JPH0818956B2 - Hair nourishment - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing and hair-growth agent, and more particularly, it has an excellent antiseborrheic effect on the scalp and provides good hair-growth, hair-growth and hair loss prevention effects, and has high safety for a long time The present invention relates to a hair nourishing / hair-growth material.

[0002]

2. Description of the Related Art Conventionally, the problems to be solved by the invention
Hair-restoring and hair-growth agents containing anti-seborrheic agents are known, but in order for anti-seborrheic agents to exert their effects in hair-growth and hair-growth agents, they are not only excellent in their action but also It is required that the seborrheic agent can be absorbed from the scalp with high efficiency without being decomposed.

However, most of the antiseborrheic agents which have been used so far have side effects particularly when used for a long period of time, and a satisfactory hair nourishing and hair-growing agent having an antiseborrheic effect is not yet obtained. Has not been done.

Therefore, there has been a demand for the development of a hair nourishing and hair-growth agent which exhibits an excellent antiseborrheic effect, provides good hair-growth / hair-growth and hair loss-preventing effects, and is highly safe for a long period of time.

[0005]

Means for Solving the Problems As a result of intensive studies in view of such actual circumstances, the present inventors have recently come to be known to have a hair-growth / hair-growth effect (for example, JP-A-3-1).
No. 63026) A composition containing a Hypericum perforatum extract and an antiseborrheic agent shows a dramatically improved antiseborrheic effect, and also provides good hair-growth / hair-growth and hair-prevention preventive effects, and has high long-term safety. The present invention has been completed and the present invention has been completed.

[0006] That is, the present invention provides a hair nourishing and hair-growth material containing a Hypericum perforatum extract and an antiseborrheic agent.

The Hypericum perforatum extract used in the present invention is a Hypericumaceae (GUTTIFERAE or HYP).
After crushing the whole plant of ERICAEE) or any one or more of its leaves, stems, roots, fruits, seeds and flowers (hereinafter referred to as “the drug substance”) or crushing without drying, It can be obtained by extracting with a solvent at room temperature or under heating, or by using an extraction device such as a Soxhlet extractor.

The solvent used here includes water and organic solvents, with organic solvents being particularly preferred. Preferable specific examples of the organic solvent include polyhydric alcohols such as glycerin, polyethylene glycol, propylene glycol, etc., a mixed liquid of these polyhydric alcohols and water (preferably 5 to 30% aqueous solution); anionic surfactant aqueous solution. , Nonionic surfactant aqueous solution, amphoteric surfactant; alcohols such as methanol, ethanol, butanol; a mixed solution of these alcohols and water (10 to 90%, preferably 20 to 90% aqueous solution); hexane, benzene, Hydrocarbons such as toluene, xylene and petroleum ether; halogenated hydrocarbons such as chloroform, dichloromethane and 1,2-dichloroethane; ethers such as diethyl ether and tetrahydrofuran; esters such as ethyl acetate and isopropyl myristate; flow Paraffin, soybean oil, sesame oil, etc. Various mineral oils, animal oils, vegetable oils, and the like and mixtures thereof.

As a specific example of a preferable extraction method from the drug substance, (a) a method in which the drug substance is crushed, and then extracted with a solvent such as hydrocarbons or hydrous lower alcohol and the solvent is distilled off;
(B) A method of treating the extract obtained in (a) with one or more selected from activated carbon, a polyamide resin, a polystyrene resin such as HP-20 and a polyethylene methacrylate resin for decolorization; After crushing the body, it is extracted with a solvent such as anhydrous or hydrous lower alcohol, and then the extract is a liquid using hydrous lower alcohol and hydrocarbons.
Method of subjecting to liquid extraction and further distilling off the solvent from the hydrocarbons phase to which the active ingredient has transferred; (d) After crushing the raw material, extraction with a solvent such as anhydrous or hydrous lower alcohol, and then the extract Is subjected to liquid-liquid extraction using a water-immiscible solvent such as ethyl acetate and water, and the solvent is distilled off from the organic phase or the aqueous phase; (e) the aqueous phase obtained in (d) above is butanol. A liquid-liquid extraction using water and water, and further distilling off the solvent from the butanol phase; (f) the extraction liquid before or after liquid-liquid extraction in (d) or (e) above. Is treated with one or more kinds selected from activated carbon, polyamide resin, polystyrene resin such as HP-20 and polyethylene methacrylate resin; (g) the raw material is crushed and then extracted with a suitable solvent, and then the extraction phase is Activated carbon, polyamide resin, HP-2 Is treated with one or more selected from polystyrene methacrylate resins such as to adsorb the active ingredient, and then the active ingredient is extracted with methanol, ethanol, acetone, or a mixed solution of these and water, and the solvent is distilled off. Method etc. are mentioned. These methods may be appropriately selected depending on the purpose and application, but for the purpose of the present invention, the above method (d), (e) or (g) is preferable. When ethanol, water, hydrous ethanol or the like is used as the extraction solvent, the concentration can be adjusted by appropriately adding ethanol, water or the like without completely distilling off the solvent. Further, it can be used after producing impurities at room temperature or lower and removing the impurities by filtration or the like.

The extract can be used as it is as an active ingredient of the hair nourishing and hair-growing agent of the present invention. However, the extract can be further separated by an appropriate separation means such as gel filtration method, silica gel column chromatography method or reverse phase method. It is also possible to fractionate and use a highly active fraction by a normal phase high performance liquid chromatography method.

The Hypericum perforatum extract thus obtained is
Usually, it is preferable to use it after dissolving it in a solvent such as water or water-lower alcohol. Hypericum perforatum extract is 0.001 to 5% by weight on a dry weight basis in the hair nourishing and hair-growing material of the present invention.
(Hereinafter, simply indicated by "%") is preferably blended. 0.
If it is less than 001%, a sufficient effect cannot be obtained. On the other hand, if it exceeds 5%, unpleasant irritation to the skin such as the scalp is given, which is not preferable.

Examples of the antiseborrheic agent used in the present invention include diethylstilbestrol, cyclotene acetate,
Chlormadinone acetate, progesterone, S-carboxy-methyl-L-cystine, oxendron, androstenedione, testosterone-17β-halogenated acetate, deoxycorticosterone, pyridoxine hydrochloride and allantoin chlorhydroxyaluminum also known as astringents. , Allantoin dihydroxy aluminum, aluminum hydroxy chloride, zinc chloride, aluminum chloride, zinc paraphenol sulfonate and the like. Of these, diethylstilbestrol chlormadinone acetate and pyridoxine hydrochloride are particularly preferred. This antiseborrheic agent is preferably used by dissolving it in water or a water-lower alcohol solvent.

The antiseborrheic agent is added to the hair nourishing / hair-growing agent of the present invention in an amount of 0.
It is preferable to add 001 to 5%. If it is less than 0.001%, a sufficient effect cannot be obtained, and if it exceeds 5%, it gives an unpleasant sensation to the scalp, which is not preferable.

It is particularly preferable that the hair nourishing and hair-restoring material of the present invention further contains carbon dioxide gas. It is known that carbon dioxide exists as a CO ₂ molecule when the pH of the solution in which it is dissolved is acidic, and exhibits a vasodilatory action. Therefore, the liquid property of the hair nourishing and hair-restoring agent of the present invention is pH 7 or less,
Especially, it is preferable to adjust the pH to 4.5 to 6.5. It should be noted that carbon dioxide gas is press-fitted into the hair / hair-growth agent, and if this is dissolved in the hair-growth / hair-growth agent, the acidity becomes stronger,
The final pH may be adjusted so that it falls within the above range. This pH
As the regulator, for example, an organic acid such as citric acid, tartaric acid, lactic acid or a salt thereof, or phosphoric acid or a salt thereof is preferably used.

In order to mix carbon dioxide into the hair nourishing and hair-growing material of the present invention, other components except carbon dioxide are put in a pressure resistant container, and high pressure carbon dioxide is sealed therein, sodium hydrogen carbonate or the like is placed in the pressure resistant container. The method of putting components excluding carbon dioxide gas containing carbonate of the above, adding a pH adjusting agent to this to generate carbon dioxide gas and immediately sealing it, or putting dry ice pellets in a container and sealing it is adopted. However, the method of enclosing high-pressure carbon dioxide is particularly preferable.

In this case, a part of the carbon dioxide gas is dissolved in the hair nourishing and growing agent of the present invention to be blended, and a part of the carbon dioxide gas exists as a gas in the container. In the present invention, it is important that carbon dioxide is dissolved and mixed in the hair nourishing / hair-growth agent, and it is preferable that the amount of carbon dioxide is 60 ppm or more. Can not be obtained. The amount of carbon dioxide gas can be adjusted by adjusting the amount of carbon dioxide gas injected (injected). Generally, the pressure in the container is 1.2 to 8 kg / cm ² (gauge pressure) at a temperature of 35 ° C. It is preferred that

In addition to the above-mentioned essential components, the hair nourishing and hair-restoring agent of the present invention may optionally contain, within a range that does not impair the effects of the present invention, an oily base, emollient agent, gel used in ordinary cosmetics. Agents, various emulsifiers, fragrances, antioxidants such as parahydroxybenzoic acid ester, colorants such as dyes, cooling agents such as menthol, bactericides, and wetting agents such as propylene glycol can be added.

The hair nourishing and hair-growing material of the present invention can be produced by subjecting the above-mentioned essential components and optional components to operations such as mixing according to a conventional method.

[0019]

The hair nourishing and hair-growth agent of the present invention exhibits an excellent antiseborrheic effect on the scalp, provides good hair-growth, hair-growth, and hair loss prevention, and has high safety for a long period of time. .

[0020]

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited thereto.

Reference Example 1 kg of a dry ground product of St. John's wort whole plant was digested by digestion in 8 liters of hydrous ethanol (70 vol% ethanol) at 40 ° C.-60 ° C., and the residue was digested again in the same manner. Repeatedly, 15 l of filtrate was obtained. This was concentrated under reduced pressure, purified water was added to the residue to make 2.5 l, and the mixture was aged for 7 days.
The extract obtained by filtering off the insoluble portion was treated with activated carbon, concentrated under reduced pressure, and added with ethanol to adjust the ethanol content of the extract to 20% by weight. After aging for another 3 days, it was filtered. The final extract solution was 3.5 kg.

Examples 1 to 3 and Comparative Examples 1 to 2 Hair nourishing and hair-growing agents having the compositions shown in Table 1 were prepared according to a conventional method. C3H mice in resting period (15 mice per group)
The back was shaved, and the hair nourishing and hair-growth agents shown in Table 1 were each applied once a day (20 μl), and the regenerated hair area ratio (regenerated hair area / shaving area) 20 days after shaving was measured. The results are also shown in Table 1.

[0023]

[Table 1]

As is clear from the results shown in Table 1, the product of the present invention (Examples 1 to 3) shows remarkable hair regrowth as compared with the comparative product (Comparative Examples 1 and 2). The product of the present invention showed a better antiseborrheic effect on the scalp and higher safety for a long period of time as compared with the comparative product.

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Claims (3)

[Claims] 1. A hair nourishing and hair-growth material comprising a Hypericum perforatum extract and an antiseborrheic agent. 2. The hair nourishing and hair-restoring agent according to claim 1, which contains 0.001 to 5% by weight of Hypericum perforatum extract. 3. The hair nourishing and hair-restoring agent according to claim 1, which contains 0.001 to 5% by weight of an antiseborrheic agent.