CN112587460A - A composition with antipruritic, antiinflammatory and dandruff removing effects, and its preparation method - Google Patents
A composition with antipruritic, antiinflammatory and dandruff removing effects, and its preparation method Download PDFInfo
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- CN112587460A CN112587460A CN202011632996.XA CN202011632996A CN112587460A CN 112587460 A CN112587460 A CN 112587460A CN 202011632996 A CN202011632996 A CN 202011632996A CN 112587460 A CN112587460 A CN 112587460A
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- sophorae flavescentis
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- 208000001840 Dandruff Diseases 0.000 title claims abstract description 31
- 230000000694 effects Effects 0.000 title claims abstract description 17
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 11
- 230000001139 anti-pruritic effect Effects 0.000 title claims description 8
- 239000003908 antipruritic agent Substances 0.000 title claims description 8
- 238000002360 preparation method Methods 0.000 title claims description 7
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
Abstract
The invention discloses a composition with itching relieving, anti-inflammatory and dandruff removing functions, which comprises lightyellow sophora root, cassia bark, liquorice and shaddock peel. The invention has the advantages that: the natural medicinal materials with bacteriostatic, anti-inflammatory, itching relieving and soothing biological activities, namely cinnamon, radix sophorae flavescentis, liquorice and shaddock peel, are selected as raw materials, active substances in the raw materials are fully enriched, and the product with the effects of relieving itching, removing dandruff and soothing is compounded, so that the trouble of dandruff is solved, the scalp health is promoted, and the hair quality is improved.
Description
Technical Field
The invention belongs to the technical field of daily chemical articles, and particularly relates to a composition with itching relieving, anti-inflammatory and dandruff removing functions and a preparation method thereof.
Background
The human attention to self image and the pursuit of beauty make the demand of cosmetics increasingly increase, and with the progress of the times and the improvement of the living standard of human beings, people also pay more and more attention to the effectiveness and safety of cosmetics, and 'green and natural' is the focus of attention of current cosmetics. The safe and effective natural plant cosmetic raw materials have good competitive advantages in the cosmetic market.
Studies have found that in china, 60% of adults suffer to varying degrees from dandruff, a problem that is more prevalent than in the european and american countries. This is mainly due to the fact that Chinese consumers do not pay attention to head skin care, bad hygiene habits and the selection of uncomfortable hair washing and care products. Therefore, the consumption of anti-dandruff products is increased, and the existing anti-dandruff antipruritic in the anti-dandruff shampoo in the domestic market is basically chemical substances (such as ZPT, OCT and the like), but the substances have certain sensitization, irritation and instability.
The principle of the shampoo products for treating dandruff on the market at present lies in bacteriostasis and degreasing. The bactericide added in the dandruff removing product comprises copper Zinc Pyrithione (ZPT), copper ethanolamine pyridinium (OCT), hexamidine di (isethionic acid) salt, etc. Roughly classified into three categories: 1. an antifungal agent; 2. a keratolytic agent which is capable of effectively removing a certain proportion of keratocytes, and relieving clinical symptoms to a certain extent, such products including coal tar, thioflavin and salicylic acid; the long-term application of the product can damage the epidermal structure, disturb the self balance of the epidermis and influence the hair quality; 3. cytostatic agents, which mainly reduce the rate of replacement of the cells of the stratum corneum, improve the processes of keratinization and desquamation with the recovery of the length of the circulation cycle of the stratum corneum, but have a strong irritant effect on the main components, leave the hair feeling thick after use, may also cause cosmetic problems, in particular sensitive skin, and may have off-flavors and the like.
There are also dandruff-removing and itching-relieving hair products extracted from plants or traditional Chinese medicines in the market, but some products have poor safety, or contain synthetic bacteriostatic agents, and easily generate irritation to the head skin, and generate phenomena such as pruritus, red swelling and the like; still other compositions are dark in color, heavy in taste and highly precipitated, and are not convenient for use in cosmetics.
Disclosure of Invention
The invention aims to provide a safe and effective composition with the functions of relieving itching, resisting inflammation and removing dandruff.
In order to achieve the purpose of the invention, the technical scheme adopted by the invention is as follows: a composition with antipruritic, antiinflammatory and antidandruff effects comprises radix Sophorae Flavescentis, cortex Cinnamomi, Glycyrrhrizae radix and pericarpium Citri Grandis.
From the perspective of holism, the traditional Chinese medicine emphasizes that the scurf is removed, and simultaneously, the scalp health is improved, so that the aim of treating both symptoms and root causes is achieved. The healthy head skin ecological environment is maintained while the exuberant sebum secretion and the abnormal malassezia reproduction are removed. Based on the consideration, on the basis of the classical external preparation and modern pharmacological knowledge, the sophora flavescens is used for controlling sebum secretion; cinnamon, radix sophorae flavescentis and shaddock peel with antifungal effect are used for achieving the purpose of removing dandruff; repairing scalp barrier with Glycyrrhrizae radix; the shaddock peel is added to maintain the healthy and balanced scalp ecological environment, so that the scurf problem is fundamentally solved.
Preferably, the composition is prepared from the following raw materials in parts by weight: 1-5 parts of radix sophorae flavescentis, 1-5 parts of cinnamon, 1-5 parts of liquorice and 1-5 parts of shaddock peel.
Preferably, the composition is prepared from the following raw materials in parts by weight: 3 parts of radix sophorae flavescentis, 3 parts of cinnamon, 2 parts of liquorice and 2 parts of shaddock peel.
The present invention also provides a method for preparing the composition, comprising the steps of: weighing radix Sophorae Flavescentis, cortex Cinnamomi, Glycyrrhrizae radix and pericarpium Citri Grandis, extracting with ethanol under reflux, filtering, and concentrating.
Preferably, the ethanol solution with the mass percentage concentration of 50-85 percent; the temperature of the reflux extraction is 80-85 ℃; the reflux extraction frequency is 1-5 times, and the reflux extraction time is 1-5 hours each time.
Preferably, the concentration temperature is 55-70 ℃; the concentration also comprises a decolorization step.
The invention also provides shampoo containing the composition, which is prepared from the following raw materials in parts by weight: the component A, the component B, the component C, the component D, the component E, the component F and the component G; the component A is a surfactant; the component B is guar gum hydroxypropyl trimethyl ammonium chloride aqueous solution; the component C comprises a polyquaternium-10 aqueous solution; the component D comprises glycerin, sour bean seed extract, polygonatum kingianum extract, gentiana macrophylla extract, the composition and water; the component E is coconut oil fatty acid diethanolamide; the component F is a preservative; the component G is a pH regulator.
Preferably, the surfactant is one of sodium laureth sulfate, cocamidopropyl betaine, coco glucoside or sodium cocamidopropionate, or a mixture of the sodium laureth sulfate, the cocoamidopropyl betaine, the coco glucoside and the sodium cocamidopropionate in any proportion; the preservative is selected from one of sodium benzoate or phenoxyethanol, or a mixture of the sodium benzoate and the phenoxyethanol in any proportion; the pH regulator is citric acid aqueous solution.
The invention has the following technical advantages:
(1) the composition is natural and safe, and has small irritation.
(2) The composition of the invention has light color, light taste and no sediment, and is suitable for being added into various cosmetic systems.
(3) The compositions of the present invention have antipruritic, anti-inflammatory and anti-dandruff applications in hair products.
Drawings
FIG. 1 is a graph of the inhibition of malassezia by different compositions;
FIG. 2 shows the inhibition of Malassezia by composition 4 at various concentrations;
FIG. 3 shows the results of the assay for keratinocyte cytotoxicity at various concentrations of composition 4;
FIG. 4 shows the morphological results of keratinocytes formed at various concentrations of composition 4;
FIG. 5 shows the inhibition of IL-6 by different concentrations of composition 4;
FIG. 6 is a graph of the inhibition of TNF- α by various concentrations of composition 4.
Detailed Description
The following further describes embodiments of the present invention with reference to the drawings. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1
The composition with the functions of relieving itching, resisting inflammation and removing dandruff is prepared from the following raw materials in parts by weight: 3 parts of radix sophorae flavescentis, 3 parts of cinnamon, 2 parts of liquorice and 2 parts of shaddock peel.
Example 2
The composition with the functions of relieving itching, resisting inflammation and removing dandruff is prepared from the following raw materials in parts by weight: 5 parts of radix sophorae flavescentis, 5 parts of cinnamon, 1 part of liquorice and 1 part of shaddock peel.
Example 3
The composition with the functions of relieving itching, resisting inflammation and removing dandruff is prepared from the following raw materials in parts by weight: 1 part of radix sophorae flavescentis, 1 part of cinnamon, 5 parts of liquorice and 5 parts of shaddock peel.
Example 4
The composition with the functions of relieving itching, resisting inflammation and removing dandruff is prepared from the following raw materials in parts by weight: 5 parts of sophora flavescens, 5 parts of cinnamon, 5 parts of liquorice and 5 parts of shaddock peel.
Example 5
The composition with the functions of relieving itching, resisting inflammation and removing dandruff is prepared from the following raw materials in parts by weight: 5 parts of sophora flavescens, 1 part of cinnamon, 1 part of liquorice and 1 part of shaddock peel.
In order to verify the technical effect of the invention, the following tests are specially carried out:
selecting 13 Chinese medicinal materials and different solvents for extraction, and screening the malassezia bacteriostasis experiment.
The experimental method comprises the following steps: as the number of samples is too many, 2 samples in part of experiments share one flat plate, and the diameter of the flat plate is 9cm, the bacteriostatic effect is judged to be better when the radius of the bacteriostatic zone reaches 2cm (refer to the positive ZPT effect).
Preparation of a screening sample: extracting the 13 Chinese medicinal materials with water and 75% ethanol for 2 hr, filtering, and collecting filtrate. Concentrating to 1 time of the feed amount to obtain the product.
The results are shown in Table 1.
TABLE 1
The obtained extract for inhibiting Malassezia (ATCC44344) has effects of inhibiting Malassezia by six extracts including cortex Cinnamomi extract (ethanol extraction), pericarpium Citri Grandis extract (ethanol extraction), fructus Cnidii extract (water extraction), radix Sophorae Flavescentis extract (ethanol extraction), and radix Sophorae Flavescentis extract (water extraction).
The experiment results are optimized, and different combinations of the optimized materials are used for carrying out the bacteriostasis experiment on the malassezia
The experimental method comprises the following steps: the diameter of the flat plate is 9cm by an oxford cup method, so that the bacteriostatic effect is judged to be better when the radius of the bacteriostatic zone reaches 2cm (refer to positive ZPT effect).
Test samples: screening composition 1: cinnamon, sophora flavescens, pomelo peel; screening composition 2: cinnamon, radix sophorae flavescentis and fructus cnidii; screening composition 3: cinnamon, radix sophorae flavescentis, pomelo peel and fructus cnidii.
The results are shown in Table 2.
TABLE 2
As can be seen from table 2, the composition of cinnamon, sophora flavescens and grapefruit peel has a better efficacy of inhibiting malassezia. See fig. 1.
A method of preparing a composition of the invention comprising the steps of:
weighing 3 parts of radix sophorae flavescentis, 3 parts of cinnamon, 2 parts of liquorice and 2 parts of grapefruit and uniformly mixing to obtain a material 1.
Mixing the material 1 obtained in the above steps with 50-85% ethanol solution, heating and refluxing at 80-85 deg.C for 2h, vacuum filtering, and collecting filtrate, wherein the mass volume ratio of the material 1 to the ethanol solution is 1:8-1: 20. Obtaining a material 2;
injecting the material 2 obtained in the above step into a rotary steaming bottle, rotary steaming all ethanol at 55-70 deg.C to obtain plant extract, decolorizing, filtering, and collecting filtrate to obtain material 3;
adding the material 3 into 1, 3-butanediol for redissolving to obtain a composition 4 which has the effects of relieving itching, resisting inflammation and removing dandruff and is applied to hair. The obtained composition 4 has light color, light taste, and no precipitate, and is suitable for various cosmetic system compositions.
And (3) safety testing:
based on the results of keratinocyte toxicity assays
The sample composition 4 was set at 6 concentrations low to high and MTT assay was performed on keratinocytes, the results of which are shown in table 3.
TABLE 3
From the MTT and morphological results, composition 4 was considered to exhibit no cytotoxicity to keratinocytes at a concentration range of 10%. See fig. 3.
And (3) testing the efficacy:
inhibiting malassezia
The experimental method comprises the following steps: the diameter of the flat plate is 9cm by an oxford cup method, so that the bacteriostatic effect is judged to be better when the radius of the bacteriostatic zone reaches 2cm (refer to positive ZPT effect).
Test samples: 10% composition 4; 5% composition 4; 3% composition 4
The results are shown in table 4 and fig. 2.
TABLE 4
As can be seen from Table 4, composition 4 had efficacy against Malassezia and the limiting concentration was 3-10%.
Anti-inflammatory testing:
the results of the IL-6 inflammatory factor assay are shown in Table 5 and FIG. 5.
TABLE 5
Compared with a negative control group (BC), the IL-6 secretion amount after LPS stimulation (NC group) is obviously increased (# # # P < 0.001), the IL-6 concentration of the positive control group and the experimental group is obviously lower than that of the NC group, the secretion of IL-6 is obviously inhibited at the concentration of 200nM of the positive control drug pomalidomide (# # P < 0.001), the secretion of IL-6 can be obviously reduced/inhibited by different compositions 4, and the inhibition effect of IL-6 is increased along with the increase of the sample concentration.
The results of the TNF- α inflammatory factor assay are shown in Table 6 and FIG. 6.
TABLE 6
As can be seen from Table 6, TNF-. alpha.secretion was significantly increased after LPS stimulation (NC group) as compared with that of negative control group (BC) ((###P is less than 0.001), the concentration of TNF-alpha of the positive control group and the experimental group is obviously lower than that of the NC group, and the positive control drug pomalidomide obviously inhibits the secretion of TNF-alpha at the concentration of 500nM (**P＜0.01，*P is less than 0.05), the gentiana macrophylla extract with different concentrations can obviously reduce/inhibit the secretion of TNF-alpha, and the inhibition effect of the TNF-alpha is increased along with the increase of the concentration of the sample.
The invention also provides application of the composition in cosmetics with the effects of relieving itching, resisting inflammation and removing dandruff. The formulation of the anti-dandruff comfortable shampoo is shown in table 7.
TABLE 7
After being tried by suitable people, the anti-dandruff comfortable shampoo obtained from the table 7 has obvious effects of relieving itching, resisting inflammation and removing dandruff.
The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.
Claims (8)
1. A composition with antipruritic, anti-inflammatory and anti-dandruff effects, comprising: comprises radix Sophorae Flavescentis, cortex Cinnamomi, Glycyrrhrizae radix and pericarpium Citri Grandis.
2. The composition with antipruritic, anti-inflammatory and anti-dandruff effects according to claim 1, wherein: the composition is prepared from the following raw materials in parts by weight: 1-5 parts of radix sophorae flavescentis, 1-5 parts of cinnamon, 1-5 parts of liquorice and 1-5 parts of shaddock peel.
3. The composition with antipruritic, anti-inflammatory and anti-dandruff effects according to claim 2, wherein: the composition is prepared from the following raw materials in parts by weight: 3 parts of radix sophorae flavescentis, 3 parts of cinnamon, 2 parts of liquorice and 2 parts of shaddock peel.
4. A process for preparing the composition of any one of claims 1 to 3, characterized in that: the method comprises the following steps: weighing radix Sophorae Flavescentis, cortex Cinnamomi, Glycyrrhrizae radix and pericarpium Citri Grandis, extracting with ethanol under reflux, filtering, and concentrating.
5. The method of preparation according to claim 4, characterized in that: the ethanol solution with the mass percentage concentration of 50-85 percent; the temperature of the reflux extraction is 80-85 ℃; the reflux extraction frequency is 1-5 times, and the reflux extraction time is 1-5 hours each time.
6. The method of preparation according to claim 4, characterized in that: the concentration temperature is 55-70 ℃; the concentration also comprises a decolorization step.
7. A shampoo containing the composition of any of claims 1-3, characterized by: the shampoo is prepared from the following raw materials in parts by weight: the component A, the component B, the component C, the component D, the component E, the component F and the component G; the component A is a surfactant; the component B is guar gum hydroxypropyl trimethyl ammonium chloride aqueous solution; the component C comprises a polyquaternium-10 aqueous solution; the component D comprises glycerin, sour bean seed extract, polygonatum kingianum extract, gentiana macrophylla extract, the composition and water; the component E is coconut oil fatty acid diethanolamide; the component F is a preservative; the component G is a pH regulator.
8. Shampoo according to claim 7, characterised in that: the surfactant is one of sodium laureth sulfate, cocamidopropyl betaine, coco glucoside or sodium cocamidopropionate or a mixture of the sodium laureth sulfate, the cocoamidopropyl betaine, the coco glucoside and the sodium cocamidopropionate in any proportion; the preservative is selected from one of sodium benzoate or phenoxyethanol, or a mixture of the sodium benzoate and the phenoxyethanol in any proportion; the pH regulator is citric acid aqueous solution.
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| CN105310915A (en) * | 2014-06-29 | 2016-02-10 | 王岚 | Hair-growth shampoo and preparation method thereof |
| CN106726850A (en) * | 2015-11-20 | 2017-05-31 | 赖婷婷 | A kind of shaddock shampoo |
| CN108969420A (en) * | 2018-09-03 | 2018-12-11 | 邵传冲 | A kind of antidandruff and antipruritic shampoo and preparation method thereof containing sophora flavescens ait extracting solution |
| CN109172633A (en) * | 2018-10-19 | 2019-01-11 | 中国科学院西北高原生物研究所 | A kind of Radix Gentianae Macrophyllae extract and the preparation method and application thereof |
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