JPH059110A - Bathing agent - Google Patents

Abstract

PURPOSE:To obtain a bathing agent, containing an active vitamin B1 derivative- containing garlic extract and a vegetable extract which is a pruritic alleviating ingredient and used by adding to hot water of a bath for treating atopic dermatitis, senile dermal pruritis, etc., and relieving symptoms. CONSTITUTION:A bathing agent is obtained by including (A) an active vitamin B1 derivative-containing extract, prepared by grinding a garlic, adding a vitamin B1 salt in an amount of 0.05-3.0%, preferably 0.5-2.0% based on the raw material garlic to the resultant garlic squeezed juice and regulating the pH to 6.0-9.0, preferably 7.0-8.5 and (B) a vegetable extract containing an ingredient effective for allevating pruritus, e.g. an extract obtained from Artesimia princeps Pamp., Sophorae Radix, Matricaria chamomilla L., Ligustici Radix, Nepeta Herba or Scutellariae Radix in an amount so as to provide the solid content of the ingredient (B) of >=0.1, preferably 0.5-2 times based on the solid content of the ingredient (A). Allithiamin, thiamine propyl disulfide, thiamine tetrahydrofururyl disulfide, etc., are used as the active vitamin B1 derivative.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bath agent useful as a medical agent, a health agent, etc., and more specifically, atopic dermatitis, senile cutaneous pruritus, pruritus cutaneus in artificial dialysis patients, and other diseases accompanied by itching. The present invention relates to a bath agent used in addition to hot water in a bathtub for the treatment of the above and alleviation of symptoms.

[0002]

2. Description of the Related Art Conventional bath agents include inorganic salts having a heat retaining action, skin cleansing action, moisturizing action, bactericidal action, crude drug, proteolytic enzyme, moisturizing agent, bactericide, etc. It has been used by blending various components. The main effects of such a bath agent are a heat effect and a skin irritating effect, and it is said that the bath agent is effective for coldness, stiff shoulders, neuralgia, recovery from fatigue by promoting blood circulation. However, there is a problem in that itching is enhanced by the blood circulation promoting action. On the other hand, for the treatment of atopic dermatitis, pruritus senile dermatitis, and pruritus dermatitis in dialysis patients, external use of corticosteroids, oral administration of antiallergic agents, dietary restrictions, etc. appear,
There are problems such as ineffectiveness and difficulty in implementation,
No satisfactory treatment has been established. Also, for these patients, bathing and the use of bathing agents that promote blood circulation have been limited because they result in increased itching.
The present inventors have found that garlic extract containing alliamine has a very high heat retaining effect as a bath agent and promotes blood circulation (Japanese Patent Laid-Open No. 63-307812). Then, as a result of repeated studies, it was found that the garlic extract also has an action of reducing itch, and it was confirmed that the garlic extract has a clinical effect on patients with itch associated with itch, but the effect is not sufficient. There wasn't.

[0003]

The inventors of the present invention have studied to solve the above-mentioned problems. As a result, it was found that a particular plant extract generally used for bath preparations produces pruritus when the plant extract alone is used. Although the effect of reducing the effect is small, it has been found that it has an effect of remarkably reducing pruritus by using it in combination with an active vitamin B ₁ derivative, such as garlic extract containing alliamine, thiaminepropyl disulfide, or thiamine tetrahydrofurfuryl disulfide. Completed the invention.

That is, the present invention provides a bath preparation containing as an active ingredient a garlic extract containing an active vitamin B ₁ derivative and a plant extract containing an ingredient effective for reducing pruritus.

The active vitamin B ₁ derivative used in the present invention refers to a derivative which exhibits excellent intestinal absorption and tissue translocation, has good sustainability in the body, and easily returns to thiamine in the living body. Specific examples thereof include alliamine, thiaminepropyl disulfide, and thiamine tetrahydrofurfuryl disulfide.

The garlic extract containing the active vitamin B ₁ derivative used in the present invention is easily prepared by mixing the active vitamin B ₁ derivative and the garlic extract. For example, garlic extract containing alliamine is disclosed in JP-A-63-
As described in JP-A-307812, since it is possible to produce alliamine by allowing vitamin B ₁ and garlic extract to coexist under suitable conditions, according to the method exemplified below, alliamine-containing garlic can be efficiently prepared. You can get the extract. First, a garlic juice obtained by grinding and squeezing garlic by a conventional method is supplemented with a vitamin B ₁ salt (eg, hydrochloride or nitrate) in an amount of 0.05 to 3.0%, preferably 0.5 ~ 2.0%
PH 6.0-9.0, preferably pH 7.0-8.
Adjust to 5. Next, the treatment temperature is set to 50 to 70 ° C., preferably 55 to 65 ° C., and 5 minutes to 4 hours, preferably 30.
Incubate for minutes to 2 hours. After that, the precipitate that is immediately formed is removed by filtration or centrifugal precipitation to obtain an almost odorless allylic amine-containing garlic extract.

If the amount of vitamin B ₁ salt added, the pH, the treatment temperature and the treatment time are below the respective lower limit values, the production of alliamine is insufficient. Ingredients may be altered. When the generated precipitate is removed by filtration or centrifugal precipitation, a filter aid such as Celite or Perlite or a protein flocculant such as calcium chloride or magnesium chloride may be used if necessary. Alternatively, the pH may be adjusted to 3 to 5 to precipitate the protein.

[0008] Next, the plant extract used in the present invention may be any one as long as it contains an ingredient effective in reducing itch, and examples thereof include extracts obtained from plants such as mugwort, spruce, chamomile, sugar beet, mussel, and sardine. Can be mentioned. The plant extract can be obtained, for example, by crushing a raw plant or a dried plant product and extracting it with water, hot water, hot water, ethanol or the like by a conventional method. In the present invention, two or more kinds of plant extracts may be mixed and used.

The active ingredients of the bath agent of the present invention are the above-mentioned active vitamin B ₁ derivative-containing garlic extract and plant extract. The mixing ratio of the active vitamin B ₁ derivative-containing garlic extract solid matter is the plant extract. It is desirable that the solid content is at least 0.1 times, preferably 0.5 to 2 times.

The bath preparation of the present invention comprises the above-mentioned active vitamin B ₁
Derivative-containing garlic extract and plant extract are used as active ingredients, but if necessary, herbal ingredients such as senkyu, chimpi, soup, ginger and hot spring ingredients such as sodium sulfide, sodium carbonate, sodium hydrogen carbonate and sodium chloride, Proteolytic enzyme, moisturizer, bactericide,
Furthermore, fragrances, pigments, etc. can be added as appropriate.
The shape of the bath agent can be a desired shape such as liquid, powder, granules, and plate, and if necessary, extenders, excipients, etc. may be added. In addition, in the formulation,
The active vitamin B ₁ derivative-containing garlic extract and the plant extract may be mixed and formulated, or both may be formulated separately.

The amount of the bath agent of the present invention used is 20
It is suitable that the amount of the active ingredient of the bath agent is 0.05 to 10 g, preferably 1 to 5 g per 0 liter in terms of solid content.

[0012]

EXAMPLES The present invention will now be described with reference to examples, but the present invention is not limited thereto. Production Example 1 50 kg of thiamine hydrochloride was added to an extract obtained by crushing and squeezing 5 kg of raw garlic, and the mixture was kept at pH 8 for 1 hour at 60 ° C., and then the supernatant obtained by centrifugation was concentrated to dryness. As a result, 1 kg of garlic extract powder containing alliamine was obtained.

Production Example 2 10 kg of water was added to 1 kg of crushed dried leaves of mugwort, and the mixture was extracted with stirring at 80 ° C. for 2 hours and then filtered. Lactose (1 kg) was added to the filtrate, which was then concentrated to dryness to give 1.15 kg of mugwort extract powder.

Production Example 3 8 liters of water was added to 800 g of crushed dried roots of ginseng, and the mixture was extracted at 80 ° C. for 2 hours with stirring.
Filtered. After lactose (412 g) was added to the filtrate, it was concentrated to dryness to obtain 550 g of jinjin extract powder.

Production Example 4 To 800 g of dried chamomile flowers, 8 liters of water was added, and the mixture was extracted at 80 ° C. for 2 hours with stirring, and then 733 was added to the filtrate.
After lactose (g) was added, the mixture was concentrated to dryness to obtain 916 g of chamomile extract powder.

Production Example 5 10 kg of water was added to 1 kg of crushed dry root of Touki, which was extracted with stirring at 80 ° C. for 2 hours and then filtered. After lactose (1 kg) was added to the filtrate, the filtrate was concentrated to dryness to obtain 1.25 kg of Toki extract powder.

Production Example 6 5 kg of raw garlic was crushed and squeezed, and then the supernatant obtained by centrifugation was concentrated to dryness to give garlic extract powder 0.98.
I got kg.

Example 1 1 kg of the garlic extract powder containing alliamine obtained by the method described in Production Example 1 and 1 kg of mugwort extract powder obtained by the method described in Production Example 2 were mixed, and 8 kg of anhydrous sodium sulfate was added.
And a slight amount of fragrance were added to obtain 10 kg of a bath agent.

Example 2 1 kg of the garlic extract powder containing alliamine obtained by the method described in Production Example 1 and 1 kg of the jinjin extract powder obtained by the method described in Production Example 3 were mixed, and 8 kg of anhydrous sodium sulfate was added to the mixture.
And a slight amount of fragrance were added to obtain 10 kg of a bath agent.

Example 3 1 kg of the garlic extract powder containing alliamine obtained by the method described in Production Example 1 and 1 kg of chamomile extract powder obtained by the method described in Production Example 4 were mixed, and anhydrous sodium sulfate 8
kg and a trace amount of fragrance were added to obtain 10 kg of a bath agent.

Example 4 1 kg of the alliamine-containing garlic extract powder obtained by the method described in Production Example 1 and 1 kg of the Touki extract powder obtained by the method described in Production Example 5 were mixed, and 8 kg of anhydrous sodium sulfate was added to the mixture.
And a slight amount of fragrance were added to obtain 10 kg of a bath agent.

Example 5 Garlic extract powder 0.9 obtained by the method described in Production Example 6.
5 kg, thiaminepropyl disulfide hydrochloride 50 g and 1 kg of ginseng extract powder obtained by the method described in Production Example 3 were mixed, and 8 kg of anhydrous sodium sulfate and a trace amount of fragrance were added to obtain 10 kg of a bath agent.

Example 6 0.9 garlic extract powder obtained by the method described in Production Example 6
5 kg, thiaminetetrahydrofurfuryl disulfide hydrochloride (50 g) and kujin extract powder (1 kg) obtained by the method described in Production Example 3 were mixed, and anhydrous sodium sulfate (8 kg) and a trace amount of fragrance were added to obtain a bath preparation (10 kg).

Test Example 1 Using a patient with atopic dermatitis as a test subject, the garlic extract containing alliamine and a plant extract containing an ingredient effective for alleviating pruritus were used alone and in a mixture thereof. The improvement effect was investigated by the following method. Fifty atopic dermatitis patients aged 3 to 10 years were divided into 5 groups of 10 groups, the first group being allylic amine-containing garlic extract (obtained in Production Example 1), second group.
Group is chamomile extract (those obtained in Production Example 4)
Hot water, the third group is hot water containing an equal amount of garlic extract containing alliamine (obtained in Production Example 1) and chamomile extract (obtained in Production Example 4), and the fourth group is Kujin extract (obtained in Production Example 3). Hot water, and the fifth group was bathed with equal amounts of hot water of garlic extract containing alithiamine (obtained in Production Example 1) and kujin extract (obtained in Production Example 3) as test hot water. The effect of improving itching was examined. The test hot water was prepared by dissolving 3 g of each extract powder per 200 liters of hot water in the bath. The test period was one month, and bathing was once a day. As a general rule, external use and oral administration of steroid ointment, antiallergic agent, etc. were not performed during the test period, but if they were unavoidably used, the degree of improvement was evaluated and the effect was judged at that time. For the degree of itch, the criteria based on the self-administration table used by the Oxatomida clinical research group (Saijin skin, 45 , 1042 (1983)) were used. This is shown in Table 1.

[0025]

[Table 1]

The degree of improvement was evaluated on the basis of Table 1 according to the extent to which the degree of itching at the time of evaluation was improved, and the following five levels were evaluated. Score Change in itching degree Significant improvement 3 points 4 → 0,4 → 1,3 → 0,2 → 0 Moderate improvement 2 points 4 → 2,3 → 1,1 → 0 Mild improvement 1 point 4 → 3,3 → 2,2 → 1 Invariant 0 points 4 → 4,3 → 3,2 → 2,1 → 1,0 → 0 Deterioration-2 points Deterioration of itching

The effect is evaluated by summing daytime and nighttime improvement scores, and is judged to be excellent in 5 points or more, 4 to 3 points are effective, 2 to 1 points are slightly effective, and 0 points or less are ineffective in four stages. did. Table 2 shows the results of evaluation and determination by the above method. The itching sensation before use and the score of improvement degree after use were shown as the average value of 10 persons in each group, and the judgment of the effect was shown as a ratio of not less than effective and a ratio of not less than effective.

[0028]

[Table 2]

As is clear from Table 2, in the 1st, 2nd, and 4th groups, in which the garlic extract containing alliamine or the plant extract containing the pruritus-reducing component was used alone, the effective or higher was 40 to 50%, or slightly higher than the effective. Is 50-7
It was 0%, but in the 3rd and 5th groups where both were mixed and used, the effective rate was 60 to 70%, and the effective rate was 90%.
%, The effect was obviously high.

Test Example 2 A patient with pruritus senile dermatitis was used as a test subject, and the itching-improving effect when a bath preparation containing an alliamine-containing garlic extract and a kujin extract was used was examined by the following method. Eleven patients with pruritus senile skin were used as test subjects to prepare test hot water using the bath preparation containing the allylicamine-containing garlic extract and kujin extract obtained in Example 2, and bathed to examine the effect of improving itching. The test hot water was prepared by dissolving 15 g of the bath agent per 200 liters of hot water in the bath. The test period was one month, and bathing was once a day. As a general rule, external use and oral administration of steroid ointment, anti-allergic agents, etc. were not performed during the test period. The degree of improvement in itching and the determination of the effect were carried out according to Test Example 1. The results are shown in Table 3.
Shown in.

[0031]

[Table 3]

As is clear from Table 3, of the 11 subjects, 2 were excellent and 6 were effective.
The effectiveness of the bath agent in which 90% or more of the garlic extract and the kujin extract containing alliamine were blended was confirmed.

Test Example 3 An artificial dialysis patient with pruritus dermatitis was used as a test subject, and the itching-improving effect when a bath agent containing an alliamine-containing garlic extract and a chamomile extract was used was examined by the following method. Ten hot dialysis patients with pruritus skin were used as test subjects, and test hot water was prepared using the bath agent containing the allylicamine-containing garlic extract and chamomile extract obtained in Example 3, and bathed to improve itching. I investigated the effect. The test hot water was prepared by dissolving 15 g of the bath agent per 200 liters of hot water in the bath. The test period is one month,
Bathing was once a day. Steroid ointment during the test period,
As a general rule, no external use or internal use of anti-allergic agents etc. The degree of improvement in itching and the determination of the effect were carried out according to Test Example 1. The results are shown in Table 4.

[0034]

[Table 4]

As is clear from Table 4, 6 or more were effective or more effective, and if a little effective was included, the effectiveness of the bath agent containing the allylic amine-containing garlic extract and chamomile extract was improved in 9 out of 10 patients. Admitted.

[0036]

EFFECT OF THE INVENTION The bath preparation of the present invention has atopic dermatitis and pruritus senile due to the synergistic action of the active vitamin B ₁ derivative, the garlic extract, and the plant extract which are pruritus-relieving components contained as active ingredients. , It is useful for the treatment and relief of symptoms associated with itching such as skin pruritus in dialysis patients.

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Atsunori Okada             304 Ionoura, Nio-machi, Mitoyo-gun, Kagawa Prefecture

Claims (2)

[Claims] 1. A bath agent containing as an active ingredient a garlic extract containing an active vitamin B ₁ derivative and a plant extract containing an ingredient effective in reducing pruritus. 2. The bath agent according to claim 1, wherein the active vitamin B ₁ derivative is any one of alliamine, thiaminepropyl disulfide and thiamine tetrahydrofurfuryl disulfide.