JPH06506973A - 平滑筋細胞増殖のインヒビターとしての硫酸化多糖類 - Google Patents

平滑筋細胞増殖のインヒビターとしての硫酸化多糖類

Info

Publication number
JPH06506973A
JPH06506973A JP4510890A JP51089092A JPH06506973A JP H06506973 A JPH06506973 A JP H06506973A JP 4510890 A JP4510890 A JP 4510890A JP 51089092 A JP51089092 A JP 51089092A JP H06506973 A JPH06506973 A JP H06506973A
Authority
JP
Japan
Prior art keywords
so3r
mixture
smooth muscle
compound
heparin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4510890A
Other languages
English (en)
Japanese (ja)
Inventor
コンラッド，エイチ．　エドワード
フュージェディ，ピーター
ブランドレイ，ブライアン　ケイ．
ラム，ルン　エイチ．
レイン，ロジャー　エイ．
Original Assignee
グライコメッド　インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by グライコメッド　インコーポレイテッド filed Critical グライコメッド　インコーポレイテッド
Publication of JPH06506973A publication Critical patent/JPH06506973A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP4510890A 1991-04-17 1992-04-15 平滑筋細胞増殖のインヒビターとしての硫酸化多糖類 Pending JPH06506973A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68654091A 1991-04-17 1991-04-17
US686,540 1991-04-17
PCT/US1992/003092 WO1992018546A1 (en) 1991-04-17 1992-04-15 Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation

Publications (1)

Publication Number Publication Date
JPH06506973A true JPH06506973A (ja) 1994-08-04

Family

ID=24756732

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4510890A Pending JPH06506973A (ja) 1991-04-17 1992-04-15 平滑筋細胞増殖のインヒビターとしての硫酸化多糖類

Country Status (6)

Country Link
EP (1) EP0582665A1 (no)
JP (1) JPH06506973A (no)
AU (1) AU1902592A (no)
CA (1) CA2108569A1 (no)
NO (1) NO933699L (no)
WO (1) WO1992018546A1 (no)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11504018A (ja) * 1995-04-28 1999-04-06 ジ・オーストラリアン・ナショナル・ユニバーシティ 硫酸化オリゴ糖の製造および使用
WO2005092348A1 (ja) * 2004-03-29 2005-10-06 Kringle Pharma Inc. ヘパリン様オリゴ糖含有ｈｇｆ産生促進薬剤
JP2013501838A (ja) * 2009-08-14 2013-01-17 サノフイ Ｆｇｆ受容体活性化ｎ−硫酸塩オリゴ糖、該オリゴ糖の調製および該オリゴ糖の治療用途

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
DE69435137D1 (de) * 1993-05-13 2008-10-16 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
US5888984A (en) * 1994-05-12 1999-03-30 Dermal Research Laboratories, Inc. Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
AUPO556297A0 (en) 1997-03-11 1997-04-10 Australian National University, The Sulfated oligosaccharides having anticoagulant/ antithrombotic activity
AUPO888497A0 (en) * 1997-09-01 1997-09-25 Australian National University, The Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
AUPO976897A0 (en) * 1997-10-14 1997-11-06 Australian National University, The Use of sulfated oligosaccharides in lowering blood triglyceride levels
DE60034667T2 (de) 1999-02-01 2008-03-13 Dermal Research Laboratories, Inc. Pharmazeutische zusammensetzung aus komplexen kohlenhydraten und deren anwendung
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
FR2949114B1 (fr) * 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11504018A (ja) * 1995-04-28 1999-04-06 ジ・オーストラリアン・ナショナル・ユニバーシティ 硫酸化オリゴ糖の製造および使用
WO2005092348A1 (ja) * 2004-03-29 2005-10-06 Kringle Pharma Inc. ヘパリン様オリゴ糖含有ｈｇｆ産生促進薬剤
JP2013501838A (ja) * 2009-08-14 2013-01-17 サノフイ Ｆｇｆ受容体活性化ｎ−硫酸塩オリゴ糖、該オリゴ糖の調製および該オリゴ糖の治療用途

Also Published As

Publication number Publication date
NO933699D0 (no) 1993-10-14
AU1902592A (en) 1992-11-17
CA2108569A1 (en) 1992-10-18
EP0582665A1 (en) 1994-02-16
WO1992018546A1 (en) 1992-10-29
NO933699L (no) 1993-12-07

Similar Documents

Publication Publication Date Title
US5380716A (en) Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation
AU634199B2 (en) Heparin fragments as inhibitors of smooth muscle cell proliferation
US5280016A (en) Non-anticoagulant heparin derivatives
US5250519A (en) Non-anticoagulant heparin derivatives
US5767269A (en) Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
DE69733493T2 (de) Dermatandisulfat,ein hemmer von thrombinerzeugung und komplementaktivierung
EP1300412B1 (en) Hyaluronic acid oligosaccharide fractions and drugs containing the same
JPH09512822A (ja) Ｏ−脱硫酸化ヘパリン誘導体とその製造法および使用
JPS6227402A (ja) グリコサミノグリカンの硫酸化方法、該方法によつて得られる新規グリコサミノグリカン及びその生物学的適用
JPH06506973A (ja) 平滑筋細胞増殖のインヒビターとしての硫酸化多糖類
Garg et al. Effect of fully sulfated glycosaminoglycans on pulmonary artery smooth muscle cell proliferation
JP2014514424A (ja) 同じ多糖鎖の４位または６位でバイオテクノロジー的に硫酸化されたコンドロイチン硫酸、およびその調整方法
JP4051099B2 (ja) 低分子化ヘパリン、その製造法及び医薬組成物
Cifonelli Acid hydrolysis of acidic mucopolysaccharides
WO1990008784A1 (en) New sulfated polysaccharide, pharmaceutically acceptable salts thereof, preparation thereof, and drug containing the same as active ingredient
US7618652B2 (en) Glycosaminoglycan anticoagulants derived from fish
WO1994008595A1 (en) Use of non-anticoagulant heparin for treating ischemia/reperfusion injury
JP4462826B2 (ja) 骨疾患治療剤
WO1992017506A1 (en) MODULATION OF tPA ACTIVITY BY HEPARIN FRAGMENTS
JP4331917B2 (ja) 部分的脱硫酸化ｎ−アセチルラクトサミンオリゴ糖の製造方法
JP5051999B2 (ja) 炎症性骨・軟骨疾患の処置剤
JPH11166001A (ja) 過硫酸化コンドロイチン硫酸、その製造方法及びそれを有効成分として含有する抗血液凝固剤