JPH07504321A - マラリアワクチンにおけるまたはそれに関する改良 - Google Patents
マラリアワクチンにおけるまたはそれに関する改良Info
- Publication number
- JPH07504321A JPH07504321A JP5513568A JP51356893A JPH07504321A JP H07504321 A JPH07504321 A JP H07504321A JP 5513568 A JP5513568 A JP 5513568A JP 51356893 A JP51356893 A JP 51356893A JP H07504321 A JPH07504321 A JP H07504321A
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- sequence
- vector
- seq
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (14)
- 1.実質的に図1(Seq.IDNo.1)に示す配列を含むポリペプチドであ って、メロゾイト表面プロテイン1(MSP1)において本来近接して生じる配 列から分離した、ポリペプチド。
- 2.実質的に図2(Seq.IDNo.2)に示す配列を含むポリペプチドであ って、MSP1において本来近接して生じる配列から分離した、ポリペプチド。
- 3.請求項1および/または請求項2のポリペプチドをコードする配列を含む、 ヌクレオチド配列またはその機能的均等物。
- 4.請求項3のヌクレオチド配列を含む、ベクター。
- 5.適当な宿主細胞に挿入されるとき、MSP1で採用されるコンフォメーショ ンの請求項1および/または請求項2に記載のポリペプチドを発現させる、請求 項4に記載のベクター。
- 6.請求項1および/または請求項2のポリペプチドが融合タンパク質として発 現される、請求項4または5に記載のベクター。
- 7.融合タンパク質が、その精製を促進する部分を含む、請求項6に記載のベク ター。
- 8.融合タンパク質が、請求項1および/または請求項2に記載のポリペプチド がタンパク質の残りのものから開裂されるかもしれないようになっている、請求 項6または7に記載のベクター。
- 9.請求項1および/または請求項2に記載のポリペプチドを作製する方法であ って、請求項4から9のいずれか1つのベクターを、適当な宿主細胞に導入する ことと、その宿主細胞を増殖させることと、ポリペプチドまたはそのように生産 されたポリペプチドを分離することを含む、ポリペプチドの作製方法。
- 10.請求項4から8のうちいずれか1つに従うベクターを用いて形質転換され た宿主細胞。
- 11.請求項1および/または請求項2に記載のポリペプチドと、生理学的に受 容できる担体とを含む、ワクチン。
- 12.請求項1および/または請求項2のポリペプチドが融合タンパク質として 存在する、請求項11に記載のワクチン。
- 13.請求項1および請求項2のポリペプチドが、MSP1で採用されたコンフ ォメーションに存在する、請求項11または12に記載のワクチン。
- 14.人体を取扱う方法であって、請求項11、12または13に従う、効果的 な量のワクチンを投与することを含む、治療方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9203821.5 | 1992-02-22 | ||
GB929203821A GB9203821D0 (en) | 1992-02-22 | 1992-02-22 | Improvements in or relating to malaria vaccine |
PCT/GB1993/000367 WO1993017107A1 (en) | 1992-02-22 | 1993-02-22 | Improvements in or relating to malaria vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH07504321A true JPH07504321A (ja) | 1995-05-18 |
Family
ID=10710868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5513568A Pending JPH07504321A (ja) | 1992-02-22 | 1993-02-22 | マラリアワクチンにおけるまたはそれに関する改良 |
Country Status (13)
Country | Link |
---|---|
US (1) | US5720959A (ja) |
EP (1) | EP0627004B1 (ja) |
JP (1) | JPH07504321A (ja) |
KR (1) | KR100262624B1 (ja) |
AT (1) | ATE231555T1 (ja) |
AU (1) | AU666519B2 (ja) |
CA (1) | CA2128109C (ja) |
DE (1) | DE69332652T2 (ja) |
DK (1) | DK0627004T3 (ja) |
ES (1) | ES2192556T3 (ja) |
GB (1) | GB9203821D0 (ja) |
NZ (1) | NZ249208A (ja) |
WO (1) | WO1993017107A1 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2697022B1 (fr) | 1992-10-19 | 1994-12-16 | Pasteur Institut | Antigènes de Plasmodium falciparum capables d'induire des anticorps protecteurs à large spectre - Application à la vaccination. |
FR2744724B1 (fr) | 1996-02-14 | 2002-08-02 | Pasteur Institut | Proteine recombinante contenant un fragment c-terminal de la proteine msp-1 d'un plasmodium infectieux pour l'homme pour la production de vaccins anti-paludiques |
US6828416B1 (en) | 1998-08-21 | 2004-12-07 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant multivalent malarial vaccine against Plasmodium falciparum |
AU1600401A (en) | 1999-11-12 | 2001-06-06 | Chinese University Of Hong Kong, The | Malaria vaccine |
CN1176945C (zh) * | 2001-02-01 | 2004-11-24 | 中国人民解放军第二军医大学 | 疟原虫融合抗原及其制法和用途 |
US20030104003A1 (en) * | 2001-05-25 | 2003-06-05 | James Anthony A. | Novel surface protein of the malaria parasite plasmodium falciparum |
WO2006124712A2 (en) * | 2005-05-16 | 2006-11-23 | Merck & Co., Inc. | A method for improving the immunogenicity of plasmodium antigens |
US7931908B2 (en) | 2007-02-23 | 2011-04-26 | Philadelphia Health Education Corporation | Chimeric MSP-based malaria vaccine |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0071705B1 (en) * | 1981-05-21 | 1989-11-23 | The Wellcome Foundation Limited | Protozoal antigen |
-
1992
- 1992-02-22 GB GB929203821A patent/GB9203821D0/en active Pending
-
1993
- 1993-02-22 CA CA002128109A patent/CA2128109C/en not_active Expired - Lifetime
- 1993-02-22 KR KR1019940702941A patent/KR100262624B1/ko not_active IP Right Cessation
- 1993-02-22 EP EP93904239A patent/EP0627004B1/en not_active Expired - Lifetime
- 1993-02-22 WO PCT/GB1993/000367 patent/WO1993017107A1/en active IP Right Grant
- 1993-02-22 DE DE69332652T patent/DE69332652T2/de not_active Expired - Lifetime
- 1993-02-22 ES ES93904239T patent/ES2192556T3/es not_active Expired - Lifetime
- 1993-02-22 US US08/290,919 patent/US5720959A/en not_active Expired - Lifetime
- 1993-02-22 DK DK93904239T patent/DK0627004T3/da active
- 1993-02-22 JP JP5513568A patent/JPH07504321A/ja active Pending
- 1993-02-22 AT AT93904239T patent/ATE231555T1/de not_active IP Right Cessation
- 1993-02-22 NZ NZ249208A patent/NZ249208A/en not_active IP Right Cessation
- 1993-02-22 AU AU35704/93A patent/AU666519B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
US5720959A (en) | 1998-02-24 |
EP0627004B1 (en) | 2003-01-22 |
DE69332652T2 (de) | 2003-11-27 |
KR950700415A (ko) | 1995-01-16 |
KR100262624B1 (ko) | 2000-08-01 |
ES2192556T3 (es) | 2003-10-16 |
DK0627004T3 (da) | 2003-05-12 |
NZ249208A (en) | 1996-03-26 |
ATE231555T1 (de) | 2003-02-15 |
AU3570493A (en) | 1993-09-13 |
CA2128109A1 (en) | 1993-09-02 |
DE69332652D1 (de) | 2003-02-27 |
EP0627004A1 (en) | 1994-12-07 |
GB9203821D0 (en) | 1992-04-08 |
CA2128109C (en) | 2007-09-25 |
WO1993017107A1 (en) | 1993-09-02 |
AU666519B2 (en) | 1996-02-15 |
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