JPH0924050A - 医療用縫合材 - Google Patents
医療用縫合材Info
- Publication number
- JPH0924050A JPH0924050A JP7117541A JP11754195A JPH0924050A JP H0924050 A JPH0924050 A JP H0924050A JP 7117541 A JP7117541 A JP 7117541A JP 11754195 A JP11754195 A JP 11754195A JP H0924050 A JPH0924050 A JP H0924050A
- Authority
- JP
- Japan
- Prior art keywords
- suture material
- suture
- suturing
- medical
- sewn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B17/07207—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously the staples being applied sequentially
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B17/07292—Reinforcements for staple line, e.g. pledgets
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
Abstract
がなく、例えば肺の手術に、用いた場合に空気漏れを確
実に防止することが可能な医療用縫合材を提供する。 【構成】 ステープルラインを有する自動縫合器に装着
される縫合材を、先端が閉塞された袋状に縫い合わせて
構成する。この場合、1枚の縫合材料を袋状に縫い合わ
せてもよいし、複数枚の縫合材を袋状に縫い合わせても
よい。縫合材料としては、ポリグリコール酸等の生体吸
収性高分子や臓器保護膜等の生体組織を用いる。
Description
に縫い合わされる医療用縫合材に関するものであり、特
に自動縫合器に装着して使用される医療用縫合材に関す
るものである。
手術によるのが一般的であるが、患者に対する負担の軽
減などを目的に、内視鏡下での手術等が施術されるよう
になってきている。
その一例である。自動縫合器は、穿孔から生体内へ導入
され、患部を切除すると同時に切除部位の縫合を行うも
のであり、これを用いることで患部の切開が不要となる
という利点がある。したがって、上記自動縫合器は、先
端に生体組織の切除部位を挟み込む縫合機構部を有し、
さらにこの縫合機構部には、縫合のための複数のステー
プルラインや生体組織の切断機構(例えばナイフ)が設
けられている。
合器の使用は、縫合、切開時間の短縮や、施術の簡便化
に有利である。
脆弱な組織に対して前述の自動縫合器で施術する場合、
ステープルによる縫合のみでは、組織の断裂の虞があ
り、また、例えば肺の手術においては、空気漏れが発生
する虞がある。前記空気漏れは、患者にとって致命的で
あり、これを確実に防止することが望まれる。
着しておき、これを生体組織の切除部位にステープルで
縫い合わせるということが行われている。
とし、確実に患部に到達させるためには、何らかの工夫
が必要であり、例えば、フェルト状の縫合材に伸縮性ニ
ットを重ね、これらを仮縫い糸で両側縁に沿って縫い付
け、筒状にしたものが提案されている。
ニットを縫い付けて自動縫合器への装着を可能とした縫
合材では、自動縫合器を生体内に挿入して患部へ導入す
る際に、挿入方向で収縮し自動縫合器の基端側に片寄っ
たり、自動縫合器の周囲で回転(いわゆるツイスト)す
る等の不都合が発生している。
処置が難しく、特に内視鏡下のような限られた視野での
施術の際に、大きな問題となる。
提案されたものであって、自動縫合器の挿入時に片寄り
や回転による不都合が発生することがなく、例えば肺の
手術に用いた場合に空気漏れを確実に防止することが可
能な医療用縫合材を提供することを目的とする。
めに、本発明の医療用縫合材は、縫合材料が先端が閉塞
された袋状に縫い合わされてなり、ステープルラインを
有する自動縫合器に装着されることを特徴とするもので
ある。
縫合材料には、フェルトのような不織布や、織布、ニッ
ト等、ある程度の柔軟性、伸縮性を有するものであれば
任意の形態のものが使用でき、その材質も公知のものが
いずれも使用できるが、術後を考えると、ポリグリコー
ル酸のような生体吸収性高分子や、生体組織の一部、例
えば心のう膜等の臓器保護膜を用いることが望ましい。
のを袋状に縫い合わせてもよいし、複数枚、例えば2枚
の縫合材料を袋状に縫い合わせるようにしてもよい。後
者の場合、2枚の縫合材料は同一の材料であってもよい
し、別の材料であってもよい。また、2枚の縫合材料の
うちの一方は、必ずしも縫合材料でなくともよく、例え
ば通常のニット等も使用可能である。
い合わされたものであるため、自動縫合器挿入の際に挿
入方向に収縮することによる片寄りが発生することはな
い。
料を袋状に縫い合わせた縫合材は、全周に亘り縫合材料
のみによって構成されるため、不用意に回転(ツイス
ト)したとしても問題はない。
いて、図面を参照しながら詳細に説明する。
ば吸収性ポリグリコール酸のフェルト(例えば、グンゼ
社製、商品名ネオベール等)よりなる1枚の主縫合材2
を先端が閉塞された袋状に縫合せてなるものであり、極
めてシンプルな構成を有するものである。
グリコール酸のような生体吸収性高分子の他、従来縫合
材として用いられているものがいずれも使用可能であ
る。例えば、心のう膜等の臓器保護膜のような生体組織
の一部を使用することも可能である。
着部位の長さとほぼ等しい長さを有し、2つ折りにし
て、幅方向一側縁に沿って縫糸3によって縫い合わされ
ている。
と、いわゆるモノフィラメントがよく、その材質は任意
である。例えば、生体吸収性ポリマーの糸や、滑り性の
良好なポリアミド糸(いわゆるナイロン糸)等が好適で
ある。
縫合器に装着して使用される。そこで次に、自動縫合器
の構造、並びに本実施例の医療用縫合材の使用方法につ
いて説明する。
ト11の先端に開閉自在な縫合部12を有してなるもの
であって、基端部には把持・操作するための操作部13
が設けられている。
テープルが収容されたカートリッジやナイフブレードが
装填される縫合機構部12a及び生体組織を挟み込むた
めの顎部12bとからなり、縫合機構部12aの挟み込
み面には、複数(本例では、3列×3列=6列)のステ
ープルライン14やナイフの走査ライン15が臨んでい
る。
るアタッチメントを介して生体内に導入される。すなわ
ち、先ず、生体に設けた穿孔にサージポートを装着し、
このサージポートを通して自動縫合器のシャフト11を
生体内へと挿入する。これによって、生体に設けた穿孔
の密閉が保たれる。
縫合部12に装着して使用される。図4は、縫合材1を
自動縫合器の縫合部12に装着した状態を示すもので、
縫合機構部12a及び顎部12bにそれぞれ縫合材1が
取り付けられる。
縫合材1を縫合部12に被せることで円滑に行うことが
できる。
トを介して自動縫合器を生体内へと挿入し、患部へと到
達させる。このとき、自動縫合器に装着される縫合材1
は、袋状のものを閉塞された部分より押し込むかたちに
なっているので、収縮による片寄りやツイストが発生す
ることはない。
すように、生体組織20の切除部位を縫合機構部12a
及び顎部12bによって挟み込む。これによって、前記
切除部位は主縫合材2で覆われることになる。
た操作レバー13aを操作し、前記ステープルライン1
3からステープルを打針する。
沿ってステープルが打針され、縫合処置が施されるが、
このとき、同時に縫合部12に装着された縫合材1の主
縫合材2が生体組織20の切除部位に押し当てられ、前
記ステープルによって縫合される。
て機能し、生体組織20の切断部分をこの主縫合材2を
介して縫合することで、組織の断裂が防止され、例えば
巨大肺のう胞の切除術等においては、空気漏れが防止さ
れる。
イフを走査ライン15に沿って走査し、生体組織20及
び主縫合材2を切断する。
の縫合材1を用いることによって、縫合操作を円滑に進
めることができ、しかも確実に縫合部位の補強、空気漏
れの防止を行うことができる。図6は、縫合終了状態を
示すものであり、生体組織20の縫合部位には、主縫合
材2が縫い合わされ、縫合状態が極めて安定なものとな
っている。
合材料22、23を先端が閉塞する袋状に縫い合わせて
なるものである。
向かって次第に幅狭となるような形状とされており、縫
糸24、25により両側縁に沿って縫い合わされてい
る。また、これら縫糸24、25は、前記縫合材料2
2、23の形状により、縫合材料22、23の先端部に
おいて交差され、袋状の縫い合わせを確実なものとして
いる。
であってもよいし、別の材料であってもよい。具体的に
本例では、第1の縫合材料22を吸収性ポリグリコール
酸のフェルト(例えば、グンゼ社製、商品名ネオベール
等)により構成し、第2の縫合材料23を別の材料によ
り構成した。
り、コストを削減することができ、製造上有利である。
合材と同様、自動縫合器に装着して使用されるものであ
り、その使用方法は実施例1のものと同様である。
明してきたが、本発明がこの実施例に限られるものでは
なく、材質、形状等において種々の変形が可能であるこ
とは言うまでもない。
明の縫合材においては、自動縫合器挿入時に発生する縮
みによる片寄りを防止することができる。また、ツイス
トが発生したとしても、常に縫合材料が患部に当接され
る。
によって、縫合部位の補強を確実に行うことができ、組
織の断裂や空気漏れを抑えることが可能である。
図である。
る。
視図である。
図である。
視図である。
Claims (11)
- 【請求項1】 縫合材料が先端が閉塞された袋状に縫い
合わされてなり、ステープルラインを有する自動縫合器
に装着されることを特徴とする医療用縫合材。 - 【請求項2】 1枚の縫合材料が袋状に縫い合わされて
いることを特徴とする請求項1記載の医療用縫合材。 - 【請求項3】 複数枚の縫合材料が袋状に縫い合わされ
ていることを特徴とする請求項1記載の医療用縫合材。 - 【請求項4】 縫合材料と他の材料が袋状に縫い合わさ
れていることを特徴とする請求項1記載の医療用縫合
材。 - 【請求項5】 縫合材料が不織布、織布、ニットから選
ばれる少なくとも1種よりなることを特徴とする請求項
1記載の医療用縫合材。 - 【請求項6】 縫合材料が合成高分子よりなることを特
徴とする請求項1または請求項5記載の医療用縫合材。 - 【請求項7】 合成高分子が生体吸収性高分子であるこ
とを特徴とする請求項6記載の医療用縫合材。 - 【請求項8】 生体吸収性高分子がポリグリコール酸で
あることを特徴とする請求項7記載の医療用縫合材。 - 【請求項9】 縫合材料が生体組織の一部よりなること
を特徴とする請求項1記載の医療用縫合材。 - 【請求項10】 生体組織が臓器保護膜であることを特
徴とする請求項9記載の医療用縫合材。 - 【請求項11】 生体組織が心のう膜であることを特徴
とする請求項10記載の医療用縫合材。
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11754195A JP3795100B2 (ja) | 1995-05-08 | 1995-05-16 | 医療用縫合材 |
AU56588/96A AU711168B2 (en) | 1995-05-08 | 1996-05-08 | Medical suturing material |
US08/765,882 US5843096A (en) | 1995-05-08 | 1996-05-08 | Medical suturing material |
CA002194240A CA2194240C (en) | 1995-05-08 | 1996-05-08 | Medical suturing material |
PCT/JP1996/001219 WO1996035376A1 (fr) | 1995-05-08 | 1996-05-08 | Matiere de suture medicale |
AT96922672T ATE230582T1 (de) | 1995-05-08 | 1996-05-08 | Medizinisches nähmaterial |
ES96922672T ES2185784T3 (es) | 1995-05-08 | 1996-05-08 | Material medico de sutura. |
KR1019960707422A KR100289263B1 (ko) | 1995-05-08 | 1996-05-08 | 의료용 봉합재 |
DK96922672T DK0770357T3 (da) | 1995-05-08 | 1996-05-08 | Medicinsk suturmateriale |
KR1019960707423A KR100289262B1 (ko) | 1995-05-08 | 1996-05-08 | 의료용봉합재 |
EP96922672A EP0770357B1 (en) | 1995-05-08 | 1996-05-08 | Medical suture material |
DE69625664T DE69625664T2 (de) | 1995-05-08 | 1996-05-08 | Medizinisches nähmaterial |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10983495 | 1995-05-08 | ||
JP7-109834 | 1995-05-08 | ||
JP11754195A JP3795100B2 (ja) | 1995-05-08 | 1995-05-16 | 医療用縫合材 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005234839A Division JP4351660B2 (ja) | 1995-05-08 | 2005-08-12 | 医療用縫合材 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH0924050A true JPH0924050A (ja) | 1997-01-28 |
JP3795100B2 JP3795100B2 (ja) | 2006-07-12 |
Family
ID=26449549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11754195A Expired - Fee Related JP3795100B2 (ja) | 1995-05-08 | 1995-05-16 | 医療用縫合材 |
Country Status (11)
Country | Link |
---|---|
US (1) | US5843096A (ja) |
EP (1) | EP0770357B1 (ja) |
JP (1) | JP3795100B2 (ja) |
KR (1) | KR100289263B1 (ja) |
AT (1) | ATE230582T1 (ja) |
AU (1) | AU711168B2 (ja) |
CA (1) | CA2194240C (ja) |
DE (1) | DE69625664T2 (ja) |
DK (1) | DK0770357T3 (ja) |
ES (1) | ES2185784T3 (ja) |
WO (1) | WO1996035376A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998043543A1 (fr) * | 1997-03-31 | 1998-10-08 | Kabushikikaisha Igaki Iryo Sekkei | Element de maintien de suture utilisable a des fins medicales |
AU2003212041B2 (en) * | 1997-03-31 | 2005-02-10 | Kabushikikaisha Igaki Iryo Sekkei | Medical Suture Holding Member |
JPWO2004043503A1 (ja) * | 2002-11-14 | 2006-03-09 | 財団法人化学及血清療法研究所 | トロンビン固定化生体吸収性合成不織布 |
WO2008078697A1 (ja) * | 2006-12-25 | 2008-07-03 | Gunze Limited | 自動縫合器用縫合補強材 |
US8177797B2 (en) | 2003-07-17 | 2012-05-15 | Gunze Limited | Suture reinforement material for automatic suturing device |
JP2014050693A (ja) * | 2012-09-05 | 2014-03-20 | Covidien Lp | アンビルおよびカートリッジのためのステープルライン補強 |
JP2021016620A (ja) * | 2019-07-22 | 2021-02-15 | グンゼ株式会社 | 自動縫合器用縫合補綴材及び自動縫合器用縫合補綴材の製造方法 |
Families Citing this family (608)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU765367B2 (en) * | 1997-03-31 | 2003-09-18 | Kabushikikaisha Igaki Iryo Sekkei | Medical suture holding member |
CA2479765C (en) * | 2002-04-15 | 2009-01-27 | Cook Biotech Incorporated | Apparatus and method for producing a reinforced surgical staple line |
EP2228018B1 (en) | 2002-06-17 | 2012-05-09 | Tyco Healthcare Group LP | Annular support structures |
US7794494B2 (en) | 2002-10-11 | 2010-09-14 | Boston Scientific Scimed, Inc. | Implantable medical devices |
KR101213460B1 (ko) * | 2003-01-20 | 2012-12-20 | 잇판자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 지혈용 재료 |
US20070084897A1 (en) | 2003-05-20 | 2007-04-19 | Shelton Frederick E Iv | Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism |
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US2712843A (en) * | 1952-07-05 | 1955-07-12 | Bemis Bro Bag Co | Woven fabric bags |
US4834090A (en) * | 1987-03-02 | 1989-05-30 | Moore J Paul | Suture boot |
EP0465610B1 (de) * | 1990-01-26 | 1995-02-22 | PILLET, Jean-Francois | Gaskissen, verfahren und vorrichtung zu seiner herstellung |
US5263629A (en) * | 1992-06-29 | 1993-11-23 | Ethicon, Inc. | Method and apparatus for achieving hemostasis along a staple line |
US5397324A (en) * | 1993-03-10 | 1995-03-14 | Carroll; Brendan J. | Surgical stapler instrument and method for vascular hemostasis |
US5542594A (en) * | 1993-10-06 | 1996-08-06 | United States Surgical Corporation | Surgical stapling apparatus with biocompatible surgical fabric |
JP2604025Y2 (ja) * | 1993-11-29 | 2000-04-10 | グンゼ株式会社 | 自動縫合器用縫合補綴材 |
US5503638A (en) * | 1994-02-10 | 1996-04-02 | Bio-Vascular, Inc. | Soft tissue stapling buttress |
JP3136392B2 (ja) * | 1994-06-03 | 2001-02-19 | グンゼ株式会社 | 縫合補綴材 |
-
1995
- 1995-05-16 JP JP11754195A patent/JP3795100B2/ja not_active Expired - Fee Related
-
1996
- 1996-05-08 AT AT96922672T patent/ATE230582T1/de not_active IP Right Cessation
- 1996-05-08 DE DE69625664T patent/DE69625664T2/de not_active Expired - Lifetime
- 1996-05-08 US US08/765,882 patent/US5843096A/en not_active Expired - Fee Related
- 1996-05-08 WO PCT/JP1996/001219 patent/WO1996035376A1/ja active IP Right Grant
- 1996-05-08 DK DK96922672T patent/DK0770357T3/da active
- 1996-05-08 AU AU56588/96A patent/AU711168B2/en not_active Ceased
- 1996-05-08 ES ES96922672T patent/ES2185784T3/es not_active Expired - Lifetime
- 1996-05-08 CA CA002194240A patent/CA2194240C/en not_active Expired - Fee Related
- 1996-05-08 EP EP96922672A patent/EP0770357B1/en not_active Expired - Lifetime
- 1996-05-08 KR KR1019960707422A patent/KR100289263B1/ko not_active IP Right Cessation
Cited By (13)
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EP0922435A1 (en) * | 1997-03-31 | 1999-06-16 | Kabushikikaisha Igaki Iryo Sekkei | Suture retaining member for use in medical treatment |
EP0922435A4 (en) * | 1997-03-31 | 2001-10-10 | Igaki Iryo Sekkei Kk | PRESSURE HOLDING DEVICE FOR MEDICAL TREATMENT |
AU746934B2 (en) * | 1997-03-31 | 2002-05-09 | Kabushikikaisha Igaki Iryo Sekkei | Suture retaining member for use in medical treatment |
AU2003212041B2 (en) * | 1997-03-31 | 2005-02-10 | Kabushikikaisha Igaki Iryo Sekkei | Medical Suture Holding Member |
WO1998043543A1 (fr) * | 1997-03-31 | 1998-10-08 | Kabushikikaisha Igaki Iryo Sekkei | Element de maintien de suture utilisable a des fins medicales |
JPWO2004043503A1 (ja) * | 2002-11-14 | 2006-03-09 | 財団法人化学及血清療法研究所 | トロンビン固定化生体吸収性合成不織布 |
US8177797B2 (en) | 2003-07-17 | 2012-05-15 | Gunze Limited | Suture reinforement material for automatic suturing device |
WO2008078697A1 (ja) * | 2006-12-25 | 2008-07-03 | Gunze Limited | 自動縫合器用縫合補強材 |
JP2008154844A (ja) * | 2006-12-25 | 2008-07-10 | Gunze Ltd | 自動縫合器用縫合補強材 |
KR101442283B1 (ko) * | 2006-12-25 | 2014-09-22 | 군제 가부시키가이샤 | 자동 봉합기용 봉합 보강재 |
JP2014050693A (ja) * | 2012-09-05 | 2014-03-20 | Covidien Lp | アンビルおよびカートリッジのためのステープルライン補強 |
JP2019000706A (ja) * | 2012-09-05 | 2019-01-10 | コヴィディエン リミテッド パートナーシップ | アンビルおよびカートリッジのためのステープルライン補強 |
JP2021016620A (ja) * | 2019-07-22 | 2021-02-15 | グンゼ株式会社 | 自動縫合器用縫合補綴材及び自動縫合器用縫合補綴材の製造方法 |
Also Published As
Publication number | Publication date |
---|---|
WO1996035376A1 (fr) | 1996-11-14 |
US5843096A (en) | 1998-12-01 |
JP3795100B2 (ja) | 2006-07-12 |
DE69625664T2 (de) | 2003-10-16 |
AU5658896A (en) | 1996-11-29 |
EP0770357B1 (en) | 2003-01-08 |
CA2194240A1 (en) | 1996-11-14 |
CA2194240C (en) | 2007-07-17 |
AU711168B2 (en) | 1999-10-07 |
DE69625664D1 (de) | 2003-02-13 |
DK0770357T3 (da) | 2003-05-05 |
KR100289263B1 (ko) | 2001-05-02 |
ES2185784T3 (es) | 2003-05-01 |
EP0770357A4 (en) | 1998-02-11 |
EP0770357A1 (en) | 1997-05-02 |
ATE230582T1 (de) | 2003-01-15 |
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