JPH0588228B2 - - Google Patents

Info

Publication number
JPH0588228B2
JPH0588228B2 JP60022821A JP2282185A JPH0588228B2 JP H0588228 B2 JPH0588228 B2 JP H0588228B2 JP 60022821 A JP60022821 A JP 60022821A JP 2282185 A JP2282185 A JP 2282185A JP H0588228 B2 JPH0588228 B2 JP H0588228B2
Authority
JP
Japan
Prior art keywords
sulfamoylbenzo
furan
alkyl
formula
freel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60022821A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60184074A (ja
Inventor
Eru Shepaado Kenesu
Eru Gurahamu Samyueru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS60184074A publication Critical patent/JPS60184074A/ja
Publication of JPH0588228B2 publication Critical patent/JPH0588228B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
JP60022821A 1984-02-09 1985-02-09 上昇した眼内圧の治療用の２‐スルフアモイルベンゾ〔ｂ〕フラン誘導体 Granted JPS60184074A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US578463 1984-02-09
US06/578,463 US4544667A (en) 1984-02-09 1984-02-09 2-Sulfamoylbenzo[b]furan derivatives for the treatment of elevated intraocular pressure

Publications (2)

Publication Number Publication Date
JPS60184074A JPS60184074A (ja) 1985-09-19
JPH0588228B2 true JPH0588228B2 (OSRAM) 1993-12-21

Family

ID=24312989

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60022821A Granted JPS60184074A (ja) 1984-02-09 1985-02-09 上昇した眼内圧の治療用の２‐スルフアモイルベンゾ〔ｂ〕フラン誘導体

Country Status (4)

Country Link
US (1) US4544667A (OSRAM)
EP (1) EP0152340B1 (OSRAM)
JP (1) JPS60184074A (OSRAM)
DE (1) DE3570076D1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6163671A (ja) * 1984-09-05 1986-04-01 Shionogi & Co Ltd ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤
ATE41002T1 (de) * 1984-12-12 1989-03-15 Merck & Co Inc Substituierte aromatische sulfonamide, ihre herstellung und diese enthaltende ophthalmische zubereitungen.
JPS62155269A (ja) * 1984-12-29 1987-07-10 Kaken Pharmaceut Co Ltd ベンゾフラン誘導体
EP0271273A3 (en) * 1986-12-08 1989-07-12 Merck & Co. Inc. Thieno-and furopyridine sulfonamides
US4731368A (en) * 1986-12-08 1988-03-15 Merck & Co., Inc. Thienopyridine sulfonamides and their ophthalmological formulation
US4808595A (en) * 1986-12-24 1989-02-28 Merck & Co., Inc. Furopyridine sulfonamides and their opthalmological compositions
US4914111A (en) * 1987-03-23 1990-04-03 Merck & Co., Inc. 4-Benzylthiophene (or furan)-2-sulfonamides as antiglaucoma agents
EP0309028A3 (en) * 1987-09-16 1990-06-27 Merck & Co. Inc. Substituted thieno(2,3-b)furan-2-sulfonamides as antiglaucoma agents
US5300499A (en) * 1992-09-02 1994-04-05 Allergan, Inc. 5-substituted 3-thiophene sulfonamides as antiglaucoma agents
US5519040A (en) * 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
CN105085450A (zh) * 2015-09-14 2015-11-25 中国药科大学 苯并呋喃类衍生物、其制备方法及其治疗作用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391627A (en) * 1980-07-25 1983-07-05 E. I. Du Pont De Nemours And Company Herbicidal benzothiophene and benzofuran sulfonamides
AR241136A1 (es) * 1981-07-13 1991-11-29 Merck E Co Inc Procedimiento para preparar esteres de 6-hidroxi-2-benzotiazolsulfonamida para tratamiento topicode presion intraocular elevada"
US4416890A (en) * 1981-07-13 1983-11-22 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
BR8204028A (pt) * 1981-07-16 1983-07-05 Du Pont Composto herbicida composicao adequada e processo para controlar o crescimento de vegetacao indesejada
US4386098A (en) * 1981-11-03 1983-05-31 Merck & Co., Inc. 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
US4426388A (en) * 1982-04-02 1984-01-17 Merck & Co., Inc. 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure

Also Published As

Publication number Publication date
DE3570076D1 (en) 1989-06-15
EP0152340A1 (en) 1985-08-21
EP0152340B1 (en) 1989-05-10
JPS60184074A (ja) 1985-09-19
US4544667A (en) 1985-10-01

Similar Documents

Publication Publication Date Title
US4668697A (en) Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
US4847289A (en) Thiophene sulfonamide antiglaucoma agents
JPH0588228B2 (OSRAM)
KR890000386B1 (ko) 2-설파모일벤조[b]티오펜 유도체 및 이의 제조방법
US4840963A (en) 2-Sulfamoyl-1H-indole derivatives for the treatment of elevated intraocular pressure
US4678855A (en) Substituted benzenesulfonamides
US5538966A (en) Carbonic anhydrase inhibitors
US4665090A (en) Substituted thiophene-2-sulfonamide antiglaucoma agents
JPS62158273A (ja) 置換チオフエン−２−スルホンアミド抗緑内障剤
JPH04330078A (ja) 抗緑内障剤としての置換チエノ［２，３−ｂ］［１，４］チアジン−６−スルホンアミド類
US4788192A (en) 2-Sulfamoylbenzo(b)thiophene derivatives pharmaceutical compositions and use
JPH0219837B2 (OSRAM)
EP0182691B1 (en) Substituted thiophene-2-sulfonamides and their preparation
US4803286A (en) Amino-2-hydroxypropyloximinoheterocycle α-blockers
US4505923A (en) Ethers of hydroxybenzothiazole-2-sulfonamide for the topical treatment of elevated intraocular pressure
JPH064636B2 (ja) 抗緑内障剤としての置換チエノ〔２，３‐ｂ〕チオフエン−２−スルホンアミド類
US4798831A (en) Substituted thieno[2,3-B]furan-2-sulfonamides as antiglaucoma agents
US4721794A (en) Substituted thiophene-2-sulfonamide antiglaucoma agents
EP0268396B1 (en) 4-(benzoyl)thiophene(or furan)-sulfonamide and derivatives thereof for the topical treatment of elevated intraocular pressures
EP0155214B1 (en) 2-sulfamoyl-1h-indole derivatives for the treatment of elevated intraocular pressure
JPH01110686A (ja) 抗緑内障剤としての置換チエノ〔２，３‐ｂ〕フラン―２―スルホンアミド類
JPH0971562A (ja) チオカルバミン酸誘導体