpex Bioscience, Inc. | Minicell compositions and methods |
US20070036769A9 (en) * | 2004-06-03 | 2007-02-15 | Linheng Li | BMP pathway methods and compositions |
US20060073117A1 (en) * | 2004-10-01 | 2006-04-06 | Stowers Institute For Medical Research | Methods and compositions for controlling hair follicle stem cell fate |
US20100292454A1 (en) * | 2005-06-22 | 2010-11-18 | Yuji Mishina | Neuronal regeneration promoting agent |
EP2578684B1 (en) * | 2007-03-19 | 2016-02-24 | National Research Council Of Canada | Antagonists of ligands and uses thereof |
EP2414043B1 (en) | 2009-03-30 | 2016-01-13 | Acceleron Pharma Inc. | Bmp-alk3 antagonists and uses for promoting bone growth |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE234920T1 (de) | 1992-11-17 | 2003-04-15 | Ludwig Inst Cancer Res | Aktivin-rezeptor-ähnliche kinasen, proteine mit serin/threonin kinase domänen und deren anwendungen |
-
1993
- 1993-11-24 US US08/158,735 patent/US6248554B1/en not_active Expired - Fee Related
-
1994
- 1994-11-23 WO PCT/US1994/013534 patent/WO1995014778A2/en not_active Application Discontinuation
- 1994-11-23 BR BR9408139A patent/BR9408139A/pt not_active Application Discontinuation
- 1994-11-23 CZ CZ961516A patent/CZ151696A3/cs unknown
- 1994-11-23 EP EP95903593A patent/EP0730647A1/en not_active Withdrawn
- 1994-11-23 NZ NZ277389A patent/NZ277389A/en unknown
- 1994-11-23 CN CN94194218A patent/CN1135771A/zh active Pending
- 1994-11-23 HU HU9601402A patent/HUT74838A/hu unknown
- 1994-11-23 SG SG1996008294A patent/SG52721A1/en unknown
- 1994-11-23 PL PL94314624A patent/PL179196B1/pl unknown
- 1994-11-23 JP JP51521395A patent/JP3632977B2/ja not_active Expired - Fee Related
- 1994-11-23 CA CA002173102A patent/CA2173102C/en not_active Expired - Fee Related
- 1994-11-24 ZA ZA949326A patent/ZA949326B/xx unknown
-
1996
- 1996-05-22 NO NO962084A patent/NO962084L/no not_active Application Discontinuation
- 1996-05-23 FI FI962182A patent/FI962182A0/fi unknown
Also Published As
Publication number | Publication date |
---|---|
AU699824B2 (en) | 1998-12-17 |
FI962182A (fi) | 1996-05-23 |
CN1135771A (zh) | 1996-11-13 |
JP3632977B2 (ja) | 2005-03-30 |
BR9408139A (pt) | 1997-08-12 |
HU9601402D0 (en) | 1996-07-29 |
NO962084L (no) | 1996-07-24 |
PL179196B1 (pl) | 2000-08-31 |
SG52721A1 (en) | 1998-09-28 |
CA2173102A1 (en) | 1995-06-01 |
WO1995014778A2 (en) | 1995-06-01 |
CZ151696A3 (en) | 1996-10-16 |
EP0730647A1 (en) | 1996-09-11 |
CA2173102C (en) | 2002-10-29 |
ZA949326B (en) | 1995-08-08 |
HUT74838A (en) | 1997-02-28 |
NO962084D0 (no) | 1996-05-22 |
FI962182A0 (fi) | 1996-05-23 |
AU1259495A (en) | 1995-06-13 |
PL314624A1 (en) | 1996-09-16 |
WO1995014778A3 (en) | 1995-07-27 |
NZ277389A (en) | 1998-06-26 |
US6248554B1 (en) | 2001-06-19 |
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Legal Events
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