JPH0569113B2 - - Google Patents
Info
- Publication number
- JPH0569113B2 JPH0569113B2 JP1146186A JP1146186A JPH0569113B2 JP H0569113 B2 JPH0569113 B2 JP H0569113B2 JP 1146186 A JP1146186 A JP 1146186A JP 1146186 A JP1146186 A JP 1146186A JP H0569113 B2 JPH0569113 B2 JP H0569113B2
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- platinum
- aminomethylaziridine
- water
- dichloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 17
- 229910052697 platinum Inorganic materials 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 6
- 230000000259 anti-tumor effect Effects 0.000 description 6
- AEXCVBXGIHNPIK-UHFFFAOYSA-N aziridin-2-ylmethanamine Chemical compound NCC1CN1 AEXCVBXGIHNPIK-UHFFFAOYSA-N 0.000 description 6
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 201000009030 Carcinoma Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229960004316 cisplatin Drugs 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 150000003057 platinum Chemical class 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010029155 Nephropathy toxic Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000005917 in vivo anti-tumor Effects 0.000 description 1
- 230000007694 nephrotoxicity Effects 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60-8383 | 1985-01-22 | ||
| JP838385 | 1985-01-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61267595A JPS61267595A (ja) | 1986-11-27 |
| JPH0569113B2 true JPH0569113B2 (no) | 1993-09-30 |
Family
ID=11691693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61011461A Granted JPS61267595A (ja) | 1985-01-22 | 1986-01-22 | 新規白金錯体 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61267595A (no) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH093711A (ja) * | 1995-06-16 | 1997-01-07 | Nagai Emiko | 長袖部肩部襟部開閉衣類 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6310724A (ja) * | 1986-03-11 | 1988-01-18 | Chugai Pharmaceut Co Ltd | 新規白金錯体を有効成分として含有する制癌剤 |
| JPS6310725A (ja) * | 1986-03-11 | 1988-01-18 | Chugai Pharmaceut Co Ltd | 新規白金錯体化合物を有効成分として含有する制癌剤 |
-
1986
- 1986-01-22 JP JP61011461A patent/JPS61267595A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH093711A (ja) * | 1995-06-16 | 1997-01-07 | Nagai Emiko | 長袖部肩部襟部開閉衣類 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61267595A (ja) | 1986-11-27 |
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