JPH067828B2 - 生体組織の局部色素濃度を求める装置 - Google Patents
生体組織の局部色素濃度を求める装置Info
- Publication number
- JPH067828B2 JPH067828B2 JP1191593A JP19159389A JPH067828B2 JP H067828 B2 JPH067828 B2 JP H067828B2 JP 1191593 A JP1191593 A JP 1191593A JP 19159389 A JP19159389 A JP 19159389A JP H067828 B2 JPH067828 B2 JP H067828B2
- Authority
- JP
- Japan
- Prior art keywords
- curve
- remission
- wavelength
- wavelength region
- hemoglobin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000001554 Hemoglobins Human genes 0.000 claims description 87
- 108010054147 Hemoglobins Proteins 0.000 claims description 87
- 238000005259 measurement Methods 0.000 claims description 50
- 238000006213 oxygenation reaction Methods 0.000 claims description 47
- 238000011156 evaluation Methods 0.000 claims description 17
- 238000001514 detection method Methods 0.000 claims description 16
- 238000001228 spectrum Methods 0.000 claims description 15
- 230000000694 effects Effects 0.000 claims description 8
- 238000010521 absorption reaction Methods 0.000 claims description 7
- 230000008520 organization Effects 0.000 claims description 4
- 230000035515 penetration Effects 0.000 claims description 4
- 238000004364 calculation method Methods 0.000 claims description 3
- 238000010606 normalization Methods 0.000 claims 2
- 238000000034 method Methods 0.000 abstract description 26
- 238000010586 diagram Methods 0.000 description 17
- 239000013307 optical fiber Substances 0.000 description 16
- 230000008859 change Effects 0.000 description 11
- 238000005286 illumination Methods 0.000 description 10
- 239000011159 matrix material Substances 0.000 description 10
- 239000002245 particle Substances 0.000 description 10
- 230000001419 dependent effect Effects 0.000 description 8
- 230000003647 oxidation Effects 0.000 description 6
- 238000007254 oxidation reaction Methods 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 230000010412 perfusion Effects 0.000 description 4
- 229910052724 xenon Inorganic materials 0.000 description 4
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 4
- 239000004020 conductor Substances 0.000 description 3
- 230000002438 mitochondrial effect Effects 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 238000012935 Averaging Methods 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
- 102000018832 Cytochromes Human genes 0.000 description 2
- 108010052832 Cytochromes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 239000011651 chromium Substances 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 206010048962 Brain oedema Diseases 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
- 239000005083 Zinc sulfide Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 208000006752 brain edema Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000001700 effect on tissue Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005258 radioactive decay Effects 0.000 description 1
- 238000005316 response function Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229910052984 zinc sulfide Inorganic materials 0.000 description 1
- DRDVZXDWVBGGMH-UHFFFAOYSA-N zinc;sulfide Chemical compound [S-2].[Zn+2] DRDVZXDWVBGGMH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3825352A DE3825352A1 (de) | 1988-07-26 | 1988-07-26 | Verfahren und vorrichtung zur bestimmung von lokalen farbstoff-konzentrationen und von streuparametern in tierischen und menschlichen geweben |
| DE3825352.6 | 1988-07-26 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5108184A Division JP2886031B2 (ja) | 1988-07-26 | 1993-05-10 | 生体組織における光の後方散乱を検出する装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02257930A JPH02257930A (ja) | 1990-10-18 |
| JPH067828B2 true JPH067828B2 (ja) | 1994-02-02 |
Family
ID=6359575
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1191593A Expired - Lifetime JPH067828B2 (ja) | 1988-07-26 | 1989-07-26 | 生体組織の局部色素濃度を求める装置 |
| JP5108184A Expired - Lifetime JP2886031B2 (ja) | 1988-07-26 | 1993-05-10 | 生体組織における光の後方散乱を検出する装置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5108184A Expired - Lifetime JP2886031B2 (ja) | 1988-07-26 | 1993-05-10 | 生体組織における光の後方散乱を検出する装置 |
Country Status (5)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0613652T3 (da) * | 1990-02-15 | 1997-08-25 | Hewlett Packard Gmbh | Apparat og fremgangsmåde til ikke invasiv måling af oxygenmåling |
| DE9110757U1 (de) * | 1991-08-30 | 1992-02-13 | Klein, Rainer, 5840 Schwerte | Integriert-optischer Stoffsensor |
| JP2586278B2 (ja) * | 1992-03-30 | 1997-02-26 | 株式会社島津製作所 | 光測定装置の吸光度原点標準器 |
| IL107396A (en) * | 1992-11-09 | 1997-02-18 | Boehringer Mannheim Gmbh | Method and apparatus for analytical determination of glucose in a biological matrix |
| DE4337570A1 (de) * | 1993-11-04 | 1995-05-11 | Boehringer Mannheim Gmbh | Verfahren zur Analyse von Glucose in einer biologischen Matrix |
| US20050245850A1 (en) * | 1994-03-30 | 2005-11-03 | Freyre Carlos V | Method and apparatus for inhibiting the growth of and shrinking cancerous tumors |
| DE19512478C2 (de) * | 1994-08-10 | 2001-05-31 | Bernreuter Peter | Verfahren zur Bestimmung der arteriellen Sauerstoffsättigung |
| CA2210791A1 (en) * | 1997-07-18 | 1999-01-18 | The University Of Manitoba | Diagnosis of edema |
| US6850656B1 (en) | 1998-10-07 | 2005-02-01 | Ecole Polytechnique Federale De Lausanne | Method and apparatus for measuring locally and superficially the scattering and absorption properties of turbid media |
| US6615068B1 (en) * | 2000-01-20 | 2003-09-02 | The Research Foundation Of Cuny | Technique for examining biological materials using diffuse reflectance spectroscopy and the kubelka-munk function |
| FR2806609B1 (fr) * | 2000-03-24 | 2002-10-11 | Medick S A | Procede et dispositif de mesure non invasive d'un tissu et notamment du taux de bilirubine de la peau |
| EP1860993B1 (en) * | 2005-03-01 | 2019-01-23 | Masimo Laboratories, Inc. | Noninvasive multi-parameter patient monitor |
| US20090312646A1 (en) * | 2007-09-13 | 2009-12-17 | The Regents Of The University Of California | Optical detection of seizure, a pre-seizure state, and cerebral edema and optical fiber detection of the same |
| DE102009043523A1 (de) * | 2009-09-30 | 2011-04-07 | Siemens Aktiengesellschaft | Endoskop |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US455179A (en) * | 1891-06-30 | Horse-detacher | ||
| US455579A (en) | 1891-07-07 | Hand-car | ||
| US3653767A (en) * | 1967-04-10 | 1972-04-04 | American Standard Inc | Particle size distribution measurement using polarized light of a plurality of wavelengths |
| US3830568A (en) * | 1973-05-25 | 1974-08-20 | Texas Instruments Inc | Multiple detection volume laser doppler velocimeter |
| US3916197A (en) * | 1973-11-28 | 1975-10-28 | Particle Technology Inc | Method and apparatus for classifying biological cells |
| US4114604A (en) * | 1976-10-18 | 1978-09-19 | Shaw Robert F | Catheter oximeter apparatus and method |
| US4281645A (en) * | 1977-06-28 | 1981-08-04 | Duke University, Inc. | Method and apparatus for monitoring metabolism in body organs |
| US4463762A (en) * | 1977-10-18 | 1984-08-07 | Institute Of Applied Biology Special Cancer Research Project | Apparatus for obtaining an objective determination of the rate of oxygen utilization in peripheral tissue |
| JPS54123084A (en) * | 1978-03-16 | 1979-09-25 | Aroozu Kk | Optical mechanism |
| US4178917A (en) * | 1979-01-03 | 1979-12-18 | Shapiro Howard M | Method and system for non-invasive detection of zinc protoporphyrin in erythrocytes |
| FR2448145A2 (fr) * | 1979-02-05 | 1980-08-29 | Oreal | Appareil destine a reperer la quantite de sebum secretee par une peau |
| JPS55118738A (en) * | 1979-03-07 | 1980-09-11 | Sumitomo Electric Industries | Measuring device for breathing function of internal organ and tissue of living body |
| DE3019234C2 (de) * | 1980-05-20 | 1984-08-30 | Duke University Inc., Durham, N.C. | Einrichtung zur in vivo Blutmessung |
| DE3175632D1 (en) * | 1980-08-21 | 1987-01-08 | Oriel Scient Ltd | Analytical optical instruments |
| DE3032150A1 (de) * | 1980-08-26 | 1982-04-01 | Hellige Gmbh, 7800 Freiburg | Verfahren und messeinrichtung zur kolorimetrischen bestimmung der konzentration eines chemischen stoffs, insbesondere des partialdrucks eines im blut geloesten gases |
| JPS57175345A (en) * | 1981-04-22 | 1982-10-28 | Sumitomo Electric Industries | Sensor for live body organ spectrum analyser |
| JPS57199943A (en) * | 1981-06-03 | 1982-12-08 | Hitachi Ltd | Measuring device for wetness of steam |
| DE3134124A1 (de) * | 1981-08-28 | 1983-03-10 | Erwin Braun Institut, 6390 Engelberg | Verfahren und geraet zur ueberwachung der sauerstoffsaettigung des blutes in vivo |
| DE3581325D1 (de) * | 1984-06-30 | 1991-02-21 | Toshiba Kawasaki Kk | Apparat zur messung der abmessungen von teilchen. |
| US4718417A (en) * | 1985-03-22 | 1988-01-12 | Massachusetts Institute Of Technology | Visible fluorescence spectral diagnostic for laser angiosurgery |
| DE3512602A1 (de) * | 1985-04-06 | 1986-10-09 | Richard Wolf Gmbh, 7134 Knittlingen | Endoskop zur bestimmung von objektgroessen in hohlraeumen |
| JPS62109547A (ja) * | 1985-08-30 | 1987-05-20 | クリテイケア システムズ インコ−ポレ−テツド | オキシメトリ−方法および装置 |
| DE3700577A1 (de) * | 1987-01-10 | 1988-07-21 | Helge Eichholz | Verfahren und untersuchungsvorrichtung zur untersuchung von menschlichem oder tierischem gewebe oder menschlicher oder tierischer koerperfluessigkeit auf einen bestimmten stoffgehalt |
-
1988
- 1988-07-26 DE DE3825352A patent/DE3825352A1/de active Granted
-
1989
- 1989-07-26 AT AT89113803T patent/ATE210406T1/de not_active IP Right Cessation
- 1989-07-26 DE DE58909882T patent/DE58909882D1/de not_active Expired - Fee Related
- 1989-07-26 EP EP89113803A patent/EP0353619B1/de not_active Expired - Lifetime
- 1989-07-26 JP JP1191593A patent/JPH067828B2/ja not_active Expired - Lifetime
-
1993
- 1993-05-10 JP JP5108184A patent/JP2886031B2/ja not_active Expired - Lifetime
-
1994
- 1994-09-01 US US08/299,816 patent/US5645061A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0353619B1 (de) | 2001-12-12 |
| EP0353619A1 (de) | 1990-02-07 |
| JPH0698892A (ja) | 1994-04-12 |
| DE58909882D1 (de) | 2002-01-24 |
| DE3825352A1 (de) | 1990-02-01 |
| JPH02257930A (ja) | 1990-10-18 |
| ATE210406T1 (de) | 2001-12-15 |
| DE3825352C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-09-27 |
| JP2886031B2 (ja) | 1999-04-26 |
| US5645061A (en) | 1997-07-08 |
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