JPH0560455B2 - - Google Patents

Info

Publication number
JPH0560455B2
JPH0560455B2 JP60183768A JP18376885A JPH0560455B2 JP H0560455 B2 JPH0560455 B2 JP H0560455B2 JP 60183768 A JP60183768 A JP 60183768A JP 18376885 A JP18376885 A JP 18376885A JP H0560455 B2 JPH0560455 B2 JP H0560455B2
Authority
JP
Japan
Prior art keywords
aminophenyl
piperazino
mice
alkyl
crl41153
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60183768A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6183149A (ja
Inventor
Rui Rafuon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of JPS6183149A publication Critical patent/JPS6183149A/ja
Publication of JPH0560455B2 publication Critical patent/JPH0560455B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
JP60183768A 1984-08-20 1985-08-20 １―（アミノフェニル）―２―アミノプロパノン誘導体及びこれを含むうつ病治療用組成物並びにその製造方法 Granted JPS6183149A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8412962 1984-08-20
FR8412962A FR2569184A1 (fr) 1984-08-20 1984-08-20 Derives de 1-(aminophenyl) therapeutique et leur procede de preparation

Publications (2)

Publication Number Publication Date
JPS6183149A JPS6183149A (ja) 1986-04-26
JPH0560455B2 true JPH0560455B2 (en, 2012) 1993-09-02

Family

ID=9307106

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60183768A Granted JPS6183149A (ja) 1984-08-20 1985-08-20 １―（アミノフェニル）―２―アミノプロパノン誘導体及びこれを含むうつ病治療用組成物並びにその製造方法

Country Status (15)

Country Link
US (1) US4980377A (en, 2012)
EP (1) EP0174242B1 (en, 2012)
JP (1) JPS6183149A (en, 2012)
AT (1) ATE31915T1 (en, 2012)
AU (1) AU576886B2 (en, 2012)
CA (1) CA1240993A (en, 2012)
DE (1) DE3561391D1 (en, 2012)
DK (1) DK378685A (en, 2012)
ES (1) ES8604856A1 (en, 2012)
FR (1) FR2569184A1 (en, 2012)
GR (1) GR851997B (en, 2012)
IE (1) IE58214B1 (en, 2012)
NZ (1) NZ213097A (en, 2012)
PT (1) PT80991B (en, 2012)
ZA (1) ZA856149B (en, 2012)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1250838A (fr) * 1983-10-14 1989-03-07 Louis Lafon Procede de preparation de derives de 1-(acetylaminophenyl)-2-amino-propanone et les derives ainsi obtenus
US5236922A (en) * 1984-08-20 1993-08-17 Laboratoire L. Lafon Method for treating depression using 1-(aminophenyl)-2-aminopropanone derivatives
FR2626879B1 (fr) * 1988-02-10 1990-06-08 Lafon Labor Derives de 1-(aminophenyl)-2-(n-2-hydroxyethylamino)-propanone, procede de preparation et utilisation en therapeutique
FR2626878B1 (fr) * 1988-02-10 1990-06-08 Lafon Labor Derives de 1-(aminophenyl)-2-dimethylaminopropanone, procede de preparation et utilisation en therapeutique
FR2626881B1 (fr) * 1988-02-10 1990-07-27 Lafon Labor 1-(4-aminophenyl)-2-hexamethyleneiminopropanone, procede de preparation et utilisation en therapeutique
FR2653767B1 (fr) * 1989-10-30 1992-02-14 Lafon Labor Derives de 1-(aminophenyl)-2-piperidinopropanone, procede et utilisation en therapeutique.
US5132457A (en) * 1991-08-26 1992-07-21 Mallinckrodt Specialty Chemicals Company Stereospecific synthesis of 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP)
US5162566A (en) * 1991-08-26 1992-11-10 Mallinckrodt Specialty Chemicals Company Stereospecific synthesis of tetrasubstituted acrylic esters
US6150420A (en) * 1998-06-01 2000-11-21 Theramax, Inc. Method for enhanced brain delivery of bupropion
EP2474308A1 (en) * 2005-06-27 2012-07-11 Valeant International (Barbados) SRL Pharmaceutical formulations containing bupropion hydrobromide
AU2010236404B2 (en) * 2009-04-15 2016-11-03 Research Triangle Institute Monoamine reuptake inhibitors
WO2011146821A2 (en) 2010-05-21 2011-11-24 Research Triangle Institute 1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA658735A (en) * 1963-03-05 Parke, Davis And Company Isobutyrophenone compounds and their production by reaction of epoxy ethers with alkylamines
US2128255A (en) * 1934-12-22 1938-08-30 Gen Aniline Works Inc Azo dyestuffs
GB785988A (en) * 1954-05-03 1957-11-06 Du Pont Basic monoazo dyes of the benzene-azo-benzene series
DE1618005A1 (de) * 1966-09-22 1971-09-09 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen Amino-dihalogen-phenyl-aethylaminen
DE1618007A1 (de) * 1967-05-09 1970-10-29 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen Amino-monohalogenphenylaethanolaminen
GB1262965A (en) * 1969-03-21 1972-02-09 Ferrosan As Butyrophenones
BE759838A (fr) * 1969-12-04 1971-06-03 Wellcome Found Cetones a activite biologique
US4119710A (en) * 1972-12-18 1978-10-10 Boehringer Ingelheim Gmbh Bronchospasmolytic 1-(p-amino-phenyl)-2-amino-ethanols-(1) and salts
US4282206A (en) * 1979-11-15 1981-08-04 Westwood Pharmaceuticals Inc. Method of protecting human skin from ultraviolet radiation
US4393078A (en) * 1982-03-15 1983-07-12 Burroughs Wellcome Co. Bupropion and ethanol
CA1250838A (fr) * 1983-10-14 1989-03-07 Louis Lafon Procede de preparation de derives de 1-(acetylaminophenyl)-2-amino-propanone et les derives ainsi obtenus
EP0171227B1 (en) * 1984-07-25 1988-11-02 The Wellcome Foundation Limited Use of propiophenone compound
DE3508398A1 (de) * 1985-03-08 1986-11-06 Hoechst Ag, 6230 Frankfurt Fungizide mittel auf der basis von 3-(hetero)-arylpropylaminen sowie neue (hetero)-aryl-propylamine und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DK378685D0 (da) 1985-08-20
DE3561391D1 (en) 1988-02-18
EP0174242A2 (fr) 1986-03-12
FR2569184A1 (fr) 1986-02-21
JPS6183149A (ja) 1986-04-26
IE58214B1 (en) 1993-08-11
IE851984L (en) 1986-02-20
GR851997B (en, 2012) 1985-12-17
DK378685A (da) 1986-02-21
PT80991B (pt) 1987-09-30
ES546857A0 (es) 1986-03-01
ATE31915T1 (de) 1988-01-15
ZA856149B (en) 1986-04-30
NZ213097A (en) 1988-03-30
EP0174242B1 (fr) 1988-01-13
AU576886B2 (en) 1988-09-08
AU4646585A (en) 1986-02-27
ES8604856A1 (es) 1986-03-01
CA1240993A (en) 1988-08-23
EP0174242A3 (en) 1986-03-26
US4980377A (en) 1990-12-25
PT80991A (fr) 1985-09-01

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