JP2652913B2 - Medicated cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmeceutical, and more particularly to a cosmeceutical which is excellent in promoting hair growth and is safe.

[0002]

2. Description of the Related Art Conventionally, synthetic or natural extract extracts having a hair growth promoting action have been applied to medicinal cosmetics such as hair nourishing and hair restoratives, but a sufficient effect can be obtained by adding a small amount thereof. In addition, when incorporated in a large amount, the effect can be obtained to some extent, but unpleasant irritation is given to the application site, and further, there are drawbacks such as dermatitis when used continuously.

On the other hand, carbon dioxide is known to have a vasodilatory effect, and is also used clinically as a carbon dioxide bath for rehabilitation and the like.

[0004] Hypericum perforatum has long been used as an internal medicine for decocting whole plants for the purpose of hemostasis, convergence and gargle in Chinese medicine, and squeezing of fresh leaves and stems in folk medicine. Has been used as an external medicine for applying to wounds, bruises or hemorrhoids.

[0005]

By the way, in various external preparations and cosmeceuticals, two or more kinds of medicinal ingredients are often used in combination, but it is difficult to predict the interaction between the medicinal ingredients used in combination. Therefore, it may be contraindicated in combination, and the study of the interaction is extremely important. Therefore,
There has been a demand for the development of cosmeceuticals containing two or more medicinal ingredients and having both excellent safety and efficacy.

[0006]

Under such circumstances, the present inventors have conducted intensive studies on the interaction between carbon dioxide and various plant extracts, and as a result, if hair extracts were used in combination with carbon dioxide, hair The present inventors have found that a medicated cosmetic having excellent growth promoting action and high safety can be obtained, and completed the present invention.

That is, the present invention provides a cosmeceutical composition characterized by containing a hypericum extract and carbon dioxide.

[0008] The extract of Hypericum perforatum, which is one of the active ingredients of the cosmeceutical of the present invention, may be, for example, whole plant of Hypericum perforatum as a raw material, or any one of leaves, stems, roots, fruits, seeds, flowers or After drying or pulverizing two or more places (hereinafter abbreviated as "the raw material") without drying, extract with a solvent at room temperature or under heating, or extract with an extractor such as a Soxhlet extractor. It can be obtained by: Here, Hypericum perforatum (GUTTT)
All of the plants of IFERAE HYDERI (ACEAE), the genus Hypericum L., the genus Trichonumum Rafin, and the genus Sareothra L.
In particular, the genus Hypericum spp., Hypericum perforatum and the like of the genus Hypericum is preferred.

The solvent used here includes water, an organic solvent and a mixture thereof, and it is particularly preferable to use an organic solvent. Specific examples of these organic solvents include polyhydric alcohols such as glycerin, polyethylene glycol, and propylene glycol; a mixture of these polyhydric alcohols and water (preferably a 5 to 30% aqueous solution)
An aqueous solution of an anionic surfactant, an aqueous solution of a nonionic surfactant, or an aqueous solution of an amphoteric surfactant; alcohols such as methanol, ethanol, and butanol; and a mixture of these alcohols and water (10 to 90%, preferably 20 to 80%).
% Aqueous solution); hydrocarbons such as hexane, benzene, toluene, xylene and petroleum ether; halogenated hydrocarbons such as chloroform, dichloromethane, 1,2-dichloroethane; ethers such as diethyl ether and tetrahydrofuran; ethyl acetate, isopropyl Esters such as myristate; various mineral oils such as liquid paraffin, soybean oil and sesame oil, animal oils, vegetable oils, and mixtures thereof, among which hexane, acetone, petroleum ether,
Solvents such as diethyl ether, tetrahydrofuran, chloroform and benzene are preferred.

As a specific example of a preferred method of extracting from the drug substance, (a) a method in which the drug substance is pulverized, then extracted with a solvent such as hydrocarbons or a lower alcohol containing water, and the solvent is distilled off;
(B) a method of treating the extract obtained in (a) with one or more selected from activated carbon, a polyamide resin, a polystyrene resin such as HP-20, and a polyethylene methacrylate resin for decolorization, etc .; After pulverizing the body, the mixture is extracted with a solvent such as anhydrous or water-containing lower alcohol, and then the extract is subjected to liquid-liquid extraction using a water-containing lower alcohol and hydrocarbons. (D) grinding the raw material, extracting with a solvent such as anhydrous or water-containing lower alcohol, and then extracting the extract with a water-immiscible solvent such as ethyl acetate and water;
(E) subjecting the aqueous phase obtained in the above (d) to liquid-liquid extraction using butanol and water, and further subjecting the aqueous phase obtained from the above (d) to liquid-liquid extraction. (F) in the above (d) or (e),
Before or after performing liquid-liquid extraction, a method of treating the extract with one or more selected from activated carbon, polyamide resin, polystyrene resin such as HP-20, and polyethylene methacrylate resin; After pulverized and extracted with a suitable solvent, the extracted phase is then treated with one or more selected from activated carbon, polyamide resin, polystyrene resin such as HP-20 and polyethylene methacrylate resin to adsorb the active ingredient, Next, a method of extracting the active ingredient with methanol, ethanol, acetone, or a mixed solution thereof with water and distilling off the solvent may be used. For the purpose of the present invention, those obtained from the aqueous phase (d), the butanol phase (e) and (g) are preferred.

These extracts can be used as they are as an active ingredient of the cosmeceutical composition of the present invention. However, the extracts can be further subjected to a suitable separation means, for example, a gel filtration method, a silica gel column chromatography method or a reverse phase or forward phase. It is also possible to use a fraction having a high activity fractionated by a high-performance liquid chromatography method.

The Hypericum perforatum extract thus obtained is usually used by dissolving it in water or a solvent such as water-lower alcohol. The hypericum extract is preferably incorporated into the cosmeceutical composition of the present invention in an amount of 0.001 to 10% by weight (hereinafter simply referred to as%) by dry weight. If the content is less than 0.001%, a sufficient effect cannot be obtained. If the content is more than 10%, the feeling of hair is inferior, which is not preferable.

By the way, when the pH of a solution in which carbon dioxide is dissolved is acidic, CO ₂ exists as CO ₂ molecules,
It is known to exhibit a vasodilator effect. Accordingly, the liquid cosmetic composition of the present invention has a pH of 7 or less, especially pH 4.5 to 6.
Adjustment to 5 is preferred. The pH of the cosmeceutical is increased by injecting carbon dioxide gas and dissolving it into the cosmeceutical, but the pH may be adjusted so that the final pH is in the above range. As the pH adjuster, for example, organic acids such as citric acid, tartaric acid, and lactic acid or salts thereof, or phosphoric acid or salts thereof are suitably used.

In order to mix carbon dioxide into the cosmeceutical composition, a component other than carbon dioxide is placed in a pressure-resistant container, and high-pressure carbon dioxide is sealed therein. The pressure-resistant container contains a carbonate such as sodium hydrogen carbonate. Add a component excluding carbon dioxide, and add a pH adjuster to the mixture to generate carbon dioxide, and immediately seal the container, or place a dry ice pellet in a container and seal the container. A method of filling high-pressure carbon dioxide gas is preferable.

At this time, a part of the carbon dioxide gas is dissolved in the cosmeceutical composition, and a part thereof is present as a gas in the container. In the present invention, it is important that the carbon dioxide gas is dissolved in the cosmeceutical composition and the compounding amount is preferably 60 ppm or more, and if it is less than this, the effect of the present invention is sufficient. Cannot be obtained. The amount of carbon dioxide gas can be adjusted by adjusting the amount of carbon dioxide gas injected (injected). Generally, the pressure in the container is 1.2 to 8 kg / cm ² (gauge pressure) at a temperature of 35 ° C. It is preferred that

The pressure-resistant container used in the present invention must be capable of withstanding the above-mentioned pressure and holding the cosmeceutical in a sealed state until it is used after its preparation. Metal containers, synthetic resin containers such as acetal-based resins and polycarbonate-based resins, and glass containers are used.

On the other hand, if the diameter of the discharge nozzle is small, the filling liquid is sprayed in the form of a mist, and if it is large, the filling liquid is sprayed in the form of a foam or a liquid. The injection form also varies depending on the can internal pressure, but generally, the diameter of the discharge nozzle of the aerosol spray container is 0.3 mm or less, and when this is applied to the cosmeceutical of the present invention, it is sprayed in a mist and carbon dioxide gas is sprayed. Scatters immediately, so that a sufficient effect cannot be obtained. In order to further enhance the effects of the present invention, it is necessary to lengthen the residence time at the application site of carbon dioxide in the cosmeceutical, and when the cosmeceutical of the present invention is used on the head, it may adhere to the hair. Instead, it is preferable to apply it directly to the scalp in the form of a foam or a liquid and foam it on the scalp. Therefore, it is preferable that the diameter of the discharge nozzle is 0.3 to 1.5 mm and the length is 1 to 15 cm. Furthermore, in order to prevent a decrease in the amount of dissolved carbon dioxide due to a decrease in the internal pressure of the can caused by use, and to keep the injection state constant, a mini cylinder of carbon dioxide is built in the container, and when the usage pressure decreases. It is preferable to combine with an aerosol injection device as disclosed in JP-A-57-153752, which newly supplies carbon dioxide gas. So,
The carbon dioxide concentration can be kept constant from the beginning to the end of use.

In the cosmeceutical of the present invention, in addition to the above essential components, an oily base, an emollient, a gelling agent, various emulsifiers, a solubilizer, a fragrance, a parahydroxybenzoic acid used in ordinary cosmetics are used. Preservatives such as esters, antioxidants such as butylhydroxyanisole, coloring agents such as dyes, cooling agents such as menthol, bactericides such as hinokitiol, wetting agents such as propylene glycol, and other medicinal agents. Can be added and blended in a range that does not impair.

The medicated cosmetic of the present invention thus obtained has an excellent hair growth promoting action and is highly safe.
It can be used as a skin cosmetic for the head, limbs and the like. When applied to the head, hair growth and hair growth effects are obtained,
When applied to limbs, etc., the effect of improving symptoms of diseases such as sprouts can be obtained.

[0020]

The cosmeceutical of the present invention has an excellent hair growth promoting effect due to the synergistic effect of St. John's wort and carbon dioxide gas, and is highly safe and less irritating to the skin. is there. Therefore, the cosmeceutical composition of the present invention can be used for the purpose of improving the symptoms of skin diseases such as hair restoration / hair restoration and suppleness.

[0021]

Next, the present invention will be described in detail with reference to Reference Examples and Examples, but the present invention is not limited thereto.

Reference Example 1 500 g (dry weight) of Hypericum perforatum was ground, 2 l of a 70% aqueous methanol solution was added, the mixture was heated to 50 ° C., shaken for one week, and the extract was filtered and obtained. The filtrate was used as Sample 1.

Reference Example 2 500 g (dry weight) of Hypericum perforatum was pulverized, added with 2 l of ethanol, and immersed and extracted at room temperature for 1 week. The solvent was distilled off, and 0.5 l of a 90% aqueous methanol solution was added to the residue.
2l) Liquid-liquid partition. The hexane fraction obtained by evaporating the solvent from the hexane layer was used as Sample 2.

Reference Example 3 1 kg of a dry and ground product of Hypericum perforatum was put in 8 liters of aqueous ethanol (70 v / v% ethanol) at a temperature of 40 ° C. to 60 ° C.
, And the residue was similarly digested again to obtain 15 l. This was concentrated under reduced pressure, purified water was added to the residue, and the mixture was adjusted to 2.5 l. After aging for 7 days, the extract obtained by filtering off the insoluble portion was treated with activated carbon,
The extract was concentrated under reduced pressure, and ethanol was added to adjust the extract to have an ethanol content of 20% by weight. After aging for 3 days, the extract was filtered. The final extract weighs 3.5 kg.

Example 1 The back of a resting C3H mouse was shaved, the drug shown in Table 1 was applied (20 μl once a day), and the regenerated hair area ratio was measured 20 days after shaving. . Table 1 shows the obtained results.
Shown in

[0026]

[Table 1]

Example 2 Hair tonic Hypericum extract ^{* 2} 1 (% by weight) l-menthol 0.1 ethanol 60 fragrance 0.2 water balance * 2: What was obtained in Reference Example 1 The above components were mixed by a conventional method. , Put in a pressure vessel, add 2% carbon dioxide to the liquid and discharge nozzle (diameter 1.0mm,
10 mm in length) to obtain a jet-type hair tonic.

Example 3 Hair Pack Hypericum extract ^{* 3} 2 (% by weight) Hydroxyethylcellulose 2 Ethanol 50 Fragrance 0.1 Preservative 0.1 Water Balance * 3: What was obtained in Reference Example 2 The mixture was placed in a pressure vessel, and 2% carbon dioxide was added to the solution to obtain a hair pack.

 ──────────────────────────────────────────────────続 き Continuation of the front page (72) Yoshio Ikeda 1010-5 Maegaizuka-cho, Funabashi-shi, Chiba Joyfull C 102 No. 56 1113 (JP, A) JP-A-60-149514 (JP, A) JP-A-59-141512 (JP, A)

Claims (1)

(57) [Claims] 1. A medicated cosmetic comprising a hypericum extract and carbon dioxide.