JPH07503465A - コレシストキニンアンタゴニストとして有用な３‐フェニルウレイド‐アゼピン‐２‐オン及び‐ベンゾアゼピン‐２‐オン - Google Patents

コレシストキニンアンタゴニストとして有用な３‐フェニルウレイド‐アゼピン‐２‐オン及び‐ベンゾアゼピン‐２‐オン

Info

Publication number
JPH07503465A
JPH07503465A JP5513196A JP51319693A JPH07503465A JP H07503465 A JPH07503465 A JP H07503465A JP 5513196 A JP5513196 A JP 5513196A JP 51319693 A JP51319693 A JP 51319693A JP H07503465 A JPH07503465 A JP H07503465A
Authority
JP
Japan
Prior art keywords
phenyl
formula
ureido
butyl
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5513196A
Other languages
English (en)
Japanese (ja)
Inventor
ロウ，ジョン・エイ・ザ・サード
Original Assignee
フアイザー・インコーポレイテツド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フアイザー・インコーポレイテツド filed Critical フアイザー・インコーポレイテツド
Publication of JPH07503465A publication Critical patent/JPH07503465A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP5513196A 1992-01-27 1992-12-16 コレシストキニンアンタゴニストとして有用な３‐フェニルウレイド‐アゼピン‐２‐オン及び‐ベンゾアゼピン‐２‐オン Pending JPH07503465A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82567792A 1992-01-27 1992-01-27
US825,677 1992-01-27
PCT/US1992/010720 WO1993015059A1 (en) 1992-01-27 1992-12-16 3-phenylureido-azepin-2-ones and -benzazepin-2-ones useful as cholecystokinin antagonists

Publications (1)

Publication Number Publication Date
JPH07503465A true JPH07503465A (ja) 1995-04-13

Family

ID=25244657

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5513196A Pending JPH07503465A (ja) 1992-01-27 1992-12-16 コレシストキニンアンタゴニストとして有用な３‐フェニルウレイド‐アゼピン‐２‐オン及び‐ベンゾアゼピン‐２‐オン

Country Status (19)

Country Link
EP (1) EP0625145A1 (de)
JP (1) JPH07503465A (de)
KR (1) KR950700257A (de)
CN (1) CN1074903A (de)
AU (1) AU3276193A (de)
BR (1) BR9207071A (de)
CA (1) CA2117367A1 (de)
CZ (1) CZ391092A3 (de)
FI (1) FI943513A (de)
HU (1) HUT70496A (de)
IL (1) IL104472A0 (de)
MX (1) MX9300409A (de)
NO (1) NO942775L (de)
NZ (1) NZ245759A (de)
RU (1) RU94038063A (de)
TW (1) TW213901B (de)
WO (1) WO1993015059A1 (de)
YU (1) YU4393A (de)
ZA (1) ZA93582B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2097688A1 (es) * 1993-07-14 1997-04-01 Pfizer Hexahidroazepinonas y tetrahidrobenzazepinonas sustituidas.
DE69419157T2 (de) * 1993-07-26 1999-10-14 Pfizer Inc. Tetrahydro-1h-benzazepinone und hexahydro azepinone als selektive cholecystokinin-b rezeptor antagonisten
US5453424A (en) * 1993-11-22 1995-09-26 Merck & Co., Inc. Furanodiazepines
ATE206402T1 (de) * 1993-11-22 2001-10-15 Merck & Co Inc 3-acylaminobenzazepine
MX9702507A (es) * 1994-10-04 1997-07-31 Pfizer Nuevos intermedios y procedimientos para preparar antagonistas cck.
AU3745795A (en) 1994-10-14 1996-05-06 Glaxo Wellcome S.P.A. Use of CCK-B receptor antagonists for the treatment of sleepdisorders
DE10153348A1 (de) * 2001-10-29 2003-05-08 Gruenenthal Gmbh Substituierte Benzo(b)azepin-2-on-Verbindungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166357A3 (de) * 1984-06-26 1988-10-26 Merck & Co. Inc. Kondensierte Benzo-Laktame und deren pharmazeutische Zusammensetzungen
US4767756A (en) * 1987-07-17 1988-08-30 E. R. Squibb & Sons, Inc. 3-substituted benzazepines
EP0322779A3 (de) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Benzolaktam-Verbindungen und deren pharmazeutische Verwendungen
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck

Also Published As

Publication number Publication date
WO1993015059A1 (en) 1993-08-05
AU3276193A (en) 1993-09-01
CA2117367A1 (en) 1993-08-05
KR950700257A (ko) 1995-01-16
BR9207071A (pt) 1995-12-05
ZA93582B (en) 1994-07-27
RU94038063A (ru) 1996-05-27
YU4393A (sr) 1996-01-09
FI943513A0 (fi) 1994-07-26
IL104472A0 (en) 1993-05-13
FI943513A (fi) 1994-07-26
TW213901B (de) 1993-10-01
EP0625145A1 (de) 1994-11-23
NO942775L (no) 1994-09-20
CN1074903A (zh) 1993-08-04
NZ245759A (en) 1997-06-24
NO942775D0 (no) 1994-07-26
MX9300409A (es) 1993-07-01
HU9402195D0 (en) 1994-09-28
HUT70496A (en) 1995-10-30
CZ391092A3 (en) 1994-01-19

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JPH07503465A (ja) コレシストキニンアンタゴニストとして有用な３‐フェニルウレイド‐アゼピン‐２‐オン及び‐ベンゾアゼピン‐２‐オン