JPH08838B2 - 新規シクロスポリン類 - Google Patents

新規シクロスポリン類

Info

Publication number
JPH08838B2
JPH08838B2 JP60059339A JP5933985A JPH08838B2 JP H08838 B2 JPH08838 B2 JP H08838B2 JP 60059339 A JP60059339 A JP 60059339A JP 5933985 A JP5933985 A JP 5933985A JP H08838 B2 JPH08838 B2 JP H08838B2
Authority
JP
Japan
Prior art keywords
cyclosporine
formula
ser
nva
cyclosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60059339A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60215700A (ja
Inventor
ローラント・ベンガー
ルネ・ペー・トラバー
ハンス・コーベル
ハンス・ホフマン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848407618A external-priority patent/GB8407618D0/en
Priority claimed from GB848411922A external-priority patent/GB8411922D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of JPS60215700A publication Critical patent/JPS60215700A/ja
Publication of JPH08838B2 publication Critical patent/JPH08838B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP60059339A 1984-03-23 1985-03-22 新規シクロスポリン類 Expired - Lifetime JPH08838B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB848407618A GB8407618D0 (en) 1984-03-23 1984-03-23 Organic compounds
GB8407618 1984-03-23
GB848411922A GB8411922D0 (en) 1984-05-10 1984-05-10 Organic compounds
GB8411922 1984-05-10

Publications (2)

Publication Number Publication Date
JPS60215700A JPS60215700A (ja) 1985-10-29
JPH08838B2 true JPH08838B2 (ja) 1996-01-10

Family

ID=26287502

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60059339A Expired - Lifetime JPH08838B2 (ja) 1984-03-23 1985-03-22 新規シクロスポリン類

Country Status (24)

Country Link
US (1) US4639434A (enExample)
JP (1) JPH08838B2 (enExample)
AT (1) AT388737B (enExample)
BE (1) BE901980A (enExample)
CA (1) CA1247546A (enExample)
CH (1) CH667274A5 (enExample)
CS (1) CS249542B2 (enExample)
DE (1) DE3509809A1 (enExample)
DK (1) DK128285A (enExample)
ES (1) ES8702926A1 (enExample)
FI (1) FI851120A7 (enExample)
FR (1) FR2561651B1 (enExample)
GB (1) GB2155936B (enExample)
GR (1) GR850716B (enExample)
HU (1) HU200786B (enExample)
IL (1) IL74681A (enExample)
IT (1) IT1199962B (enExample)
LU (1) LU85819A1 (enExample)
NL (1) NL8500828A (enExample)
NO (1) NO851160L (enExample)
NZ (1) NZ211526A (enExample)
PH (2) PH23357A (enExample)
PT (1) PT80149B (enExample)
SE (1) SE461334B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002080A1 (en) 1984-10-04 1986-04-10 Sandoz Ag Monoclonal antibodies to cyclosporings
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
ES2059558T3 (es) * 1987-06-17 1994-11-16 Sandoz Ag Ciclosporins y su uso como productos farmaceuticos.
EP0373260B1 (en) * 1987-06-22 1994-03-09 Merck & Co. Inc. Cyclosporin derivatives with modified "8-amino acid"
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
ATE109970T1 (de) * 1987-09-03 1994-09-15 Univ Georgia Res Found Cyclosporin-augenmittel.
US5089390A (en) * 1987-09-04 1992-02-18 Syntex (U.S.A.) Inc. 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
CH679119A5 (enExample) * 1988-05-13 1991-12-31 Sandoz Ag
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
CZ280909B6 (cs) * 1990-11-02 1996-05-15 Novartis Ag Nové cyklosporiny
DE69121844T2 (de) 1990-11-20 1997-01-23 Behringwerke Ag Immunotest für Cyclosporin
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
RU2170741C2 (ru) * 1996-08-16 2001-07-20 Новартис Аг Способ получения циклоспорина
NZ502362A (en) 1997-10-08 2001-05-25 Isotechnika Inc Deuterated cyclosporine A derivatives and their use as immunomodulating agents
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US5990274A (en) * 1997-11-25 1999-11-23 Dade Behring Inc. Cyclosporine derivatives and uses thereof
US7449544B2 (en) * 1999-11-30 2008-11-11 Cyclacel Limited p21 peptides
JP4261355B2 (ja) 2001-10-19 2009-04-30 アイソテクニカ インコーポレイテッド シクロスポリン類似体の合成法
RU2317067C2 (ru) * 2001-10-19 2008-02-20 Изотехника Инк. Микроэмульсионный предконцентрат аналога циклоспорина
WO2004082629A2 (en) * 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
WO2006039164A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Novel cyclosporin analogues and their pharmaceutical uses
JP2008514701A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
JP2008515886A (ja) * 2004-10-06 2008-05-15 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
WO2008069917A2 (en) 2006-11-20 2008-06-12 Scynexis, Inc. Novel cyclic peptides
NZ611620A (en) 2010-12-15 2016-02-26 Ciclofilin Pharmaceuticals Corp Cyclosporine analogue molecules modified at amino acid 1 and 3
TR201909840T4 (tr) 2011-03-11 2019-07-22 Beth Israel Deaconess Medical Ct Inc Anti-CD40 antikorları ve kullanımları.
CN104877013B (zh) * 2015-06-03 2018-04-20 兰州大学 环孢菌素t及其制备方法和应用
JP6976931B2 (ja) 2015-09-04 2021-12-08 プリマトープ・セラピューティクス・インコーポレイテッド ヒト化抗ｃｄ４０抗体及びその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4384996A (en) * 1981-01-09 1983-05-24 Sandoz Ltd. Novel cyclosporins
JPS57140753A (en) * 1981-01-09 1982-08-31 Sandoz Ag Novel cyclosporine

Also Published As

Publication number Publication date
IT1199962B (it) 1989-01-05
GB2155936A (en) 1985-10-02
IL74681A0 (en) 1985-06-30
DE3509809A1 (de) 1986-01-09
NO851160L (no) 1985-09-24
HU200786B (en) 1990-08-28
NL8500828A (nl) 1985-10-16
LU85819A1 (fr) 1985-12-12
FR2561651B1 (fr) 1990-03-09
IT8547852A0 (it) 1985-03-22
JPS60215700A (ja) 1985-10-29
FI851120A0 (fi) 1985-03-20
FI851120L (fi) 1985-09-24
SE8501392L (sv) 1985-09-24
ATA86385A (de) 1989-01-15
CA1247546A (en) 1988-12-28
DK128285D0 (da) 1985-03-21
GR850716B (enExample) 1985-07-19
GB2155936B (en) 1987-09-16
US4639434A (en) 1987-01-27
PT80149A (en) 1985-04-01
HUT38370A (en) 1986-05-28
PT80149B (en) 1987-03-23
CS249542B2 (en) 1987-03-12
GB8507270D0 (en) 1985-04-24
CH667274A5 (de) 1988-09-30
FR2561651A1 (fr) 1985-09-27
ES8702926A1 (es) 1987-01-16
SE8501392D0 (sv) 1985-03-21
SE461334B (sv) 1990-02-05
BE901980A (fr) 1985-09-23
DK128285A (da) 1985-09-24
FI851120A7 (fi) 1985-09-24
AT388737B (de) 1989-08-25
IL74681A (en) 1989-09-10
NZ211526A (en) 1988-08-30
ES541465A0 (es) 1987-01-16
PH21868A (en) 1988-03-25
PH23357A (en) 1989-07-14
IT8547852A1 (it) 1986-09-22

Similar Documents

Publication Publication Date Title
JPH08838B2 (ja) 新規シクロスポリン類
US4764503A (en) Novel cyclosporins
CA1338728C (en) Cyclosporins and their use a pharmaceuticals
US4384996A (en) Novel cyclosporins
JP2740775B2 (ja) 新規シクロスポリン類
US4914188A (en) Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US5227467A (en) Immunosuppressive fluorinated cyclosporin analogs
US5122511A (en) Immunosuppressive cyclosporin analogs with modified amino acids at position-8
EP0373260B1 (en) Cyclosporin derivatives with modified "8-amino acid"
KR100201174B1 (ko) 사이클로스포린 유도체
GB2207678A (en) Novel immunosuppressive fluorinated cyclosporin analogs
AU596071B2 (en) Novel cyclosporins
JPH0559046A (ja) 免疫調節剤
JPH0338280B2 (enExample)
GB2227244A (en) Immunosuppressive fluorinated cyclosporin analogs
WO2001053322A2 (en) Aerothricin analogs, their preparation and use
RO110144B1 (ro) Noi ciclosporine, procedeu de sinteză a acestora și metodă de tratament și prevenire a SIDA