JP3516306B2 - New dandruff agent - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [0001] TECHNICAL FIELD The present invention relates to tea leaves that have not been subjected to anaerobic treatment.
Obtained by heating and extracting with alcohols that do not contain water.
Dandruff containing an extract as an active ingredient
Things. [0002] [Background Art] Dandruff blocks pores due to its excessive occurrence.
It interferes with hair growth, and the accumulated dandruff can be
It is understood, and it is accompanied by itching and inflammation
It also causes pityriasis. Conventionally, as dandruff agent,
Sulfur, zinc pyridinium-1-thiol-N-oxo
Sulfur compounds such as side, triclosan, halocarba
, Allantoin, menthol, salicylic acid, undeci
Lenoic acid has been known for a long time and is widely used.
By now, nothing has been offered yet
It is in. The present inventor has conducted various studies on tea leaves.
As a result, remarkable dandruff
Has been found to work. Traditionally, tea leaves alcohol
It is completely known that heated extract has dandruff action
Not in. In addition, the alcoholic heated extract of tea leaves
Compared to the water extract and the extract obtained by cold soaking tea leaves
And found that the dandruff effect was particularly remarkable
Was. Therefore, the present invention provides tea leaves that have not been subjected to anaerobic treatment to water.
Obtained by heat extraction using alcohols that do not contain
Provide dandruff agent containing extract as active ingredient
Things. Effective use of tea leaves is further expanded by the present invention
Is a big turning point for tea breeding and cultivation.
it is considered as. [0004] DISCLOSURE OF THE INVENTION Hereinafter, the present invention will be described in detail. Departure
The tea leaves used in Ming Ming are the Camellia family
Cha section (Camellia Sinensis)
Tea leaves, and raw tea leaves
May be used, or may be used after processing.
No. Non-fermented tea that has been processed
Green tea, for example, sencha, bancha, jade green tea, pot roasted tea, gyokuro, or
There are bush tea, tencha, etc.
Fermented tea oolong tea, wrapping tea, new flavored tea, post-fermented tea
Ear tea, etc., and these raw tea leaves are used alone or
Can be used in combination of two or more. As a method for producing the dandruff agent of the present invention,
Is heat-extracted the above-mentioned raw tea leaves using alcohol,
The extract is used as an active ingredient. In this case, the raw material
Leave the tea leaves as they are or cut as needed
As alcohols, for example, methanol, ethanol,
Propylene glycol, 1,3-butylene glycol
For use alone or in combination
And perform a heat extraction operation. This operation starts the stirrer
With stirring. Highly volatile
Extraction solvent such as methanol, ethanol, etc.
When used as the extraction, it is preferable to perform the heating and reflux extraction.
No. The obtained extract is filtered or centrifuged as necessary.
After separation, the filtrate or supernatant can be used.
In addition, extract liquid is kept liquid or concentrated to dryness
It can be collected as a solid and its solid can be used. Me
As in the case of the ethanol extract, the solvent methanol itself
If the extract is harmful, once concentrate the extract to dryness,
The ethanol is distilled off, and the extract is collected as a solid.
It is preferable to use a solid material of [0006] The extract used in the present invention is as it is.
It can be used as an anti-drinking agent, but a suitable base
And can be used after being diluted in the base.
When using an appropriate base and diluting, use this extract
Can be used as a liquid or concentrated to dryness for cosmetics,
Any carrier commonly used in the technical field such as pharmaceuticals,
Use additives such as emulsifiers, suspending agents, fragrances, etc.
Formulation into the required dosage form. [0007] As an example of the materials used in the formulation of these
Is oleic acid, triethanolamine, salamander
C, cetyl alcohol, sodium lauryl sulfate, grease
Serine, sodium alginate, gum arabic, carbo
Xymethylcellulose sodium, methylcellulose,
Bentonite, petrolatum, liquid paraffin, alcohol
And its esters such as ethanol and propylene glycol.
Recall, cetostearyl alcohol, sorbitan mono
Stearate and the like.
, Hair cream, hair lotion, hair shampoo,
Hair rinse, hair liquid, hair treatment, hair
Can be provided in various other forms such as spray
You. Also, in the form of a composition for ointment or a composition for plaster
Can also be provided. The formulation in this case is well known and customary.
Carriers for preparations such as petrolatum, paraffin,
Water lanolin, plastibase, hydrophilic petrolatum, macrogo
Containing products, waxes, resins, purified lanolin, rubber, etc.
It may be. Alcohol of tea leaves to be contained in these external preparations
The content of the heated extract is usually about 0.05 to 10%, preferably
Preferably it is 0.1-5%. The alcohol of tea leaves used in the present invention is described below.
Production example of heated extract, pharmacological action test, safety test and
And prescription examples. [0010] [Example] [Example 1] 1 kg of green tea is used as a tea leaf material, and methanol 4
One liter is added, and the mixture is heated and refluxed for 30 minutes on a water bath.
After extraction, the mixture is allowed to stand, and the supernatant is collected. Filtration of the obtained liquid
After that, the filtrate is concentrated to dryness under reduced pressure, and the green tea methanol
226 g of extract are obtained. [Embodiment 2] The operation was performed using oolong tea instead of green tea in Example 1.
The same operation as in Example 1 was carried out, and methanol
162 g are obtained. [Embodiment 3] Black tea was used in place of the green tea of Example 1, and the operation was the same as that of Example 1.
Perform the same operation and add 185g of black tea methanol extract.
obtain. [Embodiment 4] 1 kg of green tea is used as a tea leaf material, and ethanol 5
One liter is added, and the mixture is heated and refluxed for 30 minutes on a water bath.
After extraction, the mixture is allowed to stand, and the supernatant is collected. Filtration of the obtained liquid
After that, the filtrate is concentrated to dryness under reduced pressure, and the green tea ethanol
136 g of extract are obtained. [Embodiment 5] The operation was performed using oolong tea instead of the green tea of Example 4.
The same operation as in Example 4 was carried out, and ethanol
To obtain 65g. Embodiment 6 Black tea was used in place of the green tea of Example 4, and the operation was the same as in Example 4.
Perform the same operation to obtain 84 g of black tea ethanol extract.
You. [Embodiment 7] Using 1 kg of green tea shreds as a tea leaf material,
Add 5 liters of pyrene glycol and add on a water bath for 30 minutes.
Perform heat extraction. After extraction, the mixture is allowed to stand, and the supernatant is collected. Profit
The liquid is filtered and green tea propylene glycol extract
Obtain 3.5 liters. Embodiment 8 The operation was performed using oolong tea instead of green tea of Example 7.
The same operation as in Example 7 was performed to obtain propylene glycol of oolong tea.
Obtain 3.4 liters of coal extract. Embodiment 9 Using black tea instead of green tea of Example 7, the operation was the same as in Example 7.
Proceed in the same manner to produce propylene glycol extract of black tea.
Obtain 3.2 liters. [Embodiment 10] Using 1 kg of green tea shreds as a tea leaf material,
Add 5 liters of 3-butylene glycol and place on a water bath for 30 minutes.
Perform heat extraction for minutes. After extraction, leave still and collect the supernatant
You. The obtained liquid was filtered, and green tea 1,3-butylene glycol was removed.
Obtain 3.2 liters of coal extract. [Embodiment 11] The operation was performed using oolong tea instead of the green tea of Example 10.
The same operation as in Example 10 was performed, and 1,3-butyl oolong tea was used.
3.3 liters of Tylene glycol extract are obtained. Embodiment 12 Using black tea instead of green tea of Example 10, the operation is Example 1.
Perform the same operation as described above, and use 1,3-butylene glyco
To obtain 3.2 liters of wool extract. The following are examples of the dandruff agent used in the present invention.
Dandruff effect of alcoholic heated extract of tea leaves, acute
Experimental examples confirmed for toxicity and safety are shown. [Experimental example 1] (Dander action) The following samples were used in the experiment. (A) Sample prepared in the same manner as in Formulation Example 1 described below
(A) (B) In Formulation Example 1, the “green tea obtained in Example 4
Without using 0.5 g of ethanol extract,
Sample (B) prepared as the same blending component as in Formulation Example 1 (C) Formulation Example 1 “Etano of green tea obtained in Example 4”
Ethanol Extract 0.5g "
Others are the same as in Formulation Example 1
Sample (C) created as a blending component (D) Formulation Example 1 "Etano of green tea obtained in Example 4"
"Water extract 0.5g"
0.5g ", and the other ingredients were the same as in Formulation Example 1.
Sample (D) The subjects were 20 to 30 years old (four), 31 to 31
12 males aged 40 (4) and 41-50 (4)
Select men with relatively many dandruff, and each age group is equal
The test was performed in four groups such that Note 1: (cold ethanol extract) 1 kg of green tea is used as a raw tea leaf, and ethanol 5
Add a liter and stir occasionally at 15-25 ° C
After 5 days, the supernatant is collected. The obtained liquid
After filtration, the filtrate is concentrated to dryness under reduced pressure, and the green tea ethanol
To obtain 58 g of a cold soaked extract. Note 2; (Water extract) 1 kg of green tea is used as a tea leaf material
Add 4 liters of water and heat on a water bath for 30 minutes
Perform flow extraction. After extraction, the mixture is allowed to stand, and the supernatant is collected. Profit
After filtering the obtained liquid, the filtrate is concentrated to dryness under reduced pressure,
206 g of tea water extract is obtained. Wash with a commercial shampoo before applying the sample
Hair was collected, and the dandruff accumulated for 3 days after washing was collected and its weight was measured.
Was measured. After that, wash your hair with the same shampoo and wash your hair
Later, three members of the first group received the sample (A) and the second group
Three of the groups tested sample (B) and three of the third group tested.
Charge (C), the fourth group of three samples (D),
Applied to the scalp twice a day for 3 days in the evening and accumulated for 3 days
The dandruff was collected and its weight was measured. The result is given by the following equation:
% (%) "And shown in Table 1. Dandruff reduction rate (%) = (KL) × 100 / K K: Weight of dandruff before sample application L: Weight of dandruff after sample application As seen in Table 1, the dandruff agent according to the present invention includes:
Significant dandruff action and ethanol cold soak
Is superior to water or water extract.
Was done. [0028]Experimental Example 2 (Acute toxicity) In this experiment, Std: ddY strain male mice (2
0-25 g) was used. Obtained in Examples 1 to 6.
When using extracted extracts as samples,
Suspended in water using sterile distilled water, and a concentration of 1 g / 10 ml
And used as a sample solution. Obtained in Examples 7 to 12.
Propylene glycol extract and 1,3-butyle
When using glycol extract as a sample,
Propylene glycol extract and 1,3-butylene
Glycol extract was prepared using the same solvent as the extract sample.
Was dissolved to make the total volume exactly 5 liters, and used as a sample solution.
Each sample solution was orally administered to the test animal at a rate of 10 ml / kg.
And the number of deaths 72 hours after administration was determined. As a result,
No mortality was observed in the sample solution,
Low toxicity was observed. [Experiment 3] (Safety) The test method is a 24-hour human forearm closed batch test
Using. The test subjects were three adult males and one adult female.
You. The criteria were as follows. The sample was Formulation Example 1.
A sample prepared in the same manner as described above was used. ++: strong erythema ±: faint erythema +: Erythema-: Negative Table 2 shows the results. As shown in Table 2, this sample solution
Has no skin irritation or allergenicity,
It was found that their safety was extremely high. In addition,
No particular side effect was observed in the examiner. [0031] The following is an example of the formulation of the dandruff agent according to the present invention.
Show. [Formulation Example 1] Hair tonic 50 ml of ethanol Propylene glycol 3g 0.5 g of green tea ethanol extract obtained in Example 4Appropriate amount of fragrance Add purified water to make 100 ml. [0033] [Formulation Example 2] Hair lotion 2 g of ethanol Glycerin 0.5g 0.4 g of isopropylmethylphenol 2 g resorcinol 1-menthol 1g 0.5 g of green tea methanol extract obtained in Example 1Appropriate amount of fragrance Add purified water to make 100 ml. [0034] [Formulation Example 3] Hair cream (A) An oil phase component is prepared according to the following composition.       Liquid paraffin 40g     Sara Shimitsu Wax 2.5g     1.5 g of polyoxyethylene stearyl ether (20E.0.)     3.0 g of polyoxyethylene stearyl ether (5E.0.0)     1.5 g of sorbitan monostearate     0.3 g of oolong tea ethanol extract obtained in Example 5 (B) An aqueous phase component is prepared according to the following composition.     Borax 0.4g     Tetrasodium edetate 1g     Propylene glycol 5g   Appropriate amount of purified water (add to 100 ml) The oil phase component of (A) was brought to 75 ° C., and the aqueous phase component of (B) was brought to 77 ° C.
C., warm, stir, and slowly stir (A) and (B)
Each of them is added to form an emulsion. [0035] [Formulation Example 4] Hair shampoo (A) component     Lauryl ether sulfate triethanolamine 15g     Coconut oil fatty acid diethanolamide 5g     2 g of ethylene glycol monostearate (B) component     0.2 g of the ethanol extract of black tea obtained in Example 6     Sodium lauryl sulfate 5gAppropriate amount of purified water (add to 100 ml) The components (A) and (B) were each heated and stirred.
Then, while stirring, the component (B) is gradually added to the component (A).
Prepare a shampoo solution. [0036] [Formulation Example 5] Hair rinse     6 g of polyoxyethylene oleyl ether     Lanolin (10 E0) 1g     4 g of benzalkonium chloride   0.3 g of oolong tea methanol extract obtained in Example 2     Add purified water to make the total volume 100 ml. [0037] [Formulation Example 6] Hair liquid     10 g of polyoxypropylene butyl ether     2 ml of propylene glycol extract of green tea obtained in Example 7   50 g of ethanol     Add purified water to make the total volume 100 ml. [0038] [Formulation Example 7] Hair treatment     4 g of polyoxyethylene oleyl ether     Stearyl trimethyl ammonium chloride 3g     Behenyl alcohol 6g     1.5 g anhydrous lanolin     1.5 g of 2-octyldodecanol     8g isopropyl myristate3 ml of 1,3-butylene glycol extract of green tea obtained in Example 10     Add purified water to make the total volume 100 ml. [0039] [Formulation Example 8] Ointment   25g white petrolatum   Stearyl alcohol 22g   Propylene glycol 12g3 ml of propylene glycol extract of oolong tea obtained in Example 8   Purified water is added to bring the total amount to 100 g.

Claims (1)

(57) [Claims] [Claim 1] Tea leaves that have not been subjected to anaerobic treatment contain no water.
Dandruff and because agent containing as an active ingredient an extract obtained by thermal extraction with alcohols are.