JPH08502293A - 認識疾患の治療に有用な３，３−ジ置換された三環式および四環式インドリン−２−オン - Google Patents

認識疾患の治療に有用な３，３−ジ置換された三環式および四環式インドリン−２−オン

Info

Publication number
JPH08502293A
JPH08502293A JP6510082A JP51008294A JPH08502293A JP H08502293 A JPH08502293 A JP H08502293A JP 6510082 A JP6510082 A JP 6510082A JP 51008294 A JP51008294 A JP 51008294A JP H08502293 A JPH08502293 A JP H08502293A
Authority
JP
Japan
Prior art keywords
compound
group
single bond
carbons
mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6510082A
Other languages
English (en)
Japanese (ja)
Inventor
アール，リチヤード・アラン
マイアーズ，メルビン・ジヨン
Original Assignee
ザ・デュポン・メルク・ファーマシュウティカル・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ・デュポン・メルク・ファーマシュウティカル・カンパニー filed Critical ザ・デュポン・メルク・ファーマシュウティカル・カンパニー
Publication of JPH08502293A publication Critical patent/JPH08502293A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP6510082A 1992-10-13 1993-10-12 認識疾患の治療に有用な３，３−ジ置換された三環式および四環式インドリン−２−オン Pending JPH08502293A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96052292A 1992-10-13 1992-10-13
US07/960,522 1992-10-13
PCT/US1993/009476 WO1994009009A1 (en) 1992-10-13 1993-10-12 3,3-disubstituted tri- and tetracyclic indolin-2-ones useful for the treatment of cognitive disorders

Publications (1)

Publication Number Publication Date
JPH08502293A true JPH08502293A (ja) 1996-03-12

Family

ID=25503278

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6510082A Pending JPH08502293A (ja) 1992-10-13 1993-10-12 認識疾患の治療に有用な３，３−ジ置換された三環式および四環式インドリン−２−オン

Country Status (8)

Country Link
EP (1) EP0664810A1 (es)
JP (1) JPH08502293A (es)
AU (1) AU6242294A (es)
CA (1) CA2146000A1 (es)
IL (1) IL107251A0 (es)
MX (1) MX9306337A (es)
WO (1) WO1994009009A1 (es)
ZA (1) ZA937604B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112624972A (zh) * 2019-09-24 2021-04-09 中国人民解放军军事科学院军事医学研究院 吖啶酮类化合物及医药用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
US5173489A (en) * 1986-04-10 1992-12-22 The Dupont Merck Pharmaceutical Co. α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US5278045A (en) * 1990-02-28 1994-01-11 Du Pont Merck Pharmaceutical Company Method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function

Also Published As

Publication number Publication date
AU6242294A (en) 1994-05-09
MX9306337A (es) 1995-01-31
IL107251A0 (en) 1994-01-25
EP0664810A1 (en) 1995-08-02
ZA937604B (en) 1995-04-13
CA2146000A1 (en) 1994-04-28
WO1994009009A1 (en) 1994-04-28

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