JPH06502729A - 放射性標識化合物の配合物 - Google Patents
放射性標識化合物の配合物Info
- Publication number
- JPH06502729A JPH06502729A JP5515158A JP51515893A JPH06502729A JP H06502729 A JPH06502729 A JP H06502729A JP 5515158 A JP5515158 A JP 5515158A JP 51515893 A JP51515893 A JP 51515893A JP H06502729 A JPH06502729 A JP H06502729A
- Authority
- JP
- Japan
- Prior art keywords
- rcp
- composition according
- composition
- control
- labeled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
- C07B63/04—Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Seasonings (AREA)
- Indole Compounds (AREA)
Abstract
Description
Claims (12)
- 1.β線放出型の放射性核種で標識した有機化合物であって放射性標識した該有 機化合物が貯蔵および輸送に際して放射線分解を生じるもの、ならびにトリプト ファン、パラ−アミノベンゾエート、インドールアセテート、ルミノール、およ び互いに直結した少なくとも2個の環窒素原子を含む5員環を有する化合物であ る一群のアゾールから選ばれる安定剤を含む組成物。
- 2.β線放出型の放射性核種で標識した有機化合物および色素の溶液を含む組成 物。
- 3.β線放出型の放射性核種で標識した放射性標識有機化合物、色素、ならびに L−トリプトファン、パラ−アミノベンゾエート、インドールアセテート、ルミ ノール、および互いに直結した少なくとも2個の環窒素原子を含む5員環を有す る化合物である一群のアゾールから選ばれる安定剤を含む組成物。
- 4.放射性標識有機化合物が溶液中に存在する、請求の範囲第1項または第3項 に記載の組成物。
- 5.放射性標識有機化合物がヌクレオチドである、請求の範囲第1項ないし第4 項のいずれかに記載の組成物。
- 6.放射性標識有機化合物がアミノ酸である、請求の範囲第1項ないし第4項の いずれかに記載の組成物。
- 7.放射性標識が32−P、35−S、33−P、3−Hおよび14−Cから選 ばれる、請求の範囲第1項ないし第6項のいずれかに記載の組成物。
- 8.安定剤が10−100mMの濃度で存在する、請求の範囲第1項および第3 項ないし第7項のいずれかに記載の組成物。
- 9.色素が50−400μg/mlの濃度で存在する、請求の範囲第2項ないし 第7項のいずれかに記載の組成物。
- 10.4℃または周囲温度での輸送および貯蔵に適した、請求の範囲第1項ない し第9項のいずれかに記載の組成物。
- 11.色素がスルホローダミンB、キシレンサイアノール、アゾカルミンBおよ びニューコクシンから選ばれる、請求の範囲第2項ないし第10項のいずれかに 記載の組成物。
- 12.アゾールが下記の構造式を有するものである、請求の範囲第1項ないし第 11項のいずれかに記載の組成物: ▲数式、化学式、表等があります▼ (この構造式は2個の環二重結合を含み、式中の−X、YおよびZのうち1個も しくは2個はNを表すか、またはX、YおよびZのうち1個はSを表し、残りの X、YおよびZはCを表し、−R1、R2、R3、R4およびR5が存在する場 合、それらはそれぞれ環に直結した、もしくは最高10個の炭素原子の連鎖を介 して結合した−OH、−SH、−H、−COOH、−NH2、−CH3を表すか 、またはR1、R2、R3、R4およびR5のうち2個の隣接因子が一緒に芳香 環を構成してもよい)。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92303905 | 1992-04-30 | ||
EP92303905.1 | 1992-04-30 | ||
PCT/GB1993/000869 WO1993022260A1 (en) | 1992-04-30 | 1993-04-27 | Radiolabelled compound formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH06502729A true JPH06502729A (ja) | 1994-03-24 |
JP3117719B2 JP3117719B2 (ja) | 2000-12-18 |
Family
ID=8211352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP05515158A Expired - Lifetime JP3117719B2 (ja) | 1992-04-30 | 1993-04-27 | 放射性標識化合物の配合物 |
Country Status (10)
Country | Link |
---|---|
US (1) | US5494654A (ja) |
EP (1) | EP0594837B2 (ja) |
JP (1) | JP3117719B2 (ja) |
AT (1) | ATE132842T1 (ja) |
AU (1) | AU655548B2 (ja) |
CA (1) | CA2105402C (ja) |
DE (1) | DE69301300T3 (ja) |
DK (1) | DK0594837T4 (ja) |
ES (1) | ES2081717T5 (ja) |
WO (1) | WO1993022260A1 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5686058A (en) * | 1992-04-30 | 1997-11-11 | Amersham International Plc | Radiolabelled nucleotide formulations stored in an unfrozen state |
FR2727687B1 (fr) * | 1994-12-02 | 1997-01-24 | Isotopchim Sarl | Stabilisation de composes radiomarques |
DE69617685T2 (de) * | 1995-06-28 | 2002-06-13 | Nen Life Science Products, Inc.(N.D.Ges.Des Staates Delaware) | Zusammensetzung und verfahren zur stabilisierung von radiomarkierten organischen verbindungen |
US5961955A (en) * | 1997-06-03 | 1999-10-05 | Coulter Pharmaceutical, Inc. | Radioprotectant for peptides labeled with radioisotope |
HU225723B1 (en) * | 2001-03-21 | 2007-07-30 | Izotop Intezet Kft | Method for covering of plastic material |
HUP0101921A2 (hu) * | 2001-05-10 | 2004-01-28 | Izotóp Intézet Kft | Radioaktívan jelzett nukleotido/ka/t tartalmazó preparátumok és eljárás azok előállítására |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59125062A (ja) * | 1982-12-29 | 1984-07-19 | Toshiba Corp | カラム式免疫分析法 |
JPS6132291A (ja) * | 1984-07-24 | 1986-02-14 | Sony Corp | メモリ装置 |
JPS6132291B2 (ja) * | 1981-10-30 | 1986-07-25 | Amerushamu Intern Plc | |
JPS63118661A (ja) * | 1986-11-07 | 1988-05-23 | Hitachi Ltd | 核酸塩基配列決定装置 |
JPH0235100U (ja) * | 1988-08-30 | 1990-03-06 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3261747A (en) * | 1964-05-08 | 1966-07-19 | Spencer L Commerford | Stabilized iodine labeled 2'-deoxy-5-iodouridine |
US3673410A (en) * | 1969-06-25 | 1972-06-27 | John H Waite | Method of examination of cell samples using a radioactively tagged dye |
US4095950A (en) * | 1976-06-11 | 1978-06-20 | Bio-Dynamics, Inc. | Method for the chromatographic analysis of a technetium-containing mixture |
US4390517A (en) * | 1979-12-19 | 1983-06-28 | New England Nuclear Corporation | Method, composition and kit for stabilizing radiolabeled compounds |
US4411881A (en) * | 1982-07-12 | 1983-10-25 | New England Nuclear Corporation | Composition and method for stabilizing radiolabeled compounds using thiocarbonylated diethylenetriamines |
GB8510726D0 (en) * | 1985-04-26 | 1985-06-26 | Amersham Int Plc | Stabilised radio-labelled compounds |
US5101020A (en) * | 1986-02-12 | 1992-03-31 | Linus Pauling Institute Of Science And Medicine | Novel radio labeled dyes for detecting proteins in gels |
US4966854A (en) * | 1986-02-12 | 1990-10-30 | Linus Pauling Institute Of Science And Medicine | Radio labelled dye composition for detecting proteins in gels |
US4880615A (en) * | 1988-11-25 | 1989-11-14 | Merck & Co., Inc. | Stabilized radiopharmaceutical compositions |
US5262175A (en) * | 1989-05-10 | 1993-11-16 | Solanki Kishor K | Stabilization of radiopharmaceutical compositions |
US5093105A (en) * | 1991-04-09 | 1992-03-03 | Merck Frosst Canada, Inc. | Radiopharmaceutical bacteriostats |
-
1993
- 1993-04-27 DK DK93911868T patent/DK0594837T4/da active
- 1993-04-27 AU AU42665/93A patent/AU655548B2/en not_active Expired
- 1993-04-27 AT AT93911868T patent/ATE132842T1/de active
- 1993-04-27 ES ES93911868T patent/ES2081717T5/es not_active Expired - Lifetime
- 1993-04-27 CA CA002105402A patent/CA2105402C/en not_active Expired - Lifetime
- 1993-04-27 US US08/107,733 patent/US5494654A/en not_active Expired - Lifetime
- 1993-04-27 JP JP05515158A patent/JP3117719B2/ja not_active Expired - Lifetime
- 1993-04-27 EP EP93911868A patent/EP0594837B2/en not_active Expired - Lifetime
- 1993-04-27 WO PCT/GB1993/000869 patent/WO1993022260A1/en active IP Right Grant
- 1993-04-27 DE DE69301300T patent/DE69301300T3/de not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6132291B2 (ja) * | 1981-10-30 | 1986-07-25 | Amerushamu Intern Plc | |
JPS59125062A (ja) * | 1982-12-29 | 1984-07-19 | Toshiba Corp | カラム式免疫分析法 |
JPS6132291A (ja) * | 1984-07-24 | 1986-02-14 | Sony Corp | メモリ装置 |
JPS63118661A (ja) * | 1986-11-07 | 1988-05-23 | Hitachi Ltd | 核酸塩基配列決定装置 |
JPH0235100U (ja) * | 1988-08-30 | 1990-03-06 |
Also Published As
Publication number | Publication date |
---|---|
AU4266593A (en) | 1993-11-29 |
US5494654A (en) | 1996-02-27 |
AU655548B2 (en) | 1994-12-22 |
EP0594837A1 (en) | 1994-05-04 |
ATE132842T1 (de) | 1996-01-15 |
WO1993022260A1 (en) | 1993-11-11 |
DE69301300T2 (de) | 1996-05-23 |
DK0594837T3 (da) | 1996-04-09 |
DK0594837T4 (da) | 2000-03-27 |
ES2081717T5 (es) | 2000-02-16 |
DE69301300T3 (de) | 2000-07-27 |
CA2105402A1 (en) | 1993-10-31 |
ES2081717T3 (es) | 1996-03-16 |
EP0594837B1 (en) | 1996-01-10 |
JP3117719B2 (ja) | 2000-12-18 |
CA2105402C (en) | 2000-04-04 |
EP0594837B2 (en) | 1999-12-08 |
DE69301300D1 (de) | 1996-02-22 |
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