ZA925892B - Organic nitrates, processes for their preparation and their use in the treatment of cardiovascular diseases. - Google Patents

Organic nitrates, processes for their preparation and their use in the treatment of cardiovascular diseases.

Info

Publication number
ZA925892B
ZA925892B ZA925892A ZA925892A ZA925892B ZA 925892 B ZA925892 B ZA 925892B ZA 925892 A ZA925892 A ZA 925892A ZA 925892 A ZA925892 A ZA 925892A ZA 925892 B ZA925892 B ZA 925892B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
treatment
cardiovascular diseases
organic nitrates
Prior art date
Application number
ZA925892A
Other languages
English (en)
Inventor
Wolfgang Dr Koning
Gerhard Dr Zoller
Melitta Dr Just
Bernd Dr Jablonka
Original Assignee
Hoechst Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Lab filed Critical Hoechst Lab
Publication of ZA925892B publication Critical patent/ZA925892B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
ZA925892A 1991-08-07 1992-08-06 Organic nitrates, processes for their preparation and their use in the treatment of cardiovascular diseases. ZA925892B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9110039A FR2680173A1 (fr) 1991-08-07 1991-08-07 Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .

Publications (1)

Publication Number Publication Date
ZA925892B true ZA925892B (en) 1993-07-28

Family

ID=9415992

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA925892A ZA925892B (en) 1991-08-07 1992-08-06 Organic nitrates, processes for their preparation and their use in the treatment of cardiovascular diseases.

Country Status (10)

Country Link
US (1) US5591758A (xx)
EP (2) EP0530887A1 (xx)
JP (1) JPH07500817A (xx)
CA (1) CA2113922A1 (xx)
FR (1) FR2680173A1 (xx)
HU (1) HUT70546A (xx)
MX (1) MX9204613A (xx)
TW (1) TW213906B (xx)
WO (1) WO1993003037A1 (xx)
ZA (1) ZA925892B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2142773B1 (es) * 1998-10-07 2001-01-01 Lacer Sa Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
US6284790B1 (en) * 2000-06-15 2001-09-04 Sachin Gupte Methods of potentiating organic nitrates having vasodilating activity and formulations for the same
US20040019206A1 (en) * 2001-09-27 2004-01-29 Peter Ruminiski Lactone integrin antagonists
US20040254238A1 (en) * 2003-04-07 2004-12-16 Osteoscreen Bone growth stimulation with NO/statin and other NO modulating combinations
ES2258365B1 (es) 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP2149576A1 (en) 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
CA2839390C (en) 2011-10-24 2015-09-15 Nicox S.A. Quinone based nitric oxide donating compounds
EP2945950B1 (en) * 2013-01-17 2017-03-01 Sanofi Isomannide derivatives as inhibitors of soluble epoxide hydrolase
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds
CN103897023A (zh) * 2014-02-28 2014-07-02 苏州维泰生物技术有限公司 一种合成甘氨酸半胱氨酸伪二肽模块的新方法
US10913748B2 (en) 2018-11-04 2021-02-09 Coeurative, Inc. Compounds useful for treating cardiovascular diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3248548A1 (de) * 1982-12-29 1984-07-05 Heinrich Mack Nachf., 7918 Illertissen Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IT1204571B (it) * 1987-05-08 1989-03-10 Chiesi Farma Spa Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche
JP2628756B2 (ja) * 1988-09-15 1997-07-09 シュバルツファルマ アクチェンゲゼルシャフト 新規有機ニトレート及びそれらの製造方法
NL9001955A (nl) * 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.

Also Published As

Publication number Publication date
TW213906B (xx) 1993-10-01
CA2113922A1 (fr) 1993-02-18
WO1993003037A1 (fr) 1993-02-18
EP0604459A1 (fr) 1994-07-06
US5591758A (en) 1997-01-07
FR2680173B1 (xx) 1995-05-05
EP0530887A1 (fr) 1993-03-10
HU9400327D0 (en) 1994-05-30
FR2680173A1 (fr) 1993-02-12
MX9204613A (es) 1993-09-01
JPH07500817A (ja) 1995-01-26
HUT70546A (en) 1995-10-30

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