JP3138399B2 - Body rinse bath agent - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a body rinse bath agent which is used after being applied to the skin, and more particularly to a body rinse bath agent which is effective in reducing itch.

[0002]

2. Description of the Related Art In general, a bath preparation contains various components such as inorganic salts having a moisturizing action, a skin cleansing action, a bactericidal action, etc., a crude drug, a protease, a humectant, a bactericide and the like. Conventionally, the above-mentioned bath agent is used by dissolving or dispersing in hot water of a bath tub at the time of bathing, and by promoting the blood circulation by the warming action of the hot water of the bath tub containing the above components, the skin irritating action, etc. , Neuralgia, recovery from fatigue, etc.

[0003]

By the way, it was difficult to use the above-mentioned bath preparation to reduce itching. That is, the above-mentioned conventional bath agent promotes blood circulation as described above, and thus has a problem in that itching is enhanced. On the other hand, in the treatment of atopic dermatitis, senile pruritus, and skin pruritus in dialysis patients, topical use of corticosteroids, oral use of antiallergic drugs, and dietary restrictions have been performed, but side effects have been observed. There are problems such as appearing, inadequate efficacy, and difficulty in implementation, and a new method for reducing itching has been demanded.

[0004] Also, the practice of bathing in hot water in a bathtub, which is referred to as bathing, is not always worldwide, and therefore the area where conventional bath agents are used has been limited. In Japan as well, the rate of bathing with a shower alone without soaking in a bathtub is increasing.
Moreover, in recent years, a circulation type bath tub capable of taking a bath for 24 hours at home has begun to spread. The above-mentioned circulating bathtub keeps the hot water in the bathtub clean and at an appropriate temperature by circulating the hot water between the filter and the heating device and the bathtub. By not frequently heating the water, the amount of energy used such as water and gas is reduced. In the circulation bath, when a bath agent is used, the bath agent is filtered, so that it is difficult to sufficiently obtain the medicinal effect of the bath agent, and the bath agent contaminates the filter for filtration. There was a problem that it would. For these reasons, the environment in which bath agents can be used is decreasing.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a body rinse bath agent as a bath agent that can reduce itch and can be used in showers and circulation bathtubs. It is the purpose.

[0006]

Means for Solving the Problems The inventors of the present invention have studied to solve the above problems, and it has been found that adding garlic extract as a bath agent to hot water in a bathtub can reduce itch to a certain extent. It was confirmed that it had a clinical effect on patients with dry skin. However, it was not possible to obtain a sufficient itch-reducing effect only by using garlic extract as an active ingredient of a conventional bath preparation.

[0007] Therefore, the body rinse bath composition according to claim 1 of the present invention contains an ingredient effective for reducing itch and is used by being applied to the skin and then washed away.
A rinsing bath, comprising an ingredient effective in reducing the itch
Contains garlic extract (however, active vitamin B1
Garlic extract)
Keep the juice at 50-70 ° C to remove the formed precipitate
By removing the precipitate, the mesh
Insulated by 0.01-0.5 micron ultrafiltration machine
The solution of the above-described problem is that the garlic juice is filtered . In addition, pouring down here means not only bathing in hot water (water) but also immersing in a hot water stored in a bathtub or the like and flowing a body rinse bath agent. The body rinse bath agent according to claim 2 of the present invention (hereinafter, referred to as body rinsing), the plant having the above garlic extract, to reduce effects of itching other than the garlic extract as an effective ingredient in reducing the itching Means for solving the above problem include the inclusion of an extract and an animal extract having an action of reducing skin dryness.

Next, the body rinse of the present invention will be described in more detail. The body rinse contains, for example, a plant extract having an effect of reducing itch as an effective ingredient for reducing the itch. Garlic, as a plant extract having the effect of reducing the itch,
Examples of the extract include plants obtained from plants such as loquat, chamomile, perilla, mugwort, kujin, squid, scallop, and gougling, but are not particularly limited as long as they are effective in reducing itch.

When the garlic extract is used as a bath preparation, it is effective in reducing itch as described above, and the medicament for body rinse of the present invention contains garlic extract as a component effective in reducing itch. Is preferred. The garlic extract has excellent intestinal absorption and tissue transfer properties, has good sustainability in the body, and has vitamin B1 in vivo.
And its components include, specifically, allyl compounds, scordinine glycosides, and the like.

[0010] Further, it is possible to enhance the effect of reducing itch by using a mixture of a garlic extract and another plant extract having an effect of reducing itch, rather than using garlic extract alone. It is preferable that both the garlic extract and other plant extracts having an activity of reducing itch are contained in the body rinse of the present invention. The number of types of plant extracts used in combination with the garlic extract is not particularly limited, and two or more plant extracts may be used in combination with the garlic extract.

[0011] For itch accompanied by dry skin,
The addition of moisturizing ingredients is effective in reducing itch, and in addition to the above plant extracts, ingredients (animal extracts) obtained from animals such as squalane, placenta, horse oil, etc., which contain ingredients effective in reducing skin dryness. Although it is preferable to add it to the body rinse of the present invention, it is not limited to the above, and it is sufficient if it can reduce skin dryness.

Next, a method of manufacturing the above body rinse will be described. First, in the production of the garlic extract, garlic is ground by a conventional method, garlic juice obtained by squeezing after adding the same weight of purified water is kept at a low temperature,
Filtration is carried out with an ultrafilter. The processing temperature at this time is 50
5 ° C to 70 ° C, preferably 55 ° C to 65 ° C.
Incubate for a time, preferably 30 minutes to 2 hours. Thereafter, the precipitate immediately formed was removed by an ultrafilter (mesh 0.01 to 0.1.
By removing the garlic extract at 5 microns, preferably 0.05 to 0.3 microns, a garlic extract with almost no odor can be obtained.

[0013] If the treatment temperature and the treatment time are below the lower limit values, respectively, the removal of the protein is insufficient. If the treatment temperature and the treatment time exceed the upper limit values, the components of the garlic extract may be deteriorated. In addition, when the generated precipitate is removed by ultrafiltration, the treatment time is longer when the mesh of the filtration membrane is less than the lower limit, and the garlic extract component may be degraded. Insufficient filtration causes turbidity and precipitation.

In the production of a plant extract other than garlic, it can be obtained, for example, by pulverizing a raw plant or a dried product of the plant and extracting it with water, hot water, boiling water or ethanol water in a conventional manner. As the animal extract, a commercially available product that has already been purified can be used. The method for producing garlic extract, plant extract and animal extract is not particularly limited to the above-mentioned method, and those produced by other methods can also be used.

The mixing ratio of these components is such that the solid content of the plant extract is at least 0.1 times, preferably 0.5 to 4 times the solid content of the active garlic extract, Is preferably at least 0.2 times, preferably 1.0 to 8 times the solid content of garlic extract.

[0016] The body rinse of the present invention may optionally contain crude drug components other than the above plant extracts and animal extracts, moisturizing components, bactericides, as well as fragrances, pigments, extenders, excipients, emulsifiers and the like. Can be. In the body rinse of the present invention, the above components are preferably dissolved or dispersed in, for example, purified water to form a liquid or cream.

Next, a method of using the body rinse of the present invention will be described. First, a body rinse in a liquid or cream form as described above is applied to the whole body or to a part where symptoms of itching appear. At this time, although the amount of the body rinse of the present invention varies depending on the range of use, the amount of the active ingredient of the body rinse is 0.01 to 10 g in terms of solid content,
Preferably, the amount is 1 to 3 g. The body rinse in a solid state such as a powder may be dissolved or dispersed in hot water or the like and then applied to the skin.
Alternatively, the body rinse that is liquid or diluted to be liquid may be applied to the skin so as to be applied to the skin.

Next, after the body rinse is applied, the body rinse is soaked in hot water in a bathtub, or the body rinse applied to the skin is washed out of the bathtub using the hot water in the bathtub, or is showered. Pour body rinse applied to skin. That is, the body rinse of the present invention is different from a conventional bath agent dissolved or dispersed in hot water of a bathtub and a topical medicine (ointment) merely applied to the skin. And body rinse, atopic dermatitis,
It can reduce itch due to senile pruritus, pruritus due to skin pruritus in dialysis patients and other causes.

The warming action and skin irritating action obtained with the conventional bath preparation can be sufficiently obtained by, for example, immersing in hot water in a bathtub after application to the skin. In addition, promotion of blood circulation based on the warming action and skin stimulating action may lead to enhancement of itch.However, in the above-mentioned body rinse, components such as garlic extract for reducing itch are applied to hot water in a state applied to the skin. Since it is immersed, it is possible to reduce itch while suppressing the increase in itch due to promotion of blood circulation to some extent.

In addition, when bathing in hot water in a shower or the like without soaking in hot water in a bathtub, it is more effective than in bathing in hot water.
It can easily adjust the temperature of hot water and the time for bathing, can easily prevent excessive heating and skin irritation, and suppress the enhancement of itch due to promotion of blood circulation. In the state, it is possible to obtain the effect of reducing itch by garlic extract and the like.

In addition, by rinsing with hot water after application to the skin, excess body rinse can be washed out, thereby reducing irritation to the skin and keeping the skin clean. The diluted body rinse
By leaving it on the surface of the skin to some extent, the effect of the body rinse can be obtained continuously.

Even when the bathtub is a circulating bathtub, when the body rinse applied to the skin is dispersed in the hot water in the bathtub, a high concentration state is maintained near the skin for a while. Therefore, the effect as a bath agent can be obtained. That is, when the conventional bath agent is dissolved or dispersed in the circulating bath, the bath agent is sequentially removed by the filter and the concentration of the bath agent is reduced, so that a sufficient effect of the bath agent cannot be obtained. However, in the case of body rinse, the body rinse applied to the skin gradually disperses in the hot water in the bathtub over a certain amount of time,
While immersed in hot water, the body rinse is present at a relatively high concentration in the hot water near the skin, and a sufficient effect can be obtained even in a circulating bathtub.

Also, unlike conventional bath preparations, body rinse does not need to be dispersed at a certain concentration in hot water in a bathtub and is applied directly to the skin, so that the amount of the active ingredient used can be compared with that of conventional bath preparations. And can be reduced. Therefore, the contamination of the filter of the circulation bathtub can be reduced as compared with the conventional bath agent.

Further, unlike the conventional bath agent, as described above, the same effect as that of the bath agent can be obtained only by showering without soaking in the hot water of the bathtub, and there is no habit of soaking in the hot water of the bathtub. It can be used even if it is a local person, a person who uses only a shower even if there is a bathtub, or a case where bathing is completed only with a shower due to time or the like.

[0025]

Next, the present invention will be described in detail with reference to the following experimental examples, but the present invention is not limited to the following experimental examples. (Experimental example 1) 1. Production of garlic extract. 1 kg of raw garlic was crushed and squeezed, and the juice was obtained. The juice was kept at 65 ° C. for 1 hour, ultrafiltered with 0.05 micron and concentrated to dryness to obtain 75 g of garlic extract powder.

2. Production of body rinse 500 g of garlic extract powder obtained by the above method for producing garlic extract, 1 kg of chamomile extract powder and 2 kg of squalane are mixed, and 80 kg of liquid paraffin, 13 kg of emulsifier and 3.5 kg of purified water are mixed. And a small amount of fragrance was added to obtain 100 kg of body rinse.

3. Test Example A case of using a garlic extract as a conventional bath agent in a patient with atopic dermatitis,
The following methods are used to examine the effects of itching and moisturizing when using a body rinse with a plant extract containing an effective ingredient to reduce pruritus and an animal extract that has the effect of preventing skin from drying out. Was.

Atopic dermatitis patients 20 to 25 years of age
The first group was divided into two groups of 10 persons. The first group was immersed in garlic extract (the above 1, obtained by the method of producing garlic extract) hot water at the time of bathing, and the second group was body rinse at the time of bathing. 2. The effect of amelioration on itch was examined when using the product obtained by the method of producing body rinse.

That is, the first group is a hot tub 18
5 g of garlic extract powder was added per 0 liter, and the test was carried out by immersing in the above-mentioned hot water. The second group was tested by applying 2 g of body rinse weighed with a light spoon to the whole body and pouring it in a shower. . The test period was one month and bathing was once daily. One or more subjects one month or more before the test used topical or internal use of steroid ointment, nonsteroidal ointment, antiallergic agent, etc., and did not show any improvement during that period.

During the test period, steroid ointments and antiallergic agents were not applied or taken in principle, but if they were used unavoidably, the degree of improvement and the effect were judged at that time. . The degree of itching and the degree and condition of the rash were judged by a clinical research group through interviews with patients. In addition, the degree of dryness of the skin was determined by measuring the amount of keratin moisture in the forearm flexion side and the upper back. Table 1 shows the criteria for the determination.

[0031]

[Table 1]

The degree of improvement was evaluated on the basis of Table 1 according to the degree of improvement in the degree of itch at the time of evaluation, and was evaluated in four stages shown in Table 2 below.

[Table 2]

The effects were evaluated in four stages in which daytime and nighttime improvement scores were totaled, and four or more points were markedly effective, three or more points were effective, two or more points were somewhat effective, and others were invalid. Table 3 shows the results evaluated and determined by the above method. The pruritus sensation and the scores of the degree of improvement before and after use were indicated by the average value of 10 persons in each group, and the effect was judged by the ratio of effective or more effective to slightly effective or more.

[0034]

[Table 3]

As is clear from Table 3, in the first group using garlic extract as a conventional bath agent, the effectiveness was 30 to 40% or more, and the effectiveness was slightly more than 40 to 50%. In the second group using body rinse, 50% to 60% is effective or more, and 80% is slightly effective or more
The effect was clearly high. In the above experimental examples, garlic extract was used as a conventional bath agent, showing that it had a certain effect in improving pruritus, and garlic extract was mixed with other plant extracts and animal extracts to perform body rinse. This indicates that the case where the garlic extract is applied to the skin and then washed away with a shower has a higher effect than the case where the garlic extract is simply used as a conventional bath agent.

(Experimental Example 2) The following test was performed using the body rinse manufactured by the method of manufacturing the body rinse of Experimental Example 1. The ameliorating effect on itch was examined using the above body rinse with a senile pruritus patient as a test subject. At this time, 2 g of the body rinse was weighed with a light spoon, applied to the whole body, and tested by a method of flowing in a shower.

The test period was one month, and bathing was performed once daily. One or more subjects one month or more before the test used topical or oral steroid ointment, steroid-received ointment, effective allergic agent, etc., and also selected 10 subjects who showed no improvement during that period. In addition, during the test period, topical or internal use of steroid ointment, effective allergic agent, etc. was not performed in principle, but when it was unavoidable, the degree of improvement and the effect were judged at that time. The degree of itching was determined by a clinical research group based on interviews with patients. The degree of improvement of itch and the determination of the effect were determined according to Experimental Example 1. Table 4 shows the results.

[0038]

[Table 4] As is evident from Table 4, 5 out of 10 subjects were effective, and 80% or more when slightly effective was included, and the effectiveness of body rinse was also observed in senile pruritus patients.

[0039]

The body rinse of the present invention is used by applying it to the skin and then pouring it off, so that it does not necessarily need to be immersed in hot water of a bathtub as in a conventional bath agent.
The shower can be used when taking a bath. Therefore, it can be used even in an area where there is no habit of immersing in the hot water of a bathtub and a person who does not have the habit, and the range of use of the bath agent can be expanded.

Also, by immersing in body water in a bathtub after application to the skin, the body rinse applied to the skin can also be used by pouring. In this case, the body rinse applied to the skin is gradually applied. Dispersed in hot water around the skin, it can obtain the same or better effect as the conventional bath agent, and compared to the conventional bath agent which needs to be dissolved or dispersed at a certain concentration in the hot water in the bathtub. When immersed in hot water in a bathtub after being applied to the skin, the body rinse can be present at a certain concentration only in the hot water around the skin, and the amount of the active ingredient used can be reduced.

Also, when used in a circulating bathtub that constantly filters hot water, even if the hot water in the bathtub is constantly filtered by a body rinse that gradually disperses from the skin into the hot water, a relatively high concentration of water around the skin can be obtained. The body rinse will be present for some time. Therefore, the body rinse of the present invention
It can be used in a circulation bathtub where it is difficult to use a conventional bath agent. Further, when the body rinse of the present invention is used in a circulating bath, the amount of use is smaller than that of the conventional bath agent as described above, so that the dirt on the filter of the circulating bath tub due to the bath agent can be reduced. it can.

In addition, when an attempt is made to reduce itch with a conventional bath agent (including a component for reducing itch),
The itch reduction effect may be reduced due to the enhancement of itchiness caused by promoting blood circulation by immersing in hot water in a bathtub.However, when the body rinse of the present invention was used in a shower, it was immersed in the bathtub. In comparison with the case, promotion of blood circulation can be suppressed, and itching can be reduced without increasing itching due to bathing. Also, reduce the garlic juice.
Temperature and filtered with an ultrafiltration machine.
Processing temperature of 50 ° C to 70 ° C, preferably 55 ° C to 65 ° C
And keep it warm for 5 minutes to 4 hours, preferably 30 minutes to 2 hours
You. After this, the precipitate immediately formed is removed by ultrafiltration (mesh filtration).
0.01 to 0.5 micron, preferably 0.05 to
0.3 micron) to remove most
A garlic extract that is almost odorless can be obtained.

────────────────────────────────────────────────── ─── Continued on the front page (51) Int.Cl. ⁷ Identification code FI A61K 35/78 A61K 35/78 V A61P 17/16 A61P 17/16 (56) References JP-A-5-9110 (JP, A JP-A-7-53389 (JP, A) JP-A-5-124926 (JP, A) JP-A-5-124927 (JP, A) JP-A 5-124928 (JP, A) 132410 (JP, A) (58) Fields surveyed (Int. Cl. ⁷ , DB name) A61K 7/50

Claims (2)

(57) [Claims] 1. A body which contains an effective ingredient for reducing itch and is used by being applied to the skin and then washed away.
A rinsing bath containing garlic extract as an effective ingredient for reducing the itch.
In rare cases (but no active vitamin B1 derivative is added), the garlic extract is used to remove garlic juice from 50 ° C to 70 ° C.
Incubate at ℃ C and remove the resulting precipitate.
The above-mentioned precipitate is removed by a mesh of 0.01 to 0.5 micron.
Filter the garlic juice preserved by Ron's ultrafiltration machine.
A body rinse bath agent characterized by being carried out by spending. And the <br/> garlic extract as an effective ingredient in reducing wherein said itching, and plant extracts having a relief action of itch other than the garlic extract, and animal extracts having an effect of alleviating skin dryness The agent for body rinse bath according to claim 1, characterized by containing: