JPH06503829A - 補体を抑制し、かつ／または免疫活性を抑制する化合物 - Google Patents

補体を抑制し、かつ／または免疫活性を抑制する化合物

Info

Publication number
JPH06503829A
JPH06503829A JP4502730A JP50273092A JPH06503829A JP H06503829 A JPH06503829 A JP H06503829A JP 4502730 A JP4502730 A JP 4502730A JP 50273092 A JP50273092 A JP 50273092A JP H06503829 A JPH06503829 A JP H06503829A
Authority
JP
Japan
Prior art keywords
group
benzofuran
cyclohexane
substituted
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4502730A
Other languages
English (en)
Japanese (ja)
Inventor
シンデラー，ロバート　ディー．
ブラッドバリー，バートン　ジェー．
カウフマン，テオドロ　エス．
アイピー，ステファン　エイチ．
マーシュ，ジュニア，ヘンリー　シー．
リー，チュー
Original Assignee
ティーセル　サイエンシズ，インコーポレーテッド
ザ　ユニバーシティー　オブ　ミシシッピー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ティーセル　サイエンシズ，インコーポレーテッド, ザ　ユニバーシティー　オブ　ミシシッピー filed Critical ティーセル　サイエンシズ，インコーポレーテッド
Publication of JPH06503829A publication Critical patent/JPH06503829A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP4502730A 1990-12-06 1991-12-06 補体を抑制し、かつ／または免疫活性を抑制する化合物 Pending JPH06503829A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US623,849 1990-12-06
US07/623,849 US5366986A (en) 1988-04-15 1990-12-06 Compounds which inhibit complement and/or suppress immune activity
PCT/US1991/009303 WO1992010096A1 (en) 1990-12-06 1991-12-06 Compounds that inhibit complement and/or suppress immune activity

Publications (1)

Publication Number Publication Date
JPH06503829A true JPH06503829A (ja) 1994-04-28

Family

ID=24499627

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4502730A Pending JPH06503829A (ja) 1990-12-06 1991-12-06 補体を抑制し、かつ／または免疫活性を抑制する化合物

Country Status (7)

Country Link
US (2) US5366986A (enExample)
EP (1) EP0561989A1 (enExample)
JP (1) JPH06503829A (enExample)
KR (1) KR100187327B1 (enExample)
AU (1) AU663066B2 (enExample)
CA (1) CA2097826A1 (enExample)
WO (1) WO1992010096A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996036624A1 (en) * 1995-05-19 1996-11-21 Kyowa Hakko Kogyo Co., Ltd. Oxygen-containing heterocyclic compounds
WO1999062541A1 (en) * 1998-06-01 1999-12-09 Hisamitsu Pharmaceutical Co., Inc. Immunosuppressants containing clusterins

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366986A (en) * 1988-04-15 1994-11-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
US5506247A (en) * 1988-04-15 1996-04-09 T Cell Sciences, Inc. Compounds that inhibit complement and/or suppress immune activity
EP0751787B1 (en) * 1994-03-23 2005-01-12 Alexion Pharmaceuticals, Inc. Method for reducing immune and hemostatic dysfunctions during extracorporeal circulation
US6514996B2 (en) 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
US6673154B1 (en) * 2001-06-28 2004-01-06 Advanced Cardiovascular Systems, Inc. Stent mounting device to coat a stent
SE0202133D0 (sv) 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
DE10258650A1 (de) * 2002-12-13 2004-06-24 Aventis Pharma Deutschland Gmbh Neue Spirobenzofuranlactame und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben
US7160917B2 (en) * 2002-12-13 2007-01-09 Sanofi-Aventis Deutschland Gmbh Spirobenzofuran lactams and their derivatives, processes for their preparation and use thereof
SE0302755D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel compounds
SE0303090D0 (sv) 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
SE0303541D0 (sv) 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
JP2006175744A (ja) * 2004-12-22 2006-07-06 Canon Inc 記録装置、及び記録方法
CN113185383B (zh) * 2021-04-28 2022-07-12 福州大学 一种以柠檬烯环氧化物为加氢受体的香芹酚制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3128286A (en) * 1964-04-07 Process for preparing analogues
CH394240A (de) * 1960-02-12 1965-06-30 Hoffmann La Roche Verfahren zur Herstellung von spirozyklischen Ketoalkoholen
US4035509A (en) * 1974-04-22 1977-07-12 Syntex (U.S.A.) Inc. Methods and compositions for the use of 2-carboxy-5-oxo-5H-dibenzo[a,d]cycloheptenes, salts and esters thereof
FR2405941A1 (fr) * 1977-06-30 1979-05-11 Otsuka Pharma Co Ltd Nouveaux derives sesquiterpeniques utiles notamment comme inhibiteurs du systeme complementaire et leurs procedes de preparation
JPS5492680A (en) * 1977-12-29 1979-07-23 Otsuka Pharmaceut Co Ltd Novel microorganism
JPS589114B2 (ja) * 1977-06-30 1983-02-18 大塚製薬株式会社 セスキテルペン類縁体、その製造法及び腎炎治療剤
JPS5936913B2 (ja) * 1978-02-10 1984-09-06 大塚製薬株式会社 セスキテルペン誘導体
JPS6030289B2 (ja) * 1977-08-30 1985-07-16 大塚製薬株式会社 制ガン剤
US4268516A (en) * 1978-10-11 1981-05-19 Pfizer Inc. [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents
JPS5630917A (en) * 1979-08-22 1981-03-28 Otsuka Pharmaceut Co Ltd Preventive and remedy for hepatitis
US4263317A (en) * 1979-09-06 1981-04-21 Hoechst-Roussel Pharmaceuticals, Inc. Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s
US4301292A (en) * 1979-09-06 1981-11-17 Hoechst-Roussel Pharmaceuticals, Incorporated 1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol
JPS5822194B2 (ja) * 1981-09-14 1983-05-07 大塚製薬株式会社 新規な微生物
JPS5822193B2 (ja) * 1981-09-14 1983-05-07 大塚製薬株式会社 新規な微生物
US4404221A (en) * 1981-10-19 1983-09-13 Hoechst-Roussel Pharmaceuticals Inc. 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use
US4517311A (en) * 1981-10-19 1985-05-14 Hoechst-Roussel Pharmaceuticals Inc. 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions
US4426380A (en) * 1981-10-28 1984-01-17 Ciba-Geigy Corporation Benzofuran-2-ones and pharmaceutical compositions
EP0106800A1 (de) * 1982-10-08 1984-04-25 Ciba-Geigy Ag Furane
US4863958A (en) * 1984-06-20 1989-09-05 Merck Frosst Canada, Inc. Benzofuran derivatives useful as inhibitors of mammalian leukotriene biosynthesis
JPS6133183A (ja) * 1984-07-25 1986-02-17 Mitsubishi Chem Ind Ltd ２，３−ジヒドロ−７−アミノベンゾフランの製造法
LU85544A1 (fr) * 1984-09-19 1986-04-03 Cird Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
US4623657A (en) * 1985-09-05 1986-11-18 Hoechst-Roussel Pharmaceuticals Inc. Spiro [benzofuran-2(3H),1'-cycloheptane]s and their therapeutic use
DE3777366D1 (de) * 1986-12-27 1992-04-16 Takeda Chemical Industries Ltd 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung.
US5366986A (en) * 1988-04-15 1994-11-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
US5506247A (en) * 1988-04-15 1996-04-09 T Cell Sciences, Inc. Compounds that inhibit complement and/or suppress immune activity
US5173499A (en) * 1988-04-15 1992-12-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
CA2097825A1 (en) * 1990-12-06 1992-06-07 Henry C. Marsh, Jr. Synergistic compositions of soluble complement receptors and compounds that inhibit complement and/or suppress immune activity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996036624A1 (en) * 1995-05-19 1996-11-21 Kyowa Hakko Kogyo Co., Ltd. Oxygen-containing heterocyclic compounds
WO1999062541A1 (en) * 1998-06-01 1999-12-09 Hisamitsu Pharmaceutical Co., Inc. Immunosuppressants containing clusterins

Also Published As

Publication number Publication date
KR930702893A (ko) 1993-11-29
KR100187327B1 (ko) 1999-05-01
WO1992010096A1 (en) 1992-06-25
US5656659A (en) 1997-08-12
US5366986A (en) 1994-11-22
EP0561989A1 (en) 1993-09-29
EP0561989A4 (enExample) 1994-03-09
AU9127491A (en) 1992-07-08
AU663066B2 (en) 1995-09-28
CA2097826A1 (en) 1992-06-07

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