JPH07500817A - 有機ニトラート、その製造方法及びこれを心臓血管疾患の治療に使用する方法 - Google Patents

有機ニトラート、その製造方法及びこれを心臓血管疾患の治療に使用する方法

Info

Publication number
JPH07500817A
JPH07500817A JP5503265A JP50326593A JPH07500817A JP H07500817 A JPH07500817 A JP H07500817A JP 5503265 A JP5503265 A JP 5503265A JP 50326593 A JP50326593 A JP 50326593A JP H07500817 A JPH07500817 A JP H07500817A
Authority
JP
Japan
Prior art keywords
nitro
group
amino
dianhydro
deoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5503265A
Other languages
English (en)
Japanese (ja)
Inventor
ナレー・ジャン−ピエール
ドルー・ジャク
ベルドー・アレン
リシャール・ビンソン
マルトラーナ・ピーロ
ボーン・ヘルムート
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Laboratoires Hoechst SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Hoechst SA filed Critical Laboratoires Hoechst SA
Publication of JPH07500817A publication Critical patent/JPH07500817A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP5503265A 1991-08-07 1992-08-01 有機ニトラート、その製造方法及びこれを心臓血管疾患の治療に使用する方法 Pending JPH07500817A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR91/10039 1991-08-07
FR9110039A FR2680173A1 (fr) 1991-08-07 1991-08-07 Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .
PCT/EP1992/001746 WO1993003037A1 (fr) 1991-08-07 1992-08-01 Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires

Publications (1)

Publication Number Publication Date
JPH07500817A true JPH07500817A (ja) 1995-01-26

Family

ID=9415992

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5503265A Pending JPH07500817A (ja) 1991-08-07 1992-08-01 有機ニトラート、その製造方法及びこれを心臓血管疾患の治療に使用する方法

Country Status (10)

Country Link
US (1) US5591758A (enExample)
EP (2) EP0604459A1 (enExample)
JP (1) JPH07500817A (enExample)
CA (1) CA2113922A1 (enExample)
FR (1) FR2680173A1 (enExample)
HU (1) HUT70546A (enExample)
MX (1) MX9204613A (enExample)
TW (1) TW213906B (enExample)
WO (1) WO1993003037A1 (enExample)
ZA (1) ZA925892B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002526544A (ja) * 1998-10-07 2002-08-20 レイサー ソシエダッド アノニマ イソソルビドモノニトレートの誘導体及び耐性が低下した血管拡張剤としてのその使用
JP2022504403A (ja) * 2018-11-04 2022-01-13 コユーラティブ，インコーポレイテッド 心血管疾患の処置に有用な新規化合物

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284790B1 (en) * 2000-06-15 2001-09-04 Sachin Gupte Methods of potentiating organic nitrates having vasodilating activity and formulations for the same
US20040019206A1 (en) * 2001-09-27 2004-01-29 Peter Ruminiski Lactone integrin antagonists
US20040254238A1 (en) * 2003-04-07 2004-12-16 Osteoscreen Bone growth stimulation with NO/statin and other NO modulating combinations
ES2258365B1 (es) * 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP2149576A1 (en) 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
WO2013060673A1 (en) 2011-10-24 2013-05-02 Nicox S.A. Quinone based nitric oxide donating compounds
WO2014111465A1 (en) * 2013-01-17 2014-07-24 Sanofi Isomannide derivatives as inhibitors of soluble epoxide hydrolase
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds
CN103897023A (zh) * 2014-02-28 2014-07-02 苏州维泰生物技术有限公司 一种合成甘氨酸半胱氨酸伪二肽模块的新方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3248548A1 (de) * 1982-12-29 1984-07-05 Heinrich Mack Nachf., 7918 Illertissen Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IT1204571B (it) * 1987-05-08 1989-03-10 Chiesi Farma Spa Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche
JP2628756B2 (ja) * 1988-09-15 1997-07-09 シュバルツファルマ アクチェンゲゼルシャフト 新規有機ニトレート及びそれらの製造方法
NL9001955A (nl) * 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002526544A (ja) * 1998-10-07 2002-08-20 レイサー ソシエダッド アノニマ イソソルビドモノニトレートの誘導体及び耐性が低下した血管拡張剤としてのその使用
JP2022504403A (ja) * 2018-11-04 2022-01-13 コユーラティブ，インコーポレイテッド 心血管疾患の処置に有用な新規化合物

Also Published As

Publication number Publication date
HU9400327D0 (en) 1994-05-30
EP0604459A1 (fr) 1994-07-06
MX9204613A (es) 1993-09-01
WO1993003037A1 (fr) 1993-02-18
TW213906B (enExample) 1993-10-01
FR2680173A1 (fr) 1993-02-12
FR2680173B1 (enExample) 1995-05-05
EP0530887A1 (fr) 1993-03-10
US5591758A (en) 1997-01-07
HUT70546A (en) 1995-10-30
CA2113922A1 (fr) 1993-02-18
ZA925892B (en) 1993-07-28

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