JPH07101837A - New anti-dandruff agent - Google Patents

Abstract

PURPOSE:To provide the subject agent having significant anti-dandruff activity, and high in safety to the skin. CONSTITUTION:Tea leaves are either directly, or, as necessary, after finely chopped, subjected to extraction under heating in an alcohol such as methanol, ethanol, propylene glycol or 1,3-butylene glycol. The objective anti-dandruff agent contains the resultant extract as active ingredient. This extract can be directly used as an anti-dandruff agent; or may also be used in a diluted form using an appropriate base as diluent (in this case, the content of the extract in the diluent is 0.05-10wt.%, pref. 0.1-5wt.%). The anti-dandruff effect of this extract is drastically significant compared with those of extracts obtained from tea leaves using water at elevated temperatures or room temperature.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a novel antidandruff agent containing an extract obtained by heating and extracting tea leaves with alcohols as an active ingredient.

[0002]

[Background Art] Due to the excessive occurrence of dandruff, the pores are blocked and the growth of hair is hindered. Further, the accumulated dandruff is decomposed by bacteria, etc. It can be a cause. Conventionally, as an antidandruff agent,
Sulfur, zinc compounds such as zinc pyridinium-1-thiol-N-oxide, triclosan, halocarbane, allantoin, menthol, salicylic acid, undecylenic acid, etc. have long been known and widely used, but they are still satisfactory. Kimono is currently not provided.

As a result of various studies on tea leaves, the present inventor has found that an alcohol-heated extract of tea leaves has a significant antidandruff effect. Heretofore, it has not been known at all that a heated alcoholic extract of tea leaves has an antidandruff effect. Further, it was found that the alcohol-heated extract of tea leaves has a particularly prominent dandruff action as compared with the water extract of tea leaves and the extract obtained by cold soaking of tea leaves. Accordingly, the present invention provides a novel antidandruff agent characterized by containing an alcohol-heated extract of tea leaves. It is considered that the present invention further expands the effective use of tea leaves and provides a great turning point in the breeding and cultivation of tea.

[0004]

DISCLOSURE OF THE INVENTION The present invention is described in detail below. The tea leaf as a raw material used in the present invention is a tea leaf that is classified in the Camellia Sinusis genus of the Camellia family, and raw tea leaves may be used as the raw material of the tea leaf, and processed. You may use the thing. Examples of processed teas include green tea that is unfermented tea, such as green tea, bancha, gyo green tea, kettle roasted tea, gabaron tea, gyokuro, kabusecha, and tencha. Fermented tea, oolong tea, wrapped tea, new flavored tea,
There is post-fermented tea such as Puerle tea, and these raw tea leaves can be used alone or in combination of two or more kinds.

As a method for producing the antidandruff agent of the present invention, the raw tea leaves are heated and extracted with alcohol,
The extract is used as an active ingredient. In this case, the raw tea leaves as they are, or if necessary, finely chopped, alcohol as such, for example, methanol, ethanol,
One selected from propylene glycol, 1,3-butylene glycol and the like is used alone or in combination, and a heat extraction operation is performed. This operation can be performed with stirring using a stirrer. When a highly volatile alcohol such as methanol or ethanol is used as an extraction solvent, it is preferable to carry out heating under reflux extraction. The obtained extract is filtered, if necessary, or centrifuged, and the filtrate or supernatant can be used, or the extract can be used as a liquid, or can be concentrated to dryness to give a solid. The solid matter can be collected and used. When the solvent itself is harmful, as in the case of the methanol extract, the extract is once concentrated to dryness, the methanol is distilled off, and the extract is collected as a solid. Is preferably used.

The extract used in the present invention can be used as it is as an antidandruff agent, but can also be used by diluting it with an appropriate base.
When used by diluting with a suitable base, the extract may be in the form of liquid or concentrated to dryness, and any carrier commonly used in the technical field of cosmetics, pharmaceuticals, etc.,
Using an additive such as an emulsifier, a suspending agent, and a fragrance, it is formulated into a required dosage form by a conventional method.

Examples of materials used in these formulations include oleic acid, triethanolamine, salix beeswax, cetyl alcohol, sodium lauryl sulfate, glycerin, sodium alginate, gum arabic, sodium carboxymethylcellulose, methylcellulose,
Bentonite, petrolatum, liquid paraffin, alcohols and esters thereof, for example, ethanol, propylene glycol, cetostearyl alcohol, sorbitan monostearate and the like, the dosage form, hair tonic, hair cream, hair lotion, hair shampoo,
It can be provided in various forms such as hair rinse, hair liquid, hair treatment, hair spray, and the like. It can also be provided in the form of a composition for ointment or a composition for plaster. The preparation in this case may contain a carrier for well-known and conventional preparations such as petrolatum, paraffin, lanolin hydrolyzate, plastibase, hydrophilic petrolatum, macrogols, wax, resin, purified lanolin, and rubber.

The content of the heated alcoholic extract of tea leaves contained in these external preparations is usually about 0.05 to 10%, preferably 0.1 to 5%.

The production examples, the pharmacological action test, the safety test, and the prescription examples of the alcohol-heated extract of tea leaves used in the present invention will be described below.

[0010]

【Example】

[Example 1] 1 kg of green tea was used as a tea leaf raw material, 4 liters of methanol was added thereto, and heating and reflux extraction was performed for 30 minutes on a water bath. After extraction, leave still and collect supernatant. After the obtained liquid is filtered, the filtrate is dried under reduced pressure to give 226 g of a green tea methanol extract.

Example 2 Oulon tea was used in place of the green tea of Example 1, and the same operation as in Example 1 was carried out to obtain 162 g of a methanol extract of oolong tea.

Example 3 Black tea was used in place of the green tea of Example 1, and the same operation as in Example 1 was carried out to obtain 185 g of a methanol extract of black tea.

Example 4 1 kg of green tea was used as a tea leaf raw material, 5 liters of ethanol was added thereto, and the mixture was placed on a water bath for 30 days.
Perform heat reflux extraction for minutes. After extraction, leave still and collect supernatant. After filtering the obtained liquid, the filtrate is concentrated to dryness under reduced pressure to obtain 136 g of green tea ethanol extract.

Example 5 Oulon tea was used in place of the green tea of Example 4, and the same operation as in Example 4 was carried out to obtain 65 g of an ethanol extract of oolong tea.

Example 6 Black tea was used instead of the green tea of Example 4, and the same operation as in Example 4 was performed to obtain 84 g of ethanol extract of black tea.

Example 7 1 kg of finely chopped green tea was used as a tea leaf material, 5 liters of propylene glycol was added thereto, and heat extraction was performed for 30 minutes on a water bath. After extraction, leave still and collect supernatant. The obtained liquid is filtered to obtain 3.5 liters of green tea propylene glycol extract.

Example 8 Oulon tea was used in place of the green tea of Example 7, and the same operation as in Example 7 was carried out to obtain 3.4 liters of propylene glycol extract of oolong tea.

[Example 9] Black tea was used instead of the green tea of Example 7, and the same operation as in Example 7 was performed to obtain 3.2 liters of propylene glycol extract of black tea.

[Example 10] 1 kg of finely chopped green tea was used as a tea leaf raw material, and 1,3-butylene glycol 5 was added thereto.
Add 1 liter and perform heat extraction on a water bath for 30 minutes. After extraction, leave still and collect supernatant. The obtained liquid is filtered,
3.2 L of 1,3-butylene glycol extract of green tea is obtained.

Example 11 Oulon tea was used in place of the green tea of Example 10, and the same operation as in Example 10 was carried out to obtain 3.3 liters of 1,3-butylene glycol extract of oolong tea.

[Example 12] Black tea was used in place of the green tea of Example 10, and the same operation as in Example 10 was performed to obtain 3.2 liters of 1,3-butylene glycol extract of black tea.

The following is an experimental example for confirming the antidandruff effect, acute toxicity and safety of the alcohol-heated extract of tea leaves used in the antidandruff agent according to the present invention.

[Experimental Example 1] (Anti-dandruff action) The following samples were used in the experiment. (A) Sample (A) (B) prepared in the same manner as in formulation example 1 to be described later, except that formulation example 1 does not use "0.5 g of the green tea ethanol extract obtained in example 4" and the other formulations Samples (B) and (C) prepared as the same formulation components as in Example 1 Instead of “0.5 g of the green tea ethanol extract obtained in Example 4” in Formulation Example 1, the following “Note 1“ Ethanol cold-soaked extract ”was used. (C) (D) prepared using the same formulation components as in Formulation Example 1 except that 0.5 g ”was used instead of“ 0.5 g of the green tea ethanol extract obtained in Example 4 ”in Formulation Example 1. A sample (D) prepared by using the same "water extract 0.5 g" as in Note 2 below and using the same ingredients as in Formulation Example 1 except for the above.

The subjects are 20 to 30 years old (4 persons), 31 to 31
Twelve boys aged 40 years (4 people) and 41 to 50 years old (4 people) were selected, and men with a relatively large amount of dandruff were selected and divided into 4 groups so that the age groups would be even.

Note 1; (Ethanol cold-soaked extract) 1 kg of green tea was used as raw tea leaves, and ethanol 5
1 liter is added, and the mixture is left at 15 ° C to 25 ° C for 5 days with occasional stirring, and then the supernatant is collected. The obtained liquid is filtered, and then the filtrate is concentrated to dryness under reduced pressure to obtain 58 g of a green tea ethanol cold-soaked extract. Note 2; (Water extract) 1 kg of green tea is used as a tea leaf raw material, 4 liters of water is added thereto, and the mixture is heated under reflux for 30 minutes for extraction under reflux. After extraction,
Allow to stand and collect the supernatant. After filtering the obtained liquid,
The filtrate is concentrated to dryness under reduced pressure to obtain 206 g of green tea water extract.

Before the application of the sample, the hair was washed with a commercially available shampoo, and the dandruff accumulated for 3 days after the hair was washed was measured and the weight thereof was measured. After that, the hair was washed with the same shampoo, and after the hair was washed, three people in the first group had the sample (A), three people in the second group had the sample (B), and three people in the third group had the sample ( C) was applied to the scalp by the sample (D) for 3 persons in the fourth group twice a day in the morning and evening, and the dandruff accumulated for 3 days was collected, and the weight thereof was measured.

The results are shown in Table 1 by the "reduction rate (%) of dandruff" expressed by the following formula. Decrease rate of dandruff (%) = (K−L) × 100 / K K: weight of dandruff before application of sample L: weight of dandruff after application of sample As shown in Table 1, the antidandruff agent according to the present invention Has
It was found to have a pronounced antidandruff effect and to be superior to the ethanol cold soak extract or water extract.

[0028]

Experimental Example 2 (Acute toxicity) In this experiment, Std: ddY male mice (2
0-25 g) was used. When the extracts obtained in Examples 1 to 6 were used as samples, each sample was suspended in water using depleted distilled water to prepare a sample solution having a concentration of 1 g / 10 ml. When the propylene glycol extract and 1,3-butylene glycol extract obtained in Examples 7 to 12 are used as samples, the respective propylene glycol extract and 1,3-butylene glycol extract are the same as the extract samples. The solvent was dissolved to make exactly 5 liters to prepare a sample solution. Each sample solution was orally administered to the test animal at a rate of 10 ml / kg, and the number of lethality 72 hours after the administration was determined. As a result, no death was observed in any of the sample solutions, and it was confirmed that the toxicity was extremely low.

[Experimental Example 3] (Safety) As a test method, a 24-hour human forearm closed batch test was used. The test subjects are 3 adult males and 1 adult female. The criteria were as follows. Sample is Formulation Example 1
A sample prepared in the same manner as above was used. ++: Strong erythema ±: Slight erythema +: Erythema −: Negative results are shown in Table 2. As shown in Table 2, this sample solution showed no skin irritation or allergenicity, and was found to have extremely high safety to the skin. In addition, no particular side effects were observed in the subject.

[0031]

Formulation examples of the antidandruff agent according to the present invention are shown below. [Formulation Example 1] Hair tonic ethanol 50 ml Propylene glycol 3 g Green tea ethanol extract obtained in Example 4 0.5 g Fragrance An appropriate amount of purified water is added to make 100 ml.

[Formulation Example 2] Hair lotion Ethanol 2 g Glycerin 0.5 g Isopropylmethylphenol 0.4 g Resorcinol 2 g 1-Menthol 1 g Green tea methanol extract obtained in Example 1 0.5 g Fragrance A suitable amount of purified water was added, Make up to 100 ml.

[Formulation Example 3] Hair cream (A) An oil phase component is prepared by the following composition. Liquid paraffin 40 g Sarami beeswax 2.5 g Polyoxyethylene stearyl ether (20E.0.) 1.5 g Polyoxyethylene stearyl ether (5E.0.) 3.0 g Sorbitan monostearate 1.5 g Obtained in Example 5. Oolong Tea Ethanol Extract 0.3 g (B) An aqueous phase component is prepared according to the following composition. Borax 0.4 g Tetrasodium edetate 1 g Propylene glycol 5 g Purified water Appropriate amount (added so that the total amount becomes 100 ml) (A) oil phase component at 75 ° C., (B) water phase component 77
The mixture is heated and stirred at 0 ° C, and (B) is gradually added to (A) with stirring to obtain an emulsion.

[Formulation Example 4] Hair shampoo (A) component Lauryl ether sulfate triethanolamine 15 g Coconut oil fatty acid diethanolamide 5 g Ethylene glycol monostearate 2 g (B) component Ethanol extract of black tea obtained in Example 6 2 g Sodium lauryl sulfate 5 g Purified water Appropriate amount (added so that the total amount becomes 100 ml) After heating and stirring each of the components (A) and (B), the component (B) becomes the component (A) while stirring. Add gradually to prepare a shampoo solution.

[Formulation Example 5] Hair rinse Polyoxyethylene oleyl ether 6 g Lanolin (10 E0) 1 g Benzalkonium chloride 4 g Methanol extract of oolong tea obtained in Example 2 0.3 g Purified water is added to make 100 ml in total. .

[Formulation Example 6] Hair liquid Polyoxypropylene butyl ether 10 g Green tea propylene glycol extract obtained in Example 7 2 ml Ethanol 50 g Purified water is added to make a total volume of 100 ml.

[Formulation Example 7] Hair Treatment Polyoxyethylene oleyl ether 4 g Stearyl trimethyl ammonium chloride 3 g Behenyl alcohol 6 g Anhydrolanolin 1.5 g 2-Octyldodecanol 1.5 g Isopropyl myristate 8 g 1 of green tea obtained in Example 10 , 3-Butylene glycol extract 3 ml Purified water is added to make the total volume 100 ml.

[Formulation Example 8] Ointment White petrolatum 25 g Stearyl alcohol 22 g Propylene glycol 12 g Propylene glycol extract of oolong tea obtained in Example 8 3 ml Purified water is added to make a total amount of 100 g.

Claims (1)

[Claims] 1. An antidandruff agent comprising an extract obtained by heating and extracting tea leaves with alcohols as an active ingredient.