JPH0710742A - Bathing agent - Google Patents
Bathing agentInfo
- Publication number
- JPH0710742A JPH0710742A JP26289693A JP26289693A JPH0710742A JP H0710742 A JPH0710742 A JP H0710742A JP 26289693 A JP26289693 A JP 26289693A JP 26289693 A JP26289693 A JP 26289693A JP H0710742 A JPH0710742 A JP H0710742A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- thiamine
- compound
- thiamine disulfide
- bath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、浴用剤、さらに詳しく
はアセモ、湿疹、ニキビ、その他の皮膚病に対して治療
効果を有する浴用剤に関するものである。FIELD OF THE INVENTION The present invention relates to a bath agent, and more particularly to a bath agent having a therapeutic effect on asemo, eczema, acne and other skin diseases.
【０００２】[0002]
【従来技術及びその問題点】従来、入浴に際して、湯浴
中に投入使用される浴用剤は知られている。このような
浴用剤は、通常、硫酸ナトリウムや食塩等の無機塩に種
々の薬効成分や香料を配合したものから構成されてい
る。この場合、薬効成分を選ぶことにより、その薬効成
分に応じた効能を備えた浴用剤を得ることができる。こ
れまで、抗菌ないし殺菌効果を有する浴用剤成分として
は、硫化ナトリウムや、硫酸鉄、亜硫化鉄等の無機硫化
物が用いられている。しかし、これらのものは、その抗
菌効果において未だ不十分である上、皮膚に対して害を
与える等の問題もある。また、他の抗菌効果を有する浴
用成分として、薬用植物が知られているが、このもの
は、その抗菌効果において不満足であるとともに、一般
的に高価である。一方、本発明者は、先に、下記に示す
一般式で表わされる非対称型チアミンジスルフィド誘導
体が、すぐれた抗菌作用を有し、皮膚病治療薬（特開昭
６２−１９０１２４号）及び白癬菌症治療剤（特開昭６
２−１７５４２３号）として有用であることを見出し、
それぞれ特許出願している。2. Description of the Related Art Conventional bathing agents have been known to be used by throwing them into a bath for bathing. Such a bath agent is usually composed of an inorganic salt such as sodium sulfate or sodium chloride mixed with various medicinal components and fragrances. In this case, by selecting the medicinal component, it is possible to obtain a bath preparation having an effect according to the medicinal component. So far, as a bath agent component having an antibacterial or bactericidal effect, sodium sulfide and inorganic sulfides such as iron sulfate and iron subsulfide have been used. However, these are still insufficient in their antibacterial effects, and also have problems such as damage to the skin. Further, medicinal plants are known as other bath ingredients having an antibacterial effect, but these are unsatisfactory in their antibacterial effects and are generally expensive. On the other hand, the present inventor has previously found that the asymmetric thiamine disulfide derivative represented by the general formula shown below has an excellent antibacterial action, and is used as a therapeutic agent for skin diseases (JP-A-62-190124) and Trichophyton. Therapeutic agent
2-175423)),
Each has applied for a patent.
【化１】 (式中、R1はメチル基、エチル基、プロピル基、ブチル
基等を表わし、R2は、メチル基、エチル基、プロピル
基、アリル基、フリフリル基等を表わす)[Chemical 1] (In the formula, R 1 represents a methyl group, an ethyl group, a propyl group, a butyl group, etc., and R 2 represents a methyl group, an ethyl group, a propyl group, an allyl group, a furfuryl group, etc.)
【０００３】[0003]
【発明が解決しようとする課題】本発明は、皮膚に対す
る安全性が高く、かつ抗菌作用にすぐれ、皮膚病治療効
果を有する浴用剤を提供することをその目的とする。SUMMARY OF THE INVENTION It is an object of the present invention to provide a bath preparation having a high safety to the skin, an excellent antibacterial action, and a therapeutic effect on skin diseases.
【０００４】[0004]
【課題を解決するための手段】本発明者は、前記目的を
達成すべく鋭意研究を重ねた結果、本発明者が先に皮膚
病治療薬等として提案した前記非対称型チアミンジスル
フィド誘導体を浴用剤成分として用いることにより、あ
せもや、ニキビ等の皮膚病の治療効果にすぐれた浴用剤
が得られることを見出し、本発明を完成するに至った。
即ち、本発明によれば、一般式Means for Solving the Problems As a result of intensive studies aimed at achieving the above-mentioned object, the present inventor has proposed the above-mentioned asymmetric thiamine disulfide derivative, which was previously proposed by the present inventor as a therapeutic agent for skin diseases, etc. It was found that a bath agent having an excellent therapeutic effect on skin diseases such as heat rash and acne can be obtained by using it as a component, and the present invention has been completed.
That is, according to the present invention, the general formula
【化２】 (式中、R1は低級アルキル基を示し、R2は含酸素複素環
基を示す)で表わされる非対称型チアミンジスルフィド
誘導体を有効成分として含有することを特徴とする浴用
剤が提供される。[Chemical 2] A bath preparation containing an asymmetric thiamine disulfide derivative represented by the formula (wherein R 1 represents a lower alkyl group and R 2 represents an oxygen-containing heterocyclic group) as an active ingredient.
【０００５】本発明で浴用剤成分として用いる前記一般
式(I)で示される非対称型チアミンジスルフィド誘導体
は、従来公知の化合物であり、ビタミンＢ1又はその類
似体からなる下記一般式(II)で表わされるチアミン化合
物を原料として、次の反応により合成される。The asymmetric thiamine disulfide derivative represented by the above general formula (I) used as a bath agent component in the present invention is a conventionally known compound, and is represented by the following general formula (II) consisting of vitamin B 1 or its analogue. It is synthesized by the following reaction using the represented thiamine compound as a raw material.
【０００６】[0006]
【化３】 [Chemical 3]
【０００７】前記一般式（II）のチアミン化合物に反応
させる一般式（III)の反応剤は、含酸素複素環基を有す
る有機ハライドとチオ硫酸ソーダとを反応させることに
よって得ることができる。この場合、含酸素複素環基を
有する有機ハライドの種類は特に制約されないが、一般
的には、フリフリルハライド又はその環水素化物である
テトラヒドロフリフリルハライド等が用いられる。前記
のようにして得られる非対称型チアミンジスルフィド誘
導体の具体的化合物例（例えば、R2=テトラヒドロフル
フリル等)については、例えば、「ハンドブック−化粧
品、製剤原料」、改訂版（昭和52年)、P446(日光 ケミ
カルズ株式会社発行)に示されている。The reagent of the general formula (III) which is reacted with the thiamine compound of the general formula (II) can be obtained by reacting an organic halide having an oxygen-containing heterocyclic group with sodium thiosulfate. In this case, the type of the organic halide having an oxygen-containing heterocyclic group is not particularly limited, but generally a furfuryl halide or its ring hydride, such as tetrahydrofurfuryl halide, is used. For specific compound examples of the asymmetrical thiamine disulfide derivative obtained as described above (for example, R 2 = tetrahydrofurfuryl etc.), for example, “Handbook-cosmetics, drug substance”, revised edition (1972), It is shown in P446 (published by Nikko Chemicals Co., Ltd.).
【０００８】本発明で用いる非対称型チアミンジスルフ
ィド誘導体は、前記したように既に本発明者の研究によ
り、すぐれた抗菌作用を有することの見出されたもので
あり、湿疹、ニキビ、あせも等の皮膚病治療効果を示す
とともに、皮膚に対して安全性が高く、実質上無害であ
ることが確認されているものである。このチアミンジス
ルフィド誘導体は、すぐれた皮膚吸収性を示し、入浴中
において皮膚組織内に容易に浸透する。そしてこのチア
ミンジスルフィド誘導体は、組織内において分解し、再
びビタミンB1に戻るが、その分解に際し、スルホキシド
(R2SO)を生成するものと考えられる。チアミンジスルフ
ィド誘導体の使用より得られるすぐれた抗菌効果は、組
織内でのチアミンジスルフィドのビタミンＢ1への分解
に際して副生するこのスルホキシドに起因するものと考
えられる。また、このスルホキシド(R2SO)における抗菌
作用は、その硫黄原子に起因するものである。従って、
本発明では、含酸素複素環基R2の種類には格剤の制約は
なく、非対称型チアミンジスルフィド誘導体を与えるも
のであればどのようなものでも良い。本発明の浴用剤
は、前記したチアミンジスルフィド誘導体を必須成分と
して含有するもので、その他、慣用の無機塩類や、香
料、生薬等を含有することができる。チアミンジスルフ
ィド誘導体の湯浴に対する溶解度が低すぎる場合、その
チアミンジスルフィド誘導体は、これを無機酸塩や、有
機酸塩とし、水溶性のものとして使用することができ
る。このものを湯浴中に投入する場合、湯浴中における
チアミンジスルフィド誘導体の濃度が、浴湯1ｌ中、0.0
01ｇ以上、通常、0.01〜0.05ｇになるような量を投入す
ればよい。As described above, the asymmetric thiamine disulfide derivative used in the present invention has been found to have an excellent antibacterial action by the research of the present inventor, and the skin of eczema, acne, heat rash, etc. It has been confirmed that it has a disease treatment effect, is highly safe to the skin, and is substantially harmless. This thiamine disulfide derivative exhibits excellent skin absorbability and easily penetrates into skin tissue during bathing. Then, this thiamine disulfide derivative decomposes in tissues and returns to vitamin B 1 again.
It is considered to generate (R 2 SO). The excellent antibacterial effect obtained by using the thiamine disulfide derivative is considered to be due to this sulfoxide which is a by-product in the decomposition of thiamin disulfide into vitamin B 1 in the tissue. Further, the antibacterial action of this sulfoxide (R 2 SO) is due to its sulfur atom. Therefore,
In the present invention, the type of the oxygen-containing heterocyclic group R 2 is not limited to a specific agent, and any one can be used as long as it gives an asymmetrical thiamine disulfide derivative. The bath agent of the present invention contains the above-mentioned thiamine disulfide derivative as an essential component, and may further contain conventional inorganic salts, perfumes, herbal medicines and the like. When the solubility of the thiamine disulfide derivative in a hot water bath is too low, the thiamine disulfide derivative can be used as a water-soluble salt by using it as an inorganic acid salt or an organic acid salt. When this is put into a hot water bath, the concentration of the thiamine disulfide derivative in the hot water bath is 0.0
It may be added in an amount of 01 g or more, usually 0.01 to 0.05 g.
【０００９】[0009]
【発明の効果】本発明の浴用剤は、その成分として、前
記した非対称型チアミンジスルフィド誘導体を含むこと
から、あせもや、ニキビ等の細菌性皮膚病に対してすぐ
れた治療効果を示すものである。また、このチアミンジ
スルフィド誘導体は、皮膚に対する安全性が高く、実質
上無害であることから、安心して使用し得るものであ
る。さらに、そのチアミンジスルフィド自体で保温効果
等の浴用剤効果を示すものである。EFFECTS OF THE INVENTION The bath agent of the present invention contains the above-mentioned asymmetrical thiamine disulfide derivative as a component thereof, and therefore exhibits an excellent therapeutic effect on bacterial skin diseases such as heat rash and acne. . In addition, this thiamine disulfide derivative has high safety to the skin and is substantially harmless, so that it can be safely used. Further, the thiamine disulfide itself exhibits a bath agent effect such as a heat retaining effect.
【００１０】[0010]
【実施例】次に本発明を実施例及び参考例によりさらに
詳細に説明する。EXAMPLES The present invention will be described in more detail with reference to Examples and Reference Examples.
【００１１】参考例１ フルフリルブロマイド16.2gをエタノール50cc に溶かし
た液に、チオ硫酸ソーダー25.0gを水50ccに溶かした液
を加え、2時間還流加熱し後常温になるまで冷却する。
別にチアミン33.4gを70gに溶かし、カセイソーダ12gを3
0gの水に溶かした液で中和した液を用意する。このチア
ミン液に前記の反応液を速やかに加える。生成した沈殿
物をろ別乾燥して目的物27gを得た。Reference Example 1 To a solution prepared by dissolving 16.2 g of furfuryl bromide in 50 cc of ethanol was added a solution prepared by dissolving 25.0 g of sodium thiosulfate in 50 cc of water, heated under reflux for 2 hours and then cooled to room temperature.
Separately, dissolve 33.4 g of thiamine in 70 g and add 12 g of caustic soda to 3 g.
Prepare a solution neutralized with a solution dissolved in 0 g of water. The above reaction solution is immediately added to this thiamine solution. The produced precipitate was filtered and dried to obtain 27 g of the desired product.
【００１２】参考例２ 参考例1において、フリフリルブロマイドの代りにテト
ラヒドロフリフリルブロマイドを用いた以外は同様にし
て目的物を得た。Reference Example 2 A target product was obtained in the same manner as in Reference Example 1, except that tetrahydrofurifuryl bromide was used in place of the furfuryl bromide.
【００１３】実施例１ 200ｌのお湯を入れた浴槽に、フリフリルチアミンジス
ルフィドの塩酸塩2gを入れて入浴したところ、身体がよ
く温まり、肩のコリがほぐれ、本発明で用いるチアミン
ジスルフィドは、保温効果等の一般の浴用剤効果を示す
ことが確認された。また、前記と同様にして作った浴湯
に、あせものできた乳幼児を一日に二回入浴させたとこ
ろ、二日目には、そのあせもはすっかりよくなり、本発
明の浴用剤は、皮膚病治療効果を有することが確認され
た。Example 1 When 2 g of the hydrochloride of furfurylthiamine disulfide was placed in a bath containing 200 liters of hot water and bathed, the body was warmed well and the stiffness of the shoulders was loosened. The thiamine disulfide used in the present invention was kept warm. It was confirmed that the general bathing agent effect such as the effect was exhibited. In addition, when a baby with a heat rash was bathed twice a day in the bath water prepared in the same manner as described above, the heat rash was completely improved on the second day. It was confirmed to have a therapeutic effect.
【００１４】実施例２ 実施例1において、フリフリルチアミンの代りにテトラ
ヒドロフリフリルチアミンを用いた以外は同様にして実
験を行った。この場合にも、実施例1と同様の結果が得
られた。また、比較のために、塩酸チアミンを用いて同
様のテスト行ったところ、この場合には、殆んど効果が
なかった。以上の入浴テストの結果から、チアミン(ビ
タミンＢ1)自体には格別の抗菌作用はないものの、チア
ミンジスルフィドとすることによって、すぐれた抗菌作
用が発現することが確認された。Example 2 An experiment was conducted in the same manner as in Example 1 except that tetrahydrofurfurylthiamine was used in place of the furfurylthiamine. Also in this case, the same result as in Example 1 was obtained. For comparison, a similar test was carried out using thiamine hydrochloride, but in this case, almost no effect was obtained. From the results of the above bathing test, it was confirmed that thiamin (vitamin B 1 ) itself does not have a particular antibacterial action, but that thiamin disulfide exhibits an excellent antibacterial action.
Claims (1)
基を示す)で表わされる非対称型チアミンジスルフィド
誘導体を有効成分として含有することを特徴とする浴用
剤。1. A general formula: A bath agent containing an asymmetric thiamine disulfide derivative represented by the formula (wherein R 1 represents a lower alkyl group and R 2 represents an oxygen-containing heterocyclic group) as an active ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26289693A JPH0710742A (en) | 1993-09-27 | 1993-09-27 | Bathing agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26289693A JPH0710742A (en) | 1993-09-27 | 1993-09-27 | Bathing agent |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61084352A Division JPH0618771B2 (en) | 1986-04-14 | 1986-04-14 | Bath agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0710742A true JPH0710742A (en) | 1995-01-13 |
Family
ID=17382126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP26289693A Pending JPH0710742A (en) | 1993-09-27 | 1993-09-27 | Bathing agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0710742A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008193323A (en) * | 2007-02-02 | 2008-08-21 | Toshiba Corp | Distortion compensating device |
| JP2018177782A (en) * | 2017-04-14 | 2018-11-15 | 株式会社プロテクティア | Cosmetic containing catechin fatty acid derivative |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH059110A (en) * | 1990-07-20 | 1993-01-19 | Takeda Chem Ind Ltd | Bathing agent |
-
1993
- 1993-09-27 JP JP26289693A patent/JPH0710742A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH059110A (en) * | 1990-07-20 | 1993-01-19 | Takeda Chem Ind Ltd | Bathing agent |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008193323A (en) * | 2007-02-02 | 2008-08-21 | Toshiba Corp | Distortion compensating device |
| JP2018177782A (en) * | 2017-04-14 | 2018-11-15 | 株式会社プロテクティア | Cosmetic containing catechin fatty acid derivative |
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