JPH0597793A - アミジノフエニルアラニン誘導体 - Google Patents

アミジノフエニルアラニン誘導体

Info

Publication number
JPH0597793A
JPH0597793A JP4085807A JP8580792A JPH0597793A JP H0597793 A JPH0597793 A JP H0597793A JP 4085807 A JP4085807 A JP 4085807A JP 8580792 A JP8580792 A JP 8580792A JP H0597793 A JPH0597793 A JP H0597793A
Authority
JP
Japan
Prior art keywords
piperidine
group
naphthyl
compound
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4085807A
Other languages
English (en)
Japanese (ja)
Inventor
Werner Stueber
ヴエルナー・シユテユーバー
Gerhard Dickneite
ゲールハルト・デイクナイテ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of JPH0597793A publication Critical patent/JPH0597793A/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
JP4085807A 1991-04-09 1992-04-08 アミジノフエニルアラニン誘導体 Pending JPH0597793A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE41113942 1991-04-09
DE4111394A DE4111394A1 (de) 1991-04-09 1991-04-09 Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel

Publications (1)

Publication Number Publication Date
JPH0597793A true JPH0597793A (ja) 1993-04-20

Family

ID=6429103

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4085807A Pending JPH0597793A (ja) 1991-04-09 1992-04-08 アミジノフエニルアラニン誘導体

Country Status (28)

Country Link
US (1) US5274098A (zh)
EP (1) EP0508220B1 (zh)
JP (1) JPH0597793A (zh)
KR (1) KR920019738A (zh)
CN (1) CN1067431A (zh)
AT (1) ATE125549T1 (zh)
AU (1) AU650526B2 (zh)
BG (1) BG60683B1 (zh)
BR (1) BR9201253A (zh)
CA (1) CA2065585A1 (zh)
CS (1) CS106492A3 (zh)
DE (2) DE4111394A1 (zh)
DK (1) DK0508220T3 (zh)
ES (1) ES2076595T3 (zh)
FI (1) FI921525A (zh)
GR (1) GR3017107T3 (zh)
HU (1) HUT65359A (zh)
IE (1) IE67347B1 (zh)
IL (1) IL101529A (zh)
MA (1) MA22495A1 (zh)
MX (1) MX9201642A (zh)
NO (1) NO921382L (zh)
NZ (1) NZ242246A (zh)
PL (1) PL294148A1 (zh)
RO (1) RO109197B1 (zh)
TW (1) TW214542B (zh)
UY (1) UY23395A1 (zh)
ZA (1) ZA922535B (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008524119A (ja) * 2004-12-06 2008-07-10 シガ テクノロジーズ,インコーポレーテッド アレナウイルスに関連した感染をはじめとする出血熱ウイルスを処置するための、スルホニルセミカルバジド、セミカルバジドおよび尿素、その医薬組成物および方法
US8410149B2 (en) 2004-12-06 2013-04-02 Siga Technologies Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
US8658697B2 (en) 2004-12-06 2014-02-25 Siga Technologies, Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4115468A1 (de) * 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
DE4242655A1 (de) * 1992-12-17 1994-06-23 Behringwerke Ag Verwendung von Thrombin-Inhibitoren zur Inhibition okularer Fibrinbildung
DE4342154A1 (de) * 1993-12-10 1995-06-14 Behringwerke Ag Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien
AU3107795A (en) * 1994-08-09 1996-03-07 Pentapharm Ag Inhibitors of the benzamidine type
US5525617A (en) * 1994-08-24 1996-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
DE19517198C1 (de) * 1995-05-11 1996-10-10 Samson Ag Verfahren zur Führung der Hubstellung eines Stellgliedes
US5766932A (en) * 1995-12-20 1998-06-16 Hoechst Marion Roussel, Inc. Process for preparing N-acetyl(L)-4-cyanophenylalanine from a mixture of the corresponding D,L ethyl esters using subtilisin
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
KR19990074598A (ko) * 1998-03-12 1999-10-05 성재갑 고체상 반응을 이용한 벤즈아미딘 유도체의 신규한 제조방법
WO2002016329A1 (fr) 2000-08-18 2002-02-28 Ajinomoto Co., Inc. Nouveaux derives de phenylalanine
SI21137A (sl) * 2002-01-24 2003-08-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Derivati azafenilalanina
DE10330900B4 (de) * 2003-07-01 2006-09-14 Leibniz-Institut Für Polymerforschung Dresden E.V. Biomaterial mit einem modularen Beschichtungssystem zur Anwendung in Medizinprodukten mit direktem Blutkontakt
EP2803667A1 (en) * 2003-12-22 2014-11-19 Ajinomoto Co., Inc. Phenylalanine derivatives
CN101034257B (zh) * 2007-04-06 2010-09-08 上海复旦天臣新技术有限公司 用于全息记录的感光薄膜及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028380A (en) * 1974-06-01 1977-06-07 Akzona Incorporated Hydrazino-imidazole derivatives
DD155954B1 (de) * 1981-02-03 1988-11-09 Wagner Guenter Verfahren zur herstellung von n tief alpha arly-bzw. n tief alpha heteroarylsulfonylaminoacylierten amidinophenylalaninamiden
DD235866B1 (de) * 1985-03-29 1988-12-28 Univ Leipzig Verfahren zur herstellung von n alpha (2-naphthyl)-sulfonylaminoacylierten amidinophenylalanisamiden
PT84171B (pt) * 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados das n alfa-aril-sulfonilamiminoacil-p- -amidinofenil-alaninamidas, bem como dos seus derivados de sintese e das composicoes farmaceuticas que os contem
PT84170B (pt) * 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008524119A (ja) * 2004-12-06 2008-07-10 シガ テクノロジーズ,インコーポレーテッド アレナウイルスに関連した感染をはじめとする出血熱ウイルスを処置するための、スルホニルセミカルバジド、セミカルバジドおよび尿素、その医薬組成物および方法
US8410149B2 (en) 2004-12-06 2013-04-02 Siga Technologies Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
US8642596B2 (en) 2004-12-06 2014-02-04 Siga Technologies, Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arena viruses
US8658697B2 (en) 2004-12-06 2014-02-25 Siga Technologies, Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
US8664274B2 (en) 2004-12-06 2014-03-04 Siga Technologies, Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arena viruses
US9067873B2 (en) 2004-12-06 2015-06-30 Kineta Four, LLC Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
US9115065B2 (en) 2004-12-06 2015-08-25 Kineta, Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with Arenaviruses

Also Published As

Publication number Publication date
TW214542B (zh) 1993-10-11
PL294148A1 (zh) 1993-02-08
NO921382L (no) 1992-10-12
DK0508220T3 (da) 1995-11-27
EP0508220A1 (de) 1992-10-14
BG60683B1 (bg) 1995-12-29
RO109197B1 (ro) 1994-12-30
UY23395A1 (es) 1992-04-21
FI921525A (fi) 1992-10-10
HUT65359A (en) 1994-05-02
IE921123A1 (en) 1992-10-21
IL101529A (en) 1996-05-14
EP0508220B1 (de) 1995-07-26
ATE125549T1 (de) 1995-08-15
FI921525A0 (fi) 1992-04-07
CA2065585A1 (en) 1992-10-10
CS106492A3 (en) 1992-10-14
NZ242246A (en) 1993-12-23
AU650526B2 (en) 1994-06-23
ZA922535B (en) 1992-11-25
MA22495A1 (fr) 1992-12-31
DE59203006D1 (de) 1995-08-31
BR9201253A (pt) 1992-12-01
NO921382D0 (no) 1992-04-08
IL101529A0 (en) 1992-12-30
DE4111394A1 (de) 1992-10-15
US5274098A (en) 1993-12-28
MX9201642A (es) 1992-10-01
GR3017107T3 (en) 1995-11-30
AU1470392A (en) 1992-10-15
ES2076595T3 (es) 1995-11-01
IE67347B1 (en) 1996-03-20
KR920019738A (ko) 1992-11-19
HU9201189D0 (en) 1992-07-28
CN1067431A (zh) 1992-12-30

Similar Documents

Publication Publication Date Title
RU2088591C1 (ru) Производные амидинофенилаланина, способ их получения и производные амидинофенилаланина, обладающие антикоагулирующей активностью
JP3453357B2 (ja) トロンビンの阻害剤および基質
JPH0597793A (ja) アミジノフエニルアラニン誘導体
ES2439244T3 (es) Inhibidores de serina proteasa tipo tripsina, su preparación y uso
CA1133897A (en) Peptidylarginine aldehyde derivatives and process for the preparation thereof
AU685465B2 (en) New peptides derivatives
EP0097630B1 (en) New thrombin inhibiting compounds
JPH02174797A (ja) ペプチド誘導体およびその用途
JPS61189298A (ja) 新規オリゴペプチジルアルギニノール誘導体
US5798352A (en) Antithrombotic amidinotetrahydropyridylalanine derivatives
JPS62207251A (ja) オリゴペプチジルニトリル誘導体
US8124587B2 (en) 2-(aminomethyl)-5-chlorobenzylamide derivatives and their use as inhibitors of the clotting factor Xa
HU201961B (en) Process for producing 2,3-disubstituted isoxazolidines and pharmaceutical compositions comprising same
KR100438879B1 (ko) N-아세틸(L)-4-시아노페닐알라닌Ac-(L)-Phe(4-CN)-OH및N-아세틸-(L)-p-아미디노페닐알라닌-시클로헥실글리신-β-(3-N-메틸피리디늄)-알라닌Ac-(L)-pAph-Chg-PalMe(3)-NH2의신규제조방법
JP4050316B2 (ja) ペニシラミンアミド誘導体
JP2003529528A (ja) プロテアーゼインヒビターとしてのアミノ酸アミジノヒドラゾン、アルコキシグアニジン、およびアミノグアニジン
EP0486702A1 (en) Phenyl 4-guanidinobenzoate derivative, process for producing the same, and protease inhibitor containing the same
JP2008024720A (ja) ペニシラミンアミド誘導体