CN112587460B - A composition with antipruritic, antiinflammatory and dandruff removing effects, and its preparation method - Google Patents
A composition with antipruritic, antiinflammatory and dandruff removing effects, and its preparation method Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract description 52
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 16
- 239000003908 antipruritic agent Substances 0.000 title claims abstract description 15
- 230000001139 anti-pruritic effect Effects 0.000 title claims abstract description 14
- 208000001840 Dandruff Diseases 0.000 title abstract description 30
- 230000000694 effects Effects 0.000 title abstract description 14
- 238000002360 preparation method Methods 0.000 title description 4
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims abstract description 16
- 235000017803 cinnamon Nutrition 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 244000276331 Citrus maxima Species 0.000 claims abstract description 12
- 235000001759 Citrus maxima Nutrition 0.000 claims abstract description 12
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 11
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 11
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 11
- 235000011477 liquorice Nutrition 0.000 claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 239000000284 extract Substances 0.000 claims description 14
- 238000010992 reflux Methods 0.000 claims description 8
- 239000002453 shampoo Substances 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 4
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- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
- 235000010234 sodium benzoate Nutrition 0.000 claims description 4
- 239000004299 sodium benzoate Substances 0.000 claims description 4
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- 239000004094 surface-active agent Substances 0.000 claims description 4
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 3
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 3
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- 229940057950 sodium laureth sulfate Drugs 0.000 claims description 3
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 claims description 3
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 claims description 2
- 244000303965 Cyamopsis psoralioides Species 0.000 claims description 2
- 241000037826 Polygonatum kingianum Species 0.000 claims description 2
- 229940069765 bean extract Drugs 0.000 claims description 2
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- 235000019864 coconut oil Nutrition 0.000 claims description 2
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- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 5
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 4
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- GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 description 2
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- UVSMNLNDYGZFPF-UHFFFAOYSA-N pomalidomide Chemical compound O=C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O UVSMNLNDYGZFPF-UHFFFAOYSA-N 0.000 description 2
- 229960000688 pomalidomide Drugs 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 238000010025 steaming Methods 0.000 description 2
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- 210000000434 stratum corneum Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 231100000002 MTT assay Toxicity 0.000 description 1
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- 206010070834 Sensitisation Diseases 0.000 description 1
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
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- 230000000843 anti-fungal effect Effects 0.000 description 1
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- 210000004027 cell Anatomy 0.000 description 1
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- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000011280 coal tar Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- -1 copper pyrithione ethanolamine salt Chemical class 0.000 description 1
- TVZPLCNGKSPOJA-UHFFFAOYSA-N copper zinc Chemical compound [Cu].[Zn] TVZPLCNGKSPOJA-UHFFFAOYSA-N 0.000 description 1
- 239000000824 cytostatic agent Substances 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
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- 238000005238 degreasing Methods 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- OQLKNTOKMBVBKV-UHFFFAOYSA-N hexamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 OQLKNTOKMBVBKV-UHFFFAOYSA-N 0.000 description 1
- 229960001915 hexamidine Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
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- 235000019645 odor Nutrition 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
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- 229960004889 salicylic acid Drugs 0.000 description 1
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- 230000037307 sensitive skin Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a composition with antipruritic, anti-inflammatory and anti-dandruff functions, which comprises kuh-seng, cinnamon, liquorice and shaddock peel. The invention has the advantages that: the natural medicinal materials of cinnamon, radix sophorae flavescentis, liquorice and shaddock peel with antibacterial, anti-inflammatory, antipruritic and biological activities are selected as raw materials, active substances in the raw materials are fully enriched, and the raw materials are compounded to form the product with the effects of relieving itching, removing dandruff and relieving, so that the trouble of dandruff is solved, the scalp health is promoted, and the hair quality is improved.
Description
Technical Field
The invention belongs to the technical field of daily chemical products, and particularly relates to a composition with itching relieving, anti-inflammatory and anti-dandruff functions and a preparation method thereof.
Background
The attention of human beings to self-images and the pursuit of beauty are increasing the demand of cosmetics, and with the progress of the age and the improvement of human living standard, people are also paying more attention to the effectiveness and safety of cosmetics, and the 'green nature' is the focus of attention of the current cosmetics. Safe and effective natural plant cosmetic raw materials have good competitive advantages in the cosmetic market.
It was found that 60% of adults in china suffer from dandruff to a different extent, and that the problem of dandruff is more common than in the european and american countries. This is mainly caused by the fact that Chinese consumers don't pay attention to the health care of the head skin, bad hygiene habits and the selection of uncomfortable hair care products. Therefore, the consumption of the anti-dandruff product is greatly increased, and the anti-dandruff antipruritic agent adopted by the anti-dandruff shampoo in the domestic market is basically chemical substances (such as ZPT, OCT and the like), but the substances have certain sensitization, irritation and instability.
The shampoo for treating dandruff in the market at present has the principle of bacteriostasis and degreasing. The bactericide added into the anti-dandruff product comprises copper Zinc Pyrithione (ZPT), copper pyrithione ethanolamine salt (OCT), hexamidine bis (isethionate), etc. Three general categories can be distinguished: 1. antifungal agents; 2. the exfoliating agent can effectively remove a certain proportion of keratinocytes and relieve clinical symptoms to a certain extent, and the products comprise coal tar, sulfur and salicylic acid; the long-term application of the product can destroy the epidermis structure, disturb the balance of the epidermis and influence the hair quality; 3. cytostatic agents, which mainly reduce the rate of turnover of the stratum corneum cells, improve the keratinization and desquamation process with the recovery of the circulation cycle length of the stratum corneum, but are highly irritating in the main components, feel rough after use, may cause some cosmetic problems, especially sensitive skin, and have bad odors, etc.
The dandruff-removing itching-relieving hair products extracted from plants or traditional Chinese medicines are also available on the market, but have poor safety, or contain synthetic bacteriostats, so that the skin on the head is easy to be irritated, and the phenomena of itching, redness and the like are generated; still other compositions are dark, heavy and sedimented, and inconvenient to use in cosmetics.
Disclosure of Invention
The invention aims to provide a safe and effective composition with antipruritic, anti-inflammatory and anti-dandruff functions.
In order to achieve the aim of the invention, the invention adopts the following technical scheme: a composition with antipruritic, antiinflammatory and dandruff removing effects comprises radix Sophorae Flavescentis, cortex Cinnamomi, glycyrrhrizae radix and pericarpium Citri Grandis.
From the perspective of the overall concept, the traditional Chinese medicine emphasizes the removal of dandruff and improves the health of scalp so as to achieve the aim of treating both symptoms and root causes. The ecological environment of the head skin is maintained to be balanced and healthy while the vigorous secretion of sebum and abnormal propagation of malassezia are removed. Based on the above considerations, on the basis of classical external formulas and modern pharmacological recognition, sebum secretion is controlled by kuh-seng; the aim of removing dandruff is achieved by cinnamon, radix sophorae flavescentis and shaddock peel with antifungal effect; repairing scalp barrier with Glycyrrhrizae radix; the grapefruit peel is matched to maintain the ecological environment and health balance of the scalp, so that the dandruff problem is fundamentally solved.
Preferably, the composition is prepared from the following raw materials in parts by weight: 1 to 5 parts of kuh-seng, 1 to 5 parts of cinnamon, 1 to 5 parts of liquorice and 1 to 5 parts of shaddock peel.
Preferably, the composition is prepared from the following raw materials in parts by weight: 3 parts of kuh-seng, 3 parts of cinnamon, 2 parts of liquorice and 2 parts of shaddock peel.
The invention also provides a method for preparing the composition, which comprises the following steps: weighing radix Sophorae Flavescentis, cortex Cinnamomi, glycyrrhrizae radix and pericarpium Citri Grandis according to the ratio, adding ethanol, reflux extracting, filtering, and concentrating.
Preferably, the ethanol is ethanol solution with the mass percent concentration of 50-85%; the temperature of the reflux extraction is 80-85 ℃; the times of reflux extraction are 1-5 times, and the time of each reflux extraction is 1-5 hours.
Preferably, the temperature of the concentration is 55-70 ℃; the concentration further comprises a decoloring step.
The invention also provides shampoo containing the composition, which is prepared from the following raw materials in parts by weight: the component A, the component B, the component C, the component D, the component E, the component F and the component G; the component A is a surfactant; the component B is guar hydroxypropyl trimethyl ammonium chloride aqueous solution; the component C comprises polyquaternium-10 aqueous solution; the component D comprises glycerin, a sour bean extract, a Polygonatum kingianum extract, a Gentiana macrophylla extract, the composition and water; the component E is coconut oil fatty acid diethanolamide; the component F is a preservative; the component G is a pH regulator.
Preferably, the surfactant is one of sodium laureth sulfate, cocamidopropyl betaine, coco glucoside or sodium cocoamidopropionate, or a mixture of the sodium laureth sulfate, the cocamidopropyl betaine, the cocoamidoglucoside and the sodium cocoamidopropionate in any proportion; the preservative is selected from one of sodium benzoate or phenoxyethanol or a mixture of the sodium benzoate and the phenoxyethanol in any proportion; the pH regulator is citric acid aqueous solution.
The invention has the following technical advantages:
(1) The composition of the invention is natural, safe and has small irritation.
(2) The composition has light color, light taste and no sediment, and is suitable for adding various cosmetic systems.
(3) The composition of the present invention has antipruritic, anti-inflammatory and anti-dandruff applications in hair products.
Drawings
FIG. 1 is a graph showing inhibition of malassezia by different compositions;
FIG. 2 shows the inhibition of malassezia at different concentrations of composition 4;
FIG. 3 shows the results of a test for cytotoxicity of keratinocytes at various concentrations of composition 4;
FIG. 4 shows the morphological results of keratinocytes at various concentrations of composition 4;
FIG. 5 shows the inhibition of IL-6 by composition 4 at various concentrations;
FIG. 6 shows the inhibition of TNF- α by various concentrations of composition 4.
Detailed Description
The following describes the embodiments of the present invention further with reference to the drawings. The description of these embodiments is provided to assist understanding of the present invention, but is not intended to limit the present invention. In addition, the technical features of the embodiments of the present invention described below may be combined with each other as long as they do not collide with each other.
Example 1
A composition with antipruritic, anti-inflammatory and anti-dandruff functions is prepared from the following raw materials in parts by weight: 3 parts of kuh-seng, 3 parts of cinnamon, 2 parts of liquorice and 2 parts of shaddock peel.
Example 2
A composition with antipruritic, anti-inflammatory and anti-dandruff functions is prepared from the following raw materials in parts by weight: 5 parts of kuh-seng, 5 parts of cinnamon, 1 part of liquorice and 1 part of shaddock peel.
Example 3
A composition with antipruritic, anti-inflammatory and anti-dandruff functions is prepared from the following raw materials in parts by weight: 1 part of kuh-seng, 1 part of cinnamon, 5 parts of liquorice and 5 parts of shaddock peel.
Example 4
A composition with antipruritic, anti-inflammatory and anti-dandruff functions is prepared from the following raw materials in parts by weight: 5 parts of kuh-seng, 5 parts of cinnamon, 5 parts of liquorice and 5 parts of shaddock peel.
Example 5
A composition with antipruritic, anti-inflammatory and anti-dandruff functions is prepared from the following raw materials in parts by weight: 5 parts of kuh-seng, 1 part of cinnamon, 1 part of liquorice and 1 part of shaddock peel.
In order to verify the technical effect of the invention, the following tests are specifically performed:
13 traditional Chinese medicines are selected for different solvent extraction, and screening is carried out on a bacteria inhibition experiment of malassezia.
The experimental method comprises the following steps: because the number of samples is too large, 2 samples in some experiments share one flat plate, and the diameter of the flat plate is 9cm, so that the antibacterial effect (reference positive ZPT effect) is judged to be better when the radius of the antibacterial circle reaches 2 cm.
Screening sample preparation: the 13 Chinese medicines are extracted with water and 75% ethanol solvent respectively for 2 hours, and then filtered, and the filtrate is collected. Concentrating to 1 time of the feeding amount.
The experimental results are shown in Table 1.
TABLE 1
The obtained extract has effects of inhibiting Malassezia (ATCC 44344) and six extracts including cortex Cinnamomi extract (ethanol extract), pericarpium Citri Grandis extract (ethanol extract), fructus Cnidii extract (water extract), radix Sophorae Flavescentis extract (ethanol extract) and radix Sophorae Flavescentis extract (water extract).
Preferably, the experiment results are used for carrying out different combination of the optimized materials on the antibacterial experiment of malassezia
The experimental method comprises the following steps: the oxford cup method is adopted, the diameter of the flat plate is 9cm, so that the antibacterial effect of the antibacterial circle with the radius reaching 2cm is judged to be better (the reference positive ZPT effect).
Test sample: screening composition 1: cinnamon, radix sophorae flavescentis and pomelo peel; screening composition 2: cinnamon, radix sophorae flavescentis and fructus cnidii; screening composition 3: cinnamon, radix sophorae flavescentis, pomelo peel and fructus cnidii.
The experimental results are shown in Table 2.
TABLE 2
From Table 2, it is clear that the composition of cinnamon, radix sophorae flavescentis and shaddock peel has a better effect of inhibiting malassezia. See fig. 1.
A method of preparing a composition of the invention comprising the steps of:
3 parts of radix sophorae flavescentis, 3 parts of cinnamon, 2 parts of liquorice and 2 parts of grapefruit are weighed according to parts by weight and uniformly mixed to obtain a material 1.
Mixing the material 1 obtained in the step with 50-85% ethanol solution, heating and reflux-extracting the material 1 and the ethanol solution for 2 hours at 80-85 ℃ according to the mass-volume ratio of 1:8-1:20, and carrying out vacuum filtration and collecting filtrate. Obtaining a material 2;
injecting the material 2 obtained in the above step into a rotary steaming bottle, rotary steaming at 55-70deg.C to obtain total ethanol to obtain plant extract, decolorizing, filtering, and collecting filtrate to obtain material 3;
the material 3 is added into 1, 3-butanediol for redissolution, so as to obtain the composition 4 which has the effects of relieving itching, resisting inflammation and removing dandruff and is applied to hair products. The obtained composition 4 has light color, light taste, and no precipitate, and is suitable for various cosmetic system compositions.
Safety test:
based on keratinocyte cytotoxicity test results
The MTT assay was performed on keratinocytes at 6 concentrations set for sample composition 4 low to high, and the results are shown in Table 3.
TABLE 3 Table 3
Based on MTT and morphological results, composition 4 was considered to exhibit no cytotoxicity to keratinocytes over a concentration range of 10%. See fig. 3.
Efficacy test:
inhibiting malassezia
The experimental method comprises the following steps: the oxford cup method is adopted, the diameter of the flat plate is 9cm, so that the antibacterial effect of the antibacterial circle with the radius reaching 2cm is judged to be better (the reference positive ZPT effect).
Test sample: 10% composition 4;5% composition 4;3% composition 4
The experimental results are shown in table 4 and fig. 2.
TABLE 4 Table 4
As can be seen from table 4, composition 4 has an efficacy of inhibiting malassezia and a limited concentration is 3-10%.
Anti-inflammatory test:
the results of the IL-6 inflammatory factor test are shown in Table 5 and FIG. 5.
TABLE 5
The positive control and experimental groups showed significantly higher IL-6 secretion (# # P < 0.001) after LPS stimulation (NC) than the negative control group (BC), the positive control group and experimental group showed significantly lower IL-6 concentration than NC, the positive control pomalidomide showed significantly lower IL-6 secretion (P < 0.001) at 200nM concentration, and the different compositions 4 showed significantly lower/inhibited IL-6 secretion, and the inhibition of IL-6 increased with increasing sample concentration.
The results of the TNF- α inflammatory factor test are shown in Table 6 and FIG. 6.
TABLE 6
As can be seen from Table 6, the secretion of TNF-. Alpha.was significantly increased after LPS stimulation (NC group) as compared with the negative control group (BC) ### P < 0.001), the concentration of TNF-alpha in the positive control group and the experimental group is obviously lower than that in the NC group, and the positive control medicine pomalidomide obviously inhibits the secretion of TNF-alpha under the concentration of 500nM ** P＜0.01， * P < 0.05), the gentiana macrophylla extract with different concentrations can obviously reduce/inhibit the secretion of TNF-alpha, and the inhibition effect of TNF-alpha increases with the increase of the concentration of the sample.
The invention also provides application of the composition in cosmetics with antipruritic, anti-inflammatory and anti-dandruff effects. The formulation of the anti-dandruff and refreshing shampoo is shown in Table 7.
TABLE 7
The anti-dandruff refreshing shampoo obtained from the table 7 has obvious effects of relieving itching, resisting inflammation and removing dandruff after being used by suitable people.
The embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, and yet fall within the scope of the invention.
Claims (3)
1. A composition having antipruritic, anti-inflammatory and antidandruff properties, characterized in that: the composition is prepared from the following raw materials in parts by weight: 3 parts of kuh-seng, 3 parts of cinnamon, 2 parts of liquorice and 2 parts of shaddock peel;
the method of preparing the composition comprises the steps of: weighing radix Sophorae Flavescentis, cortex Cinnamomi, glycyrrhrizae radix and pericarpium Citri Grandis according to the ratio, adding ethanol, reflux extracting, filtering, concentrating, and decolorizing to obtain the final product;
the mass percentage concentration of the ethanol is 50-85% of ethanol solution; the temperature of the reflux extraction is 80-85 ℃; the times of reflux extraction are 1-5 times, and the time of each reflux extraction is 1-5 hours; the temperature of the concentration is 55-70 ℃.
2. A shampoo comprising the composition of claim 1, characterized by: the shampoo is prepared from the following raw materials in parts by weight: the component A, the component B, the component C, the component D, the component E, the component F and the component G; the component A is a surfactant; the component B is guar hydroxypropyl trimethyl ammonium chloride aqueous solution; the component C comprises polyquaternium-10 aqueous solution; the component D comprises glycerin, a sour bean extract, a Polygonatum kingianum extract, a Gentiana macrophylla extract, the composition and water; the component E is coconut oil fatty acid diethanolamide; the component F is a preservative; the component G is a pH regulator.
3. The shampoo of claim 2, wherein: the surfactant is one of sodium laureth sulfate, cocamidopropyl betaine, coco glucoside or sodium cocoamidopropionate or a mixture of the two in any proportion; the preservative is selected from one of sodium benzoate or phenoxyethanol or a mixture of the sodium benzoate and the phenoxyethanol in any proportion; the pH regulator is citric acid aqueous solution.
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| CN105310915A (en) * | 2014-06-29 | 2016-02-10 | 王岚 | Hair-growth shampoo and preparation method thereof |
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| CN108969420A (en) * | 2018-09-03 | 2018-12-11 | 邵传冲 | A kind of antidandruff and antipruritic shampoo and preparation method thereof containing sophora flavescens ait extracting solution |
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