JPH08502752A - 抗炎症剤及び抗変性剤としての新規の置換アゼチジノン - Google Patents

抗炎症剤及び抗変性剤としての新規の置換アゼチジノン

Info

Publication number
JPH08502752A
JPH08502752A JP6511259A JP51125994A JPH08502752A JP H08502752 A JPH08502752 A JP H08502752A JP 6511259 A JP6511259 A JP 6511259A JP 51125994 A JP51125994 A JP 51125994A JP H08502752 A JPH08502752 A JP H08502752A
Authority
JP
Japan
Prior art keywords
alkyl
hydrogen
diethyl
alkoxy
phenoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6511259A
Other languages
English (en)
Japanese (ja)
Inventor
ドハーテイ，ジエームズ・ビー
ドーン，コンラツド・ピー
デユレツト，フイリツプ・エル
フインク，ポール・イー
マツコス，マルコム
ミルズ，サンダー・ジー
シヤー，シユレニク・ケー
サフー，サウミヤ・ピー
ポロ，スコツト・エー
ハグマン，ウイリアム・ケー
Original Assignee
メルク エンド カンパニー インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メルク エンド カンパニー インコーポレーテッド filed Critical メルク エンド カンパニー インコーポレーテッド
Publication of JPH08502752A publication Critical patent/JPH08502752A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP6511259A 1992-10-27 1993-10-26 抗炎症剤及び抗変性剤としての新規の置換アゼチジノン Pending JPH08502752A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US96679992A 1992-10-27 1992-10-27
US99219392A 1992-12-17 1992-12-17
US966,799 1992-12-17
US992,193 1992-12-17
PCT/US1993/010269 WO1994010143A1 (en) 1992-10-27 1993-10-26 New substituted azetidinones as anti-inflammatory and antidegenerative agents

Publications (1)

Publication Number Publication Date
JPH08502752A true JPH08502752A (ja) 1996-03-26

Family

ID=27130492

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6511259A Pending JPH08502752A (ja) 1992-10-27 1993-10-26 抗炎症剤及び抗変性剤としての新規の置換アゼチジノン

Country Status (6)

Country Link
US (1) US5952321A (enExample)
EP (1) EP0666846A1 (enExample)
JP (1) JPH08502752A (enExample)
AU (1) AU5587594A (enExample)
CA (1) CA2147129A1 (enExample)
WO (1) WO1994010143A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005204A1 (en) * 1998-07-23 2000-02-03 Shionogi & Co., Ltd. MONOCYCLIC β-LACTAM COMPOUNDS AND CHYMASE INHIBITORS CONTAINING THE SAME

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2120221A1 (en) * 1993-04-23 1994-10-24 Allan W. Rey N-substituted 2-azetidinones
US6204260B1 (en) * 1996-02-23 2001-03-20 Eli Lilly And Company Non-peptidyl vasopressin V1a antagonists
WO1999004826A1 (en) * 1997-07-24 1999-02-04 The Australian National University Method for detection of fibrin clots
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
DK1353696T3 (da) 2001-01-26 2007-04-10 Schering Corp Kombinationer af peroxisomproliferatoraktiveret receptor (PPAR)-aktivator(er) og sterolabsorptionsinhibitor(er) og behandlinger til vaskulære indikationer
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
MY138301A (en) 2001-01-26 2009-05-29 Schering Corp The use of substituted azetidinone compounds for the treatment of sitosterolemia
DE60216300T2 (de) 2001-09-21 2007-06-28 Schering Corp. Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
MXPA05004810A (es) 2002-11-06 2005-07-22 Schering Corp Inhibidores de la absorcion del colesterol para el tratamiento de la desmielinizacion.
ES2311806T3 (es) 2003-03-07 2009-02-16 Schering Corporation Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
CN1756756A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
WO2004081004A1 (en) * 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
DE10336185A1 (de) * 2003-08-07 2005-02-24 Bayer Chemicals Ag Enantiomerenangereicherte 1-Phenylethylamine

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1192952A (en) * 1967-03-31 1970-05-28 Lepetit Spa Azetidine-2-One Derivatives
DE1906401A1 (de) * 1969-02-08 1970-08-27 Hoechst Ag Verfahren zur Herstellung von 4-Acyloxy-azetidin-2-onen
BE755940A (fr) * 1969-09-09 1971-03-09 Hoechst Ag Azetidinones-2 portant des substituants en position 4 et leur preparation
DE2046822A1 (de) * 1970-09-23 1972-03-30 Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt Neue Azetidinone-(2) und Verfahren zu deren Herstellung
DE2046823A1 (de) * 1970-09-23 1972-03-30 Farbwerke Hoechst AG vormals Meister Lucius & Brüning, 6000 Frankfurt Neue Azetidinone-(2) und Verfahren zu deren Herstellung
US4064120A (en) * 1976-11-01 1977-12-20 E. R. Squibb & Sons, Inc. 3,3-Dichloro-2-azetidinone derivatives having antiinflammatory activity
US4166907A (en) * 1976-11-01 1979-09-04 E. R. Squibb & Sons, Inc. 3,3-Dichloro-2-azetidinone derivatives having antiinflammatory activity
LU77306A1 (enExample) * 1977-05-09 1979-01-18
US4115382A (en) * 1977-06-06 1978-09-19 E. R. Squibb & Sons, Inc. 3,3-Dichloro-2-azetidinone derivatives having basic substituents
CA1145347A (en) * 1977-09-30 1983-04-26 Akira Sato 2-azetidinone derivatives
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
US4174317A (en) * 1978-03-24 1979-11-13 E. R. Squibb & Sons, Inc. 3,3-Dichloro-2-azetidinone derivatives
AT365594B (de) * 1978-11-24 1982-01-25 Erba Farmitalia Verfahren zur herstellung von neuen 7-oxo-4-thia1-aza-bicyclo-(3,2,0)heptanderivaten
US4536334A (en) * 1979-06-28 1985-08-20 Sumitomo Chemical Company, Limited Preparation of β-lactam derivatives
US4260743A (en) * 1979-12-31 1981-04-07 Gist-Brocades N.V. Preparation of β-lactams and intermediates therefor
DE3007298A1 (de) * 1980-02-27 1981-09-03 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur herstellung von azetidinonen und deren verwendung
HU181742B (en) * 1980-09-15 1983-11-28 Richter Gedeon Vegyeszet Process for producing new azetidinone derivatives
ATE21105T1 (de) * 1980-11-06 1986-08-15 Hoechst Uk Ltd 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
JPS5857360A (ja) * 1981-10-01 1983-04-05 Ajinomoto Co Inc アゼチジノン誘導体
US4534896A (en) * 1983-06-13 1985-08-13 E. R. Squibb & Sons, Inc. 3-Acylamino-2-oxoazetidine-1-(β-oxopropionic acid)
US4576749A (en) * 1983-10-03 1986-03-18 E. R. Squibb & Sons, Inc. 3-Acylamino-1-carboxymethylaminocarbonyl-2-azetidinones
US4559335A (en) * 1983-10-03 1985-12-17 E. R. Squibb & Sons, Inc. 3-Acylamino-1-carboxymethyloxy (or thio) carbonyl-2-azetidinones
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229381A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
DE3751700D1 (de) * 1986-11-12 1996-03-21 Merck & Co Inc Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel
NZ228600A (en) * 1988-04-11 1992-02-25 Merck & Co Inc 1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives
IL99658A0 (en) * 1990-10-15 1992-08-18 Merck & Co Inc Substituted azetidinones and pharmaceutical compositions containing them
US5104862A (en) * 1991-03-20 1992-04-14 Merck & Co., Inc. Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5348953A (en) * 1991-06-25 1994-09-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
WO1993000332A1 (en) * 1991-06-25 1993-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005204A1 (en) * 1998-07-23 2000-02-03 Shionogi & Co., Ltd. MONOCYCLIC β-LACTAM COMPOUNDS AND CHYMASE INHIBITORS CONTAINING THE SAME

Also Published As

Publication number Publication date
AU5587594A (en) 1994-05-24
CA2147129A1 (en) 1994-05-11
EP0666846A1 (en) 1995-08-16
US5952321A (en) 1999-09-14
EP0666846A4 (enExample) 1995-09-20
WO1994010143A1 (en) 1994-05-11

Similar Documents

Publication Publication Date Title
AU656591B2 (en) New substituted azetidinones as anti-inflammatory and antidegenerative agents
JP2736113B2 (ja) 抗炎症及び抗変性剤としての新規置換アゼチジノン類
JPH08502752A (ja) 抗炎症剤及び抗変性剤としての新規の置換アゼチジノン
US5348953A (en) Substituted azetidinones as anti-inflammatory and antidegenerative agents
USRE43481E1 (en) Diazepan derivatives or salts thereof
EP0481671A1 (en) New substituted azetidinones as anti-inflammatory and antidegenerative agents
JP2010513402A (ja) ステアロイル−ＣｏＡデサチュラーゼ（ＳＣＤ）阻害薬としてのイソキノリンカルボキサミド誘導体
JP2010513398A (ja) ステアロイル−ＣｏＡデサチュラーゼ（ＳＣＤ）阻害薬としてのイソキノリンカルボキサミド誘導体
JPH08504175A (ja) 製剤組成物
EP1513836B1 (fr) Derives de piperazinylacylpiperidine, leur preparation et leur application en therapeutique
EP0421861A1 (fr) Dérivés d'hydroxy-2 thiophène et furanne condensés avec un cycle azoté, leur procédé de préparation et leur application en thérapeutique
JPH11504947A (ja) ドーパミンリセプタサブタイプ特異性リガンドとしてのｎ―アミノアルキルジベンゾフランカルボキサミド
CN100379722C (zh) 新化合物
JP2010513400A (ja) ステアロイル−ＣｏＡデサチュラーゼ（ＳＣＤ）阻害薬としてのイソキノリンカルボキサミド誘導体
JP2010513401A (ja) 化合物
EP3894411B1 (en) 7-phenoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma-secretase modulators for the treatment of alzheimer's disease
FR2865205A1 (fr) Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique
EP2382206B1 (en) Compounds and methods for the treatment of pain and other diseases
JP3127436B2 (ja) 人好中球エラスターゼの阻害剤としてのフエニレンジアルカノエート類の芳香族エステル類
GB2266527A (en) Substituted azetidinones useful in the treatment of leukemia
EP0595557A1 (en) New substituted azetidinones as anti-inflammatory and antidegenerative agents
DE69734764T2 (de) Eine amidgruppe tragende schwefelhaltige verbindungen, verfahren zu ihrer herstellung, deren verwendung in medikamenten und sie enthaltende pharmazeutische zubereitungen
WO1994013636A1 (en) New substituted azetidinones as anti-inflammatory and antidegenerative agents
US5747485A (en) Substituted azetidiones as anti-inflammatory and antidegenerative agents
JPH09510212A (ja) 肺疾患を処置するための組成物